Pandora Report 8.24.2026: G20 Youth Diplomacy, H5N5, and Africa’s Health Security Index

Welcome to this week’s Pandora Report! This issue highlights reflections on the 2026 G20 Youth (Y20) Summit culminating in the G20 Youth Communiqué, emerging infectious disease threats including H5N5 and human screwworm infections, lessons from the Nuclear Threat Initiative’s Africa Health Security Index on strengthening health capacity and resilience, and the evolving landscape of biosafety, biosecurity, and AI-enabled biology.


Reflections on the 2026 G20 Youth (Y20) Summit: Realities, Global Consensus, and the Future of Diplomacy

By Carmen Shaw, U.S. Head Delegate for Food Security and Global Health (Y20 2026) | Biodefense PhD Student and Managing Editor, The Pandora Report

Figure 1. Over 100 global delegates convened in Washington, D.C., from August 11–14 for the 2026 G20 Youth (Y20) Summit. Delegates negotiated across five key tracks—global economy, energy, digital transformation, food security and global health, and conflict resolution—culminating in the 2026 G20 Youth Communiqué presented to G20 heads of state.

Over a week ago, more than 100 global delegates came together for the 2026 G20 Youth (Y20) Summit in Washington, DC. As the U.S. Head Delegate for Food Security and Global Health, participating in this summit on American soil during a period of profound political and economic transformation was both an honor and the responsibility of a lifetime. Hosted by Globally and the Young Professionals in Foreign Policy (YPFP), the summit culminated in months of rigorous multilateral negotiations among delegates, resulting in the publication of the 2026 G20 Youth Communiqué, which was formally presented to G20 leaders.

Figure 2. Delegates participate in multilateral negotiation sessions on policy proposals for the 2026 G20 Youth Communiqué report.

Containing 81 actionable policy recommendations, this communiqué offers a clear snapshot of global youth priorities across the global economy, digital innovation, energy, conflict and violence, food security, and global health. We did not shy away from hard or uncomfortable conversations; we engaged in them openly. Across these tracks, we debated frameworks for ethical AI governance, examined concrete pathways for securing energy supply chains, and pushed for Universal Health Coverage while prioritizing resilient healthcare financing. We also tackled deeply polarizing geopolitical issues, openly debating whether tariffs and economic sanctions can—and should—be used as tools of coercion in international affairs, while considering the legal protections required for displaced populations.

Throughout these negotiations, my objective was to ensure that high-level policy remained grounded in the realities facing communities and institutions. International frameworks have limited impact unless they protect and invest in the people who drive and depend on these global systems–farmers, workers, researchers, engineers, entrepreneurs, journalists, frontline healthcare professionals, humanitarian workers, and communities affected by conflict and displacement. Our experience demonstrated that effective multilateralism is built not on the absence of disagreement, but on deep empathy, strategic cooperation, and the willingness to find common ground.

There is no shortage of noise today about how divided our world has become, and America’s shifting role within it. Yet when you sit down at the negotiating table with young leaders from across the globe—doing the hours-long, painstaking work of reaching consensus across deep ideological divides—a very different story emerges. The future of international diplomacy and policy is stronger when young, empathetic, and pragmatic leaders step forward, listen openly, and work together to address the world’s most pressing challenges.

The channel between youth and our leaders is open. Our voices are unified, and the work of translating these policy recommendations into meaningful diplomatic action begins now.

Transmission Risk of Human H5N5

By Margeaux Malone, Pandora Report Associate Editor 

In a study published last week in the Journal of Virology, researchers evaluated the transmission risk of highly pathogenic avian influenza virus (HPAI) A(H5N5) following the world’s first confirmed human infection and fatality in November 2025. The patient, an older adult in Washington State with underlying health conditions, developed fever, confusion and worsening respiratory illness that required hospitalization and ultimately resulted in death. The patient kept a mixed backyard poultry flock, and environmental samples from the property tested positive for the H5N5 virus. No person-to-person spread was identified.

Testing the virus stain in human bronchial epithelial cells and in a ferret model, researchers found that the isolate replicated efficiently at human airway temperatures and caused fatal systemic disease but showed no capacity for airborne spread. Limited transmission occurred only with direct contact. Collectively, the results underscored the heterogeneity among clade 2.3.4.4b HPAI H5Nx viruses and the need for genotype-by-genotype evaluation of newly emerged influenza viruses to understand the public health risk.

The potential public health risk of HPAI is also at the forefront of the ongoing outbreak in Australian wildlife. Dr. Frank Wong, a Senior Research Scientist with the Australian Centre for Disease Preparedness (ACDP) said the risk of bird flu spreading to humans within the country remains very low. He noted an “ecological perfect storm” would be required for the virus to spill over, though that does not mitigate the need to stay on high alert. Clinicians should still inquire about recent contact with potentially infected animals and should strongly encourage seasonal influenza vaccination, particularly as national flu vaccine coverage has fallen from 45.6% in June 2020 to 26.2% in June 2026.

Human Screwworm Infections Climb in Mexico

More than 500 people in Mexico have been infected with New World screwworm (NWS), a sharp rise in infections from last year. A recent study in CDC’s Emerging Infectious Diseases examined 202 confirmed Mexican cases from April 2025 to March 2026 and found that reporting rose from roughly three cases a week in 2025 to more than nine a week in 2026. Legs or feet were affected in 55% of cases, with others involving the nose, mouth and eyes. Six patients died, though only one death was directly attributed to the infestation.

Although Mexico was declared free of NWS in 2003, this recent rise in human cases is not unexpected given the northward spread of the parasite, which re-emerged in animals in Mexico in 2024. The same obligate parasite affects livestock, wildlife, companion animals, and humans, so a rise in animal cases indicates local circulation of the fly and an increased risk for concurrent human infestation. Thus, NWS is both a public health and animal health problem and calls for a One Health approach. Since the spread of NWS is expected to continue for the foreseeable future, the authors urge surveillance, diagnostic preparedness, animal movement controls, and fly-suppression activities to be implemented proactively at the leading edge of expansion, rather than only after human cases are detected. Coordination between human health, animal health, wildlife, and agricultural sectors will be essential to guide prevention and control measures.

Further Reading: 

Exploring Global Health Security Policy: My Summer Internship Experience with the Nuclear Threat Initiative (NTI)

By Alex Kyabarongo, MS Biodefense Student, George Mason University

Figure 3. Alex Kyabarongo is a second-year MS Biodefense student at George Mason University, with a special interest in global health security policy and biothreat reduction programs. He recently completed a summer internship with NTI, where he contributed to the Africa Health Security Index.

As the Bundibugyo virus disease (BVD) outbreak in the Democratic Republic of Congo (DRC) outpaces containment efforts, with over 4,600 cases and more than 2,100 confirmed deaths as of August 12, the world remains more vulnerable to infectious disease threats than ever before. This outbreak—which experts say might be the deadliest Ebola outbreak yet due to its rapid spread—should serve as a stark reminder of the need to strengthen global health security programs. It should be a call to focus on improving disease surveillance capacities, biosafety and biosecurity, and other prevention, preparedness, and response efforts across the globe. Yet, this outbreak has occurred at a time when global health security financing remains fragmented, with shifts in international development assistance severely affecting health security programs in many countries, while the World Health Organization (WHO) Member States continue to face challenges in operationalizing the Pandemic Agreement.

It is such concerning global health security challenges that inspired me to enroll in the Master of Biodefense program at the Schar School of Policy and Government at George Mason University, with the intention of deepening my knowledge and understanding at the intersection of health and security. With the same aspirations, this summer, I joined the Nuclear Threat Initiative’s Global Biological Policy and Programs (NTI | bio) team for a 10-week internship. This internship came at an important point in my graduate school journey, as I remain with only one semester left before graduation. It was an important time to put my classroom experience into practice, and many topics explored during the previous semesters helped me transition smoothly to working in this important field during the internship period.

With the NTI | bio team, I gained hands-on experience working on projects focused on countering health security threats and emerging technology risks. It was such a unique opportunity to learn from the NTI | bio team and contribute to ongoing projects such as AIxBio and DNA synthesis screening. Importantly, it was great timing that I joined when the team was working on the Africa Health Security Index (AHS Index). The AHS Index, which was jointly developed by the Nuclear Threat Initiative, the Brown University Pandemic Centre, and the Science for Africa Foundation, builds upon the previous Global Health Security Index framework to assess African countries’ health security capacities. Working on this project after having taken Dr. Scott Wollek’s BIOD 710: Health Security Preparedness class during the spring semester was highly relevant and enabled me to put the class theoretical principles learned from class into practice. For the AHS Index, I specifically worked on the risk environment category, exploring why its regional scores have continuously declined over the last three Index issues and the implications of this trend for the implementation of Africa’s health security capacities.

The AHS Index scores show that Africa’s health security capacities have improved by 9.1 points from 2021, with strong improvements in disease surveillance, prevention, and response capacities. The region has expanded laboratory capacities but still struggles with biosafety and biosecurity systems, which increases the risks of laboratory accidents and the potential misuse of biological materials. Similarly, dual-use research oversight and the culture of responsible science remain critically low, at 1.9 out of 100 across the region, which ultimately serves as an alarming call for regional health security leaders to strengthen Dual-Use Research of Concern (DURC) governance. Most importantly, the region’s political and security risks, infrastructure inadequacies, and environmental risks remain areas of vulnerability. For more on the Index launch, explore my recently published blog article, and to explore the details of the Index data, results and the recommendations, visit the Index website.

Internship programs are an important aspect of students’ professional development. I am glad that the Schar School of Policy and Government has such a supportive career development team that continuously supported me throughout my internship period. I even got academic credit for the internship! The internship was very enriching, and I gained invaluable practical experience, which ultimately complements and enhances my current graduate program experience and prepares me for new challenges. I benefited from the excellent mentorship and support of the NTI | bio team, who provided me with an opportunity to explore the topics they were working on, guided me, and provided important feedback.

One important lesson I gained was the importance of collaboration and teamwork, which were central components of the AHS Index project. I deepened my understanding of health security policy, the research needed to identify gaps to be addressed, the importance of partnerships, and how these elements come together to address global health security challenges. The current Ebola crisis in Central Africa serves as a significant reference point of how important it is to invest in health security preparedness, improve capacity, and, most importantly, make health security an integral component of national security. It is internship programs like this that build the next generation of global health security leaders.

Further Reading:

NIH Releases a Draft Biosafety Policy for Research Involving Biohazards for Public Comment

The NIH has released a Draft Biosafety Policy for Research Involving Biohazards (Biosafety Policy) for public comment as part of its effort to strengthen and modernize biosafety oversight. In September 2025, NIH announced plans to strengthen and modernize biosafety oversight and has since engaged stakeholders to inform the development of an oversight framework that addresses risk. NIH invites stakeholders to provide feedback on the Draft Biosafety Policy and associated templates via its online portal, with comments accepted until October 19, 2026.

IN OTHER NEWS

Vaccines, Immunization Policy, and U.S. Public Health

Ebola and Other Infectious Disease Emergencies

AI, Bioweapons, and Emerging Biological Threats

Biosecurity, Resilience, and Defense Strategy

NEW: International Bio-Responsibility Conference 2027

Organized under the Bio-Responsibility Initiative at the Centre for Society and Policy (CSP), the conference brings together people to advance dialogue, build partnerships, and promote safe, secure, and responsible life science research, development, and innovation. The conference will host experts, policymakers, and practitioners around the world to discuss emerging biological risks and ways to strengthen responsible governance.

The deadline to register is September 30. Learn more and register here.

Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB)

From the Office of the Assistant Secretary for Health (OASH): “The 28th PACCARB public meeting will explore how microbiome science can support AMR prevention, drive novel interventions, and build public awareness and understanding of microbiome-focused health measures. The meeting will focus on innovative and emerging topics in antimicrobial resistance (AMR) and the microbiome.”

This hybrid meeting will take place on September 9-10 from 9:00 AM–5:00 PM ET. Learn more and register here.

Exponential AI and Biotech Growth: Translating Technical to Policy – Workshop

From AI for SynBio: “The continued acceleration of agentic artificial intelligence (AI), Biological Design Tools (BDTs), and Biological AI Models (BAIMs) has transformed the technological landscape, enabling tremendous benefits and potential misuse that could massively impact national security, defense, health, and economy. Mitigating this risk will require collaboration across Government, Industry, and Academia with both technical and policy focuses. Significant effort, especially at the federal level, has been made to raise awareness of this challenge, yet additional discussion is necessary to keep pace with the ever-evolving speed of this global technology.’

This workshop will take place from September 15-17 at the Hopkins Bloomberg Center in Washington, DC. Learn more and register here.

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.”

This in-person event will take place from August 27-28. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.”

This workshop series will take place on September 23. Learn more and register here.

Training Course on ‘Biotechnology Innovation and Biosecurity’

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).”

This in-person event will be held from October 12-16 in New Delhi, India. Learn more and apply here.

Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

Researcher, Built Environment Team – Job Opening

From Blueprint Biosecurity: “The built environment encompasses the indoor spaces where people work, learn, gather, and receive care. Equipping these spaces with additional layers of protection against infectious airborne pathogens can help reduce risk in these spaces and support safer, more resilient communities. This work will focus on identifying and advancing promising interventions to mitigate pathogen transmission in occupied indoor spaces and strengthen society’s ability to contain outbreaks before they become widespread. Blueprint Biosecurity is hiring up to two Researchers to work directly with the Built Environment Program Director to lay the groundwork for new areas of interest and expand Blueprint’s portfolio.”

Learn more and submit your application here by August 21.

Respiratory Protection Program Officer, PPE Team – Job Opening

From Blueprint Biosecurity: “One of the most impactful ways to suppress pathogen transmission and save lives in a future outbreak is to ensure that highly protective respiratory PPE can be deployed to millions of critical workers on day one. Despite this, if a pandemic occurred tomorrow, U.S. stockpiles and supply chains would be unable to meet the demand. This problem motivated the development of the Blueprint for Pandemic PPE and has shaped our efforts to mobilize tens of millions of dollars toward advancing its goals. To build upon this momentum, Blueprint Biosecurity is hiring up to two Program Officers to expand our PPE team. These program officer roles are structured into two distinct tracks: Research Management or Grant Evaluation. Both positions will work closely with the PPE Program Director to help build a more resilient future in which critical workers have access to respirators during emergencies.

Learn more and submit your application here by August 21.

Horizon Fellowship

From Horizon Institute for Public Service: “Through our fellowship, we place fully-funded fellows at host organizations to help tackle policy challenges related to artificial intelligence, biotechnology, and other emerging technologies. Fellows selected for our program receive policy-focused training, mentorship, and support in matching with a host organization for a full-time, fully-funded fellowship based in the Washington, DC area. Fellows join a collaborative, close-knit community of public service-oriented experts. Potential host organizations include executive branch offices, congressional offices, national laboratories, and think tanks.”

Learn more and submit your application here by August 30.

Asia Centre for Health Security (ACHS) Fellowship Programme

From ACHS: “The ACHS Fellowship Programme aims to inspire and connect the next generation of health security leaders and innovators. Launched in 2025 by ACHS, based at the Saw Swee Hock School of Public Health (SSHSPH), National University of Singapore (NUS), the ACHS Fellowship Programme is a highly competitive, part-time fellowship that provides graduate students and early- to mid-career professionals with an opportunity to deepen their expertise, expand their professional network, and build leadership skills through educational opportunities and project work.”

Learn more and submit your application here by August 31.

WHO Internship Programme

From WHO: “A competent and dynamic health workforce at the heart of each health system is essential to advance global health goals. Countries need a pool of health professionals trained and exposed to the systems and processes in the health sector and who understand how stakeholders interact within the international health arena. WHO’s Internship Programme offers a wide range of opportunities for students and recent graduates to gain insight into the technical and administrative programmes of WHO and enrich their knowledge and experience in various areas, thereby contributing to the advancement of public health.”

Learn more and apply here.

OpenAI Bio Bug Bounty Program

From OpenAI: “As part of our ongoing efforts to strengthen our safeguards for advanced AI capabilities in biology, we’re evolving our GPT‑5.5 Bio Bug Bounty to become an ongoing private program—the OpenAI Bio Bounty Program. The program will remain focused on universal jailbreaks that can defeat our predefined biosafety challenge against OpenAI’s frontier models, starting with GPT‑5.6 and going forward. The reward for a universal jailbreak for the OpenAI Bio Bounty Program has been raised from $25,000 to $50,000 for both GPT‑5.6 and GPT‑5.5. Smaller awards may be granted for partial wins at our discretion.”

Learn more and submit your application here.

Disarmament and non-proliferation of WMD – Training Program

From Asser Institute and OPCW: “By 2026, pressure on the international arms control system has reached a point few experts anticipated would arrive so quickly, driven largely by intense geopolitical fragmentation. There is a critical need for professionals who possess the legal, technical, and diplomatic expertise to navigate these modern complexities. This intensive five-day training provides a comprehensive, practical overview of the international non-proliferation and disarmament framework.”

This program will take place from October 26-30 in The Hague, the Netherlands. Learn more and register here.

Pandora Report 8.7.2026: Fauci Contempt Vote, AIxBio Threats, and One Health Fronts

Welcome to this week’s Pandora Report! This issue highlights continued congressional scrutiny of Anthony Fauci following his Senate hearing, ongoing One Health threats from H5N1 avian influenza and New World screwworm, and efforts to address the opportunities and risks of AI-enabled biology. The Pandora Report will be taking a break next week and will return on August 21, 2026.

Thank you for reading, and we look forward to sharing more updates with you soon!


Join the National Academy of Medicine (NAM), the National Academies of Sciences, Engineering, and Medicine (NASEM), and the Coalition for Epidemic Preparedness Innovations (CEPI) for a two-day workshop, “Preparing for a Future of AI-Enabled Biology,” on August 11-12. The event will explore emerging technology, key uncertainties, and priorities for strengthening global preparedness.

Fauci Faces Continued Congressional Scrutiny Over COVID-19 Response

Following last week’s Senate hearing, former NIAID Director Dr. Anthony Fauci is facing continued congressional scrutiny over his role in the U.S. COVID-19 response. A Senate committee voted to hold Fauci in contempt of Congress after he declined to answer questions about his handling of the COVID-19 pandemic, citing his Fifth Amendment right against self-incrimination. The vote escalated a months-long dispute between Fauci and congressional investigators over questions related to COVID-19 origins, federal research funding, and pandemic decision-making. The proceedings followed the release of Fauci’s private COVID-era diary entries and additional records, including a copy of his government-issued phone. While critics have argued the materials raise concerns about transparency, fact-checkers have noted that they provide insight into Fauci’s personal experiences and frustrations during the crisis, but do not resolve ongoing scientific questions or debates surrounding COVID-19 origins.

