The Pandora Report

Highlights include H5N1: to mutate or not to mutate, the Galveston Lab we’ve all shaken our heads at this week (we all lose a vial of virus sometimes), the UK stepping-up its bioterror prevention, the new foot-and-mouth vaccine (cloven-hoofed animals matter too – a lot, actually), antibiotic-resistant jumping from farm animals to us, and what may soon be a mumps outbreak in Richmond. Happy Friday!

short-tailed cane mouse aka Guanarito target #1
short-tailed cane mouse aka Guanarito target #1

H5N1 viral-engineering dangers will not go away

Technically we tweeted this story on Wednesday, but it presented such a nice summation against the gain-of-function research that we wanted to include it here. Not because we agree, but because the points are coherent and well-argued.

Nature – “Rather than use the avian flu moratorium to seek advice, listen and foster debate, many influenza scientists engaged in an academic exercise of self-justification. There was a single large open meeting, at the Royal Society in London, which engaged a wider audience, including bioethicists. The recent calling off of the moratorium by 40 flu researchers alone — not funders, governments or international bodies — says it all. The flu community simply hasn’t understood that this is a hot-button issue that will not go away.”

Texas Biolab Loses Deadly Virus

Before everyone freaks out, it’s only Guanarito virus – yes, losing a vial of any virus from a BSL-4 lab is not great, and yes, if you’re going to lose a vial of something, it would be better if it didn’t cause hemorrhagic fever, but 1) Guanarito virus’ natural host is thought to be  Venezuelan “short-tailed cane” mice, 2) it doesn’t replicate in US rodents, and 3) it’s not transmissible person-to-person.  And before we start a heated discussion about the disturbingly impressive ability of viruses to evolve and adapt to new hosts, 4) the vial in question is thought to have been destroyed internally.

ABC News – “The Galveston National Laboratory lost one of five vials containing a deadly Venezuelan virus, according to the University of Texas Medical Branch, which owns the $174 million facility designed with the strictest security measures to hold the deadliest viruses in the country. Like Ebola, the missing Guanarito virus causes hemorrhagic fever, an illness named for “bleeding under the skin, in internal organs or from body orifices like the mouth, eyes, or ears,” according to the Centers for Disease Control and Prevention.”

UK: Biological attacks ‘getting easier for terrorists’

Intelligence officials in the United Kingdom have prioritized the fight against bioterrorism, using lessons from the 2012 London Olympics to inform their revamped strategy.

The Telegraph – “Charles Farr, the Director of the Office for Security and Counter-Terrorism [in the United Kingdom], said that extremists have ever greater access to the information and technology required to create and spread germ agents or other biological weapons…Factors facilitating such attacks include the availability of formulae and other information on the internet; increasing teaching of biological sciences at universities, and ‘greater availability of technology,’ he said. Mr Farr, a former MI6 officer, declined to give further details of the threat, but the Home Office report hints at a range of new precautions.

Scientists develop new foot and mouth vaccine

Foot-and-mouth disease is like the be-all-end-all of animal diseases – it’s tremendously infectious, has a high mortality rate, and because we don’t vaccinate (for trade reasons – when you vaccinate an animal, when that animal is later tested for FMD it’s impossible to tell whether it has the antibodies because it was vaccinated or because it actually had the disease – if the latter, no one wants to eat it), the disease would spread like wildfire. Also, current policy dictates “containment” (read: mass culling) rather than “treatment”, which means mountains of burning carcasses. Very scary and very possible.

The Guardian – “Scientists have developed a new kind of vaccine that could prevent devastating outbreaks of foot and mouth disease among livestock. The “synthetic” vaccine was created by taking protein shells that encase the virus and strengthening them, so the vaccine can be used in warm countries without refrigeration. The technique overcomes major shortcomings of existing foot and mouth vaccines, which are made with live virus. The infectious risk means the conventional vaccine must be produced in high containment facilities, which are costly to build and maintain. Vaccines made from the live virus are also fragile, and degrade unless they are kept cool.”

