Pandora Report: 11.3.2018

November 3rd is One Health Day – how are you celebrating? Just a friendly reminder that the Pandora Report will be on hiatus next week as we’ll be attending the GHSA Ministerial Meeting. Follow us on Twitter (@PandoraReport) to get live updates from Bali!

Schar School of Policy and Government Hosts Preventing Pandemics and Bioterrorism: Past, Present, and Future
Join us on December 4th for Preventing Pandemics and Bioterrorism: Past, Present, and Future, featuring Robert Kadlec, M.D., Assistant Secretary for Preparedness and Response (ASPR)  Health & Human Services, Office of the Secretary. We are excited to announce this special event in celebration of the 15th anniversary of the George Mason University Biodefense Program at the Schar School of Policy and Government. We invite you to attend this exciting opportunity to hear from Dr. Kadlec about lessons learned for pandemic preparedness since the 1918-1919 influenza pandemic, plans for implementing the new National Biodefense Strategy, and the importance of education for the future of biodefense. Following his speech and Q&A session, you are invited to an informal reception for academic and professional members of the biodefense community to socialize and network. Make sure to RSVP here to save your spot!

GMU Master’s Open House
Now is your time to start a future in biodefense – earn a MS in biodefense at George Mason University! Whether it’s online or in person, we’re the place to be for all things health security – from anthrax to Zika. In fact, we’re sending two of our graduate students to the Global Health Security Agenda Ministerial Meeting in Bali next week to act as student ambassadors! Don’t miss the Master’s Open House on Thursday, November 15th at 6:30pm at our Arlington Campus. This is a perfect opportunity to chat with faculty and learn about the admissions process, what it takes to earn a degree in biodefense, and the type of courses you’ll get to enjoy (hint: they’re seriously awesome and diverse).

NextGen GHSA Side Event – Bali
Will you be at the GHSA Ministerial Meeting next week? Look for our two GMU student ambassadors and attend this wonderful event! The Next Generation Global Health Security Network was established in 2014 to engage and facilitate contributions by emerging scholars, scientists, and professionals from government and non-governmental institutions to the Global Health Security Agenda and other global health security initiatives. During the GHSA NextGen Side Event, Tuesday, November 6 from 7:30-9:00, conference attendees will have an opportunity to learn about the innovative project from the winning team of the NTI-sponsored “Biosecurity Competition”, collaborative projects with other GHSA partners, and upcoming priority activities aligned with the strategic vision to promote education, innovation and participation of our members in the GHSA.

NTI’s 2018 Next Generation for Biosecurity Competition
Speaking of the GHSA Ministerial Meeting…NTI|bio has just announced the winner of their collaboration with the Next Generation Global Health Security Network – the 2018 Next Generation for Biosecurity Competition. “NTI | bio, in partnership with the Next Generation Global Health Security Network, is pleased to announce the winners of the 2018 Next Generation for Biosecurity Competition: Peter Babigumira Ahabwe, Infectious Diseases Institute, Uganda; Dr. Frances Butcher, Oxford School of Public Health, UK; and Javier Rodriguez, National Commission of Atomic Energy, Argentina. Their proposal, ‘Act Like a Pro: Scenario-Based eLearning for the Next Generation of Biosecurity Learners,’ is an openly accessible online platform for students and entry-level professionals.  The ‘Act Like a Pro’ platform will also feature a forum for peer-to-peer discussion, monitored by a biosecurity expert. The winning team was selected from proposals received across 14 countries and six continents.  Proposals were evaluated by an international expert panel of 24 judges from seven countries across five continents.  The winning team will receive $15,000 to implement their proposal and will be honored during the GHSA Ministerial.  This competition underscores the importance of promoting a global cadre of multi-sectoral, young professionals dedicated to reducing catastrophic biological risks.”

Stay Connected – GMU Biodefense
Are you a GMU biodefense alum or current student? Make sure to update your information with our Stay Connected program so that we can share the latest news with you and brag about the awesome things you’re doing!

One Health Day
The connection between human, animal, and environmental health is undeniable. Check out this TED talk on human canaries in the coal mine, which discusses veterinary pathology and disease transmission between humans and animals. On November 3rd, we celebrate this day internationally – “One Health Day answers the urgent need for a One Health trans-disciplinary approach towards solving today’s critical global health challenges. It is a timely initiative that gives scientists and advocates a powerful voice for moving beyond current provincial approaches to emerging zoonotic infectious diseases, antimicrobial resistance, climate change, environmental pollution, food safety, comparative/translational medicine and many other problems, to a holistic default way of doing business.”

Conversation with Director Robert Redfield of CDC: The Latest on the DRC Ebola Outbreak
Don’t miss this even on Monday, November 5th, from 10-11am in the Dirksen Senate Office Building. “Robert Redfield, Director for the Centers of Disease Control and Prevention, will join Tom Inglesby, Director of the Johns Hopkins Center for Health Security, for a moderated discussion followed by time for questions and answers. The purpose of this seminar is to discuss the latest events in the DRC Ebola outbreak, the serious challenges involved and the possible trajectory of the outbreak, how CDC and the US government are involved, and what is needed to control the outbreak. Our goal is to provide the Hill community and other stakeholders with the most valuable and current information on this outbreak and how the United States is participating in the international response.” You can RSVP here.

Pandora Report YouTube Channel 
On top of bringing you a weekly dose of biodefense news, we also have a YouTube channel for informative videos! The latest upload is a speech Dr. Koblentz (GMU biodefense graduate program director and professor) gave at the 2016 UN Security Council meeting.

