Pandora Report: 1.27.2023

The year of the rabbit is off to one heck of a start. This week we cover COVID-19’s spread in China as the Party increasingly cracks down on Zero-COVID protesters, growing concern amount H5N1 in mammals, new insight into the history of the plague, and more. Several new publications are listed, including a fresh book from Ed Regis about the history of the Pacific Ocean Biological Survey Program and multiple works on misinformation’s impact on COVID-19 responses. As always, we round out with events and announcements, including multiple great upcoming professional opportunities. Happy Friday!

COVID-19 Multiplying Like Rabbits in China

China’s CDC claimed this week that cases of critically ill COVID-19 patients are down 72% from a peak earlier this month in the country, with daily deaths of hospitalized COVID-19 patients down 79% as well. This comes as Wu Zunyou, Chief Epidemiologist at China CDC, claims that 80% of the country’s 1.4 billion people have already been infected. This seems like an effort to indicate that a rebound is unlikely in the coming months amid concerns that the new year travel season will cause further spread and deaths. Just last week, China claimed to have 60,000 COVID-19 deaths in the month since it rolled back its notorious Zero-COVID policies, a number far below the one million some models estimated the country will suffer this winter.

However, CNBC notes, “…some experts said that figure probably vastly undercounts the full impact, as it excludes those who die at home, and because many doctors have said they are discouraged from citing Covid as a cause of death.” This understanding better aligns with reports of over-crowded funeral homes and crematoriums, and reports of coffin makers and funeral decoration companies repeatedly selling out of their products amid the spread. Because of these discrepancies, many are doubtful of the government’s official statistics.

At the same time, reports of Zero-COVID protesters being arrested or intimidated are mounting. Four women in Beijing are known to have been arrested in connection with these protests, seemingly in retaliation for their role in what has been described as “the boldest challenge to the Communist Party’s rule in decades and an embarrassing affront to its leader, Xi Jinping.” The New York Times explains the Party’s need to do this, writing “The party seems determined to warn off anyone who may have been emboldened by the remarkable outburst of public discontent, which was followed just days later by Beijing’s abrupt decision to abandon Covid restrictions. Since then, domestic challenges have mounted: Youth unemployment is high, the economy is slowing, and Covid infections and deaths have accelerated.”

The same piece continues, “The party is also working to discredit the protesters by casting them as tools of malevolent foreign powers. Beijing has long dismissed dissent at home — from calls for women’s rights to pro-democracy activism to ethnic unrest — as the result of Western-backed subversion. The protests against “zero Covid” were no exception: One Chinese diplomat suggested that some of the demonstrators had been “bought by external forces.”

Chunyun, the Lunar New Year travel period in China, typically lasts from mid-January through late-February, meaning opportunities for spread in rural parts of the country are far from over, despite China CDC’s apparent claims to the contrary. The continued supply of highly suspect statistics and crackdowns on Zero-COVID protesters presents a troubling situation and indicates that the Party has done anything but change its ways.

Thinking of Offering a Nice Egg in This Trying Time? Mink Again

US egg prices skyrocketed in price by more than 137% between December 2021 and December 2022, leaving many in constant sticker shock at the grocery store as this once reliably cheap staple becomes increasingly expensive. Much of this is attributed to outbreaks of highly pathogenic avian influenza (HPAI) A(H5N1), which has been spreading in US flocks since January 2022, resulting in cullings of over 57 million birds across industrial and backyard flocks. However, over the past year, this virus has also demonstrated its ability to spread from birds to mammals, with infections found in several species in the US so far, including raccoons, foxes, seals, grizzly bears, and, most recently, minks. Naturally, this had led to increased concern about potential spread into other mammal populations.

“Transmission electron microscopic image of two Influenza A (H5N1) virions, a type of bird flu virus Note the glycoprotein spikes along the surface of the virion and as a stippled appearance of the viral envelope encasing each virion.” Credit: CDC PHIL

Nature covered this story this week, writing “Until this particular outbreak, all mammalian infections could be attributed to direct contact with virus-contaminated material, says Hualan Chen, a virologist at the Harbin Veterinary Research Institute in China. For example, animals that ingest wild-bird droppings, or that prey on infected animals, can develop the disease. But its spread between mammals “implies that this H5N1 virus may pose a higher risk to public health”, Chen says.”

A new article in Eurosurveillance discusses the alarming spread of HPAI A(H5N1) at an American mink farm in Galicia, Spain in October 2022. In it, Agüero et al. explain that the farm experienced an acute increase in its mortality rate (.77% versus an expected range of .2-.3%), prompting the facility’s clinical veterinarian to collect samples from affected animals. These animals tested positive for H5N1, and “Post-mortem examination revealed haemorrhagic pneumonia or red hepatisation of the lungs as the most notable lesions”

The authors further explain the set-up of the farm, which housed 51,986 minks, writing “The minks were housed in wire netting cages placed in rows and situated in a series of over 30 partially open barns, which provided overhead protection but not total shelter of their sides. The minks were fed with raw fish and poultry by-products, cereals and blood meal. Poultry farms and avian slaughterhouses supplying the poultry by-products were located in Galicia. Up to 10 January 2023, H5N1 poultry outbreaks have not been reported from this region.”

The outbreak soon peaked, with a weekly mortality rate of 4.3% documented between October 17 and 23. Culling measures were ordered quickly, and all minks from infected pens were culled by November 17, along with destruction of all carcasses, fomites, and waste. Of the farm’s 12 workers, 11 were in contact with infected and culled animals, though none of them tested positive and they all completed quarantine without any problems. However, as the authors note in their abstract, “The identified viruses belong to clade 2.3.4.4b, which is responsible of the ongoing epizootic in Europe. An uncommon mutation (T271A) in the PB2 gene with potential public health implications was found. Our investigations indicate onward mink transmission of the virus may have occurred in the affected farm.”

While the mink farm seems to have been thorough in its efforts to stop this outbreak, there are concerns that this new variant may be circulating in wild bird populations. Nature writes, “But Puryear thinks that because the new variant contains genetic material from gull flu, it’s likely that at least some of its genetic changes arose in gulls before entering the mink farm. This means that a strain containing those mutations is probably still circulating in the bird population. But for human populations, the outlook is still good: if the new strain did start to infect people, health authorities could probably produce a vaccine quickly, and the antiviral drug Tamiflu (oseltamivir) can reduce the severity of the disease.”

The Nature news piece concludes with, “The potential risk to wild animals is greater. Bird flu has consistently caused high levels of sickness and death among wild birds and mammals over the past year, and how the new variant will affect that trend remains to be seen. “We just simply don’t know,” says Puryear.”