Further Reading:

One Health on Two Fronts

By Margeaux Malone, Pandora Report Associate Editor 

Australia confirmed its first mass wildlife mortality from H5N1 bird flu earlier this week after more than 80 dead and sick greater crested terns were found on an island off South Australia’s south-east coast. Seventy-four cases have been confirmed nationally since June, mostly in South Australia, but fortunately no farms have yet been affected. In response to the recent mainland wildlife detections, the Australian government performed a risk assessment to better understand the potential impact on the country’s many species of native birds and mammals. More than 2,000 birds and mammals were listed from low to high risk based on their vulnerability and susceptibility, considering their habitat, ecology, behavior, and information from the global outbreaks.

Although the country’s biosecurity response has been excellent, Invasive Species Council CEO Jack Gough noted that funding to protect wildlife has gone backwards: “We won’t be able to stop bird flu spreading through wildlife, so the best response to that needs to be dealing with all the other threats. The foxes, the cats, the rats on islands, making sure wetlands are well connected, that we’re not seeing habitat destruction occurring in key nesting areas; that work hasn’t been happening at a scale which reflects the seriousness of this list.” Five seabirds, including the critically endangered Herald petrel, face extreme risk, meaning likely extinction if the virus reaches them, and more than 80 threatened species rank high or worse. Tasmanian devils, eastern quolls and several marine mammals would probably survive infection but with severely reduced populations. Vaccination requires two doses, which is impractical, if not impossible, in wild flocks, so trials are focused on captive breeding facilities.

Half a world away, Texas and surrounding states continue to battle New World screwworm. In an article published this week in Nature Ecology & Evolution, authors Andrews, Weese and Bogoch argue that the June 2026 screwworm re-emergence in Texas, the first overland US detection since the early 1980s, is the result of waning investment rather than any failure of the science. Sterile fly production and surveillance lapsed during the COVID-19 pandemic, and a front pushed south over 47 years rebounded to the Texas border within only three. They acknowledge that this is a One Health problem, in which human and animal health are linked. Human myiasis is a real though comparatively uncommon problem; a huge economic toll is borne from livestock and companion animal infestations, and wildlife carry the biggest burden in sheer morbidity and mortality. The elimination of screwworms from the U.S. will require long-term, active effort to keep at bay, meaning infrastructure that must be funded, staffed, and defended indefinitely. Anything short of this sustained investment will only lead to continual re-emergence and subsequent animal and financial losses.

Prevention is invisible when it works. A sterile fly plant running at capacity and a seabird colony free of rats produce no headlines, which is precisely why the funding behind them erodes quietly. The gaps go unnoticed until they explode open, and by then the cost of response will be orders of magnitude higher than the sustained maintenance would have been.

Further Reading: 

IN OTHER NEWS

U.S. Public Health Leadership, Preparedness, and Trust

Global Health Security, Pandemic Preparedness, and International Cooperation

Biological Threats, Outbreaks, and One Health

Emerging Technologies and Evolving WMD Risks

Biological War: A Scenario

From investigative journalist Annie Jacobsen, this book explores the catastrophic consequences of a deliberate biological attack or laboratory accident, tracing how a rapidly spreading pathogen could trigger cascading failures across public health systems, government, critical infrastructure, and society.

Drawing on interviews with senior experts in national security, medicine, science, and the military, Jacobsen presents a fast-paced, scenario-based narrative that examines the hours, days, and weeks following the release of a biological agent. Like her bestselling Nuclear War: A Scenario, the book uses a fictionalized but research-informed account to highlight the challenges of biodefense, pandemic preparedness, and crisis response in the face of an existential biological threat.

Further Reading:

NEW: Army Mad Scientist Series with Dr. James Giordano – Lecture

From the Institute for National Strategic Studies (INSS): “Join us for our virtual event, Braking Biowarfare: Deterrence Left-of-Denial featuring Dr. James Giordano, Head of the Center for Strategic Deterrence and Weapons of Mass Destruction Studies in the Institute for National Strategic Studies at the National Defense University. He will examine the need to shift contemporary biodefense beyond traditional reactive paradigms toward proactive strategies that prevent, delay, disrupt, and disincentivize the development and operationalization of weaponizable bioscience and biotechnology before their deployment.”

This virtual event will take place on Tuesday, August 18 from 12:00 PM-1:00 PM ET. Learn more and register here.

NEW: Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB)

From the Office of the Assistant Secretary for Health (OASH): “The 28th PACCARB public meeting will explore how microbiome science can support AMR prevention, drive novel interventions, and build public awareness and understanding of microbiome-focused health measures. The meeting will focus on innovative and emerging topics in antimicrobial resistance (AMR) and the microbiome.”

This hybrid meeting will take place on September 9-10 from 9:00 AM–5:00 PM ET. Learn more and register here.

NEW: Exponential AI and Biotech Growth: Translating Technical to Policy – Workshop

From AI for SynBio: “The continued acceleration of agentic artificial intelligence (AI), Biological Design Tools (BDTs), and Biological AI Models (BAIMs) has transformed the technological landscape, enabling tremendous benefits and potential misuse that could massively impact national security, defense, health, and economy. Mitigating this risk will require collaboration across Government, Industry, and Academia with both technical and policy focuses. Significant effort, especially at the federal level, has been made to raise awareness of this challenge, yet additional discussion is necessary to keep pace with the ever-evolving speed of this global technology.’

This workshop will take place from September 15-17 at the Hopkins Bloomberg Center in Washington, DC. Learn more and register here.

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.”

This in-person event will take place from August 27-28. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.”

This workshop series will take place on September 23. Learn more and register here.

Training Course on ‘Biotechnology Innovation and Biosecurity’

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).”

This in-person event will be held from October 12-16 in New Delhi, India. Learn more and apply here.

Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

NEW: Researcher, Built Environment Team – Job Opening

From Blueprint Biosecurity: “The built environment encompasses the indoor spaces where people work, learn, gather, and receive care. Equipping these spaces with additional layers of protection against infectious airborne pathogens can help reduce risk in these spaces and support safer, more resilient communities. This work will focus on identifying and advancing promising interventions to mitigate pathogen transmission in occupied indoor spaces and strengthen society’s ability to contain outbreaks before they become widespread. Blueprint Biosecurity is hiring up to two Researchers to work directly with the Built Environment Program Director to lay the groundwork for new areas of interest and expand Blueprint’s portfolio.”

Learn more and submit your application here by August 21.

NEW: Respiratory Protection Program Officer, PPE Team – Job Opening

From Blueprint Biosecurity: “One of the most impactful ways to suppress pathogen transmission and save lives in a future outbreak is to ensure that highly protective respiratory PPE can be deployed to millions of critical workers on day one. Despite this, if a pandemic occurred tomorrow, U.S. stockpiles and supply chains would be unable to meet the demand. This problem motivated the development of the Blueprint for Pandemic PPE and has shaped our efforts to mobilize tens of millions of dollars toward advancing its goals. To build upon this momentum, Blueprint Biosecurity is hiring up to two Program Officers to expand our PPE team. These program officer roles are structured into two distinct tracks: Research Management or Grant Evaluation. Both positions will work closely with the PPE Program Director to help build a more resilient future in which critical workers have access to respirators during emergencies.

Learn more and submit your application here by August 21.

NEW: Horizon Fellowship

From Horizon Institute for Public Service: “Through our fellowship, we place fully-funded fellows at host organizations to help tackle policy challenges related to artificial intelligence, biotechnology, and other emerging technologies. Fellows selected for our program receive policy-focused training, mentorship, and support in matching with a host organization for a full-time, fully-funded fellowship based in the Washington, DC area. Fellows join a collaborative, close-knit community of public service-oriented experts. Potential host organizations include executive branch offices, congressional offices, national laboratories, and think tanks.”

Learn more and submit your application here by August 30.

NEW: Asia Centre for Health Security (ACHS) Fellowship Programme

From ACHS: “The ACHS Fellowship Programme aims to inspire and connect the next generation of health security leaders and innovators. Launched in 2025 by ACHS, based at the Saw Swee Hock School of Public Health (SSHSPH), National University of Singapore (NUS), the ACHS Fellowship Programme is a highly competitive, part-time fellowship that provides graduate students and early- to mid-career professionals with an opportunity to deepen their expertise, expand their professional network, and build leadership skills through educational opportunities and project work.”

Learn more and submit your application here by August 31.

WHO Internship Programme

From WHO: “A competent and dynamic health workforce at the heart of each health system is essential to advance global health goals. Countries need a pool of health professionals trained and exposed to the systems and processes in the health sector and who understand how stakeholders interact within the international health arena. WHO’s Internship Programme offers a wide range of opportunities for students and recent graduates to gain insight into the technical and administrative programmes of WHO and enrich their knowledge and experience in various areas, thereby contributing to the advancement of public health.”

Learn more and apply here.

OpenAI Bio Bug Bounty Program

From OpenAI: “As part of our ongoing efforts to strengthen our safeguards for advanced AI capabilities in biology, we’re evolving our GPT‑5.5 Bio Bug Bounty to become an ongoing private program—the OpenAI Bio Bounty Program. The program will remain focused on universal jailbreaks that can defeat our predefined biosafety challenge against OpenAI’s frontier models, starting with GPT‑5.6 and going forward. The reward for a universal jailbreak for the OpenAI Bio Bounty Program has been raised from $25,000 to $50,000 for both GPT‑5.6 and GPT‑5.5. Smaller awards may be granted for partial wins at our discretion.”

Learn more and submit your application here.

Disarmament and non-proliferation of WMD – Training Program

From Asser Institute and OPCW: “By 2026, pressure on the international arms control system has reached a point few experts anticipated would arrive so quickly, driven largely by intense geopolitical fragmentation. There is a critical need for professionals who possess the legal, technical, and diplomatic expertise to navigate these modern complexities. This intensive five-day training provides a comprehensive, practical overview of the international non-proliferation and disarmament framework.”

This program will take place from October 26-30 in The Hague, the Netherlands. Learn more and register here.

Pandora Report 7.31.2026: Is the U.S. Ready for the Next Pandemic?

Welcome to this week’s Pandora Report! This issue highlights Anthony Fauci’s contentious Senate hearing on the nation’s COVID-19 response, the state of U.S. public health preparedness as infectious disease threats continue to rise, ongoing H5N1 and New World screwworm challenges, and evolving biosecurity policies at home and abroad.


Anthony Fauci Pleads the Fifth During Contentious Senate COVID-19 Hearing

Former top US health official Anthony Fauci invoked his Fifth Amendment right against self-incrimination during a tense July 29 hearing before the Senate Committee on Homeland Security, declining to answer questions related to the origins of COVID-19 and the nation’s handling of the pandemic. The hearing, led by Committee Chairman Sen. Rand Paul (R-KY), followed the public release of Fauci’s COVID-era diaries and focused on allegations that federal funding supported risky viral research at the Wuhan Institute of Virology. Fauci’s attorneys advised him not to testify, citing ongoing legal concerns despite the presidential pardon he received from former President Joe Biden. Republican senators criticized his refusal to answer questions and raised the possibility of contempt proceedings, while Democratic lawmakers characterized the hearing as politically motivated and defended Fauci’s public health record.

Is America Becoming Less Prepared for the Next Pandemic?

By Carmen Shaw, Pandora Report Managing Editor

The United States is confronting several infectious disease threats at once – hantavirus, screwworm, Ebola, cyclospora, measles, whooping cough, and bird flu. Former CDC officials warn that major changes made by the administration to the nation’s public health infrastructure – reducing funding, cutting staff, changing priorities, and shuttering USAID – have left the US in worse shape than before the COVID-19 pandemic. According to The Guardian, 80% of senior leadership positions at the CDC still lack permanent officials, and the agency has lost an estimated 25-30% of its workforce. Given the dearth of proper “boots on the ground” experience, the US appears less prepared for the next major public health emergency.

It has also been reported that the Trump administration has quietly reduced the role of the HHS’ Agency for Healthcare Research and Quality (AHRQ), which supports research aimed at improving patient safety, healthcare quality, and emergency preparedness. Meanwhile, Politico reported that the State Department will move forward with dispensing approximately $600M in previously delayed vaccine funding after HHS Secretary Robert F. Kennedy Jr. held up the funding for months due to concerns about vaccine safety. Separately, a new analysis found that while the U.S. has strengthened several aspects of its Ebola response since the 2014-2016 West Africa epidemic – including airport screening, lab diagnostics, and hospital preparedness – experts warn that maintaining these capabilities will require sustained investment and experienced personnel.

These concerns surrounding the U.S. international disease response capacity grow as disease activity continues to rise nationwide. U.S. cyclospora infection cases have reached record levels in 2026 following multiple foodborne outbreaks. U.S. measles cases have surpassed last year’s total and reached their highest level in more than three decades, driven by declining childhood vaccination coverage and several outbreaks around the nation. Taken together, these developments paint a troubling picture for the US – even as disease threats continue to mount, the nation’s public health infrastructure appears to be backsliding.

California Judge Rules H5N1 Quarantine Locations to Stay Confidential

By Margeaux Malone, Pandora Report Associate Editor 

A Sacramento County Superior Court judge ruled against disclosing the names and locations of California dairies quarantined during the 2024-25 bird flu outbreak, siding with state agriculture officials. More than 750 dairies were quarantined statewide during that period as officials worked to contain the spread of highly pathogenic avian influenza. The suit was filed by the California Rural Legal Assistance (CRLA), which argued that making the information public would improve oversight of the state’s response, help protect dairy workers, and provide researchers with data to better understand the outbreak. The judge acknowledged the public interest in government transparency but concluded that protecting producer confidentiality would encourage farmers to report sick animals promptly and cooperate with disease investigations. Amanda Murray, California’s acting state veterinarian and branch chief of Animal Health and Food Safety Services, wrote, “Loss of this trust would likely have a chilling effect, wherein producers would either delay reporting or not report clinical signs of disease.” Out of fear of public backlash, some farms might have culled sick animals and disposed of them themselves, potentially spreading the disease unintentionally. Industry groups have praised the decision as vital to maintaining trust between producers and regulators, while CRLA says it’s weighing further legal options.

Cattle Imports from Mexico to Resume Amid Ongoing NWS Outbreaks

Last Friday, USDA announced a phased reopening of the US-Mexico border to cattle imports, despite the ongoing efforts to prevent further spread of New World Screwworm (NWS) into the country. Imports will start August 24 at the Douglas, Arizona port, with New Mexico crossings to follow pending Mexico’s compliance with a joint action plan targeting NWS. Sonora and Chihuahua were identified as lower-risk source states in Mexico due to stronger inspection infrastructure. The decision follows sustained pressure from Republicans and cattle industry groups to reopen the border amid elevated beef prices, a concern shared by the administration, which aims to lower prices ahead of the upcoming midterm elections.

Agriculture Secretary Brooke Rollins had previously resisted reopening the southern border over screwworm concerns, while acknowledging the economic challenges it posed to various sectors of the industry in Texas. The Biden administration first closed the border to cattle imports in late 2024 following detection of NWS in southern Mexico. The Trump administration then temporarily reopened the border from January to May 2025, before closing it again as screwworms moved northward in Mexico. While many industry groups applaud the move, others, including the United States Cattlemen’s Association (USCA), remain wary that reopening risks reintroducing the parasite before containment is complete. USCA President Justin Tupper responded to the decision, saying, “Any effort to lower beef prices must not come at the expense of U.S. cattle herd health. We’ve been encouraged to rebuild the domestic herd; it is of utmost importance, and unnecessary exposure to animal health threats is a risk we do not need to take.”

Further Reading: 

IN OTHER NEWS

Infectious Disease Outbreaks

Biosecurity Governance and High-Risk Research

Rising Temps, Rising Risks: Infectious Disease in the 2026 El Niño Year

From the Pandemic Center: “Climate variability, including El Niño-driven shifts in temperature and rainfall, is reshaping infectious disease risks by altering the environments where pathogens and vectors thrive. This year is progressing towards a historically severe El Niño event — a naturally occurring climate pattern characterized by the warming of surface waters in the central and eastern Pacific Ocean.

What impact will this compounding climate event have on disease prevalence, and which regions are most vulnerable? In this Pandemic Center webinar, we will convene an expert panel to discuss these questions and more.”

This webinar will take place on July 31 at 12:00 PM ET. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.”

This workshop series will take place on September 23. Learn more and register here.

Preparing for a Future of AI-Enabled Biology – A Workshop

From the National Academy of Medicine (NAM): “Artificial intelligence (AI) is transforming the life sciences, including how researchers study biology, develop vaccines and treatments, and detect disease outbreaks. While these advances could improve public health and preparedness, they also raise important questions about safety, security, and the possibility of misuse.”

This event will take place on August 11-12. Learn more and register here.

Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention

From the United Nations Office for Disarmament Affairs (UNODA): “We will convene the Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention (BWC). Chaired by Ambassador Frederico S. Duque Estrada Meyer of Brazil, the meeting will bring together State Parties, international organizations, academic institutions, and civil society representatives to continue discussions on strengthening the Convention and advancing efforts to address biological threats. Public sessions will be webcast through UN Web TV, and side events are expected throughout the week.

This event will take place from August 17-21 at the Palais des Nations in Geneva, Switzerland. Learn more and register by July 31st here.

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.”

This in-person event will take place from August 27-28. Learn more and register here.

Training Course on ‘Biotechnology Innovation and Biosecurity’

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).”

This in-person event will be held from October 12-16 in New Delhi, India. Learn more and apply here.

Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

WHO Internship Programme

From WHO: “A competent and dynamic health workforce at the heart of each health system is essential to advance global health goals. Countries need a pool of health professionals trained and exposed to the systems and processes in the health sector and who understand how stakeholders interact within the international health arena. WHO’s Internship Programme offers a wide range of opportunities for students and recent graduates to gain insight into the technical and administrative programmes of WHO and enrich their knowledge and experience in various areas, thereby contributing to the advancement of public health.”

Learn more and apply here.

OpenAI Bio Bug Bounty Program

From OpenAI: “As part of our ongoing efforts to strengthen our safeguards for advanced AI capabilities in biology, we’re evolving our GPT‑5.5 Bio Bug Bounty to become an ongoing private program—the OpenAI Bio Bounty Program. The program will remain focused on universal jailbreaks that can defeat our predefined biosafety challenge against OpenAI’s frontier models, starting with GPT‑5.6 and going forward. The reward for a universal jailbreak for the OpenAI Bio Bounty Program has been raised from $25,000 to $50,000 for both GPT‑5.6 and GPT‑5.5. Smaller awards may be granted for partial wins at our discretion.”