Stories You May Have Missed:

  • Ebola Outbreak Update – “Health officials in the Democratic Republic of the Congo (DRC) said yesterday that an Ebola case has been detected in a previously unaffected health zone, which is located between the two current hot spots, and that eight more cases have been confirmed, based on reports yesterday and today. Also, the World Health Organization (WHO) again said the increase in Beni and Butembo is concerning, as security incidents threaten residents and frontline workers and pockets of resistance pose tough challenges”. The total case counts are now 285 with 250 confirmed and 180 deaths.
  • New MERS-CoV Cases – “The World Health Organization (WHO) today released an overview of eight new MERS cases reported in Saudi Arabia from Sep 17 to Oct 15. Of the eight cases, three proved fatal. With the new cases, the total global number of laboratory-confirmed MERS-CoV (Middle East respiratory syndrome coronavirus) cases reported to WHO since 2012 is 2,262 with 803 associated deaths. Three of the new cases were in Riyadh, and two were in Buraydah. Taif, Najran, and Asyah also reported one new case each. None of the patients were healthcare workers, and all but one were men. Patients’ ages ranged from 22 to 66.”


Pandora Report 10.26.2018

Happy Friday! Halloween is next week but Europe is already taking measures against some of the scariest germs out there – antibiotic resistant microbes. The European Parliament just adopted two laws to limit the use of antimicrobials in food-producing animals.

U.S. National Security Action Plan: Strengthening Implementation of the International Health Regulations
This newly released plan is based upon the 2016 Joint External Evaluation and an effort coordinated by ASPR. “The U.S. Health Security National Action Plan follows an intensive Joint External Evaluation (JEE) of U.S. capacities in May 2016, which was conducted as part of our commitment to the domestic implementation of the International Health Regulations (IHR) (2005)—an international legal framework for global health security, where countries build their own health security capacities and take part of a global surveillance and response network created through the IHR. As a result, the activities proposed in the plan address capacity gaps found by national and international subject-matter experts during the JEE and also further the multi-sectoral and multi-disciplinary approach promoted by the IHR to adequately prevent, detect, and respond to public health security threats.” The plan reinforces participation in the GHSA and emphasizes the importance of working across multiple sectors and disciplines to help prevent, detect, and respond to public health threats.

GMU Biodefense Journal Club Meeting
Are you a current GMU biodefense graduate student? Don’t miss out on the next meet-up with a fun group of fellow biodefense nerds, where you can chat about it all- from anthrax to Zika. The next meeting is on November 5th and the topic of discussion will be the 100th anniversary of the 1918/1919 flu, so check your email for the location info, etc.

 Anticipating Emerging Biotech Threats
GMU Biodefense professor Sonia Ben Ouagrham-Gormley teamed up with Kathleen Vogel to discuss CRISPR and its potential as an emerging biotech threat. “In light of literature on the sociotechnical dimensions of the life sciences and biotechnology and literature on former bioweapons programs, this article argues that we need more detailed empirical case studies of the social and technical factors shaping CRISPR and related gene-editing techniques in order to better understand how they may be different from other advances in biotechnology — or whether similar features remain. This information will be critical to better inform intelligence practitioners and policymakers about the security implications of new gene-editing techniques.” Ouagrham-Gormley and Vogel note the importance of considering issues with off-target effects and replication of experiments when evaluating CRISPR and its popularized ease of use and diffusion.

2018 Arizona Biosecurity Workshop
Don’t miss this two-day workshop in Phoenix, AZ, on December 13th/14th. Held at the Arizona State University campus, “this two-day workshop focuses on community engagement with biosecurity concerns in an applied and practical manner. The goal of this workshop is to foster awareness and to stimulate conversation about the ethical, moral and social implications of biosecurity.” You can view the agenda here.

Ebola Updates
On Saturday, 11 civilians were killed and many more attacked in the town of Mayongose, on the outskirts of Beni. UN Secretary-General Atonio Guterres “condemned Saturday’s attack in the town of Mayongose on the outskirts of Beni, in which at least 11 civilians were killed, and several more were injured and abducted. He said he is also ‘deeply troubled’ by reports that on Friday, two Congolese health workers helping to combat the Ebola outbreak, were killed in Butembo by armed militia. Such attacks continue to hamper humanitarian access in the conflict-torn region and prevent health workers from tackling the outbreak.” Cases in Beni have topped 100 and on Thursday, 3 new cases and 2 deaths were reported in Beni, which brings the total case count to 247, including 150 deaths. “In its regular situation report, the WHO said top concerns are the spike in cases over the past 4 weeks, especially in Beni, and the security challenges response teams are facing in Beni and Butembo. ‘Continued security incidents severely impact both civilians and frontline workers, forcing suspension of EVD response activities and increasing the risk that the virus will continue to spread,’ it said. Vaccination in Beni could not take place in Beni on Oct 21 because of community demonstrations in the wake of attacks the day before, the WHO added. It also said investigations continue into the steady stream of confirmed cases that aren’t from known transmission chains, a sign that the virus continues to spread undetected.” Response efforts have also been an issue as the “The director of the Centers for Disease Control and Prevention said Tuesday that he argued that American experts should stay in the outbreak zone of the latest Ebola epidemic but was overridden by others in the Trump administration because of security concerns. ‘Those decisions are security decisions that really are outside the realm of my public health expertise,’ said the director, Robert Redfield, who said he made a case to the Department of Health and Human Services about why public health experts should remain in the outbreak area but that, at the end of the day, his argument didn’t win out.” Due to security concerns, the CDC withdrew workers from the outbreak several weeks ago. Stephen Morrison of CSIS noted that “There’s a fear of making a mistake and getting clobbered by Congress. There’s a fear of a Benghazi-type situation, that Americans might be targeted,” he said. “We’re looking at possible change of power in the House of Representatives in another 14 days.” (In 2012, an Islamic militant group attacked US government facilities in Benghazi, Libya, leading to the deaths of four Americans.)”