Shake Ups and Mess Ups at the Department of Health and Human Services

CDC Takes Major Steps in Revamp

CDC Director Dr. Rochelle Walensky announced a number of high-level changes to her agency this week, including the creation of the Office of Health Equity and the Office of Public Health Data, Surveillance, and Technology. These are steps taken in light of last year’s internal review that found, among other things, that the agency struggled with appropriately and rapidly sharing scientific findings, communications in general, and that it needed to strengthen relationships with federal, state, and local partners. Furthermore, most of the organizations under CDC will now report directly to the Office of the Director, moving away from what has been described as a “Community of Practice structure”.

MedPage Today explained this leadership re-structuring, writing “Today, additional details about that leadership structure became clear. There will be a centralized leadership team of experts housed within the director’s office, which will include the director of the CDC/Agency for Toxic Substances and Disease Registry; the principal deputy director; the deputy director for program and science/chief medical officer; the deputy director for policy, communications, and legislative affairs/chief strategy officer; the deputy director for global health; the chief operating officer; and the chief of staff.”

“These changes will improve efficiency, speed decision-making, and strengthen the communication of scientific information to the American public, ensuring CDC’s science reaches the public in an understandable, accessible, and implementable manner as quickly as possible,” an unnamed staffer told The Hill.

OIG Report Finds NIH and EcoHealth Alliance Fell Short in Monitoring and Oversight

The Office of Inspector General (OIG) at HHS released this week the findings of its audit of the National Institutes of Health’s grants to the EcoHealth Alliance. This audit was initiated because of concerns over NIH’s grant awards to EcoHealth as well as EcoHealth’s subawards to foreign entities. OIG aimed to “…determine whether NIH monitored grants to EcoHealth in accordance with Federal requirements, and whether EcoHealth used and managed its NIH grant funds in accordance with Federal requirements.”

The Office found that, “Despite identifying potential risks associated with research being performed under the EcoHealth awards, we found that NIH did not effectively monitor or take timely action to address EcoHealth’s compliance with some requirements. Although NIH and EcoHealth had established monitoring procedures, we found deficiencies in complying with those procedures limited NIH and EcoHealth’s ability to effectively monitor Federal grant awards and subawards to understand the nature of the research conducted, identify potential problem areas, and take corrective action. Using its discretion, NIH did not refer the research to HHS for an outside review for enhanced potential pandemic pathogens (ePPPs) because it determined the research did not involve and was not reasonably anticipated to create, use, or transfer an ePPP. However, NIH added a special term and condition in EcoHealth’s awards and provided limited guidance on how EcoHealth should comply with that requirement. We found that NIH was only able to conclude that research resulted in virus growth that met specified benchmarks based on a late progress report from EcoHealth that NIH failed to follow up on until nearly 2 years after its due date. Based on these findings, we conclude that NIH missed opportunities to more effectively monitor research. With improved oversight, NIH may have been able to take more timely corrective actions to mitigate the inherent risks associated with this type of research.”

Biodefense Graduate Program Director Dr. Gregory Koblentz was quoted in the New York Timespiece on this report, saying “Although concerns were identified by NIAID staff, the proposal was not referred to NIAID’s review committee for further consideration.” He continued, saying “On paper, NIAID staff were encouraged to ‘err on the side of caution’ in identifying and referring such proposals…but in practice it looks like they erred on the side of complacency.” 

Woman Pleads Guilty to Mailing Ricin Letters in 2020

Pascale Cecile Veronique Ferrier pleaded guilty this week in a US District Court “…to sending a threatening letter containing homemade ricin to then-President Donald J. Trump at the White House in September 2020, and eight similar letters, each containing ricin, to Texas State law enforcement officials.” Ferrier, a dual French-Canadian national, holds a French engineering degree and admitted in her plea agreements that she made ricin in her Quebec home in September 2020. According to the FBI, “Ferrier placed the ricin in envelopes containing letters she wrote to then-President Trump at the White House and to eight Texas State law enforcement officials.”

“Ferrier was detained in the State of Texas for around 10 weeks in the spring of 2019, and she believed that the law enforcement officials were connected to her period of detention. In early September 2020, Ferrier used the Twitter social media service to propose that someone should “please shoot [T]rump in the face.” The letters in the envelopes contained threatening language, and the letter addressed to then-President Trump instructed him to “[g]ive up and remove [his] application for this election.” Ferrier mailed each of the threatening ricin letters from Canada to the United States. Ferrier then drove a car from Canada to the Peace Bridge Border Crossing in Buffalo, New York, on Sept. 20, 2020, where border patrol officials found her in possession of a loaded firearm, hundreds of rounds of ammunition and other weapons.”

Ferrier is scheduled for sentencing on April 26. She faces 262 months imprisonment if her plea agreements are accepted.

An Oldie, But a (Not So) Goodie: Y. Pestis Strains May Have Been Around Centuries Before Outbreaks

A new article in Communications Biology discusses how Yersinia pestis spread globally over longer periods of time than previously estimated. Eaton et al. estimate that the strain of Y. pestis responsible for the Black Death in the mid-14th century diverged from the ancestral strain as early as 1214, while the one responsible for the Plague of Justinian may have cropped up between 272 and 465–up to nearly 270 years before the epidemic began in 541. “‘It shows that each major plague pandemic has likely emerged many decades to centuries earlier than what the historical record suggests,” study coauthor and evolutionary geneticist Hendrik Poinar, director of McMaster University’s Ancient DNA Centre in Canada,” said in a statement to CNN.

The authors write in their abstract: “Plague has an enigmatic history as a zoonotic pathogen. This infectious disease will unexpectedly appear in human populations and disappear just as suddenly. As a result, a long-standing line of inquiry has been to estimate when and where plague appeared in the past. However, there have been significant disparities between phylogenetic studies of the causative bacterium, Yersinia pestis, regarding the timing and geographic origins of its reemergence. Here, we curate and contextualize an updated phylogeny of Y. pestis using 601 genome sequences sampled globally. Through a detailed Bayesian evaluation of temporal signal in subsets of these data we demonstrate that a Y. pestis-wide molecular clock is unstable. To resolve this, we developed a new approach in which each Y. pestis population was assessed independently, enabling us to recover substantial temporal signal in five populations, including the ancient pandemic lineages which we now estimate may have emerged decades, or even centuries, before a pandemic was historically documented from European sources. Despite this methodological advancement, we only obtain robust divergence dates from populations sampled over a period of at least 90 years, indicating that genetic evidence alone is insufficient for accurately reconstructing the timing and spread of short-term plague epidemics.”

Read the entire article here.

“Produced by the National Institute of Allergy and Infectious Diseases (NIAID), this digitally colorized scanning electron microscopic (SEM) image depicts a number of yellow-colored, Yersinia pestis bacteria, that had gathered on the proventricular spines of a Xenopsylla cheopis flea. These spines line the interior of the proventriculus, a part of the flea’s digestive system. The Y. pestis bacterium is the pathogen that causes bubonic plague.” Credit: CDC PHIL

It’s 90 Seconds to Midnight (That’s Not Good)

“This year, the Science and Security Board of the Bulletin of the Atomic Scientists moves the hands of the Doomsday Clock forward, largely (though not exclusively) because of the mounting dangers of the war in Ukraine. The Clock now stands at 90 seconds to midnight—the closest to global catastrophe it has ever been.” Read the Bulletin’s statement here (also available in РУССКИЙ and УКРАЇНСЬКА).