Learn more and submit your application here.

Disarmament and non-proliferation of WMD – Training Program

From Asser Institute and OPCW: “By 2026, pressure on the international arms control system has reached a point few experts anticipated would arrive so quickly, driven largely by intense geopolitical fragmentation. There is a critical need for professionals who possess the legal, technical, and diplomatic expertise to navigate these modern complexities. This intensive five-day training provides a comprehensive, practical overview of the international non-proliferation and disarmament framework.”

This program will take place from October 26-30 in The Hague, the Netherlands. Learn more and register here.

Pandora Report 7.24.2026

Welcome to this week’s Pandora Report! This issue highlights a multistate Cyclospora outbreak linked to recalled iceberg lettuce served at Taco Bell locations, updates on the continued global spread of H5N1 avian influenza from Cambodia to New Zealand, and the DHS’s new AI-enabled biological threat detection challenge under the Genesis Mission.


Taco Bell Cyclospora Outbreak Linked to Recalled Iceberg Lettuce

By Carmen Shaw, Pandora Report Managing Editor

The CDC, FDA, and public health officials are investigating a new multistate outbreak of the diarrhea-causing parasite Cyclospora, which has been linked to iceberg lettuce served at Taco Bell locations in 9 states. As of July 24, at least 1,947 confirmed illnesses and 98 hospitalizations have been reported across Illinois, Indiana, Kansas, Kentucky, Michigan, Ohio, Oklahoma, Pennsylvania, and West Virginia, with no deaths recorded. Epidemiological investigations have identified iceberg lettuce sourced from central Mexico by Taylor Farms de Mexico as the likely source of the outbreak, prompting a voluntary recall of all affected lettuce products distributed to consumers, restaurants, and retailers in at least 27 states.

Illness onset dates range from June 22 to July 20, 2026. Despite the recall, public health officials expect to see the number of confirmed cases continue to rise because it can take up to 6 weeks for laboratory testing to determine whether an illness is associated with the outbreak. The FDA continues to advise the public to avoid all products listed in Taylor Farms’ voluntary recall.

The outbreak has also temporarily affected Taco Bell’s business performance, with consumer foot traffic declining nearly 30% following public notification of the investigation. However, industry analysts expect the financial impact to be short-lived, citing the company’s rapid removal of affected lettuce from its supply chain and proactive public communications. The CDC also continues to investigate other unrelated cyclosporiasis outbreaks occurring nationwide.

Further Reading:

Bird Flu Claims New Territory from Cambodia to New Zealand

By Margeaux Malone, Pandora Report Associate Editor 

Cambodia has confirmed its fifth human H5N1 case of the year, involving a 9-month-old girl who is currently hospitalized and receiving intensive care. No source of infection has yet been identified, though her close contacts are being given Tamiflu as a precaution. Cambodia reported 19 human cases in 2025, eight of them fatal, with most recent infections involving a reassorted strain which blends an older clade circulating since 2014 with the globally spreading 2.3.4.4b clade. Meanwhile in the US, APHIS reported a second consecutive egg-farm outbreak in Utah, bringing the 30-day national poultry toll to 1.49 million. New cattle detections in Utah and Idaho added four cases each, pushing the year’s total to 81.

Just days after confirming bird flu in a migratory bird, New Zealand detected the first infection of H5N1 in a native bird late last week. The country’s chief veterinary officer Mary van Andel says the disease is likely to become endemic within months, mirroring outcomes elsewhere in the world. Further spillover into native wildlife is probable and experts warn the consequences could be severe. In response, the Department of Conservation has begun vaccinating 300 core breeding birds across five of the country’s most endangered species, including kākāpō and takahē. Officials stress there is no food safety risk, and chicken and eggs remain safe to eat.

These developments fit a broader global picture. The dominant strain of highly pathogenic avian influenza, H5N1 clade 2.3.4.4b, has now reached every continent following the recent detections in Australia and New Zealand, closing the last geographic gap in the outbreak. Since 2020, the virus has proven unusually adept at jumping into mammals, including foxes, seals, and, unexpectedly, U.S. dairy cattle. Fortunately, human infection remains uncommon, with over 880 sporadic cases reported to the World Health Organization (WHO) since 1997 and no sustained human-to-human transmission documented. Still, scientists are watching newer, more severe genotypes and evidence of possible asymptomatic infection, which points to a virus that continues to evolve and could eventually pose a global pandemic risk.

Further Reading: 

DHS Launches AI-Driven Biological Threat Detection Challenge

The U.S. Department of Homeland Security (DHS) Science & Technology Directorate (S&T) announced a new set of national challenges – part of the “Genesis Mission” – aimed at bolstering the U.S.’ security and global leadership in critical and emerging technology. This includes an initiative to deploy AI-enabled platforms to rapidly detect, characterize, and attribute emerging biological threats to safeguard public health and the bioeconomy. By leveraging federal biological data resources, national laboratories, and cross-agency collaboration, this effort aims to shorten detection and response timelines, deter adversaries, and protect Americans from the misuse of biotechnology.

IN OTHER NEWS 

NEW: DC Biosecurity Happy Hour

Join the DC Biosecurity Happy Hour, an informal event for biosecurity enthusiasts in DC to get to know each other outside of Zoom calls and talk about new ideas in the space.

This event will take place on Tuesday, July 28, from 6:30 PM-8:30 PM ET. Learn more and register here.

NEW: Rising Temps, Rising Risks: Infectious Disease in the 2026 El Niño Year

From the Pandemic Center: “Climate variability, including El Niño-driven shifts in temperature and rainfall, is reshaping infectious disease risks by altering the environments where pathogens and vectors thrive. This year is progressing towards a historically severe El Niño event — a naturally occurring climate pattern characterized by the warming of surface waters in the central and eastern Pacific Ocean.

What impact will this compounding climate event have on disease prevalence, and which regions are most vulnerable? In this Pandemic Center webinar, we will convene an expert panel to discuss these questions and more.”

This webinar will take place on July 31 at 12:00 PM ET. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.”

This workshop series will take place on July 21, July 28, and September 23. Learn more and register here.

Tracking Health Security Progress and Building Resilience in Africa – A Webinar

From the Nuclear Threat Initiative (NTI): “The world is shifting from a period of urgent health actions to one of vast growing neglect, even as biological threats continue to rise. Against this backdrop, the 2026 Africa Health Security Index shows great progress has been made across the continent – but substantial gaps remain.

Join NTI, the Brown University Pandemic Center, Economist Enterprise, and the Science for Africa Foundation for a discussion of the findings and recommendations of the 2026 Africa Health Security (AHS) Index, an independent assessment of health security capacities in Africa.

This webinar will convene global experts and policymakers to discuss how the AHS Index can shape policy decision-making and drive meaningful action to strengthen health security capacities and improve preparedness for future epidemics and pandemics.”

This virtual event will take place on July 29 from 8:30 AM-10:00 AM ET (3:30-5:00 PM EAT). Learn more and register here.

Preparing for a Future of AI-Enabled Biology – A Workshop

From the National Academy of Medicine (NAM): “Artificial intelligence (AI) is transforming the life sciences, including how researchers study biology, develop vaccines and treatments, and detect disease outbreaks. While these advances could improve public health and preparedness, they also raise important questions about safety, security, and the possibility of misuse.”

This event will take place on August 11-12. Learn more and register here.

Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention

From the United Nations Office for Disarmament Affairs (UNODA): “We will convene the Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention (BWC). Chaired by Ambassador Frederico S. Duque Estrada Meyer of Brazil, the meeting will bring together State Parties, international organizations, academic institutions, and civil society representatives to continue discussions on strengthening the Convention and advancing efforts to address biological threats. Public sessions will be webcast through UN Web TV, and side events are expected throughout the week.

This event will take place from August 17-21 at the Palais des Nations in Geneva, Switzerland. Learn more and register by July 31st here.

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.”

This in-person event will take place from August 27-28. Learn more and register here.

Training Course on ‘Biotechnology Innovation and Biosecurity’

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).”

This in-person event will be held from October 12-16 in New Delhi, India. Learn more and apply here.

Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

WHO Internship Programme

From WHO: “A competent and dynamic health workforce at the heart of each health system is essential to advance global health goals. Countries need a pool of health professionals trained and exposed to the systems and processes in the health sector and who understand how stakeholders interact within the international health arena. WHO’s Internship Programme offers a wide range of opportunities for students and recent graduates to gain insight into the technical and administrative programmes of WHO and enrich their knowledge and experience in various areas, thereby contributing to the advancement of public health.”

Learn more and apply here.

OpenAI Bio Bug Bounty Program

From OpenAI: “As part of our ongoing efforts to strengthen our safeguards for advanced AI capabilities in biology, we’re evolving our GPT‑5.5 Bio Bug Bounty to become an ongoing private program—the OpenAI Bio Bounty Program. The program will remain focused on universal jailbreaks that can defeat our predefined biosafety challenge against OpenAI’s frontier models, starting with GPT‑5.6 and going forward. The reward for a universal jailbreak for the OpenAI Bio Bounty Program has been raised from $25,000 to $50,000 for both GPT‑5.6 and GPT‑5.5. Smaller awards may be granted for partial wins at our discretion.”

Learn more and submit your application here.

Disarmament and non-proliferation of WMD – Training Program

From Asser Institute and OPCW: “By 2026, pressure on the international arms control system has reached a point few experts anticipated would arrive so quickly, driven largely by intense geopolitical fragmentation. There is a critical need for professionals who possess the legal, technical, and diplomatic expertise to navigate these modern complexities. This intensive five-day training provides a comprehensive, practical overview of the international non-proliferation and disarmament framework.”

This program will take place from October 26-30 in The Hague, the Netherlands. Learn more and register here.

Pandora Report 7.17.2026

Welcome to this week’s Pandora Report! This issue highlights a new proposal to modernize U.S. biosecurity governance, the continued global spread of H5N1 avian influenza and New World screwworm, the escalating Ebola outbreak in the DRC, and upcoming events and opportunities focused on biosecurity, One Health, pandemic preparedness, and emerging biotechnology.


FAS Proposes Overhaul of U.S. Biosecurity Governance Towards Adaptive Frameworks

A new briefing paper from the Federation of American Scientists (FAS), authored by Sam Weiss Evans, argues that the United States’ fragmented biosecurity governance system is ill-equipped to address emerging risks posed by biotechnology and calls for a fundamental shift from reactive, piecemeal oversight to a centralized, adaptive governance model. The paper contends that existing authorities are dispersed across multiple agencies, creating regulatory gaps as advances in areas such as AI-enabled biology, gene synthesis, and cloud laboratories outpace current policies. To modernize biosecurity, the author outlines seven design requirements for a new institutional framework, including proactive and multi-sectoral risk identification, oversight spanning the full innovation lifecycle, the ability to develop and test new governing tools, and continuous adaptation as technologies evolve.

Bird Flu and New World Screwworm: A Week in Review

By Margeaux Malone, Pandora Report Associate Editor 

H5N1 avian influenza has once again expanded into new territory. New Zealand confirmed its first case this week after a migratory seabird found near Wellington tested positive. Fortunately, officials have found no evidence of poultry infections, mass wildlife mortality, or transmission between wild birds within the country. Nevertheless, health officials have started a vaccination program for 300 core breeding birds from five endangered species, including the flightless takahe and kakapo. The vaccine was trialed last year with no adverse side effects, but it is uncertain how effective it was given that those birds had not been exposed to the virus. “We are ​incredibly worried about New Zealand’s biodiversity because our birds have never ​had to deal with anything like this before,” said Brett Gartrell, professor of wildlife health at Massey University.

Meanwhile, multiple human H5N1 bird flu cases were reported in Asia. Cambodia reported its 5th human H5N1 case of 2026, a 9-month-old girl from Phnom Penh confirmed positive on July 9. No source of exposure has been identified yet. This brings Cambodia’s total to 39 cases since a 2023 reemergence of the older 2.3.2.1e clade. Bangladesh confirmed its 3rd H5N1 case of the year in a child from Sylhet Division.

As New World screwworm continues to spread, officials warn that feral hogs could carry the parasite into Oklahoma. So far, Texas has not reported any screwworm cases in wildlife, though this may be due to the challenge of monitoring non-domestic animals. Feral swine pose a unique risk because they roam widely, are difficult to track, and often develop injuries from fighting that would attract infestations. Screwworm control in these animals would be extremely difficult as infested animals could not be medicated. Though the wild populations are a problem, state veterinarian Dr. Rod Hall said the most immediate threat is currently illegal interstate transport of hogs, a felony in Oklahoma. Officials are coordinating with hunters, wildlife rehabilitators, and commercial hunting operations to expand surveillance. Ranchers and the public are urged to report animals with unusual wounds or maggots immediately.

Further Reading: 

IN OTHER NEWS 

Foodborne Disease & Public Health

Ebola Outbreak Response

Global Health Policy and Governance

Emerging Biotechnology, AI, and Synthetic Biology

NEW: Strategic Preparedness Exchange and Archive Repository (SPEAR) and Practical Preparedness Solutions – A Webinar

From Shield Initiative: “The SHIELD Initiative invites you to a dynamic webinar introducing SPEAR, the Strategic Preparedness Exchange and Archive Repository. This new, user-friendly platform is designed to make preparedness and response resources accessible to frontline preparedness practitioners across public health, health care, and emergency management.”

This virtual event will take place on July 21 from 3:00–4:00 PM ET. Learn more and register here.

NEW: Bagels & Biotech: Synthetic Cells

Join the National Academy of Medicine and science, technology, and policy professionals from the Washington, DC region for breakfast and conversations as we explore how breakthroughs in synthetic cell systems could transform biomedical and health applications, including therapeutics, diagnostics, regenerative medicine, and distributed biomanufacturing.

This event will take place on July 22 from 8:30-10:30 AM ET at The Keck Center in Washington, DC. Learn more and register here.  

NEW: The Global One Health Movement: Why Social Scientists are Critical to Making One Health Thinking, Acting, and Decision-Making the Default for Humankind – a Webinar

From the One Health Commission: “As global health challenges become increasingly interconnected, the integration of social sciences into the One Health approach is more important than ever. In this inspiring session, Dr. Stroud will discuss how social scientists contribute to making One Health thinking, collaboration, and evidence-based decision-making the global standard. The webinar will also explore innovative approaches to addressing food safety, food security, public health, animal health, environmental sustainability, and other complex challenges through interdisciplinary collaboration.”

This virtual event will take place on July 22 at 11:00 AM ET (5:00 PM CET). Learn more and register here.

The 100 Days Mission and the Future of Vaccine Readiness – Webinar

From the Pandemic Center Biosecurity Game Changers Fellows: “Convened and moderated by and intended for early-to-mid-career professionals, the Game Changers Seminar Series shines a spotlight on major challenges that will confront the next generation of biosecurity leaders and explores impactful next steps that can be taken to lean forward faster to prevent biological crises.

This seminar will explore the future of vaccine readiness through the lens of the 100 Days Mission. The discussion will examine the scientific, policy, financing, and implementation requirements to achieving this goal, drawing on lessons from the recent Ebola and Hantavirus outbreaks to inform future pandemic preparedness.”

This webinar will take place on July 17 at 11:00 AM ET. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.”

This workshop series will take place on July 21, July 28, and September 23. Learn more and register here.

Tracking Health Security Progress and Building Resilience in Africa – A Webinar

From the Nuclear Threat Initiative (NTI): “The world is shifting from a period of urgent health actions to one of vast growing neglect, even as biological threats continue to rise. Against this backdrop, the 2026 Africa Health Security Index shows great progress has been made across the continent – but substantial gaps remain.

Join NTI, the Brown University Pandemic Center, Economist Enterprise, and the Science for Africa Foundation for a discussion of the findings and recommendations of the 2026 Africa Health Security (AHS) Index, an independent assessment of health security capacities in Africa.

This webinar will convene global experts and policymakers to discuss how the AHS Index can shape policy decision-making and drive meaningful action to strengthen health security capacities and improve preparedness for future epidemics and pandemics.”

This virtual event will take place on July 29 from 8:30 AM-10:00 AM ET (3:30-5:00 PM EAT). Learn more and register here.

Preparing for a Future of AI-Enabled Biology – A Workshop

From the National Academy of Medicine (NAM): “Artificial intelligence (AI) is transforming the life sciences, including how researchers study biology, develop vaccines and treatments, and detect disease outbreaks. While these advances could improve public health and preparedness, they also raise important questions about safety, security, and the possibility of misuse.”

This event will take place on August 11-12. Learn more and register here.

Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention

From the United Nations Office for Disarmament Affairs (UNODA): “We will convene the Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention (BWC). Chaired by Ambassador Frederico S. Duque Estrada Meyer of Brazil, the meeting will bring together State Parties, international organizations, academic institutions, and civil society representatives to continue discussions on strengthening the Convention and advancing efforts to address biological threats. Public sessions will be webcast through UN Web TV, and side events are expected throughout the week.

This event will take place from August 17-21 at the Palais des Nations in Geneva, Switzerland. Learn more and register by July 31st here.

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.”

This in-person event will take place from August 27-28. Learn more and register here.

Training Course on ‘Biotechnology Innovation and Biosecurity’

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).”

This in-person event will be held from October 12-16 in New Delhi, India. Learn more and apply here.

Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

NEW: WHO Internship Programme

From WHO: “A competent and dynamic health workforce at the heart of each health system is essential to advance global health goals. Countries need a pool of health professionals trained and exposed to the systems and processes in the health sector and who understand how stakeholders interact within the international health arena. WHO’s Internship Programme offers a wide range of opportunities for students and recent graduates to gain insight into the technical and administrative programmes of WHO and enrich their knowledge and experience in various areas, thereby contributing to the advancement of public health.”

Learn more and apply here.

NEW: OpenAI Bio Bug Bounty Program

From OpenAI: “As part of our ongoing efforts to strengthen our safeguards for advanced AI capabilities in biology, we’re evolving our GPT‑5.5 Bio Bug Bounty to become an ongoing private program—the OpenAI Bio Bounty Program. The program will remain focused on universal jailbreaks that can defeat our predefined biosafety challenge against OpenAI’s frontier models, starting with GPT‑5.6 and going forward. The reward for a universal jailbreak for the OpenAI Bio Bounty Program has been raised from $25,000 to $50,000 for both GPT‑5.6 and GPT‑5.5. Smaller awards may be granted for partial wins at our discretion.”

Learn more and submit your application here.

NEW: Disarmament and non-proliferation of WMD – Training Program

From Asser Institute and OPCW: “By 2026, pressure on the international arms control system has reached a point few experts anticipated would arrive so quickly, driven largely by intense geopolitical fragmentation. There is a critical need for professionals who possess the legal, technical, and diplomatic expertise to navigate these modern complexities. This intensive five-day training provides a comprehensive, practical overview of the international non-proliferation and disarmament framework.”