The Dangers of Forced Quarantine
The efficacy of forced quarantine has been questioned for years. Many experts have underscored that this antiquated measure desperately needs to be evaluated in light of the growing threat of a pandemic in this globalized, heavily populated world. From the HIV/AIDS epidemic to Ebola, the stigma that has been associated with disease does little to aid response efforts. “Perhaps the greatest danger of forced quarantines that isolate the poor and vulnerable is that they often don’t work. By eroding trust in public health measures, they undermine the ultimate goal of protecting societies from the spread of disease. People find ways to break free. It is thus possible that giving patients and the public more choices—and the option to quarantine themselves—could in some instances be more effective at fighting off pandemics than police or military-enforced quarantine.”

The Price of Pandemic Prevention
The Coalition for Epidemic Preparedness Innovations (CEPI) just released a new study regarding the cost of developing vaccines for 11 epidemic infectious diseases. Accounting for the constraints of vaccine pipelines and challenges of R&D, their findings are particularly helpful for pandemic prevention efforts. “The cost of developing a single epidemic infectious disease vaccine from preclinical trials through to end of phase 2a is US$31–68 million (US$14–159 million range), assuming no risk of failure. We found that previous licensure experience and indirect costs are upward drivers of research and development costs. Accounting for probability of success, the average cost of successfully advancing at least one epidemic infectious disease vaccine through to the end of phase 2a can vary from US$84–112 million ($23 million–$295 million range) starting from phase 2 to $319–469 million ($137 million–$1·1 billion range) starting from preclinical. This cost includes the cumulative cost of failed vaccine candidates through the research and development process. Assuming these candidates and funding were made available, progressing at least one vaccine through to the end of phase 2a for each of the 11 epidemic infectious diseases would cost a minimum of $2·8–3·7 billion ($1·2 billion–$8·4 billion range).”

Stories You May Have Missed:

  • UK Parliament Emphases AMR As A Priority – “The report by members of the House of Commons’ Health and Social Care Committee warns that “modern medicine will be lost” if the government does not take more aggressive action to reduce inappropriate use of existing antibiotics and promote development of new antibiotics. ‘Visible and active Government leadership needs to be restored to tackle AMR,’ members of the committee wrote in the report. ‘We therefore urge the Prime Minister to work closely with her relevant ministers to raise the profile of AMR both at home and on the international stage’.”


Pandora Report 10.19.2018

TGIF! Before we begin our weekly biodefense news report…a friendly reminder to avoid raw chicken as there is a considerable outbreak of multidrug-resistant Salmonella Infantis tied to raw chicken across 29 states. Check out this article on the cost and challenges of vaccine development for emerging and emergent infectious diseases.

GMU Biodefense Alum Recognized for Research Regarding Airplane Infectious Disease Transmission
GMU Biodefense doctoral alum Nereyda Sevilla is an expert when it comes to germs on a plane. In her recent article, Sevilla address the “the role of air travel in the spread of infectious diseases, specifically severe acute respiratory syndrome (SARS), H1N1, Ebola, and pneumonic plague. Air travel provides the means for such diseases to spread internationally at extraordinary rates because infected passengers jump from coast to coast and continent to continent within hours. Outbreaks of diseases that spread from person to person test the effectiveness of current public health responses.” She utilizes the STEM (Spatiotemporal Epidemiological Modeler) to assess the transmission potential for outbreaks of SARS, H1N1, Ebola, and pneumonic plague spread between people via air travel. Sevilla finds that “the comparative results of each of the four modeled diseases along with the historical accounts show the importance of the disease characteristics and the impact of the infection rate. A disease that has a long period of illness, such as SARS or H1N1, is expected to cause a higher natural spread than diseases in which the period of illness is brief. In cases in which the period of illness is short, such as pneumonic plague, those individuals affected do not have the same opportunities to infect others as do those people harboring diseases with a longer period of illness.” Due to her efforts to study air travel as a transmission mechanism, Sevilla has been awarded the Uniformed Services University Alumni Association Graduate School of Medicine Graduate of the Year and the 2018 Aerospace Physiology Paul Bert Research Award! Congrats Nereyda!

Blue Ribbon Study Panel Meeting – Biodefense Indicators: Progress in Implementing Key Elements of the National Blueprint for Biodefense
The Blue Ribbon Study Panel is hosting an event on November 14th regarding the role of the Executive Branch in implementing the National Blueprint for Biodefense. “The Panel will focus specifically on illustrative action items among those the Panel felt that the federal government could complete in the three years since releasing the Blueprint in 2015. Objectives include Discuss the development and release of the National Biodefense Strategy and opportunities associated with its implementation, review current biosurveillance and biodetection programs, and efforts to improve situational awareness of biological threats, etc.” Make sure to RSVP by November 8th!

International Infection Prevention Week
This week marks International Infection Prevention Week, which recognizes the importance of infection prevention in healthcare and the infection preventionists working to promote safe patient care. You may be wondering why infection prevention is so important but here are a few reminders – influenza, antimicrobial resistance, Ebola, SARS, MERS, measles, surgical site infections, and Clostridium difficile. Those are all infections that have harnessed the awesome transmission capacity of hospitals due to poor infection prevention. Hand hygiene is just a small piece of this, but without infection prevention, we couldn’t safely seek medical care without the risk of a diverse range of infections. Just remember – infection prevention goes beyond things like MRSA and has a vital role in emerging infectious disease response and global health security.