Say “Hello” to the International Biosecurity and Biosafety Initiative for Science

The Nuclear Threat Initiative recently announced the creation of the International Biosecurity and Biosafety Initiative for Science (IBBIS), an organization “trying to prevent dramatic advances in bioscience from unleashing engineered pathogens from the lab, and wants research funders, scientists and journals to help.” NTI explains: “NTI is working with international stakeholders to establish the International Biosecurity and Biosafety Initiative for Science (IBBIS), an independent organization dedicated to reducing emerging biological risks associated with technology advances. A core element of the IBBIS mission will be to strengthen international biosecurity norms and develop innovative, practical tools and incentives to uphold them. IBBIS has a broadly defined mission, but initially it will focus on preventing the misuse of DNA synthesis technology—with the understanding that it will expand its remit over time.”

“IBBIS will collaborate with stakeholders across the global bioscience and biotechnology enterprise including academia, industry, the public health community, governments and philanthropy. These activities will complement the important work of the World Health Organization, the United Nations Office of Disarmament Affairs, and other national, regional, and international organizations. NTI’s work to establish IBBIS is rooted in the vision of a world in which bioscience and biotechnology flourish, with safeguards against deliberate or accidental misuse with potentially catastrophic consequences.”

David Matthews discusses IBBIS in-depth, including the fraught geopolitical situation it faces, in this piece for Science Business.

The Lancet Series on One Health and Global Health Security

Check out this recent series from the Lancet: “Following the 2014-2016 Ebola outbreak in West Africa, and the on-going global COVID-19 pandemic, the One Health approach (bridging the Animal-Environmental-Human Health interface)  has rapidly gained political and financial support, particularly in regional and transcontinental initiatives to improve Global Health Security, including through recently established institutions like Africa CDC and other multidisciplinary consortia. This four-paper Lancet Series explores the adoption of One Health approaches to improve health security and include an analysis of the current landscape of preventive, surveillance, and response measures in outbreak situations of emerging and re-emerging zoonotic infectious diseases with epidemic potential as well as other potential public health emergencies such as neglected endemic diseases, antimicrobial resistance, environmental and chemical hazards and natural disasters.”

“Combating Misinformation as a Core Function of Public Health”

Knudsen et al. discuss the New York City Department of Health and Mental Hygiene’s role in countering misinformation in this New England Journal of Medicine Catalyst piece: “The New York City Department of Health and Mental Hygiene determined that the spread of misinformation about Covid-19 was having a harmful health impact, particularly on communities of color with low vaccination rates. It established a dedicated Misinformation Response Unit to monitor messages containing dangerous misinformation presented on multiple media platforms, including social media, non-English media, and international sites, and proliferating in community forums. The Misinformation Response Unit and the Health Department collaborated with more than 100 community partners to tailor culturally appropriate, scientifically accurate messages to different populations. The Health Department and its partners were able to rapidly identify messages containing inaccurate information about Covid-19 vaccines, treatment, and other issues and to support the delivery of accurate information to various populations. Although the harms of misinformation and benefits of addressing the problem require additional evaluation, internal and external interviews suggested that the Misinformation Response Unit helped the Health Department counter misinformation and disseminate accurate scientific information to the community, thus improving health and vaccine equity during the Covid-19 pandemic.”

“Fault Lines: The Expert Panel on the Socioeconomic Impacts of Science and Health Misinformation”

This new report from the Council of Canadian Academies includes a number of important findings, including that COVID-19 misinformation cost at least 2,800 Canadian lives and CAD 300 million in hospital expenses over a period of just nine months. “Fault Lines details how science and health misinformation can proliferate and its impacts on individuals, communities, and society. It explores what makes us susceptible to misinformation and how we might use these insights to improve societal resilience to it. The report includes a model of the impacts of COVID‑19 misinformation on vaccination rates in Canada, producing quantitative estimates of its impacts on our health and the economy, and situating these within a broader context of societal and economic harms.”

“Battling Biological Threats: Complacency, Progress, or Both?”

“As 2023 opens, there is apprehension that partisan divisions and politicized health security approaches may worsen as the United States moves into a divided government of ultra-thin margins. But over the course of 2022, several important new national security directives and policies and bipartisan legislative actions significantly advanced thinking on health security and what is required to better protect Americans—proving that progress remains in reach, despite tough odds. Global health security, including biodefense, has been elevated to new prominence in U.S. national security thinking. The Biodefense Posture Review, expected to be released in early 2023, is mandated to unify and modernize DOD’s broad, comprehensive biodefense capabilities, and synchronize these efforts with those of other federal departments in line with the recently released National Defense and Biodefense Strategies. The United States must be resolute and clear, leaning forward not backwards, investing in new capabilities sustained over many years to protect Americans and the larger world against future dangerous pathogens. In a new commentary, Thomas R. Cullison and J. Stephen Morrison argue that it remains possible to bridge divides and make measurable progress to prepare the United States for inevitable future biological threats.” Read this CSIS report here.

“The Pentagon’s Chemical and Biological Defense Program Moves Towards Modernization, Yet Congress Slashes Funding”

Dan Regan discusses DoD’s seemingly mismatched objectives and funding decisions in this piece for the Council on Strategic Risks. He writes, “To achieve its mission set, including investing in emerging biotechnologies and bolstering industrial capacity to scale MCMs to novel threats, developing and investing in stand-off pathogen early warning detection, and advancing protective equipment for the Joint Force, the CBDP budget requires a nearly two-fold increase from the President’s request of $1.32 billion in FY23 to $3 billion for FY24. However, Congress unfortunately just dealt a 7% cut to chemical and biodefense programs with the FY23 omnibus spending bill, following years of declining funds for CBDP. As the FY24 Presidential Budget Request is being drafted, the Biden Administration and Congress should consider significant increases to CBDP’s budget, along with the other biodefense and global health security priorities outlined in the 10 + 10 over 10 strategy, to combat biological threats.”

“Virology Under the Microscope–a Call for Rational Discourse”

In this commentary in mBio, more than 130 authors call for a return to rational discourse about virology and its role in modern issues like pandemic response and debates over GoF research. “Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns – conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we – a broad group of working virologists – seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.”