This program will take place from October 26-30 in The Hague, the Netherlands. Learn more and register here.

Senior Fellow and Director, The Technology and Global Security Program – Job Opening

From The Henry L. Stimson Center: “The Henry L. Stimson Center, an award-winning foreign policy think tank, seeks a highly motivated individual to serve as Senior Fellow and Director of its newly established Technology and Global Security Program. The Program will work on the security implications of a broad range of emerging and converging technologies, including quantum technologies, artificial intelligence, biotechnology, additive manufacturing, uncrewed systems, distributed ledger technologies, nuclear technologies, and other innovations reshaping the international security landscape.”

Learn more and submit your application here.

Pandora Report 7.10.2026

Welcome to this week’s Pandora Report! This issue highlights the upcoming One Health Day campaign, the latest global H5N1 developments and renewed calls to strengthen oversight of the U.S. wildlife trade, the launch of Global BioFutures, and new analyses of evolving terrorism and counterterrorism trends in 2026.

One Health Day 2026 🌍

The annual One Health Day campaign is approaching on November 3rd and serves as a global reminder that the health of humans, animals, plants, and the environment are deeply interconnected.

Bird Flu: Australia’s seabirds to America’s dairy herds

By Margeaux Malone, Pandora Report Associate Editor 

Highly pathogenic avian influenza (HPAI) H5N1 remains a global presence, but the current impact differs by region.

In Australia, New South Wales became the latest state to confirm a case of bird flu after a migratory giant petrel tested positive, bringing the country to six infections across three states. The news follows a milestone last month, when Australia became the final continent to record a mainland case. Officials continue to stress that there is no spread to commercial poultry, that egg and chicken supplies are unaffected, and that human infections remain rare.

North America, by contrast, is in a seasonal lull. The United States passed a full month with no HPAI in commercial poultry. Canada’s last case in a commercial flock was in mid-May, and according to a recent report, all outbreaks have been declared closed. U.S. dairy cattle have not been so fortunate. Idaho recorded 40 newly infected herds in June, the bulk of all new domestic bird flu detections. Idaho’s state veterinarian, Dr. Scott Leibsle, said the virus strain is spreading cow-to-cow rather than from wild birds, complicating containment. State officials are considering expanding surveillance efforts and additional countermeasures like vaccines, if one becomes available. “Biosecurity only goes so far when you have a dairy of several thousand cattle that are infected with the virus,” Leibsle said. Nationally, the tally now stands at 1,154 affected herds across 20 states since the outbreak began.

A Call to Rethink the U.S. Wildlife Trade

The recent reemergence of New World screwworm in the U.S. has drawn national attention to livestock disease threats, but some argue it should also call attention to a historically overlooked pandemic risk: the country’s largely unregulated wildlife trade.

In a recent piece in Think Global Health, author Neil M. Vora argues that while officials police livestock and people at the border, they continue to ignore the tens of millions of live wild animals imported each year, primarily for the exotic pet market. According to the piece, most pandemics since 1918 have stemmed from zoonotic pathogens, and mammals in the wildlife trade are far more likely to share pathogens with humans. Over the past two decades, nearly three billion animals representing more than 20,000 species were legally imported into the United States; however, legal importation doesn’t mean these animals are safe. Imported wildlife are rarely screened for diseases, and importers and exporters often only need to attest to their animals’ health. Cases like the mpox outbreak in the Midwest in 2003 linked to Ghanian rodents or a mass mortality event among sloths in Florida earlier this year from a novel gammaherpesvirus highlight the disease risks posed by importation of exotic species.

The author points to fragmented oversight as a core problem, noting that responsibility is scattered across state and federal agencies with no single body accountable. Rather than waiting for Congress to pass new legislation, he contends that federal officials already have broad power under Title 42 to prevent introduction and transmission of communicable disease from foreign countries and the CDC has clear authority to regulate importation of animals into the country to reduce and prevent the spread of disease. Vora ultimately calls for creation of a carefully selected “permitted list” for trade, consisting only of species deemed to have a low risk for harboring pathogens based on rigorous review of scientific evidence, with all others barred except in limited cases. Although some may argue this conclusion is too restrictive, the article raises worthwhile points to consider for pandemic preparedness against zoonotic disease.

Further Reading:  

The Launch of Global BioFutures

This week, Dr. Aparupa Sengupta announced the launch of Global BioFutures, a mission-driven organization building talent, institutions, and governance to strengthen global health security and shape responsible biotechnology. Dr. Sengupta has worked for more than a decade, most recently at the Nuclear Threat Initiative (NTI), at the intersection of biological innovation, emerging technologies, biosecurity, and global policy. Biotechnology and artificial intelligence (AI) are advancing at an unprecedented speed, but the governance, institutions, and talent needed to guide them responsibly are not keeping pace—particularly across the Global South. Yet this is where some of the world’s fastest-growing bioeconomies, scientific talent, and biotechnology innovation are emerging. Global BioFutures was founded to strengthen biological capacity by advancing AI-biotechnology governance, biosecurity, field building in the Global South, talent development, and strategic partnerships across emerging biotechnology ecosystems. Professor Gregory D. Koblentz, Director of the Biodefense Graduate Program at the Schar School of Policy and Government, has been selected to serve on the group’s founding Strategic Advisory Board. According to Professor Koblentz, “Global BioFutures recognizes that identifying emerging biorisks and devising innovative policies for mitigating these risks will require diverse perspectives from a broad range of stakeholders, especially in countries with booming bioeconomies. Global BioFuture’s awareness-raising and capacity-building initiatives reflect the reality that today’s biosecurity challenges are global—and so are the solutions”. 

GMU Professor Highlights Terrorism and Counterterrorism Trends in First Half of 2026

In two new analyses for Homeland Security Today, Dr. Mahmut Cengiz, adjunct professor at George Mason University’s Schar School of Policy and Government, examines how both terrorist organizations and counterterrorism efforts are evolving during the first half of 2026. Taken together, these articles identify key trends shaping global threat landscape, including the growing convergence of terrorism with transnational crime and emerging technologies, as well as the ways governments are adapting their operational strategies to address increasingly complex and interconnected security challenges.

IN OTHER NEWS 

Global Health Security & Emerging Infectious Diseases

Chemical Weapons, OPCW & International Security

Biotechnology Governance & Biosecurity

Intelligence, Oversight, and Emerging Threats

NEW: The 100 Days Mission and the Future of Vaccine Readiness – Webinar

From the Pandemic Center Biosecurity Game Changers Fellows: “Convened and moderated by and intended for early-to-mid-career professionals, the Game Changers Seminar Series shines a spotlight on major challenges that will confront the next generation of biosecurity leaders and explores impactful next steps that can be taken to lean forward faster to prevent biological crises.

This seminar will explore the future of vaccine readiness through the lens of the 100 Days Mission. The discussion will examine the scientific, policy, financing, and implementation requirements to achieving this goal, drawing on lessons from the recent Ebola and Hantavirus outbreaks to inform future pandemic preparedness.”

This webinar will take place on July 17 at 11:00 AM ET. Learn more and register here.

NEW: Biomanufacturing for Defense & Security Summit

From Diversified Solutions Incorporated (DSI Groups): “This event will bring together senior thought leaders and stakeholders from across DoW, Military Research Labs, Federal Government, Commercial Industry, & Academia to discuss how each are advancing biomanufacturing to enhance national security objectives, produce critical materials for defense applications, and strengthen the overall U.S. bioindustrial manufacturing base. Biomanufacturing is crucial for U.S. national security because it enables domestic production of critical materials, medicines, and defense supplies, reducing reliance on foreign adversaries, which in turn creates resilient supply chains for the military and economy.”

This event will take place from October 27-28 at the National Harbor, MD. Learn more and register here.

Data and Situational Awareness for Medical and Public Health Preparedness and Response: A Workshop Series 

From the National Academies: “The Forum on Medical and Public Health Preparedness for Disasters and Emergencies workshop series will explore how medical, public health, emergency management, and critical infrastructure data are collected, integrated, analyzed, and translated into real-time information to support timely, coordinated decision-making before, during, and after disasters and emergencies.” 

Sessions of the workshop series will take place on July 16, July 21, and July 28, followed by a capstone session on September 23. Learn more and register here

Tracking Health Security Progress and Building Resilience in Africa – A Webinar 

From the Nuclear Threat Initiative (NTI): “The world is shifting from a period of urgent health actions to one of vast growing neglect, even as biological threats continue to rise. Against this backdrop, the 2026 Africa Health Security Index shows great progress has been made across the continent – but substantial gaps remain. 

Join NTI, the Brown University Pandemic Center, Economist Enterprise, and the Science for Africa Foundation for a discussion of the findings and recommendations of the 2026 Africa Health Security (AHS) Index, an independent assessment of health security capacities in Africa. 

This webinar will convene global experts and policymakers to discuss how the AHS Index can shape policy decision-making and drive meaningful action to strengthen health security capacities and improve preparedness for future epidemics and pandemics.” 

This webinar will take place on July 29 from 3:30 – 5:00 PM EAT (8:30 AM – 10:00 AM ET). Learn more and register here

Preparing for a Future of AI-Enabled Biology 

From the National Academy of Medicine (NAM): “Artificial intelligence (AI) is transforming the life sciences, including how researchers study biology, develop vaccines and treatments, and detect disease outbreaks. While these advances could improve public health and preparedness, they also raise important questions about safety, security, and the possibility of misuse. 

To better understand these issues, the National Academy of Medicine, in collaboration with the National Academies of Sciences, Engineering, and Medicine and with support from the Coalition for Epidemic Preparedness Innovations (CEPI), will convene a two-day workshop on preparing for the future of AI-enabled biology. 

The workshop will bring together experts from public health, medicine, biotechnology, artificial intelligence, biosecurity, government, and industry to explore how AI-enabled biological risks may evolve over the next decade.” 

This hybrid event will take place on August 11-12, 2026. Learn more and register here.

Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention  

From the United Nations Office for Disarmament Affairs (UNODA): “We will convene the Ninth Session of the Working Group on the Strengthening of the Biological Weapons Convention (BWC). Chaired by Ambassador Frederico S. Duque Estrada Meyer of Brazil, the meeting will bring together State Parties, international organizations, academic institutions, and civil society representatives to continue discussions on strengthening the Convention and advancing efforts to address biological threats. Public sessions will be webcast through UN Web TV, and side events are expected throughout the week.  

This event will take place from August 17-21 at the Palais des Nations in Geneva, Switzerland. Learn more and register by July 31 here 

Biosecurity Simulation Exercise (BSX 2026): Laboratory Incidents & Deliberate Biothreats 

From the Asia Centre for Health Security: “This table-top simulation exercise aims to enhance inter-sectoral and inter-disciplinary preparedness for laboratory biosafety and biosecurity (LBB) and deliberate biothreat events (DBE). Through lectures, discussions, and structured, scenario-driven exercises, participants will explore decision-making to detect, risk-assess, and manage high-consequence biological incidents under conditions of incomplete information and unfolding events. Participants will collaborate in teams, building on expert perspectives to address issues in surveillance, diagnostics, public health response, security assessment, and risk communication.” 

This in-person event will be held from August 27-28. Learn more and register here

Training Course on ‘Biotechnology Innovation and Biosecurity’ 

From the International Centre for Genetic Engineering and Biotechnology (ICGEB) and the Biological Weapons Convention Implementation Support Unit: “This training focuses on strengthening capacities in biosecurity, biosafety, and biological risk management in the context of rapid advances in biotechnology with an integrated, interdisciplinary approach to manage biothreats at the intersection of humans, animals, plants and the environment. It addresses the governance, technical, and operational dimensions of preventing, detecting, and responding to biological threats, while promoting responsible and peaceful scientific research and innovation in accordance with article X of the Biological Weapons Convention (BWC).” 

This in-person event will be held from October 12 – 16 in New Delhi, India. Learn more and apply here

NEW: Senior Fellow and Director, The Technology and Global Security Program – Job Opening

From The Henry L. Stimson Center: “The Henry L. Stimson Center, an award-winning foreign policy think tank, seeks a highly motivated individual to serve as Senior Fellow and Director of its newly established Technology and Global Security Program. The Program will work on the security implications of a broad range of emerging and converging technologies, including quantum technologies, artificial intelligence, biotechnology, additive manufacturing, uncrewed systems, distributed ledger technologies, nuclear technologies, and other innovations reshaping the international security landscape.”

Learn more and submit your application here.

Pandora Report 12.13.2024

This week’s Pandora Report covers the rush to find the former Assad regime’s hidden chemical weapons, a recent study on H5N1’s potential to become an efficient human pathogen, Nobel laureates’ call for the Senate to block RFK Jr. from becoming HHS Secretary, and more.

Assad Regime Falls

On Sunday, Syrian rebels continued their advance, taking the capital city of Damascus and forcing the country’s long-time leader, President Bashar al-Assad, to flee to Moscow. This ended the country’s 13-year-long civil war and toppled a brutal dictatorship known to have, among other things, used chemical weapons against its own civilians. Now, the country is strapped for cash and being led by opposition forces with limited experience in governance.

Adding to the chaos is the mad dash to locate the former Assad regime’s chemical weapons it hid from inspectors. Among the list of missing weapons are more than 360 tons of mustard gas that the Assad regime admitted to making, but never fully accounted for. There are also five missing tons of precursors for sarin that the Assad regime claimed were “Lost during transportation, due to traffic accidents.”

The OPCW said it is monitoring the situation, reaffirming its commitment to “clarifying gaps, discrepancies, and inconsistencies in Syrian chemical weapons declaration amidst political transition.” Rebels in the south of the country have reached out to the OPCW for support in safely disposing of a cache of CW they found. One US official told the press the US is working with other countries in the Middle East to prevent these weapons from falling into the wrong hands. Meanwhile, Israel reported that it has destroyed CW and other weapons caches while seizing areas along its shared border with the country it claims are part of a demilitarized buffer zone.

Further Reading and Listening:

New Study Finds Single Mutation in Bovine Influenza H5N1 Hemagglutinin Switches Specificity to Human Receptors

A recent study in Science found that a single glutamine to leucine mutation in clade 2.3.4.4b-an H5N1 virus widespread in US dairy cattle that has caused a few mild human cases-at residue 226 of the virus hemagglutinin “was sufficient to enact the change from avian to human specificity.” This means that this virus that currently cannot infect humans very easily could be just one mutation away from being able to do so much more effectively. This finding alone does not mean that this mutation in nature would be guaranteed to make this virus an efficient human pathogen, but it might mean that this version of the virus has a higher zoonotic potential than other H5N1 viruses.

Further Reading:

Investigation Launched into Queensland Lab Incident

An investigation has been launched by Australian authorities into the “major breach” of biosafety protocols that occurred at a state-run laboratory in Queensland in 2021. It was revealed that 323 virus samples-nearly 100 of which were live samples of Hendra virus-were missing. According to Health Minister Tim Nicholls, the incident was only discovered in August of 2023, and the lab is unable to confirm whether the materials were removed or destroyed, though there is no suggestion that they were taken or stolen from the lab.

Top Wuhan Virologist Says WIV Holds No Close Relatives to SARS-CoV-2

Shi Zhengli, the virologist leading coronavirus research at the Wuhan Institute of Virology (WIV) when the COVID-19 pandemic began, presented data on dozens of new coronaviruses collected from bats in southern China at a conference in Japan last week. Shi has said repeatedly that SARS-CoV-2 was never seen nor studied in her lab, but some have continued to insist that one of the bat coronaviruses collected by her team was closely related to it. As a result, Shi promised to sequence the genomes of the viruses stored in her freezers and release the resulting data.

The analysis presented at the conference has not been peer reviewed and includes data from the whole genomes of 56 new betacoronaviruses in addition to some partial sequences. All of these viruses were collected between 2004 and 2021. Shi explained at the conference that none of the viruses she has sequenced are the most recent ancestors of SARS-CoV-2 and that “We didn’t find any new sequences which are more closely related to SARS-CoV-1 and SARS-CoV-2.”

The known viruses that are closest to SARS-CoV-2 were found in bats in Laos and southern China. However, years (or decades) have passed since these viruses split from their common ancestor with SARS-CoV-2. Shi has long since collaborated with EcoHealth Alliance, which previously received US federal funding that was suspended because of inadequate oversight of research activities at the WIV. This collaboration has produced a larger analysis of more than 230 sequences that EcoHealth Alliance’s Peter Daszak says will be submitted for peer review and publication in the coming weeks.

Further Reading: “PLA Looks into China-US Collaboration in Biosecurity Research,” Stephen Chen, SCMP

75+ Nobel Laureates Urge Senate Not to Confirm RFK Jr.

77 winners of the Nobel Prize in Medicine, Chemistry, Physics, and Economics have signed a letter (below) urging the Senate not to confirm President-Elect Trump’s pick to lead HHS-Robert F. Kennedy Jr.. This is a rare example of Nobel laureates coming together against a US Cabinet choice, according to Sir Richard Roberts, winner of the 1993 Nobel Prize in Medicine and a drafter of the letter. The letter criticizes Kennedy’s lack of experience in public health in addition to his widely criticized opinions on topics like drinking water fluoridation and vaccines for measles and polio. The letter reads in part, “In view of his record, placing Mr. Kennedy in charge of DHHS would put the public’s health in jeopardy and undermine America’s global leadership in the health sciences, in both the public and commercial sectors…We strongly urge you to vote against the confirmation of his appointment as Secretary of the DHHS.”

Further Reading:

“2024 ABSA Conference Summary”

Biodefense MS Student Lena Kropke discusses her experience at the 67th Annual Biosafety and Biosecurity Conference in this Pandora Report event summary, writing in part “Attending this conference not only reaffirmed that biosafety and biosecurity are vital components of international security, but also showcased the incredible dedication of professionals who work tirelessly toward this mission. Moreover, it offered an introduction to an amazing network of biosafety and security professionals.”

Read more about Lena’s time attending the conference in Phoenix here.

“Disincentivizing Bioweapons: Theory and Policy Approaches”

This NTI essay collection is “…designed to encourage the exploration and identification of potential solutions to disincentivize states from developing or using biological weapons,” and aims to “bridge theory and practical policy-relevant approaches to develop new approaches to invigorate international efforts to reduce biological threats.” Its fifth essay, “Two Competing Bioweapons Nonproliferation Policies: Deterrence by Denial and Discussion,” was authored by Sonia Ben Ouagrham-Gormley, Associate Professor at the Schar School.