DRC Ebola Outbreak – Increasing Concern
The WHO convened a meeting on Wednesday of the IHR Emergency Committee to discuss the outbreak in the DRC. Following the meeting, they stated “It was the view of the Committee that a Public Health Emergency of International Concern (PHEIC) should not be declared at this time. But the Committee remains deeply concerned by the outbreak and emphasized that response activities need to be intensified and ongoing vigilance is critical. The Committee also noted the very complex security situation. Additionally, the Committee has provided public health advice below.” There have been 220 Ebola cases and 142 deaths reported. Perhaps one of the most challenging aspects of outbreak containment has been security within the area. Per the WHO release – “This outbreak is taking place in an active conflict zone amidst prolonged humanitarian crises. Approximately 8 major security incidents have occurred in the Beni area in the past 8 weeks. These factors have complicated contact tracing and other aspects of the response. Community mistrust, stemming from a variety of reasons, including the security situation, and people who avoid follow-up or delay seeking care, remain significant problems that require deepening engagement by community, national and international partners.” Laurie Garrett wrote about the significance of this situation given that it is the first Ebola outbreak in a war zone. “The view from the United States is different. Last week, the U.S. State Department deemed the security situation on the ground in the outbreak so dangerous that teams of U.S. Centers for Disease Control and Prevention experts were pulled back more than 1,000 miles away to the Congolese capital of Kinshasa.” Garrett underscores the complexity of the conflict, noting that “In the absence of U.S. engagement, the WHO must take a political lead, which is admittedly not its forte, by pulling national security and legal experts into immediate planning should a worst-case security breach occur. Waiting until a doctor is in the hands of the Mai-Mai Yakutumba, a nurse is raped by the Hamakombo, soldiers from the Congolese army shoot a contact-tracing health volunteer, or rival Mai-Mai factions get into a firefight that involves Ebola Treatment Center workers is a recipe for absolute disaster.”

Viral Misinformation – The Biggest Pandemic Risk 
Heidi J. Larson is highlighting a very real public health issue we’re not discussing – misinformation. “I predict that the next major outbreak — whether of a highly fatal strain of influenza or something else — will not be due to a lack of preventive technologies. Instead, emotional contagion, digitally enabled, could erode trust in vaccines so much as to render them moot. The deluge of conflicting information, misinformation and manipulated information on social media should be recognized as a global public-health threat.” Larson points to the vaccine denial phenomenon and those who pray upon it – “The second-most-dangerous category includes those who see anti-vaccine debates as a financial opportunity for selling books, services, or other products. (Wakefield, who maintains that financial concerns have not affected his research and that he has been unfairly vilified, gave paid testimony against the vaccine and filed a patent that allegedly stood to become more valuable were the vaccine to be discredited.) The next tier of damaging misinformation comes from those who see anti-vaccine debates as a political opportunity, a wedge with which to polarize society.” Among those who help spread misinformation is the “super-spreader” who helps spread misinformation through social media to those who also share the mistrust in vaccines. Ultimately, fixing these sources for misinformation is complex and requires considerable engagement and listening, but also supplying public health with more funding towards educational campaigns.

One Health Day – November 3!
One Health Day is just a few weeks away – what’re you doing to celebrate the importance of One Health? “The goal of One Health Day is to build the cultural will necessary for a sea change in how planetary health challenges are assessed and addressed. One Health Day will bring global attention to the need for One Health interactions and allow the world to ‘see them in action’.  The One Health Day campaign is designed to engage as many individuals as possible from as many arenas as possible in One Health education and awareness events and to generate an inspiring array of projects worldwide.”

Spikes of Pediatric Acute Flaccid Myelitis Illness
In 2014, there were surges of AFM associated with enterovirus D68 but a recent spike in pediatric cases is causing concern. “The US Centers for Disease Control and Prevention (CDC) said today that officials are investigating a spike in acute flaccid myelitis (AFM) cases, mostly in children, that looks similar to increases they saw in the late summer and fall of 2014 and 2016, with 127 cases under investigation in 22 states. So far 62 of the cases—marked by sudden onset of limb weakness and decreased muscle tone—have been confirmed, Nancy Messonnier, MD, director of the CDC’s National Center for Immunization and Respiratory Diseases, said today at a media briefing. More than 90% have been in children, and the average age is 4 years.” While the odds of AFM are rare and not caused by a poliovirus, the symptoms can be similar. Patterns appear to be seasonal and the CDC is working to identify trends and prevention efforts.

ASM Biothreats Call for Abstracts
The deadline is today for you to get an abstract in for the 2019 ASM Biothreats. “2019 ASM Biothreats, January 29–31, in Arlington, Virginia. ASM wants your research on high consequence pathogens, biological threat reduction, product development and policy. ‘Share your research with experts in academia, industry and government, who meet each year to learn from each other. This year, the meeting will focus on four areas: High Consequence Pathogen Research, Biological Threat Reduction, Product Development, and Policy’.”

Bioeducation Tool from FAS & FBI
Check out this app by the Federation of American Scientists and Federal Bureau of Investigation – the Bioagents Education App. This app details nearly 50 biological agents that are relevant to biodefense efforts and have the potential for misuse as a bioweapon.

Stories You May Have Missed:

  • 2019 Nuclear Scholars Initiative – Applications are due today for this exciting opportunity. “PONI is now accepting applications for the 2019 Nuclear Scholars Initiative. Those accepted into the Nuclear Scholars Initiative are hosted once per month at CSIS in Washington, DC, where they participate in daylong workshops that include discussions with senior experts, simulations and table top exercises, research reviews, and professional development opportunities. Throughout the sessions the scholars discuss and explore a full breadth of nuclear topics from deterrence, escalation control and modernization to regional dynamics, nonproliferation, nuclear security and the future of arms control.”

Pandora Report 10.12.2018

 GMU Biodefense Master’s Open House 
On Thursday, November 15th, at 6:30pm, we’ll be hosting an Open House on the MS programs within Schar School. This is a great chance to learn about the online and in-person biodefense MS programs, admission criteria, and chat with faculty. Make sure to RSVP here!