Study Shows Bacteria Moves From Animals to Humans

Bessie the cow might just be another weapon in the arsenal of the superbug. This possibility is especially disturbing given our ongoing difficulties countering antibiotic-resistant bacteria we make ourselves.

The New York Times – “A new study used genetic sequencing to establish that a strain of antibiotic-resistant bacteria has been transmitted from farm animals to people, a connection that the food industry has long disputed. Representative Louise M. Slaughter, Democrat of New York, said the study by researchers in Britain and Denmark, which drew on data from two small farms in Denmark, ‘ends any debate’ about whether giving antibiotics to livestock is a risk to humans”

LOCAL: Mumps virus infiltrates Richmond, VA campus

Before this launches a debate about the importance of vaccination, all but just six students on the Richmond campus have had  the MMR vaccine. What this illustrates instead is that no vaccine is 100% efficacious in every instance (MMR is approximately 95%).

The Collegian – “As of Tuesday, 15 cases of mumps have been confirmed on campus, said Dr. Lynne Deane, the director of the Student Health Center. Mumps is a communicable viral illness and typically carries symptoms like fever, head and body aches, tiredness and swollen or tender glands in the jaw, according to the Virginia Department of Health (VDH) Web site.Tests administered to other students are still being processed, she said. In total, 39 students have been tested for the virus since January, Deane said…The cluster of mumps outbreaks has not been limited to Richmond. Loyola University, Maryland, has seen at least 12 cases of mumps arise in the past month, according to CBS news Baltimore.”

Biodefense Faculty Member Charles Blair on Syria

(originally published in the Bulletin of the Atomic Scientists)

The thin red line

By Charles P. Blair and Mila Johns| 26 March 2013

Article Highlights

  • An attack on the village of Khan al-Assal is the latest in a number of incidents during which the use of chemical weapons has been claimed by either, or both, sides of the Syrian civil war.
  • In reporting chemical attacks, citizen journalists have apparently conflated lethal and non-lethal chemical agents, creating the perception that the United States has failed to act, even though President Obama’s “red line” warning against chemical weapons use has been crossed.
  • US policy toward Syria may unintentionally have helped erode the international taboo against chemical weapons use; to buttress that taboo, the United States now must make clear what would and would not constitute crossing the chemical warfare red line, in Syria and elsewhere.

Both opposition forces and the Syrian government have alleged that chemical weapons were used in last Tuesday’s attack on the village of Khan al-Assal, bringing to the fore one of the most potentially far-reaching of the many dangers that have arisen during Syria’s civil war. Now entering its third year, the Syrian revolt — by far the longest uprising of the Arab Spring — is the first in history that threatens to violently topple a government armed with weapons of mass destruction (WMD). This unique case naturally precipitates profound concerns that elements of Syria’s large stockpiles of chemical agents and munitions will find themselves in the hands of insurgents or terrorist groups. To date, however, the West has largely ignored the threat of non-state acquisition of such arms, instead focusing its concern around the use of chemical weapons by the regime of Bashar al-Assad.

With more than 70,000 dead and over one million Syrians displaced by civil war, international pressure mounts for more substantive intervention by Western powers. Even absent confirmed use of WMD, France and the United Kingdom are moving toward greater support of the disparate forces fighting the Assad regime.

In contrast, the United States has refrained from direct military support of the opposition. At the same time, President Obama has clearly, directly declared the use of chemical weapons in Syria as the red line that would call for substantive action from the United States. While avoiding any carte blanche backing of opposition forces that include significant numbers of jihadists and other terrorists, the US policy places significant emphasis on reinforcing the international moral norm against the use of weaponry that is considered “beyond the pale.” But recent allegations highlight the potential unintended consequences of this strategy: Khan al-Assal is the latest in a growing series of incidents in the country during which the use of chemical weapons has been claimed by either, or both, sides of the conflict.