“CRISPR Technology: A Decade of Genome Editing is Only the Beginning”

Wang and Doudna discuss the first decade of CRISPR in Science: “In the decade since the publication of CRISPR-Cas9 as a genome-editing technology, the CRISPR toolbox and its applications have profoundly changed basic and applied biological research. Wang and Doudna now review the origins and utility of CRISPR-based genome editing, the successes and current limitations of the technology, and where innovation and engineering are needed. The authors describe important advances in the development of CRISPR genome-editing technology and make predictions about where the field is headed. They also highlight specific examples in medicine and agriculture that show how CRISPR is already affecting society, with exciting opportunities for the future. —DJ”

“Zombie Viruses from the Arctic”

Jean-Michel Claverie’s new piece in Think Global Health discusses the threat global warming poses to global health by threatening Earth’s permafrost, potentially releasing ancient microbes. Claverie explains the evolution of this threat and how it may evolve throughout the piece, writing in part “This science fiction scenario became more realistic in 2015 when an international research team succeeded in resurrecting several viruses isolated from permafrost dating back 30,000 years. Following additional experiments, it is now clear that a significant proportion of prehistorical viruses can remain infectious for even longer periods of time. This article reviews the reality of the risks that their release might represent for the future.”

Science, Secrecy, and the Smithsonian

New from Ed Regis, author of The Biology of Doom, is this book, Science, Secrecy, and the Smithsonian:

“This is the story of how the Smithsonian Institute became intertwined in a secret biological warfare project.”

“During the 1960s, the Smithsonian Institution undertook a large-scale biological survey of a group of uninhabited tropical islands in the Pacific. It was one of the largest and most sweeping biological survey programs of all time, a six-year-long enterprise during which Smithsonian personnel banded 1.8 million birds, captured live specimens and took blood samples, and catalogued the avian, mammalian, reptile, and plant life of 48 Pacific islands.”

“But there was a twist. The study had been initiated, funded, and was overseen by the U.S. Biological Laboratories at Fort Detrick, Maryland. The home of the American biological warfare program. In signing the contract to perform the survey, the Smithsonian became a literal subcontractor to a secret biological warfare project. And by participating in the survey, the Smithsonian scientists were paving the way for top-secret biological warfare tests in the Pacific.”

“Critics charged the Smithsonian with having entered into a Faustian bargain that made the institution complicit in the sordid business of biological warfare, a form of combat which, if it were ever put into practice and used against human populations, could cause mass disease, suffering, and death. The Smithsonian had no proper role in any such activities, said the critics, and should never have undertaken the survey.”

Science, Secrecy, and the Smithsonian: The Strange History of the Pacific Ocean Biological Survey Program explores the workings of the survey program, places it in its historical context, describes the military tests that followed, and evaluates the critical objections to the Smithsonian’s participation in the project.”

Jonathan Tucker CBW Symposium

“The James Martin Center for Nonproliferation Studies cordially invites you to the 11th annual Jonathan Tucker Symposium on chemical and biological weapons issues on February 9th and 10th, 2023.” BW topics include “Revisiting the Siege of Caffa & Catapulting Cadavers” and “Governance of Dual-Use Biological Research,” the latter of which will be moderated by Dr. Gregory Koblentz. CW topics include “Lessons learned from the U.S. Chemical Weapons Destruction Program” and “The 2023 CWC Review Conference”. Learn more and register for the virtual events here.

Novel Applications of Science and Technology to Address Emerging Chemical and Biological Threats

For the first time since 2019, this Gordon Research Conference is back, this time in sunny Ventura, CA. “The Chemical and Biological Defense GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.” The conference will be held March 19-24, 2023. Learn more and apply here by February 19.

High School and College Student Internship: Data Analytics for Elite Young Scholars – Biology and Medical Science Experience

“This Young Scholars Research Program is designed for Elite High School Students and Undergrad Students, who are interested in pursuing their study and/or career in the fields of biology or medical science with emphasis on advanced data analytics. You will work with our esteemed George Mason University faculty members on a specific team project. The team will consist of about three to four members of both high school and undergraduate students. The project will be assigned to the students at the beginning of the program based on the preference indicated by the students prior to the program. Two outputs will be expected from each team at the end of the programs: i) a final paper which will be published on the Center for Biomedical Science and Policy website as well as a special issue of World Medical & Health Policy; and ii) Team presentation at a symposium at which students compete for prizes.”

“During this program, students will be participating in a research project applying some of the following methods, including but not limited to biostatistics using R or Stata, data visualization using QGIS or ArcGIS, and network visualization using Gephi.”

“During this program, students will be participating in a research project applying some of the following methods, including but not limited to biostatistics using R or Stata, data visualization using QGIS or ArcGIS, and network visualization using Gephi.”

Special Call for Papers-Journal of Science Policy & Governance

The Journal of Science Policy & Governance recently announced a special call for papers “and competition to provide policymakers with a new perspective on how scientific expertise could be useful to the complex brew of 21st foreign policy and national security challenges, resulting in a special issue on Policy and Governance on Science, Technology and Global Security.” The journal invites “students, post-doctoral researchers, policy fellows, early career researchers and young professionals from around the world to submit op-eds, policy position papers and other articles addressing foreign policy and national security challenges. These include concerns about the use of nuclear or radiological weapons driven by the war in the Ukraine, hypersonic weapons, immigration driven by climate change, and emerging threats in cybersecurity and biosecurity.” The deadline for submission is April 30.

Additionally, there will be a science policy writing workshop on January 30 in addition to two webinars on February 20 and March 30 (one on Policy and Governance on Science and Technology and one on Foreign Policy and National Security, respectively) to help prospective authors prepare their submissions. Learn more about these events and register here.

Weekly Trivia Question

You read the Pandora Report every week and now it’s time for you to show off what you know! The first person to send the correct answer to biodefense@gmu.edu will get a shout out in the following issue (first name last initial). For this week, our question is “On April 22, 1915, the German Army infamously unleashed more than 160 tons of chlorine gas on French trenches near which Belgian city?”

Shout out to Morgan M. for winning last week’s trivia! The correct answer to “In 1985, an American extremist group’s compound was raided by more than 300 law enforcement officers from several federal, state, and local agencies following a three-day standoff. Among other items, officers seized about thirty gallons of potassium cyanide the group intended to use to poison water supplies of several cities. What was the name of this group?” is the Covenant, the Sword and the Arm of the Lord.

Pandora Report: 1.6.2023

Happy New Year! This first edition of the year covers a number of updates from happenings over the course of our break, including the announcement of an exciting new book on genome editing from a Biodefense Program alumna. We also discuss the XBB.1.5 sub-variant, Dr. Fauci’s retirement from government, and more this week.