Review of the Blue Ribbon Study Panel “Fits and Starts: Reactionary Biodefense” 
GMU Biodefense graduate students Alexandria Tepper and Michael Krug review the latest Blue Ribbon Study Panel event in case you missed it on October 9th. “The event kicked off with an in-depth recollection by Sen. Daschle of October 16th, 2001; the day that letters containing Bacillus anthracis spores were opened in the Hart Senate Building. “Confusion and chaos” were the words the senator used to describe the situation that ensued when one of his interns opened the letter and aerosolized the fine white powder, exposing 28 staff members to the deadly B. anthracis. He expressed the helpless feeling that overcame him when he received a phone call describing the situation. As he rushed to the Hart Senate Building, he recalled the disorganization of the federal investigators during the bio-threat, as responders were devastatingly unprepared for such an event. The lack of standardized protocols became startlingly evident when the exposed staff members were cleared to return home in the same clothes worn during the attack. Fortunately, no one was killed in this specific attack and Sen. Daschle attributed that to a select few individuals who stepped up to lead the treatment and recovery process.”

Event Summary and Analysis for “The Implications of Chemical Weapons Use in Syria”
George Washington University graduate student Wardah Amir discusses the IISS event hosted last week regarding CW use in Syria. “The 2013 deal would not have been possible without Russian cooperation. At the time U.S.-Russian interests overlapped on eliminating Syria’s chemical weapons program. Unfortunately, U.S. and Russian cooperation did not last long enough to hold users of chemical weapons in Syria accountable. While the OPCW Executive Council believes in working towards accountability, Russia’s unwillingness is shown by its failure to cooperate.The deal was proof that international cooperation could help achieve results. The framework inevitably led to the creation of the OPCW Fact-Finding Mission, the Declaration Assessment Team, and the OPCW-UN Joint Investigative Mechanism.  Without Russian cooperation, or the active participation of the international community on addressing chemical weapons use, results will be harder to achieve.”

 Technologies to Address Global Catastrophic Biological Risks 
The Johns Hopkins Center for Health Security has just released a new report that discusses how investment in 15 promising technologies could make us more prepared and better at responding to biological incidents. “While systems to respond [to an outbreak] are in place in many areas of the world, traditional approaches can be too slow or limited in scope to prevent biological events from becoming severe, even in the best of circumstances,” wrote the Center authors. “This type of response remains critically important for today’s emergencies, but it can and should be augmented by novel methods and technologies to improve the speed, accuracy, scalability, and reach of the response.” The technologies were grouped into 5 categories – disease detection, surveillance, and situational awareness, infectious disease diagnostics, distributed medical countermeasures manufacturing, medical countermeasure distribution, dispensing, and administration, and medical care and surge capacity. Within the report, there is a focus on technologies like remote sensing for agricultural pathogens, hand-held mass spectrometry for diagnostics, synthetic biology for manufacturing medical countermeasures, etc. The authors note that “To realize the promise of these technologies will require significant dedicated effort and investment. While this is occurring for vaccine development, and to some extent for surveillance, other needs for pandemic and GCB event prevention and response must be addressed if we are to confront these threats in a serious way. One possible approach to closing these gaps would be through the formation of a consortium of technology developers, public health practitioners, and policymakers aimed at understanding pressing problems surrounding pandemic and GCB risks, and jointly developing technology solutions.”

Blue Ribbon Study Panel Report – Holding the Line on Biodefense: State, Local, Tribal, and Territorial Reinforcements Needed
The Blue Ribbon Study Panel on Biodefense just released their latest report, which underscores the need for first responders. “How we respond to biological events – especially those large in scale and impact – is now out of balance with how we prepare,” said former Secretary of Health and Human Services Donna Shalala, Panel Member, who co-chaired the January 2018 meeting in Miami that informed many of the report’s recommendations. “There are a number of steps we can take right now to better position SLTT governments, as well as hospitals, pharmacies, and other private sector organizations to respond immediately and then in tandem with federal support.” Within the report, there are eight recommendations, including – Unify and establish a new National Emergency Medical Services system, including the creation of a National Emergency Medical Services Agency at the Department of Health and Human Services,  Improve distribution of the Strategic National Stockpile and other stores of pharmaceuticals, equipment, and essential medical supplies, with enhanced training and assured access to pharmacy readiness data, etc.

Post-Florence Giant Mosquitoes
Like something out of a horror movie, North Carolina is getting hit with “mega-mosquitoes” following Hurricane Florence. “‘These giants have zebra-striped legs and are two to three times as big as the normal bloodsuckers encountered during summer, said Michael H. Reiskind, an assistant professor in the Department of Entomology at North Carolina State University. ‘Definitely noticeably bigger,’ he said. ‘If you see mosquitoes often, then you’re going to say, ‘Wow, that’s a big mosquito’.” While they don’t carry human diseases, these massive mosquitoes can carry dog heart worm.

Bacteriophages and Their Application For Fighting Antimicrobial Resistance
Researchers and medical providers alike are searching for the next effective tool against antibiotic resistant infections. One such tactic is bacteriophage therapy – a natural enemy to bacteria. Laura H. Kahn writes that “In addition to minimal governmental research funding, the pharmaceutical industry hasn’t been interested in developing phage therapies because of regulatory and patentability concerns. But these concerns can be readily addressed. Phages adapted to newly evolved, resistant bacteria could be analogous to updated influenza vaccines that get approved each year without undergoing time-consuming Investigational New Drug (IND) approval processes. Novel technologies to isolate, bioengineer, and produce phages at scale could be patented. For example, phages have been engineered to reduce bacterial biofilms.”

 Ebola Outbreak Update
Seven additional cases were announced in the DRC on Wednesday, bringing the total to 188 and 118 deaths. “The DRC’s ministry of health said the recent spike in cases in these areas confirms that case contacts during the initial wave of cases in August and September who avoided follow-up and vaccination have now been infected. Beni has been a hotbed of anti-response activity, especially the neighborhood of Ndindi. ‘The factors contributing to this situation are mainly misinformation, non-collaboration of the population with the response teams and insecurity,’ the Health Ministry said in its daily update. ‘More than two months after the declaration of the epidemic, the community continues to prevent the safe and dignified burial, and at-risk contacts still refuse vaccination and 21-day follow-up.'” As of Wednesday, “four administrative measures will be put in place in Beni, the new epicenter of the outbreak, the health ministry said. The steps include making it illegal to harbor a suspected Ebola patient, using security forces to monitor and implement safe burials, requiring families to show official death certificates before obtaining a burial certificate, and obligating all health professionals (including traditional healers) to report suspected cases to Ebola treatment centers.”