Undoubtedly anticipating that violation of this boundary will spur American intervention, the Syrian rebels have significant motivation to charge the Assad regime with the use of chemical weapons. Conversely, the Syrian government has a vested interest in casting the rebels as a fringe element willing to use any means necessary to overthrow the regime, including violating the opprobrium against chemical weapons use. The extreme stakes created by the American red line make it is incumbent upon the United States to articulate precisely what is meant by the term chemical weapon — which, under international law, includes non-lethal agents as well as more well-known and lethal agents such as sarin and VX.

Given the general absence of foreign media from the conflict, reports of chemical attacks increasingly are based on citizen journalism. As Western news standards evolve with the growth of social media, the nuances that differentiate classes of chemical weapons appear to be dissolving. The public conflation of lethal and non-lethal chemical agents increasingly creates the perception that the United States has failed to act, despite evidence that President Obama’s red line has been crossed. In short, US policy may unintentionally have created a situation in which the public is desensitized to chemical weapons use, eroding the international taboo against them. To buttress and even strengthen that taboo, the United States now must make crystal clear to the international community what would and would not constitute crossing the chemical warfare red line, in Syria and elsewhere.

Many chemical weapons, no proven use. Most experts assume that the Assad regime possesses a vast and sophisticated chemical arsenal. Chemical agents most frequently cited as components of the Syrian arsenal include mustard gas, a blistering agent with properties that historically have generated large numbers of casualties, the vast majority requiring long-term medical care. A persistent chemical, mustard agent also creates long-term battlefield contamination. Vastly more toxic and lethal than mustard agent, sarin nerve agent is reportedly easily readied for use by the Syrian military for delivery via aircraft, artillery, and the country’s 100 to 200 Scud missiles. Syria likely also possesses VX nerve agents; several hundred times more lethal than sarin, VX is the most deadly of all chemical agents. Apart from these three agents, some experts expand their assessment of Syrian’s probable chemical arsenal to include choking agents such as chlorine gas and phosgene, which, according to a 1997 report by the US Surgeon General and US Army, was last used militarily in 1918. The latter agent, the effects of which appear only after a delay, was responsible for 80 percent of those killed by chemicals during World War I.

Last week’s incident in Khan al-Assal, the most dramatic to date, is the latest in a series of accusations of chemical weapons use by the Syrian opposition, with counterclaims by the Syrian regime. The attack is reported to have killed at least 31 people and injured more than 100; US and other Western officials place responsibility for the attack with the Syrian government. Still, among the dead were 16 pro-Assad soldiers, and Damascus blames opposition forces for the incident, claiming they used a rocket laden with chemicals. Government officials have requested a UN investigation into chemical weapons use in Tuesday’s incident “by the terrorists groups operating in Syria.” The same day, opposition forces reportedly claimed that Syrian “chemical rockets” had also struck the village of Ataibah near Damascus.

Before recent events, two purported chemical attacks in Homs in December 2012 generated unprecedented allegations of chemical weapons use, with some observers concluding that the American red line had been crossed. In the first instance, on December 6, victims were allegedly targeted with white phosphorus munitions fired by Syrian military helicopters. Two weeks later, on December 23, another incident occurred in Homs, killing at least seven and reportedly wounding more than 70; opposition forces assert that the attack used poisonous gases. Despite some journalistic assertions that nerve agents were responsible, a US State Department investigation concluded that no chemical weapons were used. Demonstrating the need to differentiate lethal and non-lethal chemical agents, US officials reportedly believe that casualties from the December 23 Homs incident are linked to Syrian military “misuse [of] a riot-control gas.”

