Pandora Report: 1.27.2023

The year of the rabbit is off to one heck of a start. This week we cover COVID-19’s spread in China as the Party increasingly cracks down on Zero-COVID protesters, growing concern amount H5N1 in mammals, new insight into the history of the plague, and more. Several new publications are listed, including a fresh book from Ed Regis about the history of the Pacific Ocean Biological Survey Program and multiple works on misinformation’s impact on COVID-19 responses. As always, we round out with events and announcements, including multiple great upcoming professional opportunities. Happy Friday!

COVID-19 Multiplying Like Rabbits in China

China’s CDC claimed this week that cases of critically ill COVID-19 patients are down 72% from a peak earlier this month in the country, with daily deaths of hospitalized COVID-19 patients down 79% as well. This comes as Wu Zunyou, Chief Epidemiologist at China CDC, claims that 80% of the country’s 1.4 billion people have already been infected. This seems like an effort to indicate that a rebound is unlikely in the coming months amid concerns that the new year travel season will cause further spread and deaths. Just last week, China claimed to have 60,000 COVID-19 deaths in the month since it rolled back its notorious Zero-COVID policies, a number far below the one million some models estimated the country will suffer this winter.

However, CNBC notes, “…some experts said that figure probably vastly undercounts the full impact, as it excludes those who die at home, and because many doctors have said they are discouraged from citing Covid as a cause of death.” This understanding better aligns with reports of over-crowded funeral homes and crematoriums, and reports of coffin makers and funeral decoration companies repeatedly selling out of their products amid the spread. Because of these discrepancies, many are doubtful of the government’s official statistics.

At the same time, reports of Zero-COVID protesters being arrested or intimidated are mounting. Four women in Beijing are known to have been arrested in connection with these protests, seemingly in retaliation for their role in what has been described as “the boldest challenge to the Communist Party’s rule in decades and an embarrassing affront to its leader, Xi Jinping.” The New York Times explains the Party’s need to do this, writing “The party seems determined to warn off anyone who may have been emboldened by the remarkable outburst of public discontent, which was followed just days later by Beijing’s abrupt decision to abandon Covid restrictions. Since then, domestic challenges have mounted: Youth unemployment is high, the economy is slowing, and Covid infections and deaths have accelerated.”

The same piece continues, “The party is also working to discredit the protesters by casting them as tools of malevolent foreign powers. Beijing has long dismissed dissent at home — from calls for women’s rights to pro-democracy activism to ethnic unrest — as the result of Western-backed subversion. The protests against “zero Covid” were no exception: One Chinese diplomat suggested that some of the demonstrators had been “bought by external forces.”

Chunyun, the Lunar New Year travel period in China, typically lasts from mid-January through late-February, meaning opportunities for spread in rural parts of the country are far from over, despite China CDC’s apparent claims to the contrary. The continued supply of highly suspect statistics and crackdowns on Zero-COVID protesters presents a troubling situation and indicates that the Party has done anything but change its ways.

Thinking of Offering a Nice Egg in This Trying Time? Mink Again

US egg prices skyrocketed in price by more than 137% between December 2021 and December 2022, leaving many in constant sticker shock at the grocery store as this once reliably cheap staple becomes increasingly expensive. Much of this is attributed to outbreaks of highly pathogenic avian influenza (HPAI) A(H5N1), which has been spreading in US flocks since January 2022, resulting in cullings of over 57 million birds across industrial and backyard flocks. However, over the past year, this virus has also demonstrated its ability to spread from birds to mammals, with infections found in several species in the US so far, including raccoons, foxes, seals, grizzly bears, and, most recently, minks. Naturally, this had led to increased concern about potential spread into other mammal populations.

“Transmission electron microscopic image of two Influenza A (H5N1) virions, a type of bird flu virus Note the glycoprotein spikes along the surface of the virion and as a stippled appearance of the viral envelope encasing each virion.” Credit: CDC PHIL

Nature covered this story this week, writing “Until this particular outbreak, all mammalian infections could be attributed to direct contact with virus-contaminated material, says Hualan Chen, a virologist at the Harbin Veterinary Research Institute in China. For example, animals that ingest wild-bird droppings, or that prey on infected animals, can develop the disease. But its spread between mammals “implies that this H5N1 virus may pose a higher risk to public health”, Chen says.”

A new article in Eurosurveillance discusses the alarming spread of HPAI A(H5N1) at an American mink farm in Galicia, Spain in October 2022. In it, Agüero et al. explain that the farm experienced an acute increase in its mortality rate (.77% versus an expected range of .2-.3%), prompting the facility’s clinical veterinarian to collect samples from affected animals. These animals tested positive for H5N1, and “Post-mortem examination revealed haemorrhagic pneumonia or red hepatisation of the lungs as the most notable lesions”

The authors further explain the set-up of the farm, which housed 51,986 minks, writing “The minks were housed in wire netting cages placed in rows and situated in a series of over 30 partially open barns, which provided overhead protection but not total shelter of their sides. The minks were fed with raw fish and poultry by-products, cereals and blood meal. Poultry farms and avian slaughterhouses supplying the poultry by-products were located in Galicia. Up to 10 January 2023, H5N1 poultry outbreaks have not been reported from this region.”

The outbreak soon peaked, with a weekly mortality rate of 4.3% documented between October 17 and 23. Culling measures were ordered quickly, and all minks from infected pens were culled by November 17, along with destruction of all carcasses, fomites, and waste. Of the farm’s 12 workers, 11 were in contact with infected and culled animals, though none of them tested positive and they all completed quarantine without any problems. However, as the authors note in their abstract, “The identified viruses belong to clade 2.3.4.4b, which is responsible of the ongoing epizootic in Europe. An uncommon mutation (T271A) in the PB2 gene with potential public health implications was found. Our investigations indicate onward mink transmission of the virus may have occurred in the affected farm.”

While the mink farm seems to have been thorough in its efforts to stop this outbreak, there are concerns that this new variant may be circulating in wild bird populations. Nature writes, “But Puryear thinks that because the new variant contains genetic material from gull flu, it’s likely that at least some of its genetic changes arose in gulls before entering the mink farm. This means that a strain containing those mutations is probably still circulating in the bird population. But for human populations, the outlook is still good: if the new strain did start to infect people, health authorities could probably produce a vaccine quickly, and the antiviral drug Tamiflu (oseltamivir) can reduce the severity of the disease.”

The Nature news piece concludes with, “The potential risk to wild animals is greater. Bird flu has consistently caused high levels of sickness and death among wild birds and mammals over the past year, and how the new variant will affect that trend remains to be seen. “We just simply don’t know,” says Puryear.”

Shake Ups and Mess Ups at the Department of Health and Human Services

CDC Takes Major Steps in Revamp

CDC Director Dr. Rochelle Walensky announced a number of high-level changes to her agency this week, including the creation of the Office of Health Equity and the Office of Public Health Data, Surveillance, and Technology. These are steps taken in light of last year’s internal review that found, among other things, that the agency struggled with appropriately and rapidly sharing scientific findings, communications in general, and that it needed to strengthen relationships with federal, state, and local partners. Furthermore, most of the organizations under CDC will now report directly to the Office of the Director, moving away from what has been described as a “Community of Practice structure”.

MedPage Today explained this leadership re-structuring, writing “Today, additional details about that leadership structure became clear. There will be a centralized leadership team of experts housed within the director’s office, which will include the director of the CDC/Agency for Toxic Substances and Disease Registry; the principal deputy director; the deputy director for program and science/chief medical officer; the deputy director for policy, communications, and legislative affairs/chief strategy officer; the deputy director for global health; the chief operating officer; and the chief of staff.”