XBB.1.5 is the Most Transmissible COVID-19 Strain Yet According to WHO

XBB.1.5, yet another Omicron subvariant, rapidly went from accounting for just 4% of new US COVID-19 cases to more than 44% in a matter of weeks. Dr. Maria Van Kerkhove, the WHO’s COVID-19 Technical Lead, said this week “We are concerned about its growth advantage, in particular in some countries in Europe and the Northeast part of the United States, where XBB.1.5 has rapidly replaced other circulating sub-variants.” Thus far, the strain has been detected in at least 29 countries, though the WHO cautions it could be circulating in many more. Importantly, as Politico notes, “Van Kerkhove said the increase in hospitalizations in the Northeast cannot be attributed yet to XBB.1.5 because other respiratory illnesses, including flu, could be partially responsible.”

The WHO does not have data on the severity of the sub-variant yet, though it is currently conducting a risk assessment and monitoring any possible changes in severity via lab studies and real world data. Dr. Ashish Jha, White House COVID-19 Response Coordinator, recently Tweeted that immunity against this subvariant is “probably not great” if someone’s prior infection was before July 2022 or if they have not received a bivalent COVID-19 booster. However, he indicated Paxlovid and Molnupiravir as well as current COVID-19 tests should still work sufficiently against this sub-variant.

FY 2023 Omnibus Brings Changes in Global Health Funding, Gain of Function Research

Weeks before the current hullabaloo of the 118th Congress began, President Biden signed the late 2022 Omnibus appropriations bill on December 29, 2022, bringing about $1.7 trillion in funding for different programs that deal with health broadly. According to the Kaiser Family Foundation, the bill “…ncludes funding for U.S. global health programs at the State Department, U.S. Agency for International Development (USAID), Centers for Disease Control and Prevention (CDC), and National Institutes of Health (NIH). Funding provided to the State Department and USAID through the Global Health Programs (GHP) account, which represents the bulk of global health assistance, totals $10.6 billion, an increase of $731 million above the FY 2022 enacted level and $15 million below the FY 2023 request. The bill provides higher levels of funding for almost all program areas compared to the FY 2022 enacted level, with the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) and global health security receiving the largest increases; funding for bilateral HIV and family planning and reproductive health (FPRH) remained flat. Funding for global health provided to the CDC totals $693 million, an increase of $46 million compared to the FY22 enacted level, but $55 million below the FY23 request. Funding for the Fogarty International Center (FIC) at the NIH totaled $95 million, $8 million above the FY22 enacted level and essentially flat compared to the FY23 request.”

The new legislation also takes aim at gain-of-function (GoF) research, after GOP lawmakers pushed the administration to halt federally-funded GoF research, citing beliefs that such research is responsible for the COVID-19 pandemic. On page 3,354 of the more than 4,100 page bill, it reads, “(1) IN GENERAL.—Beginning not later than 60 days after the date of the enactment of this Act, the Secretary of Health and Human Services shall not fund research conducted by a foreign entity at a facility located in a country of concern, in the estimation of the Director of National Intelligence or the head of another relevant Federal department or agency, as appropriate, in consultation with the Secretary of Health and Human Services, involving pathogens of pandemic potential or biological agents or toxins listed pursuant to section 351A(a)(1) of the Public Health Service Act (42 U.S.C. 262a(a)(1)).”

The Act also includes provision for tempering undue foreign influence in biomedical research, such as foreign talent recruitment programs, and addressing national security risks related to biomedical research generally. Importantly, too, it provides greater funding for countermeasure development, including $1.5 billion for the recently formed Advanced Research Projects Agency for Health, and $3.3 billion for MCM research and improving elements like the Strategic National Stockpile.

For a concise run-down, check out the KFF’s budget tracker to see details on historical annual appropriations for global health programming.

On the Topic of Risky Research…

With all the political mudslinging regarding GoF and biomedical research in general, it is important to have access to quality information about the facilities around the world conducting this kind of research. The Bulletin of the Atomic Scientists recently highlighted the work of Drs. Greg Koblentz and Filippa Lentzos on this front–Global Biolabs. The Bulletin explains, “George Mason University biosecurity expert Gregory Koblentz, who co-leads the project with Filippa Lentzos, a King’s College London researcher, said shining a light on the proliferation of the labs can help cut through misinformation about them and allow for a clear-eyed look at how these beneficial, yet also potentially risky facilities are managed. “One of the goals of our project is to increase transparency and educate the public and policy-makers about these labs’ activities and what governance measures are necessary to ensure they are operating safely, securely, and responsibly,” Koblentz said. “Accurate information is a prerequisite for an informed debate on the benefits and risks posed by these labs.”

Throughout the rest of the piece, Dr. Koblentz addresses common questions and assumptions about high risk work and the kinds of facilities it takes place in, covering everything from national-level biosafety and dual-use research policies to the time and effort it takes to actually build these facilities, and the challenges in gauging on-the-ground implementation of good policy.

Dr. Anthony Fauci Retires From Federal Service

After a marathon 38-years as the Director of the National Institute of Allergy and Infectious Diseases, Dr. Anthony S. Fauci retired from government on December 31, 2022. During his tenure, he advised seven presidents on HIV/AIDS and other domestic and global health issues, even serving as one of the main architects of the President’s Emergency Plan for AIDS Relief (PEPFAR), a program estimated to have saved more than 20 million lives. Having served the American public for more than 50-years, Dr. Fauci has earned distinctions such as a Federal Citation for Exemplary Leadership from the National Academy of Medicine in 2020, the National Medal of Science from President George W. Bush in 2005, and, in 2008, the Presidential Medal of Freedom-the highest civilian award in the United States, bestowed by the President of the United States to recognize those who have made “an especially meritorious contribution to the security or national interests of the United States, world peace, cultural, or other significant public or private endeavors.” In a famous 1988 clip from that year’s presidential debate, then Vice President George H.W. Bush identified a then relatively unknown Dr. Fauci as his idea of an American hero, commending his work to fight HIV/AIDS.

Dr. Fauci’s career ended in a rocky last couple years as the COVID-19 pandemic gripped the world and, amid the United States’ lackluster response, public health and its leadership became increasingly politicized. The GOP has increasingly targeted Dr. Fauci, even going so far as to promise to investigate his role in the COVID-19 response upon taking control of the House of Representatives. Dr. Fauci has indicated he is fully willing to testify and cooperate with such an investigation, saying he has nothing to hide.

Despite the incessant calls to “fire” or “imprison Fauci,” the esteemed former NIAID director has indicated he does not plan to completely stop his work now that he is no longer a government employee. He told the New York Times that he “…hopes to do some public speaking, become affiliated with a university and treat patients if it has a medical center. He intends to write a memoir, he said, and he wants to encourage people to pursue careers in science, medicine and public service.”

When asked, “Are there other threats that you think about beyond infectious disease threats?,” Dr. Fauci responded: “What really, really concerns me is the politicization of public health principles. How you can have red states undervaccinated and blue states well vaccinated and having deaths much more prevalent among people in red states because they’re undervaccinated — that’s tragic for the population,” showcasing his unfailing concern and dedication to the mission to the very end.