No internationally sanctioned investigation has yet confirmed the use of chemical agents in any of these incidents. Unverified accounts and video footage of casualties purportedly caused by chemical weapons offer virtually no evidence that lethal chemical agents, including those agents likely constituting the Syrian arsenal, were used. Mustard agent, for example, dramatically affects the victim’s skin, eyes, and internal tracks. None of the filmed victims of last week’s Khan al-Assal attack evidenced the effects of such a blistering agent. Moreover, given its low volatility and high level of persistence, its presence would require victims to be handled with extreme care to avoid secondary contamination. Actions by medical staff treating the victims of the Khan al-Assal attack are incongruous with concerns about secondary contamination, and there are no known reports of subsequent negative health effects on first responders or hospital personnel. Similarly, the effects of sarin or VX nerve agents — manifest, for example, by a victim’s twitching — are absent from video of the Khan al-Assal incident. Like mustard agent, VX also is extremely persistent. Even sarin, which evaporates at a rate similar to water, is persistent enough to cause secondary contamination during transport and treatment in ambulances and hospitals, as evidenced during the response to a 1995 terror attack on the Tokyo subway. Doctors and civilians filmed at the Aleppo hospital treating the victims of the Khan al-Assal incident spoke of the agent emanating from the rocket, post-detonation, as being a powder. But choking agents, including chlorine (the smell of which reportedly was present at the Khan al-Assal attack), are delivered in a gaseous state.

No evidence yet exists to support the accusation that the Assad regime had used traditional chemical warfare agents — that is, those substances posing danger to humans and marked by exceptional lethality.

Evidence does point toward Syrian use of chemical agents designed to be non-lethal — those that are not entirely banned under the international law. With regard to the Chemical Weapons Convention (CWC), certain agents for purposes of “[l]aw enforcement including domestic riot-control purposes” are permitted. Riot-control agents, commonly lumped together in the public consciousness as tear gas or mace, cause rapid, short-lived irritation of the eyes, skin, and respiratory system, producing symptoms such as shortness of breath, choking, rashes, and temporary blindness due to swelling of the eyes. Riot-control agents are not banned under the CWC and are used by governments throughout the world, including the United States.

Loopholes in the CWC allow for use of other non-lethal agents, including so-called incapacitants, for domestic law enforcement and, in other interpretations, counterterrorism activities. In contrast to riot-control agents, the effects of incapacitants can last for days after exposure. Moreover, their effects are psychological or mental, designed to leave the victim confused, disabled, or, in general, ineffective. (Although Syria is not generally thought to possess such agents, some have theorized that the Assad regime may use incapacitants to test the waters of international reaction.) Also not addressed by the CWC is white phosphorus, an incendiary chemical agent that has been traditionally utilized by militaries to provide ground cover for operations as well as to illuminate targets. Its use as an offensive weapon lies in a legal gray area vis-a-vis chemical weapons law; it can produce severe chemical burns, irritation of mucus membranes (particularly of the eyes), and even death. From Homs forward to last week’s attack in Khan al-Assal, the symptoms displayed by victims of alleged chemical weapons are not of a severity that would evince white phosphorus use, though the mere mention of white phosphorus by a doctor treating victims of the Khan-al-Assad incident adds to the growing scrutiny of that chemical. Also, US responses to reports of Syrian use of white phosphorus are complicated by past American and Israeli military operations in which white phosphorus was used.

Strengthening the taboo. A disturbing pattern is emerging in Syria. Each purported use of chemical weapons — instantly communicated by the opposition, citizen journalists, or the Syrian government — is left unresolved, as demonstrated most recently with the Khan al-Assal attack. If chemicals were used in any of incidents to date, they were agents — white phosphorus, riot-control agents, and incapacitants — that the CWC either conditionally allows, addresses in a manner that creates a legal gray zone, or ignores altogether. Atop these realities, the nature of the Syrian conflict has severely curtailed the ability of traditional authorities to verify or refute allegations of chemical weapons use, regardless of type, often leaving international audiences uncertain at best as to whether the United States’ red line has been crossed. This dynamic likely contributes to the number of instances in which the use of chemical weapons has been alleged. More important, repeated unresolved claims of chemical weapons use slowly normalizes the concept that chemical weapons can be used, eroding the taboo against chemical warfare and desensitizing the public to its horrors.