“These changes will improve efficiency, speed decision-making, and strengthen the communication of scientific information to the American public, ensuring CDC’s science reaches the public in an understandable, accessible, and implementable manner as quickly as possible,” an unnamed staffer told The Hill.

OIG Report Finds NIH and EcoHealth Alliance Fell Short in Monitoring and Oversight

The Office of Inspector General (OIG) at HHS released this week the findings of its audit of the National Institutes of Health’s grants to the EcoHealth Alliance. This audit was initiated because of concerns over NIH’s grant awards to EcoHealth as well as EcoHealth’s subawards to foreign entities. OIG aimed to “…determine whether NIH monitored grants to EcoHealth in accordance with Federal requirements, and whether EcoHealth used and managed its NIH grant funds in accordance with Federal requirements.”

The Office found that, “Despite identifying potential risks associated with research being performed under the EcoHealth awards, we found that NIH did not effectively monitor or take timely action to address EcoHealth’s compliance with some requirements. Although NIH and EcoHealth had established monitoring procedures, we found deficiencies in complying with those procedures limited NIH and EcoHealth’s ability to effectively monitor Federal grant awards and subawards to understand the nature of the research conducted, identify potential problem areas, and take corrective action. Using its discretion, NIH did not refer the research to HHS for an outside review for enhanced potential pandemic pathogens (ePPPs) because it determined the research did not involve and was not reasonably anticipated to create, use, or transfer an ePPP. However, NIH added a special term and condition in EcoHealth’s awards and provided limited guidance on how EcoHealth should comply with that requirement. We found that NIH was only able to conclude that research resulted in virus growth that met specified benchmarks based on a late progress report from EcoHealth that NIH failed to follow up on until nearly 2 years after its due date. Based on these findings, we conclude that NIH missed opportunities to more effectively monitor research. With improved oversight, NIH may have been able to take more timely corrective actions to mitigate the inherent risks associated with this type of research.”

Biodefense Graduate Program Director Dr. Gregory Koblentz was quoted in the New York Timespiece on this report, saying “Although concerns were identified by NIAID staff, the proposal was not referred to NIAID’s review committee for further consideration.” He continued, saying “On paper, NIAID staff were encouraged to ‘err on the side of caution’ in identifying and referring such proposals…but in practice it looks like they erred on the side of complacency.” 

Woman Pleads Guilty to Mailing Ricin Letters in 2020

Pascale Cecile Veronique Ferrier pleaded guilty this week in a US District Court “…to sending a threatening letter containing homemade ricin to then-President Donald J. Trump at the White House in September 2020, and eight similar letters, each containing ricin, to Texas State law enforcement officials.” Ferrier, a dual French-Canadian national, holds a French engineering degree and admitted in her plea agreements that she made ricin in her Quebec home in September 2020. According to the FBI, “Ferrier placed the ricin in envelopes containing letters she wrote to then-President Trump at the White House and to eight Texas State law enforcement officials.”

“Ferrier was detained in the State of Texas for around 10 weeks in the spring of 2019, and she believed that the law enforcement officials were connected to her period of detention. In early September 2020, Ferrier used the Twitter social media service to propose that someone should “please shoot [T]rump in the face.” The letters in the envelopes contained threatening language, and the letter addressed to then-President Trump instructed him to “[g]ive up and remove [his] application for this election.” Ferrier mailed each of the threatening ricin letters from Canada to the United States. Ferrier then drove a car from Canada to the Peace Bridge Border Crossing in Buffalo, New York, on Sept. 20, 2020, where border patrol officials found her in possession of a loaded firearm, hundreds of rounds of ammunition and other weapons.”

Ferrier is scheduled for sentencing on April 26. She faces 262 months imprisonment if her plea agreements are accepted.

An Oldie, But a (Not So) Goodie: Y. Pestis Strains May Have Been Around Centuries Before Outbreaks

A new article in Communications Biology discusses how Yersinia pestis spread globally over longer periods of time than previously estimated. Eaton et al. estimate that the strain of Y. pestis responsible for the Black Death in the mid-14th century diverged from the ancestral strain as early as 1214, while the one responsible for the Plague of Justinian may have cropped up between 272 and 465–up to nearly 270 years before the epidemic began in 541. “‘It shows that each major plague pandemic has likely emerged many decades to centuries earlier than what the historical record suggests,” study coauthor and evolutionary geneticist Hendrik Poinar, director of McMaster University’s Ancient DNA Centre in Canada,” said in a statement to CNN.

The authors write in their abstract: “Plague has an enigmatic history as a zoonotic pathogen. This infectious disease will unexpectedly appear in human populations and disappear just as suddenly. As a result, a long-standing line of inquiry has been to estimate when and where plague appeared in the past. However, there have been significant disparities between phylogenetic studies of the causative bacterium, Yersinia pestis, regarding the timing and geographic origins of its reemergence. Here, we curate and contextualize an updated phylogeny of Y. pestis using 601 genome sequences sampled globally. Through a detailed Bayesian evaluation of temporal signal in subsets of these data we demonstrate that a Y. pestis-wide molecular clock is unstable. To resolve this, we developed a new approach in which each Y. pestis population was assessed independently, enabling us to recover substantial temporal signal in five populations, including the ancient pandemic lineages which we now estimate may have emerged decades, or even centuries, before a pandemic was historically documented from European sources. Despite this methodological advancement, we only obtain robust divergence dates from populations sampled over a period of at least 90 years, indicating that genetic evidence alone is insufficient for accurately reconstructing the timing and spread of short-term plague epidemics.”

Read the entire article here.

“Produced by the National Institute of Allergy and Infectious Diseases (NIAID), this digitally colorized scanning electron microscopic (SEM) image depicts a number of yellow-colored, Yersinia pestis bacteria, that had gathered on the proventricular spines of a Xenopsylla cheopis flea. These spines line the interior of the proventriculus, a part of the flea’s digestive system. The Y. pestis bacterium is the pathogen that causes bubonic plague.” Credit: CDC PHIL

It’s 90 Seconds to Midnight (That’s Not Good)

“This year, the Science and Security Board of the Bulletin of the Atomic Scientists moves the hands of the Doomsday Clock forward, largely (though not exclusively) because of the mounting dangers of the war in Ukraine. The Clock now stands at 90 seconds to midnight—the closest to global catastrophe it has ever been.” Read the Bulletin’s statement here (also available in РУССКИЙ and УКРАЇНСЬКА).

Say “Hello” to the International Biosecurity and Biosafety Initiative for Science

The Nuclear Threat Initiative recently announced the creation of the International Biosecurity and Biosafety Initiative for Science (IBBIS), an organization “trying to prevent dramatic advances in bioscience from unleashing engineered pathogens from the lab, and wants research funders, scientists and journals to help.” NTI explains: “NTI is working with international stakeholders to establish the International Biosecurity and Biosafety Initiative for Science (IBBIS), an independent organization dedicated to reducing emerging biological risks associated with technology advances. A core element of the IBBIS mission will be to strengthen international biosecurity norms and develop innovative, practical tools and incentives to uphold them. IBBIS has a broadly defined mission, but initially it will focus on preventing the misuse of DNA synthesis technology—with the understanding that it will expand its remit over time.”