Stories You May Have Missed:

  • Poliolike Illness Found in Children – “Health officials in Minnesota and Colorado are among the states investigating acute flaccid myelitis (AFM) cases in children, raising concerns about another possible uptick in the rare condition, similar to steep rises seen in 2014 and 2016. The hallmark of AFM is a sudden onset of limb weakness associated with spinal cord inflammation. In 2014, a large outbreak coincided with a national outbreak of severe respiratory illness causes by enterovirus D68 (EV-D68), but intensive investigations have not consistently found a specific pathogen in spinal fluid samples. In an Oct 5 statement, the Minnesota Department of Health (MDH) said it is investigating six AFM cases that have occurred in children since the middle of September. Health officials are collecting information about the cases from health providers and are in contact with the CDC, the MDH said.”


Pandora Report 10.5.2018

TGIF! This week has been pretty busy in the world of biodefense, so before we get into ricin, Insect Allies, the new Biodefense Strategy, and all the other stuff in between, make sure you’ve got a cup of coffee or tea because you won’t want to miss anything.

Attempted Ricin Attack Via Mail?
On Monday, federal authorities responded to suspicious envelopes sent to senior U.S. officials, including President Trump. “The Pentagon Force Protection Agency on Monday detected a suspicious substance, believed to be the poison ricin, on two envelopes at a mail facility on Pentagon grounds in Northern Virginia, the officials said. Initial tests indicated that the envelopes, addressed to Mattis and Adm. John M. Richardson, the chief of naval operations, contained the toxic material.” The Secret Service later noted that a letter was also addressed to President Trump. However, on Wednesday “U.S. investigators have nearly ruled out terrorism after envelopes sent to a Pentagon mail sorting facility were falsely flagged for the possible presence of the deadly poison ricin, U.S. officials said on Wednesday. A Pentagon spokeswoman said tests so far showed that the alert was triggered by castor seeds, which ricin is derived from, as opposed to the deadly substance itself.” Late Wednesday, the FBI arrested a Navy veteran who is suspected to have sent the envelopes containing castor beans. “Defense officials had suspected that the letters contained ricin, but a Pentagon spokeswoman said on Wednesday that they actually contained castor beans, the raw material from which ricin is made. She said the F.B.I. was investigating.”

 Insect Allies – Agricultural Friend or Biosecurity Foe?
A DARPA project, Insect Allies, has come under fire this week regarding its potential for spiraling out of control, but also the chance it could be perceived as a biological weapon. “Darpa launched the Insect Allies research program in 2016, budgeting $45 million over four years to transform agricultural pests into vectors that can transfer protective genes into plants within one growing season. That would be exponentially faster than modifying crops through a gene drive, which would breed specific traits into a species over several generations. (Gene drives have been proposed to reduce mosquito fertility, halting diseases like malaria.)” A recent publication in Science drew attention to the concerns for such technology being used for nefarious purposes. The authors underscored that the profound implications of releasing a horizontal environmental genetic alteration agent range from regulatory to economic, biological, and even to societal. “In the context of the stated aims of the DARPA program, it is our opinion that the knowledge to be gained from this program appears very limited in its capacity to enhance U.S. agriculture or respond to national emergencies (in either the short or long term). Furthermore, there has been an absence of adequate discussion regarding the major practical and regulatory impediments toward realizing the projected agricultural benefits. As a result, the program may be widely perceived as an effort to develop biological agents for hostile purposes and their means of delivery, which—if true—would constitute a breach of the Biological Weapons Convention (BWC).” Following this publication, DARPA Program Manager of Insect Allies, Dr. Blake Bextine, released a statement. Bextine notes that “Technologies dealing with food security and gene editing certainly do have a higher bar than most for transparency, research ethics, and regulatory engagement, and I believe Insect Allies meets that raised standard. DARPA structured Insect Allies as a university-led, fundamental research program, and has invited in representatives from U.S. regulatory agencies from the very beginning of the program to offer perspectives and learn about the work. The researchers working with DARPA are free to publish their results, encouraged to discuss their efforts, and coordinate with regulatory agencies to facilitate the transition of their technologies from laboratory demonstrations to—someday in the future—powerful new tools that can bolster the toolkit for responding to fast-moving or unanticipated threats to the global food supply.” The UDSA, EPA, and FDA have been involved throughout DARPA’s project as regulatory bodies, but there are are concerns that the requirements (a minimum of three kill switches) are not enough. Many worry that this is an example of a dangerous project done simply to prove we have the capabilities instead of asking if we should (cue Ian Malcolm line from Jurassic Park).