IAVI’s Ebola Sudan Vaccine Arrives in Uganda

IAVI, the International AIDS Vaccine Initiative, announced in late December that the first shipment of its Sudan virus (SUDV) vaccine arrived in Entebbe, Uganda, on December 17. IAVI’s press release explains the goal of shipping its candidate, writing “The IAVI vaccine candidate is one of three intended to be evaluated in a “ring vaccination” clinical trial being planned to assess vaccine effectiveness in preventing Ebola Sudan disease, should the outbreak in Uganda continue or recur. In November, a WHO-convened expert independent group ranked IAVI’s investigational SUDV vaccine candidate as the number one priority investigational vaccine for inclusion in the trial. As public health measures implemented in Uganda have fortunately been successful in limiting new cases of Ebola Sudan virus disease, it may not be possible to conduct a formal ring vaccination study. Even if the ring vaccination trial cannot be conducted as currently designed, IAVI will continue to move our program forward as expeditiously as possible. Alternative clinical studies are being considered that would contribute to the evidence base needed to bring promising vaccine candidates to regulatory approval and support their use to control future outbreaks. These studies will be co-sponsored by the Ministry of Health in Uganda and WHO, with support from other partners.”

“Genome Editing and Biological Weapons: Assessing the Risk of Misuse”

In her new book, GMU Biodefense PhD alumna Dr. Katherine Paris introduces state-of-the-art genome editing technologies, and she assesses the risk that nefarious actors could intentionally misuse these technologies to develop more dangerous biological weapons. Dr. Paris uncovers how concerns over the possible misuse of genetic engineering began in the mid-1970s, and she traces how these warnings unfolded over time. These cautions came to a head in the 2016 Worldwide Threat Assessment of the United States Intelligence Community, which warned about the deliberate or unintentional misuse of genome editing to create harmful biological agents or products. In the foreword of Genome Editing and Biological Weapons: Assessing the Risk of Misuse, Dr. Gregory Koblentz, Biodefense Graduate Program Director, emphasizes the need for a “thorough, informed, and accessible analysis” of genome editing technologies, which Dr. Paris delivers in her book.

Dr. Paris systematically assesses both the risk of misuse and the potential governability of genome editing technologies. Policymakers have the ultimate challenge of protecting and safeguarding the continued development and use of genome editing for legitimate purposes, while putting in place biodefense and biosecurity strategies to prevent misuse. Dr. Paris provides a tailored set of recommendations that are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book is a must-read for policymakers as well as researchers, defense and security personnel, and intelligence analysts.

Dr. Paris is a Senior Program Analyst with over a decade’s worth of government contracting experience, and she is a certified Project Management Professional. Prior to her studies in Biodefense at GMU, she earned her MS in Biotechnology at Johns Hopkins University and BS in Biology from the University of Virginia. Dr. Paris continues her involvement at GMU as a mentor for students in the Schar School Alumni Mentoring Program.

“The Treaties That Make the World Safer Are Struggling”

Jen Kirby, a Senior Foreign and National Security Reporter at Vox, recently authored this piece discussing current issues in international disarmament and nonproliferation, focusing in large part on the Biological Weapons Convention. Kirby summarizes last year’s BWC RevCon, writing “But after three weeks of discussions that ended about a week before Christmas, the BWC RevCon ended up a modest success. The parties basically agreed to agree to keep talking, establishing a working group, which would meet for a little more than two weeks each year and deal with a long, long list of issues related to the BWC, including evaluating developments in science and technology and potential verification and compliance measures. And the unit that implements the convention would get another staff member. A team of three people tasked with helping to keep the world free of bioweapons became four.”

She then writes, “Modest,” then, is doing a lot of work. But in this geopolitical climate, you take what you can get.”

The piece continues, covering US political wrangling at past RevCons and comparable issues with the Nuclear Nonproliferation Treaty and the New Strategic Arms Reduction Treaty. She explains that this is part of a broader issue, writing “The Ukraine war and its fallout may be among the biggest current threats to global stability. But Russia is not alone. China is expanding its nuclear arsenal and has rebuffed attempts to engage bilaterally on arms control with the US even as the competition between Washington and Beijing escalates. North Korea is likely closing in on more nuclear tests. Tensions simmer between nuclear powers India and Pakistan. The United States tore up the Iran deal during the Trump administration, one of a few arms control treaties Washington exited in recent years, including the Intermediate-Range Nuclear Forces Agreement (INF) and the Open Skies Treaty, which allowed for unarmed reconassaince flights. The latter two exits chipped away at the arms control regime with Russia, even as the US had very valid claims of Russian noncompliance.”

“The 20-Year Boondoggle”

In this piece for The Verge, Amanda Chicago Lewis writes, “The Department of Homeland Security was supposed to rally nearly two dozen agencies together in a modernized, streamlined approach to protecting the country. So what the hell happened?” In it, she discusses the early and enduring challenges of forming DHS and ensuring it meets is goals, focusing in part on the BioWatch program in addition to ongoing issues with Congressional approval and agency morale in the catch-all department.

She writes, “The dysfunction might have been funny, in a Dilbert-meets-Veep way, if the stakes weren’t so high. Albright was overseeing a project called BioWatch, a system intended to detect traces of biological and chemical weapons of mass destruction. Bush described BioWatch in his 2003 State of the Union as “the nation’s first early warning network of sensors,” which would initiate processes to mobilize hospitals, alert the public, and deploy supplies from the national stockpile.”

She continues, “There was only one problem: BioWatch never functioned as intended. The devices were unreliable, causing numerous false positives. “It was really only capable of detecting large-scale attacks,” Albright explained, because of “how big a plume would have to be” for the sensors to pick it up. And the system was prohibitively slow: every 24 hours, someone had to retrieve a filter and then send it to a laboratory for testing, which might then take another 24 hours to discover a pathogen.”

“The time required after BioWatch might pick up evidence of a toxin and the time required to get it to somebody who might be able to reach a conclusion there might be a terrorist attack — my God, by that time, a lot of people would have gotten sick or died,” former Senator Joe Lieberman told me.”

“Hacked Russian Files Reveal Propaganda Agreement with China”

In this piece for The Intercept, Mara Hvistendahl and Alexey Kovalev cover Russia’s attempts to coordinate with China to spread disinformation about the United States’ Cooperative Threat Reduction program and its facilities in Ukraine. In their piece, they explain that, “A bilateral agreement signed July 2021 makes clear that cooperating on news coverage and narratives is a big goal for both governments. At a virtual summit that month, leading Russian and Chinese government and media figures discussed dozens of news products and cooperative ventures, including exchanging news content, trading digital media strategies, and co-producing television shows. The effort was led by Russia’s Ministry of Digital Development, Communication and Mass Media, and by China’s National Radio and Television Administration.”