“IBBIS will collaborate with stakeholders across the global bioscience and biotechnology enterprise including academia, industry, the public health community, governments and philanthropy. These activities will complement the important work of the World Health Organization, the United Nations Office of Disarmament Affairs, and other national, regional, and international organizations. NTI’s work to establish IBBIS is rooted in the vision of a world in which bioscience and biotechnology flourish, with safeguards against deliberate or accidental misuse with potentially catastrophic consequences.”

David Matthews discusses IBBIS in-depth, including the fraught geopolitical situation it faces, in this piece for Science Business.

The Lancet Series on One Health and Global Health Security

Check out this recent series from the Lancet: “Following the 2014-2016 Ebola outbreak in West Africa, and the on-going global COVID-19 pandemic, the One Health approach (bridging the Animal-Environmental-Human Health interface)  has rapidly gained political and financial support, particularly in regional and transcontinental initiatives to improve Global Health Security, including through recently established institutions like Africa CDC and other multidisciplinary consortia. This four-paper Lancet Series explores the adoption of One Health approaches to improve health security and include an analysis of the current landscape of preventive, surveillance, and response measures in outbreak situations of emerging and re-emerging zoonotic infectious diseases with epidemic potential as well as other potential public health emergencies such as neglected endemic diseases, antimicrobial resistance, environmental and chemical hazards and natural disasters.”

“Combating Misinformation as a Core Function of Public Health”

Knudsen et al. discuss the New York City Department of Health and Mental Hygiene’s role in countering misinformation in this New England Journal of Medicine Catalyst piece: “The New York City Department of Health and Mental Hygiene determined that the spread of misinformation about Covid-19 was having a harmful health impact, particularly on communities of color with low vaccination rates. It established a dedicated Misinformation Response Unit to monitor messages containing dangerous misinformation presented on multiple media platforms, including social media, non-English media, and international sites, and proliferating in community forums. The Misinformation Response Unit and the Health Department collaborated with more than 100 community partners to tailor culturally appropriate, scientifically accurate messages to different populations. The Health Department and its partners were able to rapidly identify messages containing inaccurate information about Covid-19 vaccines, treatment, and other issues and to support the delivery of accurate information to various populations. Although the harms of misinformation and benefits of addressing the problem require additional evaluation, internal and external interviews suggested that the Misinformation Response Unit helped the Health Department counter misinformation and disseminate accurate scientific information to the community, thus improving health and vaccine equity during the Covid-19 pandemic.”

“Fault Lines: The Expert Panel on the Socioeconomic Impacts of Science and Health Misinformation”

This new report from the Council of Canadian Academies includes a number of important findings, including that COVID-19 misinformation cost at least 2,800 Canadian lives and CAD 300 million in hospital expenses over a period of just nine months. “Fault Lines details how science and health misinformation can proliferate and its impacts on individuals, communities, and society. It explores what makes us susceptible to misinformation and how we might use these insights to improve societal resilience to it. The report includes a model of the impacts of COVID‑19 misinformation on vaccination rates in Canada, producing quantitative estimates of its impacts on our health and the economy, and situating these within a broader context of societal and economic harms.”

“Battling Biological Threats: Complacency, Progress, or Both?”

“As 2023 opens, there is apprehension that partisan divisions and politicized health security approaches may worsen as the United States moves into a divided government of ultra-thin margins. But over the course of 2022, several important new national security directives and policies and bipartisan legislative actions significantly advanced thinking on health security and what is required to better protect Americans—proving that progress remains in reach, despite tough odds. Global health security, including biodefense, has been elevated to new prominence in U.S. national security thinking. The Biodefense Posture Review, expected to be released in early 2023, is mandated to unify and modernize DOD’s broad, comprehensive biodefense capabilities, and synchronize these efforts with those of other federal departments in line with the recently released National Defense and Biodefense Strategies. The United States must be resolute and clear, leaning forward not backwards, investing in new capabilities sustained over many years to protect Americans and the larger world against future dangerous pathogens. In a new commentary, Thomas R. Cullison and J. Stephen Morrison argue that it remains possible to bridge divides and make measurable progress to prepare the United States for inevitable future biological threats.” Read this CSIS report here.

“The Pentagon’s Chemical and Biological Defense Program Moves Towards Modernization, Yet Congress Slashes Funding”

Dan Regan discusses DoD’s seemingly mismatched objectives and funding decisions in this piece for the Council on Strategic Risks. He writes, “To achieve its mission set, including investing in emerging biotechnologies and bolstering industrial capacity to scale MCMs to novel threats, developing and investing in stand-off pathogen early warning detection, and advancing protective equipment for the Joint Force, the CBDP budget requires a nearly two-fold increase from the President’s request of $1.32 billion in FY23 to $3 billion for FY24. However, Congress unfortunately just dealt a 7% cut to chemical and biodefense programs with the FY23 omnibus spending bill, following years of declining funds for CBDP. As the FY24 Presidential Budget Request is being drafted, the Biden Administration and Congress should consider significant increases to CBDP’s budget, along with the other biodefense and global health security priorities outlined in the 10 + 10 over 10 strategy, to combat biological threats.”

“Virology Under the Microscope–a Call for Rational Discourse”

In this commentary in mBio, more than 130 authors call for a return to rational discourse about virology and its role in modern issues like pandemic response and debates over GoF research. “Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns – conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we – a broad group of working virologists – seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.”

“CRISPR Technology: A Decade of Genome Editing is Only the Beginning”

Wang and Doudna discuss the first decade of CRISPR in Science: “In the decade since the publication of CRISPR-Cas9 as a genome-editing technology, the CRISPR toolbox and its applications have profoundly changed basic and applied biological research. Wang and Doudna now review the origins and utility of CRISPR-based genome editing, the successes and current limitations of the technology, and where innovation and engineering are needed. The authors describe important advances in the development of CRISPR genome-editing technology and make predictions about where the field is headed. They also highlight specific examples in medicine and agriculture that show how CRISPR is already affecting society, with exciting opportunities for the future. —DJ”

“Zombie Viruses from the Arctic”

Jean-Michel Claverie’s new piece in Think Global Health discusses the threat global warming poses to global health by threatening Earth’s permafrost, potentially releasing ancient microbes. Claverie explains the evolution of this threat and how it may evolve throughout the piece, writing in part “This science fiction scenario became more realistic in 2015 when an international research team succeeded in resurrecting several viruses isolated from permafrost dating back 30,000 years. Following additional experiments, it is now clear that a significant proportion of prehistorical viruses can remain infectious for even longer periods of time. This article reviews the reality of the risks that their release might represent for the future.”

Science, Secrecy, and the Smithsonian

New from Ed Regis, author of The Biology of Doom, is this book, Science, Secrecy, and the Smithsonian:

“This is the story of how the Smithsonian Institute became intertwined in a secret biological warfare project.”

“During the 1960s, the Smithsonian Institution undertook a large-scale biological survey of a group of uninhabited tropical islands in the Pacific. It was one of the largest and most sweeping biological survey programs of all time, a six-year-long enterprise during which Smithsonian personnel banded 1.8 million birds, captured live specimens and took blood samples, and catalogued the avian, mammalian, reptile, and plant life of 48 Pacific islands.”

“But there was a twist. The study had been initiated, funded, and was overseen by the U.S. Biological Laboratories at Fort Detrick, Maryland. The home of the American biological warfare program. In signing the contract to perform the survey, the Smithsonian became a literal subcontractor to a secret biological warfare project. And by participating in the survey, the Smithsonian scientists were paving the way for top-secret biological warfare tests in the Pacific.”