Mitigating Arboviral Threat and Strengthening Public Health Preparedness: Proceedings of a Workshop

From NASEM: “Arboviruses, or viruses carried by arthropods like mosquitoes or ticks, are responsible for hundreds of thousands of deaths worldwide each year. As the climate changes globally, the geographic distribution of these diseases, including Zika, dengue, chikungunya, West Nile, and yellow fever, are steadily expanding. The National Academies Forum on Microbial Threats hosted a public workshop in December 2023 to explore avenues of threat reduction from known and emerging arboviral diseases in the context of public health preparedness and capacity building. The workshop featured talks from experts in entomology, public health, ecology, virology, immunology, disease modeling, and urban planning.”

Read this Proceedings of a Workshop for free here.

“The Current Pathogenicity and Potential Risk Assessment of Nipah Virus as Potential Cause of “Disease X”: A Narrative Review”

Mehnaz et al. recently published this article in Health Science Reports: “Background and Aims…The World Health Organization (WHO) recognized the potential for a severe international epidemic and introduced the term “Disease X” to classify pathogens that not yet identified. The Nipah virus (NiV) is highly dangerous due to its zoonotic nature, high mortality rate, and ability to cause severe clinical symptoms in humans. In this review, we gather the latest information on the NiV and its potential to become a significant candidate for Disease X.”

“Methods…We performed a thorough review of articles published in PubMed, Scopus, and Google Scholar using appropriate MeSH terms and keywords. Studies reported NiV infection were considered for this review.”

“Results…The NiV exhibits different epidemiological patterns in different countries that calls for customized prevention and control strategies. Genetic analysis highlights NiV’s ability to mutate that alters possible treatment options. Transmission typically involves bats as the primary reservoir, with humans becoming infected either through intermediate hosts or food. This shows NiV’s complex nature, including its ability to reach the central nervous system through the olfactory nerve. Promising treatment options, such as monoclonal antibodies, antivirals, and ongoing vaccine research, provide hope. However, the virus’s adaptability, human-to-human transmission, and the lack of specific antiviral therapy raise concerns about its potential to cause a global pandemic. The interconnection between animals, humans, and the environment stresses the need for a One Health approach to tackle emerging infectious disease by NiV.”

“Conclusion…Global collaboration, surveillance, and research investments are imperative for the preparation of future pandemics. The ongoing COVID-19 challenges underscoring the critical need for sustained scientific endeavors, global leadership, and recognition of the prominence of NiV as a candidate for the potential Disease X.”

“Engineering Biology Public Trust Survey Findings”

From the UK’s Department for Science, Innovation and Technology, these findings are the result of a survey on public perceptions of engineering biology in relation to five application areas: health, agriculture and food, low carbon fuels, chemicals and materials, and waste and environment. Key findings from this survey include “The majority of respondents felt comfortable with using new and emerging technologies on a day-to-day basis, but relatively few could explain what engineering biology is,” “There was a strong belief amongst respondents that applications of engineering biology could be useful. Similarly, the majority were comfortable with each of the specific applications and believe that they will be positive for society,” “There was broad agreement that the government is well placed to make decisions about the use of engineering biology but the public should also be involved in decision making,” and more.

“CSR Biodefense Scorecard: Winter 2024 Update”

From the Council on Strategic Risks: “In the fall of 2023, we kicked off our Biodefense Scorecard series to help inform the public on the progress and implementation status of past CSR recommendations on reducing biological risks. This update captures several areas of sustained positive action across pathogen early warning, diplomacy, and biomanufacturing.”

“Ignoring the Real Biowarfare Threat”

David Heslop and Joel Keep discuss the potential implications of recent renovations at Sergiev Posad-6 in this piece from the Lowy Institute, writing in part “While much attention has been paid to nuclear arms, Washington and Moscow must also address biological weapons, which both nations claimed to renounce many years ago. The fate of such programs is not only a matter for Russia and the United States, but for global health security at large.”

“Instrumentalising Biological Weapons-Related Allegations: Russia’s Compliance Politics and the Norms Against Biological Weapons”

Una Jakob recently published this working paper with CBWNet discussing Russia’s use of BWC compliance procedures and their effect on norms against BW. Jakob explains in part of the paper’s executive summary, “Seen in this light, the Russian activities may counterintuitively have contributed to strengthening the norms against biological weapons at the discursive level, as no actor has called them into question and as their validity has been reaffirmed repeatedly in the process, including by Russia itself. This stands in contrast, however, to Russia’s policy which may contest biological weapons norms at the action level. This discrepancy between the discursive and practical level and its implications for norm strength merit further theoretical attention. On a policy level, it will be important to increase transparency, counter disinformation, and strengthen the means to demonstrate, verify and enhance confidence in compliance with the BWC. This would also strengthen the possibilities to address biological weapons-related allegations, including those made in bad faith, and help sustain the norms against biological weapons comprehensively and in the long term.”

“Workshop on S&T Developments with Relevance for the CWC and BWC”

Anna Krin and Gunnar Jeremias edited this CBWNet working paper detailing a workshop hosted in June at Hamburg University focused on challenges and opportunities facing biological and chemical arms control. Jeremias explains in the introduction, “Throughout the workshop, four panels delved into key topics: the general concept and application of scientific and technological advice in arms control in general and particularly in chemical and biological arms control; current developments in science and technology that may necessitate attention; potential frameworks for organizing verification under the CWC and the prospects for institution building for S&T advice and verification within the BWC; and the technologies and governance methods that could be employed to enhance the efficacy of arms control measures…The insights gathered during these discussions aim to contribute to the ongoing discourse on arms control, ensuring that both the BWC and CWC remain vital in a landscape marked by rapid scientific change. This compendium encapsulates the collaborative efforts and perspectives of workshop participants, reflecting a shared commitment to advancing arms control in an increasingly complex world.”

“High-Impact, Low-Probability: NATO-EUROPOL Cooperation in Countering the CBRN Terrorist Threat to Europe”

This JCBRN Defence COE report by Mathias Katsuya “…draws on secondary-source research and insights provided by JCBRN Defence COE personnel as well as Europol’s CBRN-E Team Leader. An initial threat assessment is followed by a review of Europol’s CBRN capabilities, centring on the role of its European Counter-Terrorism Centre and inhouse CBRN-E Team as key nodes in law enforcement information-sharing, capacity-building, and operational coordination. Having identified key doctrinal and capability overlaps with NATO in addition to a stated commitment by Europol’s CBRN-E Team to enhance its civil-military relations, the report outlines a three-pillar approach to deepening connections between NATO and Europol: short-term measures to foster staff-level contacts in both organisations, a formalised relationship between Europol’s CBRN-E Team and NATO’s JCBRN Defence COE, and deeper institutional linkages to effectively confront current and emerging CBRN threats.”

“Hybrid Threats in the CBRN Environment: Challenges and Implications”

This JCBRN Defence COE paper by Paulina Frederike Gogacz discusses hybrid CBRN threats and their use by actors like Russia. Gogacz explains in the paper’s summary that “An analysis of the six strategic enablers outlined in NATO’s Chemical, Biological, Radiological and Nuclear (CBRN) Defence Policy (2022) indicates important steps to ameliorate current defences and prepare NATO and its member states for future hybrid CBRN threats, thereby increasing overall resilience. They include important aspects: robust intelligence-sharing mechanisms to ensure timely and accurate threat information; comprehensive exercises to simulate and prepare for various CBRN scenarios; strong partnerships both within the alliance and with external entities to foster cooperation and resource sharing; effective strategic communication to manage information and public perception; collaborative scientific research to advance technological capabilities and countermeasures; and the resilience of medical infrastructure to ensure a rapid and effective response to CBRN incidents. These steps collectively aim to bolster NATO’s preparedness and adaptability in the face of evolving hybrid CBRN threats.”

“Securing a Strategic Advantage in Biosecurity for NATO”

Max Breet and Lauren Ross recently authored this commentary for RUSI, writing in their summary “NATO should recognise the importance of biosecurity by understanding it as a new domain. This would allow the Alliance to more effectively leverage existing structures to defend itself against hybrid biological threats.”

“The Rise of Mpox in a Post-Smallpox World”

McQuiston et al. recently published this article in Emerging Infectious Diseases: “Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox. Sustained human-to-human transmission of mpox is occurring widely in the context of insufficient population immunity, fueling genetic mutations that affect the accuracy of some diagnostic tests and that could lead to changing virulence. Additional research should address complex challenges for control of mpox, including improved diagnostics and medical countermeasures. The availability of vaccines should be expanded not only for outbreak response but also for broader routine use for persons in mpox-endemic countries.”

“Confronting Risks of Mirror Life”

Adamala et al. recently published this Science Policy Forum piece, writing in part, “All known life is homochiral. DNA and RNA are made from “right-handed” nucleotides, and proteins are made from “left-handed” amino acids. Driven by curiosity and plausible applications, some researchers had begun work toward creating lifeforms composed entirely of mirror-image biological molecules. Such mirror organisms would constitute a radical departure from known life, and their creation warrants careful consideration. The capability to create mirror life is likely at least a decade away and would require large investments and major technical advances; we thus have an opportunity to consider and preempt risks before they are realized. Here, we draw on an in-depth analysis of current technical barriers, how they might be eroded by technological progress, and what we deem to be unprecedented and largely overlooked risks (1). We call for broader discussion among the global research community, policy-makers, research funders, industry, civil society, and the public to chart an appropriate path forward.”

Bonus: Read Carl Zimmer’s discussion of this warning in The New York Times here.

NEW: OneLab Network Webinar

“Clinical laboratories must be alert for unusual and potentially infectious agents and immediately notify their Laboratory Response Network (LRN) reference laboratory if routine diagnostic testing results in the potential identification of rare and unusual infectious agents that may be used in a bioterrorist attack or other bio-agent incident. This webinar will describe the LRN and highlight the clinical laboratory’s role and responsibilities in initiating contact with their LRN. Join us as we share an example of a response, new tools, and valuable resources to aid in the clinical laboratory’s response.”

This event will take place on December 17 at 12 pm ET. Register for this event here.

NEW: Understanding the Introduction of Pathogens into Humans- Preventing Patient Zero: A Workshop

“The past few decades have seen the emergence of several diseases with drastic public health and economic consequences. Understanding routes of pathogen emergence and transmission is critical to preventing and mitigating disease spillover and amplification. The National Academies Forum on Microbial Threats will host a hybrid public workshop to address gaps in understanding of disease emergence, with a focus on human-animal interaction and laboratory biosafety. The workshop will explore how applications of existing policy structures, emerging technologies, and actionable research can improve biosecurity measures and prevention of future disease emergence.”

This event will take place on January 15 and 16. Learn more and register here.

NEW: Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control

Johns Hopkins APL’s colloquium will feature Mindy Weisberger, author of the upcoming book Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control: “Zombies are all around us—insect zombies, that is. In Rise of the Zombie Bugs, Mindy Weisberger explores the eerie yet fascinating phenomenon of real-life zombification in the insect class and among other invertebrates. Zombifying parasites reproduce by rewriting their victims’ neurochemistry, transforming them into the “walking dead”: armies of cicadas, spiders, and other hosts that helplessly follow a zombifier’s commands, living only to serve the parasite’s needs until death’s sweet release (and often beyond).”

Learn more about this January 31 event here.

How to Avoid Human-Made Pandemics

From the Asia Centre for Health Security: “Studying viruses that could potentially cause outbreaks is one of the most effective ways to reduce the risk of pandemics. However, this type of research—especially when it involves collecting samples from the field and manipulating pathogens—can unintentionally lead to a pandemic if not managed carefully. Dr Lentzos will discuss her findings from the Pathogen Project, which brought together an international taskforce of scientists, biosecurity and public health experts, ethicists, and civil society leaders to seek consensus on this question: Can we agree on ways to manage research that carries pandemic risk as safely, securely and responsibly as possible?”

This event will take place on January 23 at 8 pm (GMT +8:00) via Zoom. RSVP here.

Preparedness in Rural Communities: National and State/Local Perspectives and Plans

From Penn State: “The COVID-19 pandemic and recent hurricanes have thrust the preparedness of rural communities into the national spotlight. At the federal level, the Administration for Strategic Preparedness and Response and the Centers for Disease Control and Prevention have recently released national goals and plans for preparedness of rural communities. The overall objective of this virtual, 2-day mini-symposium is to identify opportunities in public health and agricultural preparedness and response in rural communities. The mini-symposium will focus upon national perspectives on Thursday, January 30 and the state/local perspectives on Friday, January 31. Speakers include representatives of the Administration for Strategic Preparedness and Response, the Department of Homeland Security, US Department of Agriculture, the USA Center for Rural Public Health Preparedness, and state/local leaders.”

This event will take place on January 30 and 31, from 11 am to 2 pm ET each day. Learn more and register here.

Cyberbiosecurity Summit

From Johns Hopkins APL and Bio-ISAC: “Advancements in biomanufacturing and biotechnology drive the science we need to thrive, everything from apples to vaccines. The Cyberbiosecurity Summit 2025 convenes leading experts in biotechnology, biosecurity, and cybersecurity to explore the intersection of these fields and discuss the strategies to create a safe, secure future for us all.”
This event will take place February 25-26 in Laurel, MD. Register here and review the call for sessions here (closes 12/12).

NEW: The Independent Panel Solicits Views and Insights on Pandemic Prevention, and Response Efforts

The Independent Panel for Pandemic Preparedness and Response, co-chaired by HE Ellen Johnson Sirleaf and RH Helen Clark, welcomes you to share your insights and expertise on the status of international and regional pandemic-related reform processes and initiatives, and how progress can be continued and accelerated in the months and years ahead.”

Learn more about this survey and submit by December 20 here.

Pandora Report 1.26.2024

This week covers the updated Doomsday Clock time, new HHS cybersecurity performance goals for the health sector, a podcast episode with our own Sonia Ben Ouagrham-Gormley covering her work on barriers to biological weapons, new publications, and more!

Bulletin of the Atomic Scientists Science and Security Board Leaves Doomsday Clock at 90 Seconds to Midnight

The Bulletin of the Atomic Scientists Science and Security Board recently announced that it left the Doomsday Clock at 90 seconds to midnight this year, based on threats like nuclear risk, climate change, biological threats, and disruptive technologies. In its statement, the board said in part “Ominous trends continue to point the world toward global catastrophe. The war in Ukraine and the widespread and growing reliance on nuclear weapons increase the risk of nuclear escalation. China, Russia, and the United States are all spending huge sums to expand or modernize their nuclear arsenals, adding to the ever-present danger of nuclear war through mistake or miscalculation.”

“In 2023, Earth experienced its hottest year on record, and massive floods, wildfires, and other climate-related disasters affected millions of people around the world. Meanwhile, rapid and worrisome developments in the life sciences and other disruptive technologies accelerated, while governments made only feeble efforts to control them.”

In its in-depth explanation of biological risks that factored into this decision, the board explains that “The revolution in the life sciences and associated technologies continues to accelerate and expand in scope, enabling an increasing number of individuals, in groups and alone, to pose threats arising from both accidental and deliberate misuse. During the past six months, the potential for artificial intelligence tools to empower individuals to misuse biology has become far more apparent.”

The same sidebar also explains that “Two other types of biological risks remain causes for concern: accidental release of organisms from laboratories and naturally occurring infectious diseases, especially those with pandemic potential. Deforestation, urbanization, and climate change continue to destabilize microbe-host relationships and facilitate the emergence of infectious diseases. Meanwhile, high-biosafety-level laboratories have proliferated around the world, as has risky research motivated by interests in controlling these diseases. Despite the importance of understanding and countering naturally occurring biological threats, it isn’t clear that all of these high-biosafety-level laboratories or high-risk experiments are needed for achieving these goals. As the number of laboratories and amount of risky research increases, and the failure to standardize safe laboratory practices and to institute adequate research oversight persists, the risk of accidental release of dangerous pathogens worsens.”

HHS Announces New Voluntary Performance Goals, Resources for Health Sector Cybersecurity

This week, the Department of Health and Human Services announced via the Administration for Strategic Preparedness and Response (ASPR) that it is releasing “voluntary health care specific cybersecurity performance goals (CPGs) and a new gateway website to help Health Care and Public Health (HPH) sector organizations implement these high-impact cybersecurity practices and ease access to the plethora of cybersecurity resources HHS and other federal partners offer.”

The statement further explained “As outlined in the recent HHS Health Care Sector Cybersecurity concept paper, HHS is publishing the CPGs to help health care organizations, and health care delivery organizations in particular, prioritize implementation of high-impact cybersecurity practices. The HPH CPGs are designed to better protect the healthcare sector from cyberattacks, improve response when events occur, and minimize residual risk. HPH CPGs include both essential goals to outline minimum foundational practices for cybersecurity performance and enhanced goals to encourage adoption of more advanced practices.”

Read more here.

“Sonia Ben Ouagrham-Gormley on Barriers to Bioweapons”

From Hear This Idea: “Sonia Ben Ouagrham-Gormley is an associate professor at George Mason University and the deputy director of their biodefense program. Sonia has written extensively on the proliferation and non-proliferation of bioweapons, being one of the key voices to have emphasized the challenges that organizations, tacit knowledge, and other factors have caused for states and terrorists that have attempted to acquire weapons of mass destruction.”

“In this episode we talk about:

  • Misconceptions around the ease of bioweapon production — how and why bioweapons programs face unique challenges compared to nuclear weapons programs
  • The crucial role of tacit knowledge in bioweapons production
  • Will AI make bioweapons much easier to develop, or will human expertise remain a major bottleneck?
  • Case studies of bioweapons programs, illustrating the practical difficulties and failures encountered even by well-resourced state actors.
  • (How) has Biological Weapons Convention prevented bioweapon proliferation?
  • Do global political trends point towards proliferation, even without AI?”

“How Reliable is ISIS’s Claiming Responsibility for Deadly Attacks in Iran?”

Schar School associate professor Mahmut Cengiz recently authored this piece for Homeland Security Today, in which he writes in part “These discrepancies related to the twin blasts bring up a question of how reliable ISIS is when the group claims responsibility for terrorist attacks. Terrorist groups aim to take credit when a group spokesperson, on behalf of the organization,  states that the group is the perpetrator of the attack. They tend to claim responsibility for attacks—targeting state institutions and the military rather than civilians— when they aim to gain publicity and when the backlash from the government is not likely. As opposed to terrorist attacks that claimed most responsibility in the 1980s and 1990s, every one of seven attacks has been recorded claiming responsibility since 2018. According to the Global Terrorism and Trends Analysis Center (GTTAC) Records of Incidents Database (GRID), the attacks by ISIS and its affiliated organizations steadily increased from 2018 to 2022. They conducted 873 attacks in the first ten months of 2023. Contrary to increasing attacks, its attacks of claiming responsibility slightly increased between 2018 and 2020 and dropped in 2021 and 2022. ISIS groups claimed responsibility in its 161 attacks. “

“Beyond Borders, Beyond Biases: Building a Biosecure Future with Diverse Voices”

Aparupa Sengupta, Senior Program Officer for Global Biological Policy and Programs at NTI, discusses the importance of diversity and inclusion in biosafety and biosecurity governance in this piece for NTI. She writes in part “At NTI, we believe the greatest risk of these catastrophic effects is from the accidental or intentional misuse of a bio-engineered agent. Therefore, we focus on developing stronger biosafety and biosecurity policies and practices to protect against these manmade risks. This work requires global cooperation and shared responsibility, and an understanding that diverse perspectives and experiences are essential. Without them, we will face widening knowledge gaps and international resentment, ultimately sabotaging our ability to collectively address bio threats.”

