The Ricin Letters: Is it Terrorism?

(image via NCTC)

UPDATE: All charges have been dropped against Curtis, and he has subsequently been released.

The Background

The mailing of three letters containing ricin to Senator Roger Wicker, President Obama, and a Mississippi judge rocked the nation last week.  As developments in the case continue,  Paul Kevin Curtis, a Mississippi Elvis impersonator, has emerged as the leading suspect. Curtis was arrested last Wednesday, and appeared in a court hearing Friday.  Due to the ongoing security concerns involved with the case, Curtis was charged before forensic analysis of his car and home was finished.  However, the use of certain language in the letters was identical to language used by Curtis in a Facebook posting, and indentations on the envelopes used matched Curtis’ address.

Why Ricin?

Ricin, as all of you by now probably know, is derived from the castor bean (pictured at left), and indeed is a natural waste-product in castor oil production. When weaponized, just 1.7 mg of the substance can kill an adult male. Ricin is a tempting, if often inefficient, bioterror agent – castor beans can be purchased online, as can relatively simple production instructions. However, the toxicity of this cruder form of ricin is often much lower than weapons-grade ricin.  The FBI has yet to release information regarding the toxicity of the ricin included in last week’s attack.

Is it Terrorism?

Tentatively, yes. Let’s look at how the FBI defines domestic terrorism:

“Domestic terrorism is the unlawful use, or threatened use, of force or violence by a group or individual based and operating entirely within the United States or Puerto Rico without foreign direction committed against persons or property to intimidate or coerce a government, the civilian population, or any segment thereof in furtherance of political or social objectives” (source here)

While this definition is not complete or final (we could spend this entire post debating the meaning of terrorism), it hits the main points.  The letters meet all of the above criteria. Use of the letters falls under domestic terrorism because Curtis is believed to have acted alone, independently of any foreign group. Mailing letters containing ricin, a deadly toxin, is an unlawful attempt to cause morbidity (illness) or mortality. The political nature of the ricin letters is illustrated both by the targets – the President, a Senator – and the reason behind the attacks – Curtis’ desire to draw attention to a believed conspiracy involving the illicit sale of harvested organs. As things stand now, it looks like terrorism.

What now?

Now, we wait as more evidence is collected. Unsatisfying, we know. While we wait, let’s all take a minute to be grateful that no one was hurt,  to appreciate the sensitivity of the mail sensors at the two sorting facilities, and to hope this is the last time Mason Biodefense has to blog about ricin for a good, long, time.

The Pandora Report

It has unfortunately been an exceptionally busy week for those of us studying terrorism, bioterrorism, and pandemics. With new developments in the Boston bombing case,  the ricin letters, and H7N9 in China seemingly happening by the hour, we can guarantee only that news included in this week’s report is current as of this (Friday) morning. In the meantime, our thoughts and good wishes remain with Boston.

Castor bean - image via Mary Do
Castor bean – image via Mary Do

Ricin Letters Suspect Paul Kevin Curtis Quickly Identified by Earlier Letters

Paul Kevin Curtis is accused of mailing three letters – one to Mississippi Senator Roger Wicker, one to President Obama, and one to a local justice of the peace – containing the toxin ricin. While the FBI has positively identified the toxin, further testing is needed to determine the concentration and purity of the substance. Curtis, who was identified in part by his signature on the letters – Curtis’ sign off of “KC” on the ricin letters matched previous letters sent to Senator Wicker’s office. Curtis’ family maintains he is mentally ill, and had refused to take appropriate medication.  Now the question becomes – is this terrorism? Keep an eye out for the Mason viewpoint.

ABC News – “Investigators trying to determine who sent ricin-tainted letters to President Obama and other officials quickly traced the messages and signature of the letter to Paul Kevin Curtis, an Elvis impersonator who had written to officials in the past and consistently signed his letters “I am KC and I approve this message,” according to an FBI affidavit.About 15 members of a hazmat team, some totting M4 rifles, entered Curtis’ house today and set up an evidence-gathering area outside. Curtis was formally charged today with sending mail that contained a threat to kill or harm the president and with sending mail containing a threat to injure the president.”