“Critics charged the Smithsonian with having entered into a Faustian bargain that made the institution complicit in the sordid business of biological warfare, a form of combat which, if it were ever put into practice and used against human populations, could cause mass disease, suffering, and death. The Smithsonian had no proper role in any such activities, said the critics, and should never have undertaken the survey.”

Science, Secrecy, and the Smithsonian: The Strange History of the Pacific Ocean Biological Survey Program explores the workings of the survey program, places it in its historical context, describes the military tests that followed, and evaluates the critical objections to the Smithsonian’s participation in the project.”

Jonathan Tucker CBW Symposium

“The James Martin Center for Nonproliferation Studies cordially invites you to the 11th annual Jonathan Tucker Symposium on chemical and biological weapons issues on February 9th and 10th, 2023.” BW topics include “Revisiting the Siege of Caffa & Catapulting Cadavers” and “Governance of Dual-Use Biological Research,” the latter of which will be moderated by Dr. Gregory Koblentz. CW topics include “Lessons learned from the U.S. Chemical Weapons Destruction Program” and “The 2023 CWC Review Conference”. Learn more and register for the virtual events here.

Novel Applications of Science and Technology to Address Emerging Chemical and Biological Threats

For the first time since 2019, this Gordon Research Conference is back, this time in sunny Ventura, CA. “The Chemical and Biological Defense GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.” The conference will be held March 19-24, 2023. Learn more and apply here by February 19.

High School and College Student Internship: Data Analytics for Elite Young Scholars – Biology and Medical Science Experience

“This Young Scholars Research Program is designed for Elite High School Students and Undergrad Students, who are interested in pursuing their study and/or career in the fields of biology or medical science with emphasis on advanced data analytics. You will work with our esteemed George Mason University faculty members on a specific team project. The team will consist of about three to four members of both high school and undergraduate students. The project will be assigned to the students at the beginning of the program based on the preference indicated by the students prior to the program. Two outputs will be expected from each team at the end of the programs: i) a final paper which will be published on the Center for Biomedical Science and Policy website as well as a special issue of World Medical & Health Policy; and ii) Team presentation at a symposium at which students compete for prizes.”

“During this program, students will be participating in a research project applying some of the following methods, including but not limited to biostatistics using R or Stata, data visualization using QGIS or ArcGIS, and network visualization using Gephi.”

“During this program, students will be participating in a research project applying some of the following methods, including but not limited to biostatistics using R or Stata, data visualization using QGIS or ArcGIS, and network visualization using Gephi.”

Special Call for Papers-Journal of Science Policy & Governance

The Journal of Science Policy & Governance recently announced a special call for papers “and competition to provide policymakers with a new perspective on how scientific expertise could be useful to the complex brew of 21st foreign policy and national security challenges, resulting in a special issue on Policy and Governance on Science, Technology and Global Security.” The journal invites “students, post-doctoral researchers, policy fellows, early career researchers and young professionals from around the world to submit op-eds, policy position papers and other articles addressing foreign policy and national security challenges. These include concerns about the use of nuclear or radiological weapons driven by the war in the Ukraine, hypersonic weapons, immigration driven by climate change, and emerging threats in cybersecurity and biosecurity.” The deadline for submission is April 30.

Additionally, there will be a science policy writing workshop on January 30 in addition to two webinars on February 20 and March 30 (one on Policy and Governance on Science and Technology and one on Foreign Policy and National Security, respectively) to help prospective authors prepare their submissions. Learn more about these events and register here.

Weekly Trivia Question

You read the Pandora Report every week and now it’s time for you to show off what you know! The first person to send the correct answer to biodefense@gmu.edu will get a shout out in the following issue (first name last initial). For this week, our question is “On April 22, 1915, the German Army infamously unleashed more than 160 tons of chlorine gas on French trenches near which Belgian city?”

Shout out to Morgan M. for winning last week’s trivia! The correct answer to “In 1985, an American extremist group’s compound was raided by more than 300 law enforcement officers from several federal, state, and local agencies following a three-day standoff. Among other items, officers seized about thirty gallons of potassium cyanide the group intended to use to poison water supplies of several cities. What was the name of this group?” is the Covenant, the Sword and the Arm of the Lord.

Pandora Report 12.29.2017

This will be our last Pandora Report of 2017 and we’d like to take a moment and thank our wonderful readers for a great year of biodefense news! We hope you have a marvelous and safe New Years celebration. We’re starting the festivities early with some memories of infectious disease research from 2017.

Agroterrorism – A Threat To America’s Food Supply
Food vulnerability is not something people tend to think about very often and even less in the context of terrorism. There have been many experts noting that food safety is America’s soft underbelly for years, but just how vulnerable are we? “Agroterrorists have access to animal based bio-agents, which are easy to transport and simple to conceal. Just as ramming a speeding truck into a crowd is low-tech, an attack via the food chain has a low barrier to entry and little skill needed to execute. Weaponizing livestock is as simple as tending the flock or feeding the cattle. There is little expertise or special equipment required and given most animal borne pathogens are not communicable to humans, the logistics are easy. It really is farm to table pathogen delivery.” Increasing automation within food processing and rapid delivery from farm to table has the potential to be used as a weakness. Not only are these systems inherently weak against terrorist attacks, but one would severely damage the U.S. economy. A 2013 study found that outbreaks in FMD-free countries/zones could cause losses of more than $1.5 billion a year.

Biological Weapons Threat In The Spotlight – UN News
Check out this great podcast of UN news in which Dr. Tom Inglesby from the Johns Hopkins Center for Health Security discusses the BWC Meeting of States Parties and the importance of global cooperation to address biothreats. “He told Daniel Johnson that because most biological research now takes place ‘far outside the control of government’, a key objective should be to ensure that an information-sharing mechanism exists between industry and Member States.

Meeting of the Blue Ribbon Study Panel on Biodefense: SLTT Ability to Respond to Large-Scale Biological Events: Challenges and Solutions
Don’t miss this event on January 17th, 2018 in Miami, Florida! “The Nation continues to confront infectious disease events and the threat of biological terrorism. This meeting of the Study Panel, chaired by former Secretary of Health and Human Services Donna Shalala and former Representative James Greenwood, will provide the Study Panel with a better understanding of the ability of state, local, tribal, and territorial (SLTT) governments to: respond to large-scale biological events, identify and utilize SLTT assets and resources for immediate response (prior to a declaration of a SLTT biological emergency or disaster), operate before federal assistance arrives and after federal resources are exhausted, and shift to population management when a biological event overcomes pre-hospital and hospital response protocols.”

Analyzing the Detection and Response Aspects of Global Health Security
GMU biodefense PhD student Saskia Popescu is taking a trip down the detection and response rabbit hole of health security. Evaluating research on laboratory response networks, public health coordination, frontline epidemiology training, and more, she highlights the vulnerability we all share if even one country has a weak public health and healthcare infrastructure. “Response efforts often point to gaps within our plans, like the need to train staff on enhanced use of personal protective equipment during the Ebola outbreak, or cultural dynamics that challenge public health education efforts. Public health response is an evolving process and with each new challenge, lessons are learned and we hope that we can appropriately apply them in the future. The most important lesson is the global aspect of health security—an outbreak anywhere is an outbreak anywhere. Strengthening national prevention, detection, and response efforts will only serve to protect us all.”