The undermining of this moral prohibition relates directly to the discourse surrounding “non-lethal” chemical agents such as riot-control agents, incapacitants, and white phosphorus. While the technical and legal classifications of these agents are, one assumes, crucial to international leaders, the distinctions are lost on the layperson. With the United States’ casus belli inextricably predicated on Syria’s use of chemical weapons, and the future of the chemical warfare taboo in the balance, it is incumbent on the Obama administration to clearly articulate what definitions are being used in determining whether its red line has been breached, and to make a compelling case for why the use of certain chemical agents is not grounds for another US military foray into the Middle East.

Image of the Week: Ebola

We give you – Ebola!

The Ebola virion (image credit: CDC)

The virus and its sister, Marburg, are both marked by their distinct, filament-like morphology (which lead to their family name, Filoviridae)

Despite its high pathogenicity, filovirus infections have killed less than 2000 people since the virus family’s emergence in the late 1960s. Rigorous containment strategies are a big part of the lower fatality numbers – once infected, supportive care is the only available treatment. The natural reservoirs of the virus (not us) remain unknown.

So if for some reason you find this staring up at you from under an (extremely powerful) microscope, hold your breath and run (joke, that was a joke).

To learn more about everyone’s favorite hemorrhagic fever, check out the Federation of American Scientist’s Fact Sheet.

GMU Faculty Member and NRC Chairwoman Allison Macfarlane Nominated to New Term

Congratulations to GMU PIA Faculty Member Allison Macfarlane on her nomination to a second term as Nuclear Regulatory Commission Chairwoman!

“President Barack Obama has nominated Nuclear Regulatory Commission Chairman Allison Macfarlane to a new five-year term. Macfarlane, a geologist, took over the agency last summer after its former chairman, Gregory Jaczko, resigned amid complaints about an unyielding management style that fellow commissioners and agency employees described as bullying. Macfarlane was initially named to a one-year term that expires in June. Obama named her Thursday to a new five-year term. The appointment requires approval by the Senate.”

Read more here.

The Pandora Report

Highlights include lyssavirus, a treatment for Ebola, predicting the next pandemic, stressing out bacteria, weapons inspection in Syria, and Flu’s grappling hooks. Happy Friday!

Experts Sound Global Alert Over Deadly Bat Virus

Lyssavirus is a close cousin of rabies, both in terms of presentation and its potentially years-long incubation period. The virus does not transmit well person-to-person, though the possibility of such was enough to prompt a terse warning from the doctors involved is this case – “In short, people should stay away from bats.”

The Jakarta Globe – “Experts on infectious diseases on Thursday warned people to stay away from bats worldwide after the recent death of an eight-year-old boy bitten in Australia. The boy last month became the third person in the country to die of Australian bat lyssavirus (ABLV), for which there is no effective treatment…Other lyssavirus strains circulate in bats in the United States and Europe and the experts said their warning applies to wherever bat or flying fox populations exist.”

Chemical Compounds That Halt Virus Replication Identified

It has been literal months since we’ve mentioned Ebola, which is actually pretty good news. What better way to break the radio silence than with news of a potential treatment?

Science Daily – “In this study, researchers identified a new chemical class of compounds that effectively blocked genetically diverse viruses from replicating by limiting RNA production by the virus in cell culture. These indoline alkaloid-type compounds inhibited a number of viruses from replicating, including Ebola…’Because the production of viral RNA is the first step in successful replication, it appears that we have uncovered an Achilles heel to halt virus replication,’ said [lead author] Filone. ‘These compounds represent probes of a central virus function and a potential drug target for the development of effective broad-spectrum antivirals for a range of human pathogens.'”

UCLA-led team predicts China, Egypt could be new-flu hot spots

The team cross-referenced areas with high incidences of  H3N2 (in humans) and H5N1 (in birds) respectively, while also looking for large numbers of swine (which can be infected with both strains from both hosts, and can therefore reassort the virus before passing it along). The results? China and Egypt.

Los Angeles Times – “UCLA postdoctoral researcher Trevon Fuller and colleagues published their work online on March 13 in the U.S. Centers for Disease Control and Prevention journal Emerging Infectious Diseases…Fuller and his colleagues used new techniques to assess conditions in a number of places to see how likely a reassortment event might be. While a new pandemic could possibly emerge from a number of combinations of flu strains, the team focused on reassortment between human H3N2, a version of which was prevalent in the U.S. this flu season; and avian H5N1, a widespread bird fluthat has been rare in humans so far but has proven deadly among the hundreds of people it has infected.”