“Recently, the Center for Security and International Studies (CSIS) published a report recommending actions to strengthen global biosafety and biosecurity. As someone with more than 15 years of experience working in the interface of science, technology, and biosafety/security, I endorse all eight recommendations in the report but suggest adding a ninth one to the list: “Prioritize diversity and inclusion for effective global biosafety and biosecurity governance.”’

“Did China Keep the COVID Virus Sequence Secret for Weeks?”

Matt Field breaks down questions surrounding China’s sharing of the SARS-CoV-2 genetic sequence in the early days of COVID-19 in this piece for the Bulletin of the Atomic Scientists: “In outbreak response, speed is critical as authorities seek to quickly determine the cause of a disease and prevent it from spreading. A new report is now raising fresh questions about China’s early response to COVID-19. The Wall Street Journal revealed Wednesday that a researcher in Beijing attempted to upload the genetic sequence SARS-CoV-2, the virus that causes COVID, to a US-based public database about two weeks before the Chinese government publicized the pathogen’s sequence, a lag that potentially robbed scientists and health officials of valuable time.”

“Investigating the Potential Strategic Implications of COVID-19 for Biological Weapons Pursuit: A New Expert Simulation”

Ackerman et al. recently published this article in Health Security: “To investigate the impact of the COVID-19 pandemic on the strategic decisionmaking of leaders with respect to biological weapons, this study employed a prospective simulation technique called Asynchronous Strategic Dynamics Red Teaming. Using an immersive, multimedia simulation conducted remotely and asynchronously, the effort engaged 240 carefully selected and curated expert participants in either biological weapons or the countries of interest (as well as 60 naïve participants). Across our sample of 30 countries, simulated interest in pursuing some type of biological weapons program (defensive or offensive) remained low to moderate. While such interest increased after the simulated onset of the COVID-19 pandemic, it was limited overall, with only a handful of states showing salient increases in offensive biological weapon interest. When directly referencing why their countries might have changed their post-COVID-19 interest in biological weapons, the most commonly cited reasons were: (1) COVID-19 demonstrated the power of biological weapons to disrupt societies and cause large-scale economic harm, and (2) the pandemic revealed either the state’s own or its rivals’ vulnerability to diseases like COVID-19, as well as an inability to efficiently respond and contain such diseases. In sum, despite a global pandemic with massive consequences, the simulation revealed that most states are not likely to dramatically change their strategic posture regarding pursuit of offensive biological weapons.”

“Catalogue of Civil Society Assistance for BWC States Parties”

From the Stimson Center: “The Catalogue of Civil Society Assistance to States Parties annually highlights the contributions of civil society to the BWC and States Parties and to the enhancement of biological safety and security. From Ottawa to Hamburg, there are civil society assistance programs across the world that are available to support the implementation of the BWC. The catalogue includes organization and project descriptions and points of contact for each program, which aims to facilitate stronger connections between civil society and State Parties in need of assistance.”

“The Operational Risks of AI in Large-Scale Biological Attacks”

New from RAND: “The rapid advancement of artificial intelligence (AI) has far-reaching implications across multiple domains, including concern regarding the potential development of biological weapons. This potential application of AI raises particular concerns because it is accessible to nonstate actors and individuals. The speed at which AI technologies are evolving often surpasses the capacity of government regulatory oversight, leading to a potential gap in existing policies and regulations.”

“In this report, the authors share final results of a study of the potential risks of using large language models (LLMs) in the context of biological weapon attacks. They conducted an expert exercise in which teams of researchers role-playing as malign nonstate actors were assigned to realistic scenarios and tasked with planning a biological attack; some teams had access to an LLM along with the internet, and others were provided only access to the internet. The authors sought to identify potential risks posed by LLM misuse, generate policy insights to mitigate any risks, and contribute to responsible LLM development. The findings indicate that using the existing generation of LLMs did not measurably change the operational risk of such an attack.”

“Implementing The Bioeconomy Executive Order: Lessons Learned And Future Considerations”

Nazish Jeffrey breaks down the Federations of American Scientists’ Bioeconomy EO Tracker in this piece, writing “With the U.S. bioeconomy valued at over $950 billion and predicted to steadily increase, the potential for significant economic impact is unmistakable. To leverage this economic opportunity, the 2022 Bioeconomy Executive Order (EO) took a significant step towards addressing the complexities of the bioeconomy and creating a whole-of-government approach. The scope of the EO was vast, assigning around 40 tasks to many different federal agencies, in order to create a national framework to leverage bio-based innovations for sustainable economic growth.”

“To track the numerous tasks assigned by the EO, the Federation of American Scientists have put together a living Bioeconomy EO tracker to monitor the progress of these tasks, enhance accountability and to allow stakeholders to stay informed on the state of the U.S. bioeconomy as it evolves. This FAS tracker was inspired by the initial tracker created by Stanford University when the EO was first published.”

“Public Health Preparedness: HHS Emergency Agency Needs to Strengthen Workforce Planning”

In this new Government Accountability Office report, GAO recommends that “ASPR (1) establish specific goals and performance measures to use for its new hiring office once it is fully operational, (2) develop tailored strategies for recruiting and hiring human capital staff for the new office, (3) identify the critical areas that need workforce assessments and develop plans to implement them, and (4) conduct an agency-wide workforce assessment. HHS neither agreed nor disagreed with the first two recommendations and agreed with the last two recommendations. GAO believes actions are needed to address all of the recommendations.”

Read more here.

“Dissecting Pandemic-Prone Viral Families Volume 2: The Paramyxoviridae”

Amesh A. Adalja covers the Paramyxoviridae family in this volume of Johns Hopkins Center for Health Security’s Dissecting Pandemic-Prone Viral Families,” writing in part “Paramyxoviridae is a large viral family that contains many once common and wellknown human pathogens, such as measles and mumps, as well as other pathogens that pose concerns for their potential to cause epidemic or pandemic disease.1″

“This family of viruses infects a wide variety of species, ranging from reptiles to rodents and fish to birds. While diseases such as measles and mumps cause little morbidity and mortality in advanced societies today—because of high levels of vaccine-induced immunity—other members of this viral family have considerable burdens of infection with attendant morbidity and mortality risks. Also, within this family, there is one genus of consequence – Henipavirus – that has already been responsible for a number of serious emerging infectious diseases. The table below summarizes key genera and viruses of this family.1”

“The Overlooked Bacterial Pandemic”

Moriel et al. recently published this work in Seminars in Immunopathology: “The COVID-19 pandemic had a significant economic and health impact worldwide. It also reinforced the misperception that only viruses can pose a threat to human existence, overlooking that bacteria (e.g., plague and cholera) have severely haunted and shaped the course of human civilization. While the world is preparing for the next viral pandemic, it is again overlooking a silent one: antimicrobial resistance (AMR). This review proposes to show the impact of bacterial infections on civilization to remind the pandemic potential. The work will also discuss a few examples of how bacteria can mutate risking global spread and devastating outcomes, the effect on the global burden, and the prophylactic and therapeutic measures. Indeed, AMR is dramatically increasing and if the trend is not reversed, it has the potential to quickly turn into the most important health problem worldwide.”

“Etymologia: Ring Vaccination”

Sharma et al. recently published this short piece covering ring vaccination’s etymology in Emerging Infectious Diseases: “Ring Vaccination [rɪŋ-væk-sɪ′-neɪ-ʃn] Ring vaccination (expanding ring, surveillance and containment) is a public health measure designed to prevent spread of disease from infected persons to others. This approach targets persons who have had close contact with confirmed or suspected cases and are at a higher risk of infection by vaccinating them first (Figure).”

Read more here.

“Russian Military Thought and Doctrine Related to Non-strategic Nuclear Weapons: Change and Continuity”

William Alberque tackles Russian nuclear doctrine in this report for the International Institute for Strategic Studies: “Russian nuclear doctrine, especially regarding its large stockpile of non-strategic nuclear weapons, has become one of the most pressing issues in Euro-Atlantic security. This report aims to build an understanding of Russia’s strategic nuclear weapons doctrine through empirical research, including by examining the continuities and discontinuities in doctrine across time, through the Cold War, to the collapse of the Soviet Union, to Russia’s annexation of Crimea, and in Russia’s ongoing war on Ukraine.”

Global Partnership Against the Spread of Weapons and Materials of Mass Destruction Newsletter

The Global Partnership Against the Spread of Weapons and Materials of Mass Destruction’s newsletter is published quarterly and is available for subscription here. This quarter’s edition focuses on Italy’s upcoming Global Partnership presidency, the Partnership’s 2023 Programming Annex, featured articles, community updates, and more.

“UNITAD – Key Investigations as UN Mechanism Reaches Its Final Reporting Year”

Sam Biden covers the work of the UN Investigate Team to Promote Accountability  Crimes Committed by Da’esh/ISIL (UNITAD), providing an overview of its key investigations in the last two years in this piece for the Human Security Centre. This includes UNITAD’s work on biological and chemical weapons, under which Biden explains in part, “2023 marked a significant stride in the relentless pursuit of accountability for ISIL’s chemical and biological weapons program. The investigation during this reporting period yielded substantial evidence from earlier inquiries strategies regarding the production and delivery of the weapons themselves. These key lines of inquiry harnessed new collaborations with technical experts, including those from the Mine Action Service, provided essential insights into a wide array of attacks. UNITADs work extended to collecting and preserving evidence linked to 12 attacks yet continued to focus on gathering further evidence from the 2016 attack on Tazah Khurmatu. This ultimately led to the collection of new battlefield evidence and files, shedding light on ISIL’s operations in Kirkuk and implicating specific persons of interest. A comprehensive report focused on the 2016 attack on Tazah Khurmatu was shared with the Iraqi judiciary, encapsulating critical findings from the ongoing investigation.”

ICYMI-“Event Summary: U.S.–UK Strategic Dialogue on Biosecurity”

“On January 16, the Council on Strategic Risks (CSR) hosted senior government leaders for the launch of the U.S.–UK Strategic Dialogue on Biosecurity at the historic National Academy of Sciences Building in Washington, D.C.”

“Building upon decades of partnership between the two countries, the Strategic Dialogue is a core component of the Atlantic Declaration—the new bilateral economic partnership established in 2023 to adapt, reinforce, and reimagine the U.S.-UK alliance for the challenges of the twenty-first century. Following the event, the U.S. National Security Council and the UK Cabinet Office released a joint statement outlining the Strategic Dialogue’s intent, including coordination to uphold global norms and commitments to lead on innovation in biotechnology and biosecurity.”

Read more here.

NEW: AI Rewards, Risks, and the Future of Biosecurity by Design (Pandemic Center Webinar)

From the Brown School of Public Health: “On January 24th at 1:00 PM EST the Pandemic Center will host a webinar titled AI Rewards, Risks, and the Future of Biosecurity by Design.”

“This event will bring together experts in biosecurity, global health, and pandemic prevention and response. Together, they will discuss the relationship between AI and biosecurity, with a focus on benefits, risks, and pragmatic solutions.”

“This event will be hosted and moderated by Beth Cameron, PhD, Professor of the Practice and Senior Advisor to the Pandemic Center.”

Learn more and register here.

NEW: Kazakhstan’s Actions to Address Nuclear and Biological Risks

From the Cargenie Endowment for International Peace: “Upon the 1991 collapse of the Soviet Union, Kazakhstan found itself in possession of the world’s fourth-largest nuclear weapons stockpile and the former union’s most significant biological weapons factory. Kazakhstan’s subsequent decision to return and dismantle these weapons has solidified its position as a leader in nuclear and biological risk reduction. For the last thirty years, Kazakhstan’s actions have served as a core model for regional and international security.”

“Please join the Carnegie Endowment and the Council on Strategic Risks for a hybrid panel on Kazakhstan’s increasingly global role in the changing threat landscape of weapons of mass destruction. The discussion will feature Kazakhstan’s Ambassador to the United States of America Yerzhan Ashikbayev, the Honorable Andrew Weber, and Dr. Toghzan Kassenova. It will be moderated by Shannon Green, senior fellow at the Council on Strategic Risks.”

This event will take place on January 30 at 1:30 pm EST. Learn more and RSVP here.

NEW: WEBINAR: State Department 2023 Global Terrorism Data: Trends & Warnings

From Homeland Security Today: “Join HSToday for a Law Enforcement-only analysis of global terrorism trends from 2023 and threat forecasts for 2024. The Department of State’s yearly Annex of Statistical Information Reports uses The Global Terrorism Trends and Analysis Center (GTTAC) database.”

“Dr. Mahmut Cengiz, a senior data analyst at GTTAC since 2018, will discuss terrorism trends from 2023 and areas of concern for law enforcement in the United States (US). More specifically, his analyses will focus on HAMAS and Iran-backed terror groups targeting American facilities in the Middle East, Al Qaeda- and ISIS-affiliated organizations actively involved in terrorist attacks worldwide, increasing far-right terrorism and emerging lone actor threats in the US and Europe. The Terrorism, Transnational Crime and Corruption Center (TraCCC) is the first center in the United States devoted to understanding the links among terrorism, transnational crime and corruption, and to teach, research, train and help formulate policy on these critical issues. TraCCC is a research center within the Schar School of Policy and Government at George Mason University. TraCCC also houses the innovative and highly-respected Anti-Illicit Trade Institute (AITI).”

This event will take place on February 8 at 2 pm EST. Learn more and register here.

AI Executive Order Report Card Reviewing the First 90 Days

“On October 30, 2023, the Biden Administration issued a call to action outlining a host of requirements and deliverables for U.S. government agencies on artificial intelligence. The executive order touched on a range of AI-relevant issues, including testing and evaluation of new AI systems, developing a healthy and capable U.S. AI workforce, and ensuring U.S. competitiveness in the years to come.”

“Join CSET researchers on January 31, 2024, for a discussion of what the U.S. Government has accomplished so far, what have we learned, and what’s left to do to complete the EO’s ambitious goals.”

This online event will begin at 12 pm EST. Learn more and register here.

GP Nonproliferation and Strategic Trade Hub Virtual Launch & Demo  

“The Strategic Trade Research Institute (STRI) invites you to participate in the Global Partnership Nonproliferation and Strategic Trade Hub Virtual Launch and Demo event taking place on February 27, 2024, from 9:00-10:00 am EST.”

“Please join us to learn about the main features of the Hub, how to use it, and how it can be useful and impactful for nonproliferation and export control professionals. The event will feature Andrea Viski, Director of STRI, as well as introductory remarks from the Hub’s sponsor, the United Kingdom’s Counter-proliferation and Arms Control Center (CPACC).”

Learn more and register here.

International Conference, CBRNE Research & Innovation

“The last 40 years have demonstrated that both military and civilian populations could be exposed to highly hazardous CBRNE agents following conflicts, natural outbreaks and disasters, industrial incidents or terrorist attacks.”

“Worldwide, researchers, responders and industrial capacities have been commited to provide adapted response to these challenges.”

“Building on the success of the first 5 International Conferences « CBRNE Research and Innovation » which took place in Antibes (2015), Lyon (2017), Nantes (2019), on line (2021) and Lille (2022), we want to give you a new opportunity to build up or strengthen collaborative networks in Strabourg (March 19th – 21rst 2024).”

“The CBRNE R&I Conference is specifically devoted to scientific updates, responders’ feedbacks and expression of needs. It also includes workshops and demonstrations of innovative materials, technologies and procedures, according to the following themes: DETECTION – IDENTIFICATION, PROTECTION – DECONTAMINATION, MEDICAL COUNTERMEASURES, RISKS & CRISIS MANAGEMENT.”

“Looking forward to your proposals for communication and to welcoming you at Strasbourg in March 2024!”

Learn more here.

Registration for GHS 2024 Now Open

Registration is now open for the Global Health Security 2024 conference in Sydney, Australia. This iteration will take place 18-21 June, 2024. The call for abstracts is also still open. “The mission of the Global Health Security conference is to provide a forum where leaders, researchers, policy-makers, and representatives from government, international organisations, civil society, and private industry from around the world can engage with each other, review the latest research and policy innovations, and agree solutions for making the world safer and healthier. To that end, our mission is to help foster a genuinely multidisciplinary community of practice that is committed to working collaboratively to enhance global health security and eliminate disease, irrespective of its origin or source.”

Pandora Report 12.22.2023

Happy first day of winter! This week we are covering updates on Russia’s actions in Ukraine, anthrax outbreaks in parts of Africa, efforts to get the Pandemic and All-Hazards Preparedness Act reauthorized, and OpenAI’s plan to manage threats posed by its AI platforms. This is the last issue of the Pandora Report for 2023. We will see you next year but, until then, have a happy rest of the holiday season!

Russia Tear Gases Ukrainian Forces

Recent reporting from CNN explained that, in addition to using wave after wave of convicts-turned-recruits, Russia has increasingly begun to use CS gas on Ukrainian forces: “Those fighting in besieged Ukrainian trenches say they now face another threat: the use of gas as a weapon. Nine incidents have been recorded in recent weeks in this area, one Ukrainian combat medic told CNN, in which a caustic and flammable gas had been dropped by drones onto Ukrainian lines, causing one fatality. The gas is used to cause panic and followed by conventional shelling or drone attacks, soldiers impacted said…A Ukrainian intelligence official told CNN the substance deployed by the Russians was a form of CS gas.”

CS (chlorobenzylidenemalononitrile) gas, commonly referred to colloquially as tear gas, is used as a riot control agent. According to the CDC, these agents “…are chemical compounds that temporarily make people unable to function by causing irritation to the eyes, mouth, throat, lungs, and skin.” Use of these agents in war is prohibited under the Chemical Weapons Convention.