WHO Priority List of Antibiotic-resistant Bacteria and Tuberculosis
The WHO has released a list of priority pathogens to help encourage the development of new antibiotics. “Detailing its findings in The Lancet Infectious Diseases yesterday, the WHO Pathogens Priority List Working Group used a multicriteria decision analysis method to select 20 antimicrobial-resistant bacteria. The experts then applied 10 criteria to assess priority: mortality, healthcare burden, community burden, prevalence of resistance, 10-year resistance trends, transmissibility, preventability in the community, preventability in healthcare settings, treatability, and drug pipeline.” The list of 20 bacterial species highlights three categories (critical, high, and medium priority), which includes “carbapenem-resistant Acinetobacter baumannii andPseudomonas aeruginosa, and carbapenem-resistant and third-generation cephalosporin-resistant Enterobacteriaceae. The highest ranked Gram-positive bacteria (high priority) were vancomycin-resistantEnterococcus faecium and meticillin-resistant Staphylococcus aureus. Of the bacteria typically responsible for community-acquired infections, clarithromycin-resistant Helicobacter pylori, and fluoroquinolone-resistantCampylobacter spp, Neisseria gonorrhoeae, and Salmonella typhi were included in the high-priority tier.”

 Drug Discovery, Development and Deployment
Speaking of the importance of drug R&D…the NIH has released their Drug Discovery, Development and Deployment Maps (4DM) to help engage and support this complicated process. There are two maps – one for small molecules and one for biologics, using monoclonal antibodies as the representative therapeutic. “The maps provide a common framework for discussing the therapeutic development process and serve as an education tool for those who are new to it. A common language and collective knowledge base for therapeutic development is essential to enable systemwide improvements that will benefit patients. The 4DM can help facilitate dialogue among those interested or participating in drug development to explore innovative solutions to existing bottlenecks and potential collaborative action to overcome those barriers and accelerate new medicine discovery.”

Bird Flu in South Korea
Avian influenza is wreaking havoc in South Korea. Officials have reported the culling of 201,000 birds in efforts to prevent the spread of H5N6 after it was found in four duck farms. “Last year, South Korea slaughtered more than 30 million birds to contain the worst outbreak of bird flu in the country‘s history.” Such efforts are especially important as the country prepares to host the Winter Olympics, which begin on February 9, 2018.

ASM Supports NIH Decision To Lift Funding Pause on GoF Research
Last week saw a surge of news regarding the official lift on the funding moratorium on GoF research. The news released an onslaught of over-the-top headlines and debates, but nonetheless the existence of GoF research will likely remain one that sparks concerns on both ends of the spectrum. The American Society for Microbiology (ASM) has come out in support of the lift on the funding pause though, noting that they are “in complete support of the National Institutes of Health lifting the funding pause on gain-of-function (GoF) experiments involving influenza, SARS, and MERS viruses. GoF research studies ways nature might make some viruses more virulent or transmissible. This is important in helping identify and develop strategies and effective countermeasures against rapidly evolving pathogens that pose a threat to public health, as well as to prepare for pandemics. ASM also applauds the review framework released by the Department of Health and Human Services. This process will ensure that any proposal that passes scientific peer review and fits the Potential Pandemic Pathogen (PPP) definition will undergo a multidisciplinary review process before funding is received. The review panel will provide oversight and facilitate safe and responsible conduct of this type of research.”

Stories You May Have Missed:

  • United States Flu Season Update– This flu season is already shaping up to be rough, so where are we? “Influenza A viruses have been most commonly identified, with influenza A(H3N2) viruses predominating. Several influenza activity indicators were higher than is typically seen for this time of year. The majority of influenza viruses characterized during this period were genetically or antigenically similar to the 2017–18 Northern Hemisphere cell-grown vaccine reference viruses. These data indicate that currently circulating viruses have not undergone significant antigenic drift; however, circulating A(H3N2) viruses are antigenically less similar to egg-grown A(H3N2) viruses used for producing the majority of influenza vaccines in the United States.” Outpatient visits have spiked with patients seeking care for influenza-like illness (ILI) across the U.S. The national average is 2.2% and last week saw 2.7% however, this week is now 3.5%, which points to a growing influenza season.

Thank you for reading the Pandora Report. If you would like to share any biodefense news, events, or stories, please contact our Editor Saskia Popescu (biodefense@gmu.edu) or via Twitter: @PandoraReport

Pandora Report 9.18.2015

What an interesting week! Ongoing salmonella cases, imported plague in Michigan, ISIS was found to be using chemical weapons, and a new prion disease was discovered. Pretty busy in the world of biodefense, I’d say. The Pandora Report is also fortunate to share with you a great piece by one of our graduate students, Greg Mercer, who tapped into Google Trends to look at ISIS nomenclature, and an upcoming book written by Dr. Brian Mazanec, regarding cyber warfare. So sit back and relax while we catch up on the week’s biodefense news.

US Confirmation of Islamic State Chemical Weapons

Operational_Readiness_Exercise_121014-F-LP903-827Sulfur mustard traces were found on fragments of ordnance used by the Islamic State, as well as on scraps of clothing from victims in Syria and Iraq. There have been several accounts by Kurdish officials that have claimed chemicals, like chlorine, were dispersed this summer, which is concerning for the ongoing use of these internationally banned substances. Testing done in the US was reported by officials on Friday, September 11, 2015, stating that, “there’s no doubt ISIS has used this,”. Officials have also said that the chemical residue recently found does not match known chemical ordinance that was used in the former Iraqi inventory. Overall, the use of chemical weapons is highly distressing and the method of acquisition, either manufacturing or from undeclared stocks, is under investigation.

Michigan Experiences Imported Plague Case

 A Michigan woman is the second case of bubonic plague that was traced back to the Little Rainbow area of Colorado. The Michigan resident was visiting family in Salida, CO during a music festival in late August. While her exact exposure hasn’t been established, she became ill after returning home and was hospitalized shortly thereafter. Lucky for the diagnosticians, she displayed textbook plague symptoms, leading to CDC involvement and antimicrobial treatment. Fortunately, she was released from the hospital and is beginning the long road to recovery, although it’s probably the last time she’ll attend that particular music festival or go hiking around it….

The So-Called Islamic State 2
By Greg Mercer

In February, I wrote about a topic that had been puzzling me- the contentious nomenclature of the Islamic State, or ISIS, or ISIL, or Daesh.  I decided to revisit this question now that the issue is a staple in the news, and that we’re probably saying it more frequently while thinking less about what we call it.  So I fired up my good friend Google Trends[1] again to take a look.  Google is a decent measure of public interest in a subject.  It’s the most popular search engine[2] in the world, with 66.78% of search volume worldwide as of August 2015.

Last time, I found that ISIS was the most popular term by a fair amount.[3]  This seems to be true this time around too, which isn’t terribly surprising.  Here’s what I got:
Screen Shot 2015-09-17 at 6.24.26 PM

 

 

 

 

 

This time around, ISIS is still the most popular, but Google’s added a feature that tells us a little more.  While I suspected that the terrorist organization was driving most of the searches for ISIS before, it’s true that ISIS is the only of the names that has other popular uses, notably an Egyptian goddess, a think tank, and of course a fictional intelligence organization.  The new “topics” option in Google Trends lets us identify search volume for an entire subject.  The dotted purple line indicates all searches for the organization, regardless of naming specifics.  Since the searches for “ISIS” specifically and all of the searches for the organization are strongly correlated, it’s safe to say that mythology enthusiasts, nuclear scholars, and Archer fans aren’t skewing the trends.

It’s also still the case that search volumes for all of the names spike with major news events- no surprise there.