Bacterial byproduct offers route to avoiding antibiotic resistance

Researchers at Princeton are using bacteria’s natural susceptibility to oxidative stress to develop safer antibiotics. Contrary to popular  belief, “oxidative stress” does not refer to one’s state of being upon entering the Metro, but rather is a bacterial state induced as a result of increasing bacterial production of reactive oxygen species [ROS].

Princeton News – “In a recent paper in the journal Nature Biotechnology, first author Mark Brynildsen, a Princeton assistant professor of chemical and biological engineering, reported that scientists can force bacteria to increase their production of a class of molecules called reactive oxygen species, which can either kill the bacteria outright or make them far more vulnerable to antibiotics. Bacteria normally produce reactive oxygen species during growth. Small amounts don’t hurt them because of certain protective enzymes within the bacteria, but too much of the substances can lead to “oxidative stress.” The researchers decided this weakness could be exploited.”

Syria’s chaos complicates task for chemical weapons investigators

Syria continues apace, with rebels and the Assad regime swapping allegations regarding chemical weapons use. Now it’s just the simple matter of getting an inspections team into the middle of a civil war to attempt to collect biological samples. Weapons inspecting – not for the weak.

NBC News – “Secretary-General Ban Ki-moon said Thursday that he had agreed to conduct an investigation of allegations of an attack in the northern city of Aleppo. The government and the opposition have accused each other of carrying out that attack on Tuesday…Ralf Trapp, a German who works on disarmament and non-proliferation issues, specializing on chemical and biological weapons, said…a big question will be how soon the UN and the Organization for the Prohibition of Chemical Weapons – of which Trapp is a former official — can get a team into Aleppo. He said the team would have to be large and varied, with security officers and medical officers as well as inspectors. But each day lost will influence the speed with which the investigation can be concluded, he said, because as more time elapses before biological sampling occurs, more sophisticated DNA and other toxicological testing is required.”

A viral grappling hook: Flu virus attacks like a pirate boarding party

Included in part because there was a pirate simile in the title. Leave me alone, it’s Friday. But also, read the article, because it’s an interesting presentation of flu’s mechanism,  and because it used a pirate simile in the title.

Phys.org – “When the virus encounters a cell—in your lung, for example—that cell may engulf the virus inside an internal membrane called an endosome. To escape that bubble, the virus fuses its membrane with the endosome’s, opening a window into the cell’s interior…To fuse the two membranes, the virus carries a protein called hemagglutinin (the “H” in H1N1). Triggered by the acidic environment of an endosome, that protein will extend from the viral membrane and attach, like a grappling hook, to the endosome’s membrane. When enough hooks are set, they draw the membranes together until they fuse.”

 

“After SARS: A New Virus in Saudi Arabia Underscores the Need to Police Disease in Animals”

Good opinion piece on the need for greater animal health monitoring (most of the scariest pandemic threats are, in fact, zoonotic):

“Animal health gets just a fraction of the resources that human health does, which is why we are rarely able to detect new viruses before it’s too late and they’ve already crossed the species barrier. In the wake of SARS and the avian flu flare-ups over the past decade, however, that is beginning to change. I’ve written before about the virologist Nathan Wolfe and his Global Viral Forecasting group, which tries to use on-the-ground surveillance and computer modeling to predict when and where new viruses will emerge to threaten the human race. But there other groups working to police the boundaries between human and animal health, and one of them — the New York City–based EcoHealth Alliance — has a new paper out that demonstrates just how many unknown coronaviruses are out there, competing to be the next SARS.”

Read more

Image of the Week!

E.Coli Fireworks!


Description via the American Society for Microbiology:

“Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. Using a new imaging technique, researchers can map the proteins one at a time and combine them into a single image. This lets them study patterns within and among protein clusters in bacterial cells, which don’t have nuclei or organelles like plant and animal cells. Seeing how the proteins arrange themselves should help researchers better understand how cell signaling works.”