Horsepox Synthesis – A Biosecurity Zombie
We’re not quite done with DURC and since this resurrected poxvirus news occurred in October, we’ll stick with a zombie theme. 2017 was the year of the horsepox synthesis (here’s a refresher), but a recent PLOS Pathogens publication by David Evans and Ryan Noyce stoked the embers of the debate. Within their opinion piece, Evans and Noyce discuss the DURC implications of their work and note that their interest in testing the horsepox virus “as a potentially safer vaccine was prompted by phylogenetic and historical evidence suggesting that smallpox vaccines might have originated in horses.” They also note that ” the authors respect the concerns that have been expressed about this work, but note that our lives have been profoundly improved by technologies, like genetic engineering, that were once viewed as threats to humanity”. Ultimately, Evans and Noyce state that the bigger challenge is actually education. On the heels of their comments, Ed Yong from The Atlantic discusses how this study revealed some flaws in DURC and genome synthesis experiments. Yong discusses the claims Noyce and Evans make regarding the benefits of the horespox synthesis and that while some may not agree with the flurry of concern, there are others that worry the tacit knowledge barriers are deteriorating. Filippa Lentzos noted the intensity of academia and the pursuit of funding/publications that can encourage moral hazard and a lack of transparency. Bioethicist Kelly Hills remarked that she “sees a sense of impulsive recklessness in the interviews that Evans gave earlier this year. Science reported that he did the experiment ‘in part to end the debate about whether recreating a poxvirus was feasible.’ And he told NPR that ‘someone had to bite the bullet and do this.’ To Hills, that sounds like: I did it because I could do it. ‘We don’t accept those arguments from anyone above age six,’ she says.” Much of the debate highlights the lack of training for scientists to anticipate the consequences of their work. “More broadly, Hills says, there’s a tendency for researchers to view ethicists and institutional reviewers as yet more red tape, or as the source of unnecessary restrictions that will stifle progress.” As Lentzos emphasized, these topics need to be addressed and discussed with scientists starting earlier on in their careers – at the undergrad level.

ETA of the Next Pandemic: Shorter Than You’d Think
If you’re reading a biodefense newsletter, you’re likely some one who understands and appreciates the potential threat that infectious disease outbreaks pose. Unfortunately, not everyone truly comprehends this issue. “Pandemic disease is arguably one of the greatest threats to global stability and security. But investments to contend with such outbreaks have declined to their lowest levels since the height of the Ebola response in 2014, with U.S. federal dollars cut by over 50 percent from those peak levels.” Hits to funding, personnel gaps in departments, elimination of the NSC Global Health Security Office, and a general lack of focus have raised concerns for the current state of U.S. biodefense. From Ebola in the DRC to H7N9 in China, and even the quarantined flights in NYC, it’s becoming increasingly difficult to ignore the impending pandemic. While the White House released their strategy, the biodefense community awaits the execution of such efforts.

 A Multi-Disciplinary Approach to Multi-Disciplinary Threats
GMU Biodefense MS student Janet Marroquin discusses the latest Biodefense Strategy. “A new Biodefense Steering Committee is now housed under HHS and supported by various other agencies including the Dept. of State, Dept. of Defense (DOD), U.S. Drug Administration, Dept. of Homeland Security (DHS), and the Environmental Protection Agency, in order to ensure implementation. Additionally, there is an interagency Biodefense Coordination Team that also engages with non-governmental stakeholders for a multi-disciplinary effort in implementing the Strategy. Reassuringly, this interagency stakeholder collaboration began with the drafting of the Strategy by DOD, DHS, HHS, and Department of Agriculture that ensured support for a comprehensive One Health approach to health security.”

Dutch Expel Four Russian GRU Members Attempting to Hack OPCW
Don’t mess with the OPCW – “Dutch security services say they expelled four Russians over a cyber attack plot targeting the global chemical weapons watchdog. The operation by Russia’s GRU military intelligence allegedly targeted the Organisation for the Prohibition of Chemical Weapons in The Hague in April. The OPCW has been probing the chemical attack on a Russian ex-spy in the UK.” British Prime Minister May and Prime Minister Rutte released a joint statement, noting that “This attempt, to access the secure systems of an international organisation working to rid the world of chemical weapons, demonstrates again the GRU’s disregard for the global values and rules that keep us all safe.” The Dutch Ministry of Defence has released a detailed account of the operations and their findings, which you can access here, revealing the use of cell phone records, taxi receipts, and more to track the GRU team. This comes after it was a revealed that the Dutch had also expelled Russians over plans to hack into a Swiss chemical laboratory where the novichok “nerve agent samples from the Salisbury attack were analysed”. The OPCW released a statement on Thursday regarding the incident, noting that “The Netherlands is the OPCW’s host country and, as such, is in charge of ensuring and exercising due diligence in protecting the OPCW Headquarters. The OPCW thanks the Netherlands for its actions and will remain in contact in regards to any further developments. The OPCW takes very seriously the security of its information systems and networks. Since early 2018, the Organisation has observed increased cyber-related activities. The Director-General has informed OPCW Member States about these activities and the OPCW Technical Secretariat has undertaken measures to mitigate them.”

DRC Ebola Updates
Four additional cases of Ebola were reported over the past few days and security concerns are growing. Nearly 13,000 people have been vaccinated, but all the new cases were in the recent hot spot of Beni. This area has challenged response efforts due to civil unrest. “Tthe DRC outbreak coordinator held a press conference in Beni to detail the impact the recent community protests had on the outbreak response. He said contact tracing dipped from 98% to 50% during the protest days, held in the wake of deadly violence between rebels and DRC armed forces, and that the actions slowed active case finding and port-of-entry monitoring. Ndjoloko Tambwe Bathe, MD, said the protest sidelined vaccination activities for 3 days and brought sample testing to a halt on Sep 25. Also, he said the actions hurt disinfection efforts and impeded the supply of personal protective equipment for health providers.” The outbreak has now resulted in 161 cases and 105 deaths. On Wednesday, it was announced that three volunteers with the International Committee of the Red Cross, were injured in an attack by villages. This attack prompted “the ICRC to suspend burials in the area, health officials said on Wednesday. The attack on an ambulance transporting the body to a cemetery in North Kivu province’s Beni region is the latest disruption to efforts to control the current outbreak, which is believed to have killed 106 people since July.”

GMU Biodefense Journal Club
Current GMU biodefense students – check out the newly formed journal club! Check your email from Thursday, but keep the evening of Monday, October 15th open if you’d like to geek out with some of your fellow biodefense classmates. This will be a great, stress-free (a journal article is way more fun than a book club!) environment to get your health security nerdom on.