I also found the search trends by country interesting, here’s a look at the different terms and how they show up globally:

Screen Shot 2015-09-17 at 7.33.14 PM
Click on image to see Google Trend analysis and additional graphs

 

 

 

 

 

 

 

 

 

 

A couple of takeaways:  Looking at the organization as a whole, the two most interested parties (by Google search) are Iraq and Iran.  That’s not too surprising.  Iran is also #1 for “Daesh”, which is used in both Arabic and Farsi and is considered more a disparaging name.  In fact, the Iranian foreign minister told Iranian state media in January (fair warning, this links to Iran Daily) that he hates the term “Islamic State” and prefers “Daesh.”  In my earlier article, I noted that other foreign policy practitioners share this sentiment, and prefer a name that doesn’t recognize the organization as a state or representative of Islam.  This is also definitely the least popular name in mainstream American media.[4]  Ethiopia and Peru are the highest by volume for ISIS and ISIL, respectively, neither of which I would have expected offhand.

It’s interesting to see how these trends break down, and to look at a single massive political issue and international crisis with such a proliferation of terms.  I think the name that finally sticks remains to be seen.

[1] This links to the search parameters I used for this article, so you can play around with the data.
[2] This site is really cool if you’re into this sort of thing- you can see what site users choose based on browser, operating system, and device type.
[3] Personally, I tried ISIL in the name of accurate translation, but I tended to use ISIS when being flippant, and then it ended up sticking.
[4] To get anecdotal, the only person I’ve heard use it is my buddy who does Arabic translation and Middle East studies for a living.

The Evolution of Cyber War

Screen Shot 2015-09-18 at 6.39.11 AMGMU’s very own, Dr. Brian Mazanec, delves into the world of cyber warfare and the reality of this threat. “Already, major cyber attacks have affected countries around the world: Estonia in 2007, Georgia in 2008, Iran in 2010, and most recently the United States. As with other methods of war, cyber technology can be used not only against military forces and facilities but also against civilian targets. Information technology has enabled a new method of warfare that is proving extremely difficult to combat, let alone defeat.” Available on November 1, 2015, we’re excited to share Brian’s phenomenal work!

Stories You May Have Missed:

  • Flu vaccination rates went up a bit for the 2014/2015 season, however, the efficacy was only 18% due to an antigenic drift. Fortunately, vaccination compliance for healthcare workers increased and overall rates showed that women were more likely than men to get vaccinated.
  • The Australian government will pass a new law, the “No Jab, No Pay Bill“, that will penalize parents who don’t vaccinate their children by withholding child care and other payments.
  • An additional 77 cases of Salmonella Poona were reported since September 9, 2015, related to the multi-state cucumber outbreak. The total infected is now 418 people across 31 states, with 91 hospitalizations.
  • A new prion disease has been identified by a team of scientists led by Stanley Prusiner. Their report outlines the discovery and the potentially infectious nature of this new prion.

Pandora Report 7.11.15

Sorry for the late update here at Pandora Report. We’ve got how the plague turned so deadly, an Ebola update, and of course other stories you may have missed.

Have a great week!

These Two Mutations Turned Not-so-Deadly Bacteria Into the Plague

Researchers at Northwestern University have been investigating how Yersinia pestis—the bacteria that causes bubonic, pneumonic, and septicemic plague—became the infective cause of the Black Death. They discovered two mutations that help to explain the bacteria’s lethality.

Smithsonian.com—“The first mutation gave the bacteria the ability to make a protein called Pla. Without Pla, Y. pestis couldn’t infect the lungs. The second mutation allowed the bacteria to enter deeper into the bodies, say through a bite, to infect blood and the lymphatic system. In other words, first the plague grew deadly, then it found a way to leap more easily from infected fleas or rodents to humans.

Ebola Strain Found on Teen in Liberia Genetically Similar to Viruses in Same Area Months Ago

I’m sure you’ve heard that there were three new cases of Ebola in Liberia—a country that was declared free of the disease on May 9. According to the World Health Organization, samples taken from a teenager who died from Ebola two weeks prior indicate that the disease is genetically similar to strains that infected people in the same area over six months ago—while the outbreak was still ongoing.

US News and World Report—“That finding by genetic sequencing suggests it is unlikely the virus was caught from travel to infected areas of Guinea or Sierra Leone, the group said. “It also makes it unlikely that this has been caused by a new emergence from a natural reservoir, such as a bat or other animal,” it said.”

Stories You May Have Missed

Image Credit: en.wikipedia

Pandora Report 6.14.15

I’ve got brunch reservations this morning so the big story about the coming egg shortage is hitting close to home. We’ve also got a story about ISIS’ WMD and a bunch of stories you may have missed.

As a final reminder, the Early Registration Deadline for the Pandemics, Bioterrorism, and International Security is tomorrow, Monday, June 15. For more information and registration, please click here.

Enjoy the rest of your weekend!

Egg Shortage Scrambles U.S. Food Industries

The unprecedented outbreak of avian influenza in the U.S. has meant massive losses in the domestic poultry industry which has left experts warning that U.S. consumers are very likely to see an increase in egg prices. Cases of avian flu have been reported in 15 states, with Iowa and Minnesota being some of the hardest hit. “In Minnesota, the number of lost turkeys represent about 11 percent of our total turkey production…of the chickens we’ve lost that are laying eggs, 32 percent… have been affected by this” In Iowa, about 40 percent of the state’s egg-laying chickens and 11 percent of its turkeys have been affected. All these losses will mean a shortage of whole eggs and other egg-based products.

U.S. News and World Report—“Consumers haven’t felt the pinch too much just yet, but they are unlikely to emerge with their pocketbooks unscathed, [Rick] Brown [Senior VP at Urner Barry, a food commodity research and analysis firm]. He says two-thirds of all eggs produced in the U.S. remain in a shell, many of which are placed in cartons and sold in grocery stores. This stock of eggs has been hit significantly less by the avian flu outbreak than those used in the egg products industry, which Brown says encompasses “everything from mayonnaise to salad dressings to cake mixes to pasta to bread.”

Australian Official Warns of Islamic State Weapons of Mass Destruction

You may have already seen this, since this story was everywhere this week. Julie Bishop, Australia’s Minister for Foreign Affairs, said the Islamic State (ISIS) already has and is already using chemical weapons. Bishop made these comments in an address to the Australia Group—a coalition of 40 countries seeking to limit the spread of biological and chemical weapons. In a follow-up interview, Bishop also said that NATO was concerned about the theft of radioactive material and what that could mean for nuclear weapons proliferation.

The Washington Post—“‘The use of chlorine by Da’ish, and its recruitment of highly technically trained professionals, including from the West, have revealed far more seriou­s efforts in chemical weapons development,” Bishop said, using an alternate name for the Islamic State in a speech reported by the Australian. She did not specify the source of her information.  “… Da’ish is likely to have amongst its tens of thousands of recruits the technical expertise necessary to further refine precursor materials and build chemical weapons.’”

Stories You May Have Missed

 

Image Credit: Hannahdownes

Pandora Report 3.1.15

My apologies for no update last week, I had to make an unexpected, emergency, work-related trip to Dulles Airport, my old stomping grounds. But everything is under control and we’re back at it, covering stories from the past two weeks. Fittingly, we start off with airport screening, and also cover the Black Death, chemical weapons in Libya, Ebola, and other stories you may have missed.

Have a great week and stay safe in the weather out there!

Airport Screening for Viruses Misses Half of Infected Travelers

A team led by UCLA researchers has found that airport screening—for viruses like H1N1 and Ebola—misses at least half of infected travelers. The team found that no more than 25% of passengers answered honestly about their exposure to influenza in 2009 and that some may have been able to hide symptoms by taking over-the-counter drugs like acetaminophen. Timing of the screening may impact detection ability, too.