“In the propaganda agreement, the two sides pledged to “further cooperate in the field of information exchange, promoting objective, comprehensive and accurate coverage of the most important world events.” They also laid out plans to cooperate on online and social media, a space that both countries have used to seed disinformation, pledging to strengthen “mutually beneficial cooperation in such issues as integration, the application of new technologies, and industry regulation.” 

Read this piece here.

Managing Hazardous and Biohazardous Materials/Waste in the Laboratory Setting

The Chesapeake Area Biological Safety Association recently announced this technical seminar offering from Triumvirate Environmental, which will take place at 6 pm on January 10, 2023 both virtually and in-person in Gaithersburg, MD. “Laboratories can generate biohazardous and hazardous waste. Confusion is not uncommon on what the differences are when it comes to disposal and handling.  This webinar will review the differences and discuss proper handling and disposal of each type of waste.  Potential recycling options will also be discussed.” Learn more and register here.

Closing the Knowledge Gaps

“BIO-ISAC, in partnership with the Department of Homeland Security and Johns Hopkins Applied Physics Laboratory, will host a one-day event (with remote participation available) on January 24, 2023.”

“This gathering of thought leaders across the industry and its partners will address knowledge gaps about the bioeconomy itself. The event is expected to deliver recommendations that demonstrate the scope and breadth of industry impacts, identify specific safety needs and goals, and carve the path forward for a secure future.” Learn more and register here.

Novel Applications of Science and Technology to Address Emerging Chemical and Biological Threats

For the first time since 2019, this Gordon Research Conference is back, this time in sunny Ventura, CA. “The Chemical and Biological Defense GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.” The conference will be held March 19-24, 2023. Learn more and apply here by February 19.

Weekly Trivia Question

You read the Pandora Report every week and now it’s time for you to show off what you know! The first person to send the correct answer to biodefense@gmu.edu will get a shout out in the following issue (first name last initial). For this week, our question is “Before perpetrating the infamous Tokyo subway sarin attack in 1995, this Japanese cult attempted to disseminate botulinum neurotoxin and Bacillus anthracis, among other agents. What was the name of this cult prior to its split/name change in 2007?”

Shout out to Scott H. (a loyal reader and proud parent of a talented Biodefense MS student!) for winning last week’s trivia! The correct answer to “In 2016, there was an outbreak of what disease in reindeers in the Yamalo-Nenets region of Russia?” is anthrax.

Pandora Report 5.13.2016

Nothing like a little biodefense news to get your Friday the 13th started off on an auspicious note! If you happened to be in Grand Central terminal in New York City on Monday, you may have witnessed a bioweapon simulation drill. A harmless, odorless gas was released on a subway platform to test air movement and the potential contamination range for a biological weapon within the subway system. The perfluorocarbon tracer gases allowed officials to observe particle dispersal and settlement. Last but not least, hundreds of passengers on a UK-to-US cruise are victims of a suspected norovirus outbreak. Health officials are working with the cruise line to determine the source of the outbreak and reduce transmission.

Evaluation and Oversight Recommendations for Gain-of-Function Research
The National Science Advisory Board for Biosecurity (NSABB) Working Group has released a draft of their evaluations and subsequent recommendations regarding the risks and benefits associated with gain-of-function (GOF) research. The report highlights the existing Federal policies in place to ensure the safety of current work with biological organisms and the recent biosafety failures at several Federal facilities. The NSAAB working group established seven major findings and seven recommendations. Findings include focus on the specific types of GOF research as only a small subset of GOF research (GOF research of concern – GOFROC) which may entail risks that are significant enough to warrant oversight, need for an adaptive policy approach, limited scope and applicability of oversight policies, etc. Recommendations include an external advisory body that is built upon transparency and public engagement, adaptive policy approaches to ensure oversight remains “commensurate with the risks associated with the GOF research of concerns”, etc. The recommendations also emphasized the need for strengthening of U.S. laboratory biosafety and biosecurity. The report provides a substantial overview of the GOF debate and existing concerns related to GOF studies with influenza, SARS, and MERS.

GMU Biodefense MS Application Deadline – June 1st!
Learn about the complex world of global health security from your living room or at one of our amazing campuses! GMU’s Biodefense MS program provides you with the knowledge and skills to understand and operate within the unique field of biodefense – where science and policy meet. Fall application deadlines have been extended to June 1st, which means you still have time to apply! Our MS program is offered in person or online, which allows students to balance work or family responsibilities while still earning a graduate degree in this exciting field.

Military & CDC Lab Biosafety Failures 
A few weeks ago, we wrote on the GAO office report on the laboratory failures and biosafety issues in relation to the investigations surrounding the 2014 National Institute of Health (NIH) smallpox discovery. The GAO report also points to laboratory safety/security failures that include shipping live anthrax and the poor dissemination of information to NIH staff after the smallpox discovery. This article, like many, emphasizes the lackluster Department of Defense (DoD) efforts regarding safety and security within their labs that handle select agents. Despite reports highlighting the poor education and training of laboratory personnel, infrequent lab inspection, and gaps in reporting, some are pointing to the eventual regression back to poor habits. Despite the GAO report, ‘the program is going to continue as before, with a new layer of managerial review that will not change matters, and with no accountability,’ says Richard Ebright, a molecular biologist and professor of chemistry and chemical biology at Rutgers University who has been critical of the operations of high-containment labs. ‘The report makes it clear that DOD considers the matter concluded, and any impetus for change is going to have to come from outside DOD,’ Ebright says.” A recent report also noted that the CDC is among several other facilities to have their permits suspended in recent years for serious lab safety and security violations.  “The CDC’s own labs also have been referred for additional secret federal enforcement actions six times because of serious or repeated violations in how they’ve handled certain viruses, bacteria and toxins that are heavily regulated because of their potential use as bioweapons, the CDC admitted for the first time on Tuesday.” The CDC has stated that the suspensions involved a specific lead scientist and those labs associated with his/her work, which focused on Japanese encephalitis virus.

Is Dole the Food Safety Canary in the Coal Mine?
Food safety has long been considered America’s soft underbelly. Food-borne illness outbreaks are relatively common but are some a canary in the coal mine for diminishing industry standards? Executives at Dole are now involved in a criminal investigation related to their knowledge of the Listeria outbreak at their Springfield, Ohio plant. Executives were aware of the Listeria issues for over a year prior to shutting down the production plant. The company is now under investigation, highlighting a growing concern related to food safety standards within the U.S. This particular outbreak involved 33 people in the U.S. and Canada, of which four died. Rep. Rosa DeLauro, D-CT, the senior Democrat on the U.S. House Committee that oversees FDA funding, wrote a letter to the FDA regarding the lag between company knowledge and action. DeLauro wrote: “Given that consumers have been severely sickened, and even killed, by salads produced at this facility, I urge you to immediately shut down the Dole Springfield plant. Their blatant disregard for the health and safety of American families shows that Dole executives put company profits first, at the expense of consumers, and this type of behavior should not be tolerated. The fact that Dole officials were aware of a food borne illness contamination in their facility, yet continued to ship out the product, is absolutely unconscionable. People have died, and rightfully the Department of Justice has opened an investigation into Dole’s Springfield plant. However, it is more than just foodborne pathogens that the FDA inspection reports point to. FDA reports dating back to March 2014 cite at least sixteen problems that could contribute to food safety issues in the facility. It is an outrage that people had to die in order for Dole to temporarily close this plant for four months during the January Listeria outbreak. … Dole must be held accountable”. Dole isn’t the only company heavily scrutinizing their processes. In light of recent outbreaks associated with their restaurants, Chipotle has hired two former food safety critics and consultants to help improve food safety. 