Credit Line
Derek Greenfield and Ann McEvoy, University of California, Berkeley”

This Week in DC: Events

Don’t forget the Biodefense Policy Series inaugural lecture  is this Wednesday at 7:20PM! The seminar will feature Dr. Charles Bailey, Executive Director of the National Center for Biodefense and Infectious Diseases. Click here for more details – we hope to see you there! 

DC EventsTuesday, March 19th

Setting Priorities for American Leadership: A New National Security Strategy for the U.S.’
12:30 – 2:00PM
Johns Hopkins University SAIS

Jim Goldgeier, co-chair of the Project for a United and Strong America and dean of American University’s School of International Studies; Kurt Volker, co-chair of the Project for a United and Strong America, executive director of Arizona State University’s McCain Institute for International Leadership and senior fellow at the SAIS Center for Transatlantic Relations (CTR); and Hans Binnendijk (moderator), CTR senior fellow and visiting scholar, will discuss this topic.

Wednesday, March 20th

Awareness and Impressions of Synthetic Biology: Results of the 2013 Poll
12:00 – 2:00PM
Woodrow Wilson Center

In our latest survey, conducted in January 2013, three-fourths of respondents say they have heard little or nothing about synthetic biology, a level consistent with that measured in 2010. While initial impressions about the science are largely undefined, these feelings do not necessarily become more positive as respondents learn more. The public has mixed reactions to specific synthetic biology applications, and almost one-third of respondents favor a ban on synthetic biology research until we better understand its implications and risks…Please join us Wednesday, March 20, 2013, at noon to discuss the complete results from the latest poll. A light lunch will be served beginning at 11:30 am.

Counterterrorism Policies and Priorities: Addressing the Evolving Threat
2:15PM
U.S. Senate Committee on Foreign Relations (Senate Dirksen 419)

Witnesses include: Jane Harman (President, CEO Woodrow Wilson International Center for Scholars), Michael E. Leiter (Senior Counselor to the CEO, Palantir; former Director of the National Counterterrorism Center), Kenneth L. Wainstein (Partner, Cadwalader, Wickersham & Taft LLP; Former Assistant to the President for Homeland Security and Counterterrorism)

Biodefense Policy Series
7:20 PM
George Mason University (Johnson Center Meeting Room B)

Dr. Charles Bailey is the Executive Director of the National Center for Biodefense and Infectious Diseases. He manages a Biosafety Level -3 containment laboratory and conducts translational research aimed at developing diagnostics, antiviral drugs, therapeutics and vaccines against biological threat pathogens or newly emerging infectious diseases. Prior to joining George Mason, Dr. Bailey served in the US Army for 25 years where he conducted research on arthropod borne viral diseases in the US, Southeast Asia and Africa. Dr. Bailey also served as a senior analyst with the Defense Intelligence Agency and as an analyst for the Battelle Memorial Institute.

Thursday, March 21st

Why this defense drawdown must be different for the Pentagon
9:00 AM
American Enterprise Institute

America’s military drawdown is well underway. For years, the Pentagon has been cutting capability and capacity, scaling back war plans, absorbing ever more efficiencies, canceling weapons systems, and reducing readiness in response to roughly $1 trillion in defense budget cuts before sequestration. The onset of sequestration means that this approach is no longer feasible…At this event, AEI’s Marilyn Ware Center for Security Studies will host a panel of defense experts to discuss the right and wrong ways to further cut the defense budget.

Friday, March 22nd

Phantom Menace or Looming Danger?: A New Framework for Assessing Bioweapons Threats
12:00PM – 1:30PM
Woodrow Wilson Center

This book discussion event with author Kathleen Vogel is part of an ongoing series that provides a forum for policy specialists from Congress and the Executive, business, academia, and journalism to exchange information and share perspectives on current nonproliferation issues.