Chinese Government Suspects Human-to-Human Transmission of H7N9 Bird Flu

China is unfortunately following a storied pattern of waiting until critical information is leaked before acknowledging it openly  – according to unofficial sources, as many as 40% of H7N9 cases had no contact with poultry. Exacerbating the pandemic potential of H7N9 are theunique difficulties associated with developing a vaccine to the strain – it’s proven very hard to culture in the lab. However, don’t panic just yet. Even if the virus proves capable of limited human-to-human transmission, further mutations rendering it “casual contact” transmissible would be necessary for a pandemic.

US News – “As the Chinese government openly begins to speculate about the possibility of human-to-human transmission of the H7N9 bird flu strain, an international team of experts, including some from the World Health Organization, have been deployed to investigate the disease in the country. If true, the development would quickly raise concerns of the disease outbreak leading to a pandemic. Flu experts have long warned once a particularly deadly strain of the flu, as H7N9 appears to be – it has killed 17 of the 87 people it has infected – becomes transmissible between humans, it can quickly spread.”

4-year-old bird flu ‘carrier’ worries China

A four-year old in China has emerged as an asymptomatic carrier of H7N9, further complicating epidemiological efforts in the area to discover the source of the outbreak – if you don’t know who’s sick, determining how they became sick becomes very tricky. It is known that the boy’s family handled poultry and fish. Although health investigators are currently looking at “family clusters” of infection,  human-to-human transmission is not suspected.

CNN – “Doctors say the discovery of a 4-year-old carrier of the H7N9 bird flu virus who shows no symptoms of the potentially lethal virus is a worrying development that could make the spread of the infection more difficult to monitor. The Beijing Municipal Health Bureau said the boy was detected from a group of close contacts of the first infection in Beijing and the laboratory results showed the boy was an asymptomatic carrier of the disease.”

Terrorism Updates:

Watertown, Mass., Shut Down in Manhunt for Second Boston Marathon Suspect

The two suspects in the Boston Marathon bombing have been identified as brothers Tamerlan and Dzhokhar Tsarnaev, with the former killed during the night. The manhunt continues throughout Watertown for the Dzhokhar Tsarnaev, who has already killed an MIT police officer and hijacked a car. Residents of the Boston suburb are being ordered to remain indoors as police officers comb the area. The two suspects are believed to be of Chechen descent, but have lived in the United States for several years.

ABC News – “”The at-large suspect is considered armed and extremely dangerous. Police are going door to door in search for the second suspect.’We believe this is a terrorist, we believe this is a man that’s come here to kill people,’ Boston Police Commissioner Ed Davis said.”

Up to 40 Dead in Texas Blast

While preliminary investigations at the fertilizer plant in West, Texas indicate an industrial accident, a full investigation into the source of the explosion will take six months. We’ve included it as a potential act of terrorism due to it’s proximity to Waco (less than 20 miles) and  it’s occurring within two days of both the 20th anniversary of the end of the Waco, Texas siege (today) and the Boston Marathon bombing (Monday). Current numbers indicate 160 injured and at least 35 dead or missing.

Wall Street Journal – “[Mayor] Muska, who is one of more than 30 volunteer firefighters in the city, was on his way to help colleagues put out the initial fire at West Fertilizer Co. that began around 6 p.m. Central time on Wednesday night. Volunteer firefighters in the town of about 2,800 people roughly 80 miles south of Dallas tried to extinguish the fire at the industrial facility.About two hours later, a thunderous explosion ripped through the plant, registering as strong as a magnitude 2.1 earthquake, according to federal seismologists. It sent a column of smoke hundreds of feet into the air.”

Image of the Week: Ricin

For those of you not 100% up to date on your ricin knowledge, we thought a quick refresher course might be useful.