A Dash of Zika Goes a Long Way ZikaFunding
The 2016 Rio de Janeiro Olympics are fast approaching and the “wait and see” trepidation is starting to evolve into more heated debates about the safety of the games. With Brazil being the epicenter of this particular Zika virus outbreak, many are calling for action before the international games. “Simply put, Zika infection is more dangerous, and Brazil’s outbreak more extensive, than scientists reckoned a short time ago.  Which leads to a bitter truth: the 2016 Olympic and Paralympic Games must be postponed, moved, or both, as a precautionary concession.  There are five reasons.” These reasons include the heavy hit Rio took by Zika, the current Zika strain is considered much more dangerous, the games will surely speed up the transmission of the virus on an international level and when this does happen, the role of technological response will become more challenging. Lastly, “proceeding with the Games violates what the Olympics stand for.  The International Olympic Committee writes that ‘Olympism seeks to create … social responsibility and respect for universal fundamental ethical principles’.  But how socially responsible or ethical is it to spread disease? ” The CDC updated diagnostic testing guidelines this week, noting that higher levels of the virus can be found in the urine rather than blood. The White House is calling for emergency funding to help combat the spread of the disease and speed the development of a vaccine. What impact will Zika have in the future? The unique aspect of a virus that impacts developing brains earns it a special place in the history books and as this outbreak unfolds, the long-term impacts of infectious diseases will become all the more evident. As of May 11th, the CDC has reported 503 travel-associated cases in the the U.S. 

Stories You May Have Missed:

  • Challenges of Emerging Infections and Global Health Safety – you can now access the Indo-U.S. workshop summary regarding the collaborations between people, businesses, and governments. “The Indo-U.S. Workshop on Challenges of Emerging Infections and Global Health Safety, held in November 2014, encouraged scientists from both countries to examine global issues related to emerging and existing infections and global health safety, to share experience and approaches, and to identify opportunities for cooperation to improve practice and research in these areas. This report summarizes the presentations and discussions from the workshop.”
  • The Internet of Things and Infectious Diseases – “The Internet of Things (IoT) is all about devices that are programmed to sense, report on and react to certain behaviours or conditions, providing a new level of efficiency, evidence-based data and automation.” So how can we use this for infectious diseases? Validation of outcomes, analysis of behaviors, and collaboration may just help us use the Internet of Things in healthcare to reduce infection and even perform syndromic surveillance. Outcomes and objective behavior analysis may help us increase hand hygiene or reduce hospital-acquired infections.
  • Anthrax Outbreak in Kenya– 16 people were sickened and hospitalized in Kenya after consuming tainted cows. Joseph Mbai, Murang’a County health chief officer said, “The four cows that were slaughtered were sickly and the owner decided to sell the meat to neighbors and share with others”. Those hospitalized (ten children, five men, and a woman) have been treated and discharged.

Pandora Report 9.6.14

This week we cover dengue in Japan, dog flu in NYC, more forgotten lethal specimens in government labs, and of course, an Ebola update.

Canine Influenza Cases Spreading in Manhattan

Flu season is rapidly approaching, and evidently, it doesn’t only affect humans. Veterinarians in Manhattan have reported cases throughout the borough. The cases are likely due to dogs playing with other infected dogs at parks and dog runs. Vets warn owners to watch for coughing dogs and if they are present to take their dog to another area. The good news is, just like their human counterparts, dogs, too, can receive a flu vaccine.

The Gothamist—“According to the ASPCA, symptoms include coughing, sneezing, difficulty breathing, fever, lethargy and loss of appetite; most dogs will recover within a month, but secondary infections like pneumonia can be problematic.”

 

New Cases of Dengue Fever Should be a Wake-Up Call for Japan

As many as 70 people in Japan have been infected with Dengue fever—traditionally, a disease found in tropical climates—the country’s first outbreak since 1945. The diagnoses prompted authorities to fumigate an area of Yoyogi Park in Tokyo’s Shibuya Ward, which was the apparent source of the infections. Dengue fever is transmitted by mosquitos and produces an extremely high fever and pain in the joints. The disease is not transmitted person to person.

The Asahi Shimbun—“The most effective way to deal with a global dengue epidemic is to step up the efforts to exterminate mosquitoes in countries with a large number of patients, especially in urban areas.”

 

Forgotten Vials of Ricin, Plague, and Botulism found in U.S. Government Lab 

A strong feeling of deja vu hit this week when we learned about yet another case of forgotten vials of dangerous pathogens at U.S. labs. In this case, the containers were discovered during an investigation of NIH facilities after scientists found vials of smallpox earlier this summer. This search discovered a century (!!) old bottle of ricin, as well as samples of tularemia and meliodosis. The FDA also reported they found an improperly stored sample of staphylococcus enterotoxin.

The Independent—“The NIH does have laboratories that are cleared to use select agents, and those pathogens are regularly inventoried, the director of research services Dr. Alfred Johnson said. However, these samples were allowed to be stored without regulation.”

 

This Week in Ebola

We learned that new cases of Ebola in Democratic Republic of Congo are genetically unrelated to the West African strain and that researchers from the Broad Institute and Harvard are working to sequence and analyze virus genomes from the West African outbreak. Senegal is working hard to manage contacts with the Guinean student who tested positive for the virus in the capital, Dakar. Human trials of an Ebola vaccine continued in the U.S. and are planned to take place in Mali, the U.K., and Gambia. A third American infected with Ebola will return to the U.S. and will be treated at a Nebraska medical containment unit which was built for the SARS outbreak. I read an article that hypothesized that Ebola may be able to be transmitted sexually which could account for a high number of cases, while the Washington Post pointed to the fact that the West Africa outbreak is drawing attention from diseases which are more widespread and kill more people—it’s the Kardashian of diseases. Lastly, CDC Director Dr. Thomas Frieden said that this outbreak of Ebola is “threatening the stability” of affected and neighboring countries, and Dr. Daniel Lucey, of the Georgetown University Medical Center, predicts that the current outbreak “will go on for more than a year, and will continue to spread unless a vaccine or other drugs that prevent or treat the disease are developed.”

 

Image Credit: Wikimedia Commons