Science 2.0—“‘We found that for diseases with a long incubation period, such as Marburg and Ebola, taking passenger’s temperature to test for fever is particularly ineffective at the start of the epidemic but does pick up more cases as the epidemic stabilizes,” said Katelyn Gostic, a lead author of the study and a UCLA doctoral student in the laboratory of Professor James Lloyd-Smith. “With diseases such as swine flu, which take a shorter time to incubate, fever screening is the most effective method throughout an epidemic.’”

Plague Pandemic May Have Been Driven by Climate, Not Rats

Rats may have been incorrectly receiving centuries of blame for European plague, or Black Death. According to Nils Stenseth, of the University of Oslo, the introduction, and re-introduction, of the disease to Europe may have been caused by Asian climate events. Additionally, black rats where rare in Northern Europe, so the likely rodent culprit may have actually been gerbils. Moreover, the plague is not naturally found in Europe, but it is endemic in Asia in the rodents that live there. However, when the climate becomes warmer and wetter, rodent numbers drop and the fleas seek out alternative hosts, like domestic animals and humans.

Smithsonian—“The scientists will need more data to prove that Asian climate was responsible for all the reintroductions of plague to Europe. For instance, analysis of plague DNA from European victims who died at different time periods could strengthen the link between climate and outbreaks. “If our theory of climate-driven successive reintroductions is correct, we would expect to find great genetic bacterial variation between plague victims across time,” Stenseth explains. If the bacteria had instead come from a single introduction, there would be less genetic variation in the pathogen’s DNA, even when taken from victims from different times and locations.”

ISIS Chemical Weapons Libya: Military Warns Islamic State Might Have Mustard Gas, Sarin

Islamic State fighters in Libya have allegedly seized large amounts of chemical weapons including mustard gas and Sarin that reportedly belonged to the regime of Moammar Gadhafi. Last year, though, Libyan officials said they destroyed the last known stockpile from Gadhafi’s regime.

International Business Times—“The weapons are likely 10 years old and in a degraded state, but remain dangerous, former British Army officer Hamish de Bretton-Gordon told The Daily Mail Sunday. “While we don’t know how much IS has acquired, and though the Libyan Sarin dates back to the Gadhafi era, it would still have a toxicity and pose a danger,” he said. “Libya is virtually Europe and so the fear factor from a European perspective is huge. I should think the security forces will be watching this situation very closely.’”

This Week in Ebola

It’s been awhile since an Ebola update, but there was some good news worthy of coverage as schools re-opened in Liberia on February 16, as a sign that life is starting to return to normal. Countries are still keeping an eye out for the virus, including, inexplicably, North Korea, who has banned foreign runners from their April marathon (yes, that is actually a thing!) A piece appeared in the Journal of the American Society of Microbiology that indicated it is “very likely that at least some degree of Ebola virus transmission currently occurs via infectious aerosols generated from the gastrointestinal tract, the respiratory tract, or medical procedures.” However, there is some good news including a new product, similar to hand sanitizer, that can kill bacteria and viruses within 15 second of application and can work for up to six hours and a rapid diagnostic test for both Ebola and Dengue. Lastly, it wouldn’t be an Ebola update without a questionable article—this one is about a Baltimore wedding gown designer who went to New York Fashion with an Ebola suit. Sigh.

Stories You May Have Missed

 

Image Credit: Micah Sittig

Pandora Report 11.23.14

Thanksgiving is mere days away so it makes sense to look at some stories that can provide appropriate dinner discussion during those awkward lulls, right? These stories may provide that, though, I suppose that depends on who you eat your holiday dinner with (my family is very tolerant of my eccentricities.) With that said, this week we will look at plague in Madagascar, polio in Africa, antibiotic resistance in turkeys, and, of course, an Ebola update.

In observance of Thanksgiving there will not be a news wrap up next weekend. From all of us at the Pandora Report, we wish you a safe, warm, and delicious Thanksgiving!

Madagascar Plague Outbreak Kills 40, Says WHO

The World Health Organization has reported that an outbreak of plague in Madagascar has killed 40 and infected almost 80 others. The WHO warned that rapid spread of the disease could take place in the capital, Antananarivo. Humans usually develop the bubonic form of plague after being bitten by an infected flea carried by a rodent. This type, if diagnosed early, can be treated with antibiotics. However, 2% of the cases in Madagascar are pneumonic plague, which can be spread much more easily from person-to-person through coughing.

BBC—“Last year health experts warned that the island was facing a plague epidemic unless it slowed the spread of the disease. It said that inmates in Madagascar’s rat-infested jails were particularly at risk.”

Africa Nears Polio Eradication, CDC Says 

Maybe Ebola will be a topic of conversation at your Thanksgiving table. Maybe not. If you want to share some great news out of Africa, share this story. According to the Centers for Disease Control, wild polio virus has nearly been eradicated! The drop in cases in Africa has been attributed to successful vaccination campaigns in Nigeria.

Time—“No case of polio has been recorded on the continent since August, the report finds. There have been 22 cases of polio in Africa overall since the beginning of 2014, six of which were in Nigeria, one of the last three endemic nations alongside Pakistan and Afghanistan. The latest tally marked a drastic reduction from 49 cases in Nigeria the previous year.”

To Slow Down Drug Resistance in Health Care, Buy an Antibiotic-Free Turkey for Thanksgiving

We’ve seen, here at Pandora Report, that growing antibiotic resistance is a problem that spans countries and continents. Just in time for the best holiday, the Health Care without Harm nonprofit has suggested that health care workers (and, well, everyone else, too) can contribute to slowing the growth of antibiotic resistance by buying an antibiotic-free turkey for Thanksgiving. If you haven’t yet bought your turkey, maybe you’ll be motivated by what they say.

Wired—“Antibiotic resistance is a growing problem that more and more patients and providers are facing each day, and antibiotic overuse is a major contributor to this problem. While as many as 50% of antibiotic prescriptions may be overly broad or even unnecessary, animal agriculture uses four times the amount of antibiotics as human medicine, and mostly in healthy animals for growth promotion or disease prevention on crowded farms…

We are advocating for a broader concept of antimicrobial stewardship.”

This Week in Ebola

The doctor who was flown to Nebraska for treatment for Ebola died this week from a very advanced case of the disease. The need for hospitals in the U.S. and Africa that are qualified to deal with Ebola has not waned and there is an urgent need for the reinforcement of public health systems. In the meantime, New York Senator Chuck Schumer has called for New York City to be reimbursed for the costs it incurred to quarantine and treat Dr. Craig Spencer. In airport news, the Department of Homeland Security has said that they are adding additional screening for passengers arriving from Mali as there are signs of wider Ebola exposure in that country and officials in India have quarantined a man who recovered from Ebola after treatment in Liberia in September. And while UN officials have warned that the epidemic is “not even close to over” there is good news coming out of Liberia where CDC officials say that the spread of the disease has definitely slowed. Lastly, the Gates Foundation has pledged $5.7 million to test treatments for Ebola in Guinea and other countries in West Africa and Band Aid has put together a new recording of “Do They Know It’s Christmas?” with proceeds going to the Ebola fight. (There are two other amazing anti-Ebola songs, in this link, too!)

Stories You May Have Missed

 

Image Credit: Oregon Live

Pandora Report 8.31.14

Fall classes at George Mason have already started and this Labor Day weekend marks the official end of summer. This week, we have stories covering a wide range of topics—an Ebola update (of course), a fascinating article on vaccinia infections acquired through shaving, Haj precautions, and the ISIS “laptop of doom.”

