Cowpox Case in the Netherlands

A teenage girl in the Netherlands recently developed cowpox, the viral cousin of smallpox, after trying to save a drowning kitten. Within a week of her contact with the kitten, the girl had developed a large necrotic ulcer on her wrist. Cowpox being as rare as it is, by the time doctors correctly diagnosed her, the infection had begun to clear up on its own (it’s naturally self-limiting). Cowpox is famous for being used by Edward Jenner in the first effective vaccine, against the now eradicated smallpox virus. As the above image shows, there was significant resistance on the part of the local population to intentionally infecting themselves with the harmless cowpox virus. To prove the vaccine’s safety and efficacy,  in 1796 Jenner rather dubiously inoculated an eight year old boy with the cowpox virus before infecting him with smallpox. When the boy was shown to be immune to the deadly virus, the concept of vaccination was born.

As for the teenager in the Netherlands, while we’re sure having a giant black ulcer containing dead tissue open up on your wrist is pretty scary, at least she’s protected from smallpox!

Read the full story and look at the very big picture of her ulcer here.

(image courtesy of the Library of Congress)

Read Now: Nature Report on Bioterrorist Attack Scenario

We know we live in a globalized world, which we all know means in one 48-hour period, a person can get from California to Hong Kong to London and back. What we don’t know is what this means for bioterrorism. If a bioterrorist were to release pneumonic plague in Delhi, how long would it take it spread to New York City? How many people would it infect along the way? How many fatalities would have to occur before we noticed? Nature looks at these questions, in metapopulation modelling detail, in its recent Scientific Report, Human mobility and the worldwide impact of intentional localized highly pathogenic virus release. They selected smallpox (which we think is kind of an obvious choice, to each their own) and developed a couple models of spread, with the most likely being bioterrorist “suicide bombers” – terrorists who infect themselves with the pathogen and then intermix with populations in large, metropolitan cities. The results are frightening. 

Abstract: “The threat of bioterrorism and the possibility of accidental release have spawned a growth of interest in modeling the course of the release of a highly pathogenic agent. Studies focused on strategies to contain local outbreaks after their detection show that timely interventions with vaccination and contact tracing are able to halt transmission. However, such studies do not consider the effects of human mobility patterns. Using a large-scale structured metapopulation model to simulate the global spread of smallpox after an intentional release event, we show that index cases and potential outbreaks can occur in different continents even before the detection of the pathogen release. These results have two major implications: i) intentional release of a highly pathogenic agent within a country will have global effects; ii) the release event may trigger outbreaks in countries lacking the health infrastructure necessary for effective containment. The presented study provides data with potential uses in defining contingency plans at the National and International level.”

Read the full report here