Pictured above is the lowly castor bean, harvested and processed in the millions every year, and used in everything from castor oil to perfume.  Nearly five percent of the waste product (“mash”) in castor bean (bean being loosely used here – its actually the seeds of the plant Ricinus communis) production is the toxin ricin. Ricin can be synthesized as a powder, in aerosol form, dissolved in water, or as a pellet, the latter of which was used in the assassination of Bulgarian dissident Georgi Markov.

Castor beans alone are extremely potent, with just a handful of beans capable of killing an adult human. The toxin ricin is several times more lethal –  less than 2 mg of ricin is thought to be capable of killing a human. Although extremely lethal, ricin is comparably easy to manufacture (Breaking Bad anyone?), making it a common weapon of choice for criminals and terrorists.

Ricin’s incubation period ranges from 4 to 24 hours, depending on the route of exposure. If exposed to a fine enough powder, inhalation of the toxin may occur,  resulting in flu-like symptoms – fever, cough, difficulty breathing – and gradually escalate to profuse sweating, pulmonary edema (fluid accumulation in the lungs) and eventually respiratory failure.

Breaking News: Ricin in envelope to Senator Roger Wicker

According to CNN, “an envelope that tested positive for the deadly poison ricin was intercepted Tuesday afternoon at the U.S. Capitol’s off-site mail facility in Washington, congressional and law enforcement sources tell CNN”.

Politico has reported through anonymous sources that the letter was addressed to the office of Senator Roger Wicker, R-Miss. More news to come.

NRC Chair Allison Macfarlane to Discuss Current Issues in Environmental Policy

Allison MacFarlane

When: 12:00 – 1:30PM, Thursday, April 18th
Where: Research Hall, Room 163 George Mason University, Fairfax, VA

Come and hear Dr. Allison Macfarlane, Chair of the Nuclear Regulatory Commission, discuss the intersection of environmental policy and the NRC. Dr. Macfarlane is speaking as a part of the 2013 Harold Gortner Distinguished Speaker Series in Public Administration.

Recently re-appointed to serve a second term leading the NRC, Allison Macfarlane is on leave from GMU where she is an Associate Professor in the Environmental Science and Policy Program. She is co-author of the book Uncertainty Underground: Yucca Mountain and the Nation’s High-Level Nuclear Waste.

A reception will follow—please join us!

This Week in DC: Events

DC EventsOur next Biodefense Policy Seminar is this Thursday! The Biodefense Policy Seminar is  the D.C. area’s premiere speaker series focused on biodefense and biosecurity issues. The monthly seminars – free and open to the public – feature leading figures within the academic, security, industry, and policy fields of biodefense.

This Thursday’s seminar, “Health Threats in a Security World”, features Dr. Alexander Garza,  Assistant Secretary for Health Affairs and Chief Medical Officer at the Department of Homeland Security. Join us at 7:20 PM in the Meese Conference Room in Mason Hall, Thursday April 18th!

Monday, April 15th

North Korea and Policy Priorities for the United States
Brookings Institute
10:00AM – 11:30AM

On April 15, Foreign Policy at Brookings will host a discussion on the policy priorities for the United States in dealing with North Korea during and after the current crisis. Brookings experts will debate the threat to the United States and its allies and analyze steps that the United States can take to mitigate the danger, including sanctions, engaging allies and neighbors in the region, nonproliferation efforts and, if necessary, responding to aggressive actions by North Korea.

The Future of the U.S. Nuclear Deterrent: A Conversation with Amb. Linton Brooks
American Security Project
12:30PM – 1:30PM

The future form of today’s U.S. deterrent could change. Many call for reducing the number of nuclear weapons in the U.S. arsenal while plans for the future triad are in flux. 2013 could be a critical year for many of these issues. Join us for a conversation with Linton Brooks, Ambassador and former Administrator for the National Nuclear Security Administration (NNSA). Linton F. Brooks is an independent consultant on national security issues, a senior adviser at CSIS, a distinguished research fellow at the National Defense University, and an advisor to four of the U.S. Department of Energy national laboratories.