The same CNN report later explained that “Two soldiers who survived a gas attack showed CNN medical reports indicating they had been poisoned. “At first I saw smoke,” one told CNN. “We ran out from the trench and the gas suddenly caught fire. The trench was in flames. This gas burns, blinds you, you can’t breathe, shoots down your throat immediately. We didn’t even have a second.”‘

“The alleged use of chemical agents on the battlefield marks another sign of the brutality and mendacity of Russia’s renewed fight for the terrain it lost. Ukraine had hoped for greater advances during the summer toward the Azov Sea, yet now must defend its minor gains.”

Russian Troops Reportedly Dying from “Mouse Fever”

Russian troops in Ukraine’s Kharkiv region are reportedly suffering an outbreak of “mouse fever,” a hemorrhagic fever. Ukraine’s Main Directorate of Intelligence of the Ministry of Defence of Ukraine (HUR) recently reported that “dissatisfaction is growing in the units of the Russian occupation army due to inadequate provision of winter clothing and a complete lack of medical care,” likely contributing to the rapid spread of this disease.

The Kyiv Post also explained that HUR reports that complaints about the outbreak on the front lines fell on deaf ears, with Russian leadership viewing them as “…another manifestation of attempts to avoid combat operations.” HUR has also reported that the disease initially presents with flu-like symptoms, and that it is a viral disease transmitted to humans from rodents via contact with bodily fluids. As the same Kyiv Post article explains, “Symptoms of mouse fever include severe headache, fever up to 40 degrees, rashes and redness, low blood pressure, hemorrhages in the eyes, nausea, and vomiting several times a day. The disease also affects the kidneys, a person infected with mouse fever experiences intense low back pain and will have serious difficulty urinating.”

HUR’s reporting on the outbreak did not identify a specific pathogen, though it did suggest this could be hemorrhagic fever with renal syndrome (HFRS), driving online speculation that this outbreak was caused by a hantavirus despite some outlets reporting it was caused by the bacterial rat-bite fever. The WHO explains that HFRS is “…an acute interstitial nephropathy characterized by high fever and varying degrees of renal insufficiency and hemorrhage. HFRS is caused by viruses belonging to the old world lineage of the Hantavirus genus of the family Bunyaviridae.”

The WHO further explains that “Various haemorrhagic fevers with a very similar syndrome have been reported throughout Europe and Asia, notably HFRS in the former Soviet Union, Songo fever in China, epidemic nephritis or epidemic haemorrhagic fever in Eastern Europe and Japan, and Hantaan virus in Korea. Several rodents and other small mammals harbor hantaviruses, and in urban areas, where rodent control is feasible, efforts can be made to reduce contact between humans and rodent excreta.”

Regardless of what is causing this outbreak, this is a tale as old as time. War and disease go hand-in-hand, highlighting the importance of maintaining sanitary practices, particularly when turning to trench warfare. Russia’s military has historically struggled with maintaining sanitary conditions, as noted by Amnesty International in the late 1990s and Russia’s own inspectors in the early 2010s, all of which has conicided with persistent challenges in professionalizing the military and maintaining supply lines during the current conflict.

Five African Countries Report Anthrax Outbreaks

The WHO has confirmed that five countries in eastern and southern Africa are experiencing outbreaks of anthrax, with at least 20 related deaths reported since the start of 2023. There are currently over 1,160 presumed anthrax cases in Kenya, Malawi, Uganda, Zambia, and Zimbabwe, though only 35 have been confirmed by laboratory testing. Zambia is currently fighting its largest anthrax outbreak since 2011, with nine of its ten provinces impacted. Though experts say this all is not unusual nor unreasonable, it is notable that, in Uganda, many of the presumed cases have tested negative for anthrax, potentially indicating a different disease is circulating.

The WHO explained in its December 11 press release on the matter that, “The outbreaks are presenting varied patterns in the affected countries. In Kenya, three deaths have been reported this year compared with zero fatalities from over 200 suspected cases in 2022. While the disease is endemic in animals in Malawi, the country reported its first ever human case this year. Human anthrax cases have been reported in three districts in Uganda, with 13 deaths compared with two deaths in 2022. The high case fatality ratio is due to patients reporting late to health facilities. In Zimbabwe, human cases have been reported every year since 2019, underscoring the need for stronger preventive actions.”

“Joint multidisciplinary teams have deployed at country level to support assessments, identify gaps and take measures to strengthen the outbreak response. WHO is also working closely with the Food and Agriculture Organization of the United Nations (FAO), United Nations Environment Programme and World Organisation for Animal Health to coordinate response in the affected countries leveraging the One Health Platforms…The outbreaks are likely being driven by multiple factors, including climatic shocks, food insecurity, low risk perception and exposure to the disease through handling the meat of infected animals.”

115 Organizations Urge Congress to Reauthorize PAHPA

A list of 115 organizations is formally calling on Congress to reauthorize the bipartisan Pandemic and All-Hazards Preparedness Act (PAHPA), according to a press release from the Senate Health, Education, Labor and Pensions (HELP) Committee. PAHPA expired on September 30 and has yet to be reauthorized by Congress, though the HELP Committee did pass legislation to reauthorize it in a 17-3 vote this summer.

The HELP Committee explained in its statement “Congress first enacted PAHPA in 2006, largely to address the failures of the federal response following Hurricane Katrina. The legislation sought to support states, local governments, and hospitals so they would be better prepared for future emergencies. It established the Office of the Assistant Secretary for Preparedness and Response (ASPR) and the Biomedical Advanced Research and Development Authority (BARDA). It also made improvements to the National Disaster Medical System and other resources to improve medical surge capacity during an emergency. PAHPA was previously reauthorized on a bipartisan basis in 2013 and 2019.”

A list of the 115 organizations involved is available at the link above.

OpenAI Unveils Plan for Managing AI Dangers

OpenAI, the company perhaps most famous for its ChatGPT chatbot, recently announced how it plans to prepare for what it believes to be potential threats posed by the technology it develops. A recent article from The Washington Post explains the plan, reading “OpenAI’s “Preparedness” team, led by MIT AI professor Aleksander Madry, will hire AI researchers, computer scientists, national security experts and policy professionals to monitor the tech, continually test it and warn the company if it believes any of its AI capabilities are becoming dangerous. The team sits between OpenAI’s “Safety Systems” team, which works on such existing problems as infusing racist biases intoAI, and the company’s “Superalignment” team, which researches how to ensure AI doesn’t harm humans in an imagined future where the tech has outstripped human intelligence completely.”

“The preparedness team is hiring national security experts from outside the AI world who can help OpenAI understand how to deal with big risks. It is beginning discussions with organizations, including the National Nuclear Security Administration, which oversees nuclear technology in the United States, to ensure the company can appropriately study the risks of AI, Madry said.”

“The team will monitor how and when OpenAI’s tech can instruct people to hack computers or build dangerous chemical, biological and nuclear weapons, beyond what people can find online through regular research. Madry is looking for people who “really think, ‘How can I mess with this set of rules? How can I be most ingenious in my evilness?’”

“Dr. Jomana Musmar, MS, PhD – Designated Federal Officer and Executive Director – PACCARB”

Check out this conversation with Biodefense PhD Program alumna Jomana Musmar on the Progress, Potential, and Possibilities YouTube channel: “Dr. Jomana Musmar, MS, PhD, is the Designated Federal Officer and Executive Director of the Presidential Advisory Council on Combating Antibiotic Resistant Bacteria ( https://www.hhs.gov/ash/advisory-comm… ), and Senior Public Health Advisor within the Office of Infectious Diseases and HIV/AIDS Policy ( https://www.hhs.gov/oidp/index.html ), at the U.S. Department of Health and Human Services (HHS).”

“The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria ( PACCARB – https://www.hhs.gov/ash/advisory-comm… ) is a US federal advisory committee that provides advice, information, and recommendations to the U.S. Secretary of Health and Human Services (HHS Secretary). The council supports and evaluates U.S. government activities focused on fighting antimicrobial resistance (AMR) in human health, animal health, and environmental health. Using this One Health approach, members of the PACCARB have expertise from a range of backgrounds, including academia, industry, public health, advocacy, veterinary, and agricultural production.”

“Dr. Musmar has been managing the PACCARB since its establishment in 2015, during which time she has hosted 24 public meetings and overseen the development of seven reports providing recommendations on a range of issues related to antimicrobial-resistance (AMR) for both human and animal health.”

“Dr. Musmar has over 10 years of Federal Advisory Committee experience, with a focus on the areas of public health, biodefense, and AMR. Her graduate degrees include a Master’s in Biomedical Science Policy from Georgetown University School of Medicine and a Doctorate in Biodefense and Homeland Security from George Mason University.”

“The Health Security Outcomes of APEC and the Biden-Xi Dialogue”

Recent Biodefense MS grad Sophie Hirshfield just published this piece for CSIS, addressing key global health questions following the APEC summit and Biden-Xi meeting. She explains in her introduction, “From November 14 to 16, leaders from the 21-member Asia-Pacific Economic Cooperation (APEC) group met in San Francisco to discuss promoting trade and economic growth across the Pacific region. On the sidelines of the forum, Presidents Joe Biden and Xi Jinping convened for their first in-person meeting in a year. While the meetings provided an opportunity to keep public health priorities on the diplomatic agenda, they led to few meaningful new commitments on U.S.-China health security cooperation.”

“Public Health Agencies Are Using AI Chatbots to Ease Workloads. Is It a Good Idea?”

Biodefense PhD Student Kimberly Ma recently published this piece with The Bulletin of the Atomic Scientists. In it, she explains in part, “There’s a real risk that large-language models like ChatGPT contribute to online disinformation and misinformation. In a call earlier this year for the safe and ethical use of AI, the World Health Organization (WHO) worried that AI responses “can appear authoritative and plausible to an end user” but be “completely incorrect or contain serious errors, especially for health-related” matters. Similarly, the organization warned AI may be “misused to generate and disseminate highly convincing disinformation in the form of text, audio or video content that is difficult for the public to differentiate from reliable health content.” Just as media organizations have been caught publishing AI-generated content riddled with inaccuracies, public health workers need to ensure they are not accidentally producing well-intentioned deliverables with critical errors. And in an environment when adversarial countries, antivaxxers, and politicians operate individually or in networks to spread disinformation online, public health agencies will be up against bad actors with the same technology they have.”

“Preparing for the Next Pandemic Response Through Strengthened Collaboration”

Donnel Harvin, a member of the Schar School faculty, recently co-authored this white paper for NEMA: “This report synthesizes the insights from the National Emergency Management Association (NEMA) Pandemic Workshop hosted in June of 2023. The Centers for Disease Control and Prevention (CDC) funded the project. The workshop brought together emergency management directors and state public health officers from eight states to discuss their collaborative response to the COVID-19 pandemic in the very early phases of the response, January 2020 – January 2022. The particular focus was on the identification of friction points, successes, and opportunities for increased collaboration. Federal partners were invited to discuss issues with federal integration into state COVID-19 response efforts. The discussions highlighted a range of complex issues encompassing roles and authorities, data collection and sharing, equity concerns, and communication, with an emphasis on state and local levels as well as rural and urban experiences.”

“Advancing Governance Models for Frontier for AIxBIO: Key Takeaways and Action Items from the Johns Hopkins Center for Health Security Metting with Industry, Government, and NGOs, 29 November 2023”

Johns Hopkins Center for Health Security recently published a “…summary of high-level findings that identify concrete next steps needed following its recent convening of leading AI labs, executive branch officials, and biosecurity experts…” that “was informed by discussions during a not-for-attribution meeting hosted by the Center. The meeting was attended by around 50 participants, including those from 6 different leading AI companies as well as government officials from the White House and several government agencies with responsibility for managing potential AIxBio risks.”

The report calls for “…the creation of an ongoing public-private forum to facilitate the sharing of important information related to biosecurity risks; a regulatory framework that defines mandatory practices, reporting, and oversight of highly capable AI models; and a legal accountability framework to incentivize developers and deployers of models to adequately address emergent risks.”

“Generative AI and Weapons of Mass Destruction: Will AI Lead to Proliferation?”

Ian Stewart unpacks potential proliferation threats posed by LLMs in this Medium post, writing in part “Large Language Models (LLMs) caught popular attention in 2023 through their ability to generate text based on prompts entered by the user. LLMs have also proven capable of generating code, summarizing text, and adding structure to unstructured text, among others. There remain questions around the real-world usefulness of LLMs in many domains, particularly given some of the difficulties in solving limitations of LLMs such as hallucination. Nonetheless, some have raised concerns about the ability of LLMs to contribute to nuclear, chemical and biological weapons proliferation (CBRN). Put simply, could a person learn enough through an interaction with an LLM to produce a weapon? And if so, would this differ from what the individual could learn by scouring the internet?”

“Poll: Voters Support Bringing EU-Style AI Regulations to the US, Prioritizing Safety Over Speed in Research”

New from the Artificial Intelligence Policy Institute: “A new poll conducted by the Artificial Intelligence Policy Institute (AIPI) shows that the American public supports the passage of the European Union’s AI Act by nearly a 4:1 margin, and 64% support similar regulation in the United States.”

“The survey showed strong public support for a slowdown of AI research and skepticism of tech companies; respondents decisively back federal regulation that curbs rapid AI research and development by private companies. By a 2:1 margin, respondents agree that it is the role of the government to make sure companies don’t go too fast when developing AI models. 75% say the government should restrict what private companies can do when training AI models.”

“AIPI also surveyed public opinion on risky research initiatives across AI development and dangerous virus research—particularly relevant as scientists and the federal government look to revise guidelines on potential pandemic pathogens. 83% of the public is in agreement that the federal government should implement renewed oversight protocols on research experiments using dangerous viruses. When prompted about AI being in such research, 68% say that we should be concerned that bad actors could use AI to create biological weapons.”

“Shaping the Future US Bioeconomy Through Safety, Security, Sustainability, and Social Responsibility”

Attal-Juncqua et al. recently published this article in Trends in Biotechnology: “Biomanufacturing practitioners and researchers describe the norms that should govern the growing, global field, to include safety, security, sustainability, and social responsibility. These ‘4S Principles’ should be broadly adopted so that the future of the field may provide the greatest benefits to society.”

“Stability of Pathogens on Banknotes and Coins: A Narrative Review”

Meister et al. recently published this article in the Journal of Medical Virology: “For the prevention of infectious diseases, knowledge about potential transmission routes is essential. Pathogens can be transmitted directly (i.e. respiratory droplets, hand-to-hand contact) or indirectly via contaminated surfaces (fomites). In particular, frequently touched objects/surfaces may serve as transmission vehicles for different clinically relevant bacterial, fungal, and viral pathogens. Banknotes and coins offer ample surface area and are frequently exchanged between individuals. Consequently, many concerns have been raised in the recent past, that banknotes and coins could serve as vectors for the transmission of disease-causing microorganisms. This review summarizes the latest research on the potential of paper currency and coins to serve as sources of pathogenic viral, bacterial, and fungal agents. In contrast to the current perception of banknotes and coins as important transmission vehicles, current evidence suggests, that banknotes and coins do not pose a particular risk of pathogen infection for the public.”

What We’re Watching 🍿

The Biological Weapons Convention and the Need for a Compliance and Verification Mechanism

New from the Geneva Center for Security Policy: “The GCSP’s Head of Arms Control and Disarmament speaks to three experts on biological security from King’s College London about the start of discussions by the States Parties to the Biological Weapons Convention (BWC) on compliance and verification. They discuss why a compliance and verification mechanism is needed, what can be learned from the previous verification efforts in other contexts, and what has changed in how verification is done since this was last discussed in the BWC framework over 20 years ago. The experts also discuss what the key elements of any mechanism will need to be, what are the most important bio security incidents, and how countries are working on their preparedness to respond to such incidents. The GCSP will be following the discussions in the BWC closely and stands ready to be a platform to bring together all stakeholders to generate new thinking to strengthen the BWC to respond to today’s bio security challenges.”

What We’re Listening To 🎧

PODCAST | Rethinking Our Defense Against Unknown Biothreats

“Dr. Harshini Mukundan, Program Manager and Scientist for Chemical and Biological Technologies at the Office of National and Homeland Security, Lawrence Berkeley National Laboratory, and visiting Scientist at Los Alamos National Laboratory sat down with host and AAAS STPF fellow Adejare (Jay) Atanda to discuss her research on pathogen agnostic disease detection and diagnostics, why this is important for biodefense against unknown biothreats, the role of technological innovations in pathogen agnostic detection and diagnostics, limitations of existing technological tools, and the vital importance of public-private partnerships in transforming this field. This conversation also covered the challenges women, people of color and immigrants face as scientists, the importance of mentorship in mitigating these challenges and her own mentorship and advocacy work to educate young girls about STEM careers as a AAAS IF/THEN STEM Ambassador and guest on CBS’s “Mission Unstoppable” among other efforts.”

Listen here.

Poisons and Pestilence: 20 Bonus Episode: No Fire No Thunder with Alastair Hay

Check out this episode with Alastair Hay, discussing his work as a toxicologist as it relates to the prohibition of chemical weapons.

61st ISODARCO Course: Nuclear Order and International Security after Ukraine

“The war in Ukraine has had an enormous impact on global security, reviving nuclear fears, undermining the prospects for arms control, and shattering many of the norms and constraints that were the foundation of European security.  ISODARCO 2024 will examine the global nuclear order in light of the Ukraine war, focusing on the states, the policies and the technologies that will shape the future in a much more difficult environment.  How will we cope with this more dangerous world?”

This course will take place January 7-14, 2024, at the University of Trento. Learn more and register here.

International Conference, CBRNE Research & Innovation

“The last 40 years have demonstrated that both military and civilian populations could be exposed to highly hazardous CBRNE agents following conflicts, natural outbreaks and disasters, industrial incidents or terrorist attacks.”

“Worldwide, researchers, responders and industrial capacities have been commited to provide adapted response to these challenges.”

“Building on the success of the first 5 International Conferences « CBRNE Research and Innovation » which took place in Antibes (2015), Lyon (2017), Nantes (2019), on line (2021) and Lille (2022), we want to give you a new opportunity to build up or strengthen collaborative networks in Strabourg (March 19th – 21rst 2024).”

“The CBRNE R&I Conference is specifically devoted to scientific updates, responders’ feedbacks and expression of needs. It also includes workshops and demonstrations of innovative materials, technologies and procedures, according to the following themes: DETECTION – IDENTIFICATION, PROTECTION – DECONTAMINATION, MEDICAL COUNTERMEASURES, RISKS & CRISIS MANAGEMENT.”

“Looking forward to your proposals for communication and to welcoming you at Strasbourg in March 2024!”

Learn more here.