The Pandora Report

Highlights include NCov’s mechanism of action, Dengue in Key West (Spring Breakbone?)(sorry, very sorry), the ongoing debate around stocking up on vaccines we may never use, will Assad use biological weapons?, Zithromax and irregular heartbeats, and using bacteria to deliver vaccines for us. Happy Friday!

Novel Virus Entry Portal Found

On the heels of the WHO confirming the 15th case of NCov, it’s now known that the virus utilizes the DPP4 host cell protein for entry.

The Scientist – “Dutch researchers have identified the host cell protein that allows a recently discovered coronavirus to enter its target cells, according to a study published today (March 13) in Nature. The structure of the protein, called DPP4, appears to be conserved between bats and humans, suggesting that the new findings will help shed light on zoonotic transmission of the virus, as well as provide a target for potential vaccines.”

Mosquito-borne dengue virus lands in Key West

Dengue, also known as “breakbone fever”, continues to be one of the most significant “neglected” tropical diseases, with its occurence  seeing a 30-fold increase over the last five decades. It’s re-emergence in the US, therefore, is disturbing but unfortunately not especially surprising.

LA Times – Although the mosquito-borne dengue virus was thought to be fully eradicated in the continental United States, the Centers for Disease Control and Prevention confirmed Wednesday that the tropical disease had indeed returned…after reviewing 93 dengue cases diagnosed in Florida in 2009 and 2010, study authors identified a specific strain of the virus in patients who had not recently traveled outside the country. The strain differed from those cases in which the patient had recently traveled.”

Wary of Attack With Smallpox, U.S. Buys Up a Costly Drug

This debate strikes at the heart of preparedness – do we invest in the smallpox vaccine now, in the off chance a bioterrorist attack with the pathogen occurs, or spend the money elsewhere and risk catastrophic casualties? While those of you born before 1980 (the year we stopped vaccinating) may be shrugging internally, there is some debate about the potency of the vaccine 20 years on. There’s not an easy answer.

New York Times -“The United States government is buying enough of a new smallpox medicine to treat two million people in the event of a bioterrorism attack, and took delivery of the first shipment of it last week. But the purchase has set off a debate about the lucrative contract, with some experts saying the government is buying too much of the drug at too high a price.”

Syria might be prepared to use chemical and biological weapons – US national intelligence director

Meanwhile, in Syria, (unverfiable) reports continue that Assad has already begun using chemical weapons on the rebels. Once again, it’s a poorly-kept secret that Syria had (has?) a clandestine BW program.

Radio Free Russia – “The erosion of the Syrian regime’s authority is accelerating and the ‘increasingly beleaguered’ government, which has been unable to defeat insurgents with conventional weapons, might be prepared to use chemical weapons, according to James R. Clapper, the director of national intelligence.”

FDA says Zithromax can cause fatal irregular heart rhythm

Zithromax, an anti-biotic used to treat everything from respiratory infections to STDs, is now known to cause “potentially fatal” tachycardia.

Reuters – “Last May, a study in the New England Journal of Medicine compared the risk of cardiovascular death in patients who took Zithromax with those who took several other antibiotics, including amoxicillin. It found that patients who took Zithromax, made by Pfizer Inc, had higher rates of fatal heart rhythms.”

Researchers trick bacteria to deliver a safer vaccine

Ha! Stupid bacteria. No, we’re kidding – any step towards development of elderly-, child-, and immunocompromised-friendly vaccines is good news.

R&D Magazine – “Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues, but Yale University researchers have developed a new trick to circumvent the problem—using bacteria’s own cellular mistakes to deliver a safe vaccine. The findings, published online in Nature Communications, suggest new ways to create novel vaccines that effectively combat disease but can be tolerated by children, the elderly, and the immune-compromised who might be harmed by live vaccines.”

Image of the Week: Petri Paintings

Klari Reis’ “Petri projects” was too pretty not to pass along, even if they’re not technically bacteria. Our favorite, “Prince”, is pictured below. Check out more of the artist’s work on her website.

Klari Reis' work, "Prince"
Klari Reis’ work, “Prince”