Tuesday, April 16th

The Syrian Conflict: Challenges & Opportunities for WMD Counterproliferation
Georgetown Law
12:00PM – 1:00PM

Public symposium and panel lecture on Syrian weapons of mass destruction.

Foreign Policy Panel Series: “Are North Korea’s Threats of War Real?”
World Affairs Council
6:30PM – 8:00PM

The recent threats of war by North Korea’s Kim Jong-un have caused serious alarm in the international community and tensions to rise on the Korean peninsula. This is not the first time such threats have been made. Should they be taken seriously, or are they part of a pattern of diplomatic strategy? How real is the threat of war from North Korea?

Wednesday, April 17th

‘Avoiding Armageddon: America, India, Pakistan, to the Brink and Back’
Hudson Institute
12:00PM – 2:00PM

Long-term stability in South Asia is critical to American national security. In the last 20 years, successive U.S. administrations have diplomatically intervened to keep tensions between the nuclear-armed nations of India and Pakistan from escalating into full-scale war. Moving forward, the health of the relationship between New Delhi and Islamabad will determine whether the region has a future of general stability and peace or chronic conflict. In light of this, Hudson Institute is pleased to invite you to a discussion between Senior Fellow and former Ambassador of Pakistan to the U.S. Husain Haqqani and Bruce Riedel, a Brookings Institution scholar and author of Avoiding Armageddon: America, India, and Pakistan to the Brink and Back. Lunch will be served.

Strategic Options for Iran: Balancing Pressure with Diplomacy
Woodrow Wilson Center
12:15 – 2:00PM

Former senior national security officials, military officers and experts with decades of Middle East experience have joined to present a balanced report on the strategic options for dealing with Iran. Moving the debate past politics and unexamined assumptions they argue that the time has come for Washington to strengthen the diplomatic track in the two track policy of pressure and diplomacy that has characterized current U.S. policy.

Public Presentation with Nils Daulaire, Assistant Secretary for Global Affairs, U.S. Department of Health and Human Services
Americas Society/Council of the Americas
3:15PM – 4:30PM

Please join the Council of the Americas for a public, on-the-record presentation by Dr. Nils Daulaire, assistant secretary for global affairs at the U.S. Department of Health and Human Services. With vast experience in public health in the world’s poorest communities, Daulaire will outline the United States’ health priorities in the hemisphere and highlight several key initiatives that are improving health in the region. Prior to his appointment at HHS in 2010, Daulaire served for more than a decade as president and CEO of the Global Health Council and as deputy assistant administrator for policy and senior international health advisor at USAID.

Thursday, April 18th

National Security & Foreign Policy Priorities in the FY 2014 International Affairs Budget
U.S. Senate Committee on Foreign Relations (Senate Dirksen 562)
9:30 AM

Witnesses: The Honorable John F. Kerry, Secretary of State, U.S. Department of State

Disaster Risk Reduction and Conflict Prevention
US Institute of Peace
1:00PM – 3:00PM

As the United Nations debates a new set of development priorities for the post-2015 revision of its Millennium Development Goals, USIP’s Center of Innovation for Science, Technology & Peacebuilding and the National Academy of Engineering jointly invite you to a discussion of the new challenges for peacebuilders presented by the interplay of these “natural” and political risks.

Health Threats in a Security World
Meese Conference Room, Mason Hall, George Mason University
7:20PM – 8:30PM

As the second speaker in the Biodefense Policy Seminar series, Dr. Alexander Garza will discuss emerging health threats in his capacity as the assistant secretary for health affairs and chief medical officer of the Department of Homeland Security. His bio includes managing the Department’s medical and health security matters, oversees the health aspects of contingency planning for all chemical, biological, radiological and nuclear hazards, and leads a coordinated effort to ensure that the Department is prepared to respond to biological and chemical weapons of mass destruction. Prior to joining the Department in August 2009, Dr. Garza spent 13 years as a practicing physician and medical educator.