Registration for GHS 2024 Now Open

Registration is now open for the Global Health Security 2024 conference in Sydney, Australia. This iteration will take place 18-21 June, 2024. The call for abstracts is also still open. “The mission of the Global Health Security conference is to provide a forum where leaders, researchers, policy-makers, and representatives from government, international organisations, civil society, and private industry from around the world can engage with each other, review the latest research and policy innovations, and agree solutions for making the world safer and healthier. To that end, our mission is to help foster a genuinely multidisciplinary community of practice that is committed to working collaboratively to enhance global health security and eliminate disease, irrespective of its origin or source.”

Vote: 2023 Arms Control Person(s) of the Year Nominees

“Since 2007, the independent, nongovernmental Arms Control Association has nominated individuals and institutions that have, in the previous 12 months, advanced effective arms control, nonproliferation, and disarmament solutions and raised awareness of the threats posed by mass casualty weapons.”

“In a field that is often focused on grave threats and negative developments, the Arms Control Person(s) of the Year contest aims to highlight several positive initiatives—some at the grassroots level, some on the international scale—designed to advance disarmament, nuclear security, and international peace, security, and justice.”

“Voting will take place between Dec. 8, 2023, and Jan. 11, 2024. The results will be announced on Jan. 12, 2024. Follow the discussion on social media using the hashtag #ACPOY2023.”

Learn about the nominees and vote here.

Pandora Report 12.15.2023

This week covers the FDA’s ongoing investigation into contaminated applesauce, the passing of Gao Yaojie-an activist responsible for bringing to light the extent of China’s AIDS epidemic-, and more.

Biodefense MS Graduates Riley Flynn and Sophie Hirshfield at GMU’s 2023 Winter Commencement Ceremony

FDA Leadership Says Tainted Applesauce Pouches May Have Been Intentionally Contaminated

Cinnamon applesauce pouches available Weis, WanaBanana, and Schnucks have been pulled from shelves after they were found to be contaminated with lead. Dozens of children in the United States have been sickened by the tainted products. Now, the FDA’s Deputy Commissioner for Human Foods, Jim Jones, says they may have been intentionally contaminated.

In an interview with Politico, Jones said “We’re still in the midst of our investigation. But so far all of the signals we’re getting lead to an intentional act on the part of someone in the supply chain and we’re trying to sort of figure that out.” All of the pouches in question were linked to a manufacturing facility in Ecuador that the FDA is currently inspecting.

‘“My instinct is they didn’t think this product was going to end up in a country with a robust regulatory process,” Jones said. “They thought it was going to end up in places that did not have the ability to detect something like this.”’

Politico further explained that “The FDA continues to investigate a number of theories for how the pouches became contaminated, and has not drawn any conclusions about the way the lead was added, why or by whom. The FDA says it currently believes the adulteration is “economically motivated.” That generally refers to ingredients being altered in order to make products appear higher in value, often so companies can produce a cheaper item and sell it at an elevated price.”

“The agency and the Centers for Disease Control and Prevention have collaborated with state and local health authorities as well as Ecuadorian authorities to trace the origin of the cinnamon in the applesauce pouches, which is believed to be the source of the lead contamination. More than 60 U.S. children under the age of 6 have tested positive for lead poisoning after consuming the pouches — some at levels more than 500 times the acceptable threshold for lead, according to The Washington Post.”

Gao Yaojie, Chinese Physician and Self-Exiled AIDS Activist, Dead at 95

Gao Yaojie, a gynecologist and well-known AIDS activist, died on December 10 in New York City. Gao, formerly based in China’s Henan province, was famous for her work to expose the outbreak of HIV/AIDS in the country in the 1990s and 2000s. The outbreak was large in scale and primarily driven by the country’s Plasma Economy, which arose because of restrictions on foreign imports of blood products in the 1990s. This resulted in blood plasma donation becoming a way for rural populations to make money in government-supported plasma donation centers. However, unsafe practices like repeated use of unsterilized needles and pooling multiple donors’ blood during the plasmapheresis allowed HIV to spread widely.

Because of the Chinese government’s efforts to suppress reporting on this epidemic, poor rural populations were left largely unaware of the dangers of plasma donation and the public in general was unaware of the severity of the crisis. Gao was one of the first to speak publicly about the outbreak, helping draw the attention of media outlets. She later told documentary filmmakers about her motivations for doing this, saying, “My driving thought is: how can I save more people from dying of this disease? We each only live one life.”

It is estimated that at least one million Chinese were infected with HIV during this epidemic, highlighting the importance of Gao’s and others’ bravery. For this, she garnered praise from the United Nations, several Western organizations, and even Hillary Clinton. This rising fame led to her being placed under house arrest in 2007, with about 50 police preventing her from traveling to the United States to accept an award recognizing her work. In response to this, she told NPR “I think they feel I got in the way of their political achievements and their official careers…Otherwise, why would they put me under house arrest? What law did I break to warrant mobilizing all these police?”

NPR further explained her activities later in life in their article on her passing, writing: “Despite pressure from Henan provincial authorities to stop publicizing the AIDS crisis, she continued her work, using all the proceeds from her books and pamphlets to support AIDS families, especially children orphaned by the disease or the many suicides that it caused.”

“Restrictions on her movement began hindering in work in China, however, and in 2009, she abruptly fled to the US, after fearing she would be put under house arrest again. Many admirers continued to visit her apartment in West Harlem, including a group of young Chinese students who kept her company in the loneliness of exile.”

‘”Many Chinese regarded her as a hero, and when they came to New York, if they didn’t know how to contact her , [sic] they would ask me. I would ask them for an email written in Chinese and would forward it to her. So far as I know, she always wrote back to those people and welcomed them to come visit,” remembers Andrew Nathan, a political science professor at Columbia University who handled much of Gao’s affairs in New York.”

“The Biological and Toxin Weapons Convention in 2023: Glimmers of Progress Set Against a Troubled Geopolitical Landscape”

Experts at CSR’s Nolan Center, including Biodefense PhD Program alumna and current faculty member Saskia Popescu, recently authored this blog post focused on the BWC’s potential for success in verification, universalization and effective implementation in Africa, and the creation of an International Agency for Biological Safety. They explain in their introduction: “For nearly two decades, efforts to strengthen the Biological and Toxin Weapons Convention (BWC) were in stasis, with opportunities missed and States Parties unable to agree to definite action. States Parties arrived at the Review Conference last year facing a growing biological weapons threat—augmented by rapidly converging complimentary technologies—coupled with a status quo in the BWC that was insufficient for the task. Yet nations drove a breakthrough: the consensus achieved at last year’s Review Conference proved that action is still possible despite the challenging international security environment.”

“In a world in which biological threats and vulnerabilities are exceedingly complex, there is a critical need to reinforce relationships among global experts, national governments, and civil society. Over the past two weeks, these stakeholders have met to identify, examine, and develop specific and effective measures to strengthen the Convention. An unwavering theme throughout the Meeting of States Parties underscored that preparedness and resilience are investments, rather than costs, reinforcing the deterrence by denial efforts CSR continues to promote. Although the challenging international security environment continues to hinder progress there are glimmers of genuine progress across several fronts…”

“Biosecurity in the Americas: Regional Threat Assessment”

A new from UMD’s START, co-authored by Biodefense MS Program alumna Alexandra Williams: “This publication, currently available in Spanish, provides a breadth and depth of focuses as a high-level assessment of the Central and South America regions and introduction to key topics as:

  1. The needed expansion of understanding of the differences and areas of collaboration between the concepts of biosafety and biosecurity,
  2. Existing international obligations to biosecurity through the BWC and UNSC Resolution 1540,
  3. How biosecurity applies to and may differ in application across a variety of facility types that engage in biological research or production, whether private or public laboratories, agricultural or university-based facilities,
  4. Biosecurity risks that include proliferation, bioterrorism, agroterrorism, and biocrime,
  5. The five pillars and mechanisms of biosecurity,
  6. Lastly, the application of biosecurity in the Central and South American regions.”

“NTI|Bio Convenes Workshop on Disincentivizing State Bioweapons Development and Use”

From NTI: “A week ahead of the Biological Weapons Convention (BWC) Working Group meetings in Geneva, Switzerland, NTI | bio convened a workshop on “Disincentivizing State Bioweapons Development and Use.” This two-day workshop on November 29 and 30 brought together academics, diplomats, biosecurity experts, and government policy makers to begin developing a cross-disciplinary thought and practice community to explore and develop potential disincentivizing solutions. Current thinking and policy on disincentivizing bioweapons acquisition and use is underdeveloped—especially by comparison with the nuclear security field.”

‘“We launched this effort because we see the need for more rigorous thinking on effective approaches to making bioweapons unattractive to nation-states,” said NTI | bio Vice President Jaime Yassif. “NTI’s goal is to bridge theory and practical policy-relevant approaches to develop new ideas that can invigorate international efforts to reduce biological threats.”’

Biodefense Graduate Program Director Gregory Koblentz and Associate Professor Sonia Ben Ouagrham-Gormley both participated in this workshop. Read more about it here.

“Great Powers and the Norms of the BW Prohibition Regime”

A new working paper from CBWNet: “The United States of America and the Soviet Union were instrumental in creating the biological weapons prohibition regime more than 50 years ago. This has left the regime with a big gap in its normative structure related to the verification of treaty compliance. The working paper by Alexander Kelle and Eva Siegmann analyses great power involvement in several areas of regime implementation and concludes that none of the great powers, including China, has supported the addition of declaration and inspection norms. While recent US and Chinese initiatives could still lead to a strengthening of the regime in different areas, Russian policies, most notably false accusations against the US and others, threaten to undermine the regime.”

“AI and Biorisk: An Explainer”

A new explainer from Georgetown’s CSET: “Recent government directives, international conferences, and media headlines reflect growing concern that artificial intelligence could exacerbate biological threats. When it comes to biorisk, AI tools are cited as enablers that lower information barriers, enhance novel biothreat design, or otherwise increase a malicious actor’s capabilities. In this explainer, CSET Biorisk Research Fellow Steph Batalis summarizes the state of the biorisk landscape with and without AI.”

“Bio X AI: Policy Recommendations For A New Frontier”

Jeffrey et al. discuss the work of the Federation of American Scientists’ Bio x AI Policy Development Sprint in this piece, explaining in their introduction: “Artificial intelligence (AI) is likely to yield tremendous advances in our basic understanding of biological systems, as well as significant benefits for health, agriculture, and the broader bioeconomy. However, AI tools, if misused or developed irresponsibly, can also pose risks to biosecurity. The landscape of biosecurity risks related to AI is complex and rapidly changing, and understanding the range of issues requires diverse perspectives and expertise. To better understand and address these challenges, FAS initiated the Bio x AI Policy Development Sprint to solicit creative recommendations from subject matter experts in the life sciences, biosecurity, and governance of emerging technologies. Through a competitive selection process, FAS identified six promising ideas and, over the course of seven weeks, worked closely with the authors to develop them into the recommendations included here. These recommendations cover a diverse range of topics to match the diversity of challenges that AI poses in the life sciences. We believe that these will help inform policy development on these topics, including the work of the National Security Commission on Emerging Biotechnologies.”

“Push to Improve Biosecurity in the Age of Genetic Engineering”

Wilmot James recently authored this opinion piece for Business Day, explaining in part “The possibility of using AI to develop bioweapons raises additional concerns, and remains uncharted territory. While the intersection of AI and biotechnology holds immense potential for positive applications in healthcare, research and diagnostics, it also poses risks if misused. AI algorithms could be employed to analyse vast genetic data sets and identify specific sequences for manipulation. This could accelerate the process of genetic engineering, allowing for the creation of more efficient and potentially harmful pathogens…To safeguard against such threats, multilateral and public-private sector agreements and regulations to govern the ethical use of AI in science, emphasising the prohibition of bioweapon development, should be established, with strong oversight committees responsible for assessing the ethical implications at the intersection of AI and biotechnology. These committees should include experts in AI, virology, bioethics and global health security.”

“Sounding the Alarm on Anti-Science”

Margaret Winchester provides background and overview of Peter Hotez’s latest book-The Deadly Rise of Anti-Science-in this piece for Health Affairs: “In his book, The Deadly Rise of Anti-Science, Hotez, professor and dean of the National School of Tropical Medicine at Baylor College of Medicine, and co-director of the Center for Vaccine Development at Texas Children’s Hospital, paints a bleak picture of public science denial during the pandemic, embedded in historic context. He tells the story of systematic anti-science efforts from his view in the trenches—and as a personal target for anti-science activists. This book, and his commentary in our December issue of Health Affairs on global lessons from COVID-19, highlight the very real effects of this movement, including lives lost, undermined public health efforts, foregone vaccinations, social schisms, and more, that will be felt for generations to come. As he writes, “anti-science now kills more Americans than global terrorism, or other deadly societal forces and social determinants.” Drawing from multiple sources, he estimates that approximately 200,000 people needlessly died in the US after COVID-19 vaccines became widely available.”

EU vs Disinfo Disinformation Review

The most recent edition of EU vs Disinfo’s Disinformation Review is now available and features multiple sections focused on Russia’s continued use of alleged US biological weapons laboratories as a bogeyman. Be sure to check it out for fantastic lines such as “If the only tool that you have is a hammer, everything looks like a biolab,” and “At a staged event, Putin mumbled out an announcement to veterans and the wider public that his regime would continue to rule over Russia after an orchestrated ritual not to be confused with an event known as an ‘election’ in the free world.”

2023 State of the Bioeconomy

From BIOISAC: “We have a lot to celebrate as we close 2023 and just over 12 months since the Executive Order calling for a safe, secure bioeconomy. Join us as we recap the activity, publications, outcomes, and – we will of course share a glimpse of the “behind the scenes” conversations from our 3 regional events and our one-day “Closing the Knowledge Gaps” event, our two-day table top training and the resulting “Going Viral: Bioeconomy Defense TTX” report, and, of course, the industry-demanded outputs from our hardware/software device security workgroup report and supplements, “Fortifying the Bioeconomy” as well as the Bioeconomy Security Questionnaire and Instrument Disposal Guide. We also have a lot left to do! We plan to share a few of our goals for 2024 and our upcoming regional events schedule.”

“Join us December 19th at 2pm Eastern-US for a live discussion.” Register here.

Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) Virtual Meeting

“The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) provides advice, information, and recommendations to the U.S. Secretary of Health and Human Services (HHS Secretary). The council supports and evaluates U.S. government activities focused on fighting antimicrobial resistance (AMR) in human health, animal health, and environmental health. Using this One Health approach, members of the PACCARB have expertise from a range of backgrounds, including academia, industry, public health, advocacy, veterinary, and agricultural production.”

“The PACCARB was established under Executive Order 13676 and included in the Pandemic and All-Hazards Preparedness and Advancing Innovation Act of 2019 (PAHPAIA). Since 2019, the President has given authority to the HHS Secretary as the primary recipient of PACCARB recommendations. Additional information on the authority and activities of the PACCARB can be found on the About Us page in the charter.”

“As a federal advisory committee, the PACCARB looks to engage with the public and all AMR stakeholders. The council holds several public meetings every year both in-person and live streamed on the HHS.gov website. These meetings are open to anyone with an interest in combating AMR. See how to get involved!”

This virtual meeting will take place on December 20 from 9-4 EST. Learn more here.

61st ISODARCO Course: Nuclear Order and International Security after Ukraine

“The war in Ukraine has had an enormous impact on global security, reviving nuclear fears, undermining the prospects for arms control, and shattering many of the norms and constraints that were the foundation of European security.  ISODARCO 2024 will examine the global nuclear order in light of the Ukraine war, focusing on the states, the policies and the technologies that will shape the future in a much more difficult environment.  How will we cope with this more dangerous world?”

This course will take place January 7-14, 2024, at the University of Trento. Learn more and register here.

International Conference, CBRNE Research & Innovation

“The last 40 years have demonstrated that both military and civilian populations could be exposed to highly hazardous CBRNE agents following conflicts, natural outbreaks and disasters, industrial incidents or terrorist attacks.”

“Worldwide, researchers, responders and industrial capacities have been commited to provide adapted response to these challenges.”

“Building on the success of the first 5 International Conferences « CBRNE Research and Innovation » which took place in Antibes (2015), Lyon (2017), Nantes (2019), on line (2021) and Lille (2022), we want to give you a new opportunity to build up or strengthen collaborative networks in Strabourg (March 19th – 21rst 2024).”

“The CBRNE R&I Conference is specifically devoted to scientific updates, responders’ feedbacks and expression of needs. It also includes workshops and demonstrations of innovative materials, technologies and procedures, according to the following themes: DETECTION – IDENTIFICATION, PROTECTION – DECONTAMINATION, MEDICAL COUNTERMEASURES, RISKS & CRISIS MANAGEMENT.”

“Looking forward to your proposals for communication and to welcoming you at Strasbourg in March 2024!”

Learn more here.

Registration for GHS 2024 Now Open

Registration is now open for the Global Health Security 2024 conference in Sydney, Australia. This iteration will take place 18-21 June, 2024. The call for abstracts is also still open. “The mission of the Global Health Security conference is to provide a forum where leaders, researchers, policy-makers, and representatives from government, international organisations, civil society, and private industry from around the world can engage with each other, review the latest research and policy innovations, and agree solutions for making the world safer and healthier. To that end, our mission is to help foster a genuinely multidisciplinary community of practice that is committed to working collaboratively to enhance global health security and eliminate disease, irrespective of its origin or source.”

WHO Announces Proposed Members of Technical Advisory Group on Response Use of the Life Sciences and Dual-Use Research

The WHO recently announced its proposed membership of its Technical Advisory Group on Responsible use of the life sciences and dual-use research (TAG-RULS DUR). According to WHO, “As per WHO processes, there will be now a two-week public consultation period for WHO to receive feedback on the proposed TAG-RULS DUR members and set in place the modalities for the TAG-RULS DUR’s first meeting, which is planned to take place following this consultation period…The final membership to the TAG-RULS DUR is subject to the above-mentioned public consultation period and relevant WHO practices and procedures.”

The proposed membership and instructions for providing commentary on the individuals included are both available here.

Vote: 2023 Arms Control Person(s) of the Year Nominees

“Since 2007, the independent, nongovernmental Arms Control Association has nominated individuals and institutions that have, in the previous 12 months, advanced effective arms control, nonproliferation, and disarmament solutions and raised awareness of the threats posed by mass casualty weapons.”

“In a field that is often focused on grave threats and negative developments, the Arms Control Person(s) of the Year contest aims to highlight several positive initiatives—some at the grassroots level, some on the international scale—designed to advance disarmament, nuclear security, and international peace, security, and justice.”

Voting will take place between Dec. 8, 2023, and Jan. 11, 2024. The results will be announced on Jan. 12, 2024. Follow the discussion on social media using the hashtag #ACPOY2023.”

Learn about the nominees and vote here.