Best wishes for a safe and enjoyable holiday!

Ebola Virus Outbreak Could Hit 20,000 Within Nine Months, Warns WHO

There were many stories this week covering the continuing Ebola outbreak in West Africa. Senegal saw its first (imported) case of the virus this week and has banned flights to and from the affected countries while shutting its land border with Guinea and Nigeria saw its first death outside of the capital city of Lagos. In the Democratic Republic of Congo, where Ebola first emerged in 1976, there have been reported cases of a hemorrhagic gastroenteritis similar to Ebola. I read conflicting accounts this week of the “patient zero” for the Ebola outbreak—a young boy or an older traditional healer. There were reports of some U.S. universities screening students from West Africa for Ebola. There was coverage of a Toronto medical isolation unit ready for patients and information about GlaxoSmithKline’s experimental ebola vaccine which would be tested on humans in the next few weeks.

All of this news came among World Health Organization estimates that this West African outbreak could affect 20,000 people over the next nine months and that half a billion dollars would be needed to stop the spread of the disease.

The Wall Street Journal—“The WHO program will likely cost around $490 million and require contributions from national governments, some U.N. and non-governmental agencies, as well as humanitarian organizations, it said.”

First Reported Spread of Vaccinia Virus Through Shaving After Contact Transmission

This week, reports in the August issue of Medical Surveillance Monthly Report from the Armed Forces Health Surveillance Center covered vaccinia virus infection—the virus used for smallpox vaccinations—within the U.S. Air Force. The infections in the report occurred in June 2014, and affected four individuals.

Infection Control Today—“Over the past decade, most cases of contact vaccinia (i.e., spread of the virus from a vaccinated person to an unvaccinated person) have been traced to U.S. service members, who comprise the largest segment of the population vaccinated against smallpox. Most involve women or children who live in the same household and/or share a bed with a vaccinee or with a vaccinee’s contact. Of adult female cases, most are described as spouses or intimate partners of vaccinees or secondary contacts. Of adult male cases, most involve some type of recreational activity with physical contact, such as wrestling, grappling, sparring, football, or basketball. Household interactions (e.g., sharing towels or clothing) and “unspecified contact” are also implicated.”

Government to Keep Haj Infection-Free 

This week, the Saudi Arabian Ministry of Health announced mandatory measures for Haj and Umrah pilgrims coming from countries with active outbreaks or high rates of infectious diseases. The Health Ministry sent information to embassies outlining health requirements for those seeking pilgrim visas.

Arab News—“‘Although we do not issue Haj visas for pilgrims coming from endemic countries, we will still be monitoring pilgrims coming from other African countries for Ebola symptoms,’ said [Sami] Badawood [Jeddah Health Affairs director.]

He said the ministry would also focus on diseases such as yellow fever, meningitis, seasonal influenza, polio and food poisoning.”

Is the ISIS Laptop of Doom an Operational Threat?

Discovery of a laptop, which has been linked to ISIS, raises new questions about the organization’s plans relating to use of WMD—specifically chemical or biological weapons. Over 35,000 files on the laptop are being examined and has offered new insight into ISIS and their WMD aspirations.

Foreign Policy—“Most troubling is a document that discusses how to weaponize bubonic plague. But turning that knowledge into a working weapon requires particular expertise, and it’s not clear that the Islamic State has it.”

 

Image Credit: Wikimedia Commons

Mason Researchers Looking for Fresh Answers in a Medieval Disease

George Mason University’s National Center for Biodefense and Infectious Diseases has been researching the causative agent of plague–Yersinia pestis.


George Mason University professor Ramin M. Hakami is searching for new ways to treat modern ailments by studying bacterial and viral biodefense agents, including the medieval disease notoriously known as the Black Death.

Along the way, he’s also coaching the next generation of researchers. The two endeavors are equally critical, says Hakami, who knows firsthand how crucial mentoring can be to young researchers from when he himself was a student earning his doctorate in biochemistry in the laboratory of the Nobel Laureate Professor Har Gobind Khorana at the Massachusetts Institute of Technology (MIT).

Read the full article here.

 

Image credit: George Mason University

Pandora Report 7.26.14

Highlights this week include, Dr. Frieden goes to Washington, top Ebola doc comes down with the virus, a TB patient on the loose in California, and a plague based shut-down in China. Have a great weekend!

CDC Director to Tackle MERS, Measles, Global Health Threats

It was my absolute pleasure to be able to attend a talk given by Dr. Tom Frieden, Director of the Centers for Disease Control and Prevention, at the National Press Club on Tuesday.  Though Dr. Frieden briefly covered the stated topics, he spoke primarily about the dangers of growning antibiotic resistance and hospital acquired infections. He urged everyone, including the CDC, to work hard(er) to combat these issues that may usher us into a “post-antibiotic era.” The entire speech is available here. (You may even notice me in the lower left corner chowing down on a CDC cupcake!)

USA Today—“‘Anti-microbial resistance has the potential to harm or kill anyone in the country, undermine modern medicine, to devastate our economy and to make our health care system less stable,” Frieden said.

To combat the spread of resistant bacteria, Frieden said the CDC plans to isolate their existence in hospitals and shrink the numbers through tracking and stricter prevention methods.”

 

Sierra Leone’s Top Ebola Doctor Infected as the Worst Outbreak in History Continues

You may have seen this story pop up earlier this week in our facebook or twitter, but it certainly bears repeating. Dr. Sheik Umar Khan, who has been credited with treating more than 100 Ebola victims, has come down with the virus too. He is now one of hundreds who have been affected by the virus in West Africa, which has killed over 600.

The Washington Post-“In late June, Khan seemed keenly aware of the risk he faced. “I am afraid for my life, I must say, because I cherish my life,” he told Reuters. “Health workers are prone to the disease because we are the first port of call for somebody who is sickened by disease. Even with the full protective clothing you put on, you are at risk.’”

 

California Police Seek Man Who Refused Tuberculosis Treatment

Prosecutors in Northern California have obtained an arrest warrant for Eduardo Rosas Cruz, a 25 year old transient, who was diagnosed with TB and disappeared before he started treatment. Rosas Cruz needed to complete a nine-month course of treatment. Tuberculosis spreads through the air when an infected person coughs or sneezes. It is not known if Rosas Cruz is currently contagious. By law, health officials cannot force a patient to be treated but courts can be used to isolate an infectious individual from the public at large.

FOX News—“County health officials asked prosecutors to seek the warrant, in part, because Rosas Cruz comes from a part of Mexico known for its drug-resistant strain of tuberculosis. County health officials are searching for Rosas Cruz, and his name is in a statewide law enforcement system, San Joaquin County Deputy District Attorney Stephen Taylor said.”

 

In China, A Single Plague Death Means an Entire City Quarantined

Parts of Yumen City, in Gansu Province, were quarantined after a farmer died from bubonic plague. The man developed the disease after coming in contact with a dead marmot on a plain where his animals were grazing. According to experts, Chinese authorities categorize plague as a Class 1 disease, which enables them to label certain zones as “infection areas” and seal them off. 151 people were affected by the quarantine, which was lifted after none developed symptoms.

The Guardian—“The World Health Organization’s China office praised the Chinese government’s handling of the case. “The Chinese authorities notified WHO of the case of plague in Gansu province, as per their requirements under the International Health Regulations,” it said in a statement to the Guardian. “The national health authorities have advised us that they have determined this to be an isolated case, though they are continuing to monitor the patient’s close contacts.’”

 

Image Credit: RT