Friday, April 19th

Nukes, Missiles, and Feints: The Real Deal on Iran and North Korea
Center for National Policy
9:30AM – 10:45AM

The rhetoric from North Korea has become increasingly hostile. Last Friday, April 12th, the country warned that “nuclear war is unavoidable” and declared that Tokyo would be its first target in the event of a war on the Korean Peninsula. This statement is just the latest in an escalating war of words and rising tensions between North Korean officials and the U.S. Join Truman Project President, just back from Japan, Rachel Kleinfeld and an expert panel as they discuss the current situation in North Korea, how the situation differs from that of Iran, and how we can better understand Asian hard security and the nuclear challenge.

Biodefense Policy Seminar: “Health Threats in a Security World”

Alexander Garza, MD, MPH, FACEPApril Seminar: ”Health Threats in a Security World”
Speaker: Dr. Alexander Garza
When: 7:20PM, Thursday April 18th, 2013
Where: Meese Conference Room, Mason Hall, George Mason University

The Biodefense Policy Seminar is  the D.C. area’s premiere speaker series focused on biodefense and biosecurity issues. The monthly seminars – free and open to the public – feature leading figures within the academic, security, industry, and policy fields of biodefense.

About the Speaker: Dr. Alexander Garza is the Assistant Secretary for Health Affairs and Chief Medical Officer of the Department of Homeland Security. He manages the Department’s medical and health security matters, oversees the health aspects of contingency planning for all chemical, biological, radiological and nuclear hazards, and leads a coordinated effort to ensure that the Department is prepared to respond to biological and chemical weapons of mass destruction. Prior to joining the Department in August 2009, Dr. Garza spent 13 years as a practicing physician and medical educator.

Refreshments will be available!

The Pandora Report

Highlights include the H7N9 update, funding for the NBAF, using flight patterns to stop pandemics, North Korean biosurveillance, and why biotech companies matter. Happy Friday!

North Korean bioweapons are coming for us all (Credit: Karl Baron)

Report on 3 in China Who Died From Bird Flu Points to Severity of Strain

Update: 43 cases, 10 fatalities

H7N9 continues apace in China, with the total number of cases up to 43. The virus is especially difficult to track because birds are asymptomatic carriers. While the number of laboratory-confirmed cases is closely monitored, it’s possible there are many more human cases going unnoticed due to a milder disease presentation. Still, there have been no confirmed cases of person-to-person transmission, and scientists in the US have just received the first batch of the virus, and are working on developing a diagnostic.

New York Times – “A report on three of the first patients in China to contract a new strain of bird flu paints a grim portrait of severe pneumonia, septic shock and other complications that damaged the brain, kidney and other organs. All three died…During a telephone news briefing on Thursday, Nancy J. Cox, of the influenza division at the Centers for Disease Control and Prevention, said that several features of H7N9 were particularly troubling: it causes severe disease, it has genetic traits that help it infect mammals and humans probably have no resistance to it.”

Obama proposes $714M for Kansas biodefense project

The National Bio- and Agro-Defense Facility has received the strongest funding endorsement to date from the Obama Administration, with $714 million included for the lab in the President’s FY2014 budget. The lab is slated to replace Plum Island as the nation’s premier   research center on agricultural pathogens.

Wall Street Journal – “Republican Sen. Pat Roberts of Kansas said the recommendation signals the administration’s support for building the $1.15 billion lab, which will study large animal diseases and develop measures to protect the nation’s food supply…Roberts said the proposal will require additional financial commitments from Kansas, which will be worked out by Republican Gov. Sam Brownback and legislators…Kansas agreed when it was awarded the project to contribute 20 percent of the cost of construction. Thus far, the state has issued $105 million in bonds and $35 million from the Kansas Bioscience Authority.”

New tool to identify air travelers with infectious disease developed

Researchers in Toronto, after studying the 2009 H1N1 pandemic, developed basic guidelines for passenger screenings during a pandemic. The results are relatively intuitive – screening passengers as they leave a region in which the pathogen is spreading is more useful than screening them upon arrival at their final destination.

Medical News – “Dr. Khan used his experience analyzing air traffic patterns to review the flights of the nearly 600,000 people who flew out of Mexico in May 2009, the start of the H1N1 pandemic. He found that exit screening would have caused the least disruption to international air traffic. In fact, all air travelers at risk of H1N1 infection could have been assessed as they left one of Mexico’s 36 international airports. Exit screening at just six airports in Mexico coupled with entry screening at two airports in Asia (Shanghai and Tokyo) would have allowed for screening of about 90 per cent of the at-risk travelers worldwide.”

APG working on biosurveillance in response to North Korea threats

Anything that is related to biological warfare and is also called the Kracken is automatically included in the Pandora Report. Here, the Kracken is a 15ft high thermal, acoustic, and infrared sensor.

Baltimore Sun – “While the danger of missiles is more pressing, Army officials said developing better capabilities to detect biological warfare threats has also been a priority for the past six years. The Joint Program Executive Office for Chemical and Biological Defense is working with APG’s Edgewood Chemical Biological Center on the program, which is called the Joint United States Forces Korea Portal and Integrated Threat Recognition, or JUPITR. The program will also serve to detect naturally occurring biological threats. A key part of the program is the Kraken, which Army officials described as ‘a massive, multifunctional, all-seeing sensor suite designed to rapidly establish a defensive perimeter.'”

Funding Issues Stymie Pandemic Preparation

Collaboration between the biotech industry and the US government has been notoriously difficult, starting with the threat of breaking Bayer’s patent on Cipro during the Amerithrax attacks and continuing into today. While relations have improved, and the hurdles to a successful working relationship are significant, we can’t afford to not work on this.

Genetic Engingeering and Biotechnology News – “Despite product success Acambis has had a bumpy ride with its funding. ‘Any biotech that believes developing products to serve public health emergencies is access to easy money needs to think again,’ Dr. Lewin cautioned. ‘Collaborating with the U.S. government is different from working in the biotech world. You have to produce a proposal for the government to digest, a cost of around $400,000, and if you don’t get the contract that’s all money down the drain.'”

Image of the Week

This week’s image come via Microbiology and Immunology, and is of cell lytic enzymes attached to nanoparticles, which are then used to kill listeria!

“Fighting Listeria with Nanobiotechnology: Using nature as their inspiration, the researchers successfully attached cell lytic enzymes to food-safe silica nanoparticles, and created a coating with the demonstrated ability to selectively kill listeria—a dangerous foodborne bacteria that causes an estimated 500 deaths every year in the United States. The coating kills listeria on contact, even at high concentrations, within a few minutes without affecting other bacteria. The lytic enzymes can also be attached to starch nanoparticles commonly used in food packaging.”

Read more here.

The Pandora Report

Highlights include H7N9, China’s SARS lessons, H5N1, the seminal UN global arms treaty, bird flu bureaucracy, and the problems with the term “WMD”. Happy Friday!

H7N9 Update: 14 cases, five fatalities, no evidence of person-to-person transmission

(image credit: Matt Karp)
(image credit: Matt Karp)

Scientists race to gauge pandemic risk of new bird flu

We’re keeping a very close eye on news about the H7N9 avian flu strain emerging from China. To date there have been fourteen cases with five fatalities.   Unlike the H5N1 strain of avian influenza, this is the first time we’re seeing H7N9 in humans. It’s pandemic potential is still considered low due to its current inability to transmit person-to-person. However, although there have been no confirmed cases of person-to-person transmission, it’s been reported that a person caring for one of the people who died of H7N9 has since developed similar, flu-like symptoms.

Reuters – “Genetic sequence data on a deadly strain of bird flu previously unknown in people show the virus has already acquired some mutations that might make it more likely to cause a human pandemic, scientists say. But there is no evidence so far that the H7N9 flu – now known to have infected nine people in China, killing three – is spreading from person to person, and there is still a chance it might peter out and never fully mutate into a human form of flu.”

Ten years after SARS, what has China learned?

The short answer? It depends on whom you ask. China has improved its communication with the international and scientific community. However, there have been complaints about the lack of clear communication by the Chinese government with its own people, particularly at the time of the virus’ original emergence.

Xinhua – “The news of two men dying from a new variant of bird flu has reminded Chinese of the SARS pandemic that hit the country one decade ago. Many are wondering if the government will handle the situation any better than it did in 2003, should another pandemic break out…Now, on the 10th anniversary of the pandemic, fear is spreading following reports of two Shanghai men who died from H7N9 avian influenza, a strain that has not previously been detected in humans. That fear was aggravated this week after four more patients in neighboring Jiangsu Province were confirmed to have contracted the virus. All four are in critical condition.”

Cambodia reports 10th bird flu case this year

In all the chatter about H7N9, H5N1 seems almost tame. While it may seem high, ten cases in four months is in keeping with expected numbers.

Xinhua – “A six-year-old boy from Southwestern Kampot province was confirmed to have contracted with Avian Influenza H5N1, bringing the number of the cases to 10 and the death toll remained at eight in 2013, a health expert said Wednesday. ‘The boy was admitted to the Kantha Bopha Hospital in Phnom Penh on March 31 for severe pneumonia, and he was tested positive for H5N1 at the Instituts Pasteur on Tuesday,’ Dr. Denis Laurent, deputy director of the hospital, told Xinhua.’The boy is still alive, but in severe conditions (sic).”

UN general assembly passes first global arms treaty

Including everything from battle tanks to light weapons, this is the first UN treaty “aimed at controlling the trade in conventional weapons”, and prohibits the sale of conventional weapons to state in violation of arms embargoes, in support of terrorism, war crimes, genocide, or in use against civilians (it doesn’t regulate domestic sales of arms).

The Guardian – “The United Nations…vot[ed] it through by a large majority despite earlier being blocked by three countries. Member states represented in the UN general assembly voted by 154 to three, with 23 abstentions, to control a trade worth an estimated £46bn a year. The landmark deal went to a vote after Syria, Iran and North Korea – all at odds with the US – blocked its adoption by consensus….It is expected to come into force after the first 50 ratifications next year”

Clinical Notes: Bird Flu Vaccine Delayed at FDA

It’s been an avian-themed report. This piece included in commiseration with of all of us just now getting around to taxes – filing paperwork appropriately with the government is apparently as important for billion-dollar corporations as it is for the rest of us.

MedPage – “GlaxoSmithKline’s (GSK) human vaccine against H5N1 avian influenza did not win approval from the FDA, but only on technical grounds that should not keep it off the market for long, the company said. Called Q-Pan H5N1, the product is meant to be stockpiled in case the H5N1 virus becomes capable of causing a pandemic. It received a unanimous endorsement from an FDA advisory committee last November. Nevertheless, GSK said last week that it had received a so-called complete response letter from the agency, indicating that approval was not immediately forthcoming. The company said it was ‘triggered due to an administrative matter that has recently been rectified.'”

Soapbox we love: Let’s All Stop Saying ‘Weapons of Mass Destruction’ Forever

The title says it all. It was arguably too broad when it was just chemical, biological, radiological (mass destruction? a rad bomb? really?) and nuclear, and it seems to only be getting broader.

Wired – “In fact, as a fascinating paper by W. Seth Carus at the National Defense University shows, the Defense Department’s definition of the term has long been problematic. For years, its official definition included ‘high explosives,’ to make it consistent with the federal statute that Harroun ran up against. But ‘most military weaponry relies on high explosive charges,” Carus writes, ‘meaning that even the mortars and grenades used by infantrymen might qualify as WMD.’ The doctrinal answer was ultimately to limit the definition to “chemical, biological, radiological and nuclear weapons capable of a high order of destruction or causing mass casualties.”