UNODA BWC October Newsletter
The BWC Implementation Support Unit has just released the latest newsletter, where you can get the scoop on the recent Meeting of Experts. “Up to 100 States Parties, two Signatory States and one Non-Signatory State participated in the MXs. In addition, various UN entities, international and regional organizations and 26 non-governmental organizations and research institutes also attended. The proceedings of the MXs were livestreamed via UN Web TV.” As you read the letter, it’s important to remember the importance of the BWC and the ISU, as funding has been problematic. U.S. Ambassador to the BWC, Robert Wood, recently tweeted that “Unfortunate news from the BWC Chair today that there are insufficient funds for the December Meeting of States Parties and the BWC Implementation Support Unit“.

 Achieving the Trump Administration’s National Biodefense Strategy
GMU Biodefense PhD alum Daniel M. Gerstein discusses the recent release of the biodefense strategy and how it can be successful. “In addressing this bipartisan issue, the administration largely builds on the biodefense strategies of the George W. Bush and Barack Obama administrations. Common areas across the three strategies include recognition of the global nature of biological threats; the need to collaborate with a range of key stakeholders including foreign partners, state and local authorities and industry; and the need for risk-based decisionmaking in preparedness and response activities. Like those of his predecessors, the Trump strategy was accompanied by an implementation document which provided additional details on how the goals and objectives would be achieved.”

The U.S. Government Engagement in Global Health – A Primer
The Henry J Kaiser Family Foundation just released their report on how the U.S. is responding to global health threats. “This primer provides basic information about global health and U.S. government’s response in low- and middle-income countries. Although it focuses primarily on the U.S. government, it is important to acknowledge the role played by other countries, multilateral organizations, and private sector actors such as non-governmental organizations (NGOs), foundations, corporations, and others, in the global health response. The first several sections provide an overview of the field of global health and describe current global health issues.” Overall, the report underscores the long history of U.S. engagement in global health and the myriad of agencies and programs that facilitate such efforts. Given this long history and the investment in global health, the U.S. has a critical role in responding to existing and future health events on a global level.

Infection Preventionists and Antimicrobial Stewardship Programs, A Marriage in Progress
GMU Biodefense doctoral student and infection preventionist Saskia Popescu discusses the relationship between infection prevention practitioners and antimicrobial stewardship programs. “These findings shed light into the existing antimicrobial stewardship program structure within health care facilities, as well as the challenges of incorporating infection preventionists into these programs. Although the role of infection prevention is obvious within the antimicrobial stewardship program, infection preventionists lack a clear set of responsibilities. The integration of the infection preventionists into antimicrobial stewardship programs should be evaluated and strengthened to establish a more wholistic and responsive program.”

Stories You May Have Missed:

  • Officials Worried About African Swine Fever – “Humans are suspected to have caused the recent spread to Belgium, where eight cases were confirmed, as of September 25, according to the World Organisation for Animal Health.
    The most recent cases, however, were reported September 25 in a Chinese slaughterhouse in Hohhot, the capital of Inner Mongolia, according to the organization. There have been 29 outbreaks in China since the first case was reported August 3. China has culled nearly 40,000 pigs in response, according to the the organization’s database.”
  • Beef Recall Due to Salmonella and Listeria Outbreak – “The US Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced two meat-related recalls raw beef because of possible contamination with Salmonella Newport, and ready-to-eat ham products that may be tainted with Listeria monocytogenes. Today the FSIS said JBS Tolleson, Inc., of Tolleson, Ariz., is recalling about 6.5 million pounds of raw beef products that may be contaminated with SalmonellaNewport. This includes ground beef, chuck, and burgers sold through several retailers, including Walmart, Cedar River Farms Natural Beef, and Showcase.”

Pandora Report 9.28.2018

Happy Friday biodefense gurus! October is right around the corner, which means the flu vaccine will be available soon. Make sure to get vaccinated this season, as the CDC just announced that 80,000 people died of the flu during the 2017/2018 season, which is the highest death toll in 40 years.

GMU Global Health Security Ambassador
We’re excited to announce that two graduate students from the Schar biodefense program will be attending the 5th GHSA Ministerial Meeting in Bali, Indonesia. The two students, Annette Prieto and Saskia Popescu, will observe the Global Health Security Agenda in action and the the GHSA 2024 planning. Following their attendance in early November, we’ll be providing a report out on the events. Meet our two GMU Global Health Security Ambassadors – Annette Prieto has a background in Microbiology and Immunology and is currently a Biodefense student in the Master’s Program here at George Mason University. Before coming to George Mason, Annette focused on medical Microbiology at the University of Miami before moving into the laboratory and becoming a Teacher’s Assistant. From there, Annette became an Adjunct Instructor at Daytona State College and taught for a year before entering the Biodefense Program. Annette is also a part of the Next Generation Global Health Security Network. Saskia Popescu is a biodefense doctoral candidate at GMU and infection preventionist. She worked as an infection preventionist during the Dallas Ebola cluster, a 2015 measles outbreak, and is an external expert for the ECDC. She is a 2017 ELBI fellow and trained infectious disease epidemiologist. Saskia’s research focuses on the utilization of infection control in the U.S. healthcare system and it’s impact on biodefense. Make sure to check back in the weeks following their trip to learn about their experiences at the ministerial meeting.

Why Poor Pandemic Preparedness is Deadly
Ebola response efforts in the DRC are struggling and were suspended earlier this week, after violence between rebels and armed forces. While outbreak response in Beni have resumed, events like these are a prime example of why outbreaks can quickly spread beyond control and ultimately emphasize the need for pandemic preparedness. Drs. Tom Inglesby and Eric Toner from the Johns Hopkins Center for Health Security recently discussed the importance of investing in biopreparedness and how their Clade-X tabletop revealed many of the existing weaknesses. “Could a natural or man-made pandemic happen today? Yes. New lethal viruses are emerging from nature, and dizzying developments in biotechnology mean that biological weapons no longer are the sole province of a few state-sponsored programs — a manufactured pandemic could be unleashed by a rogue regime or by terrorists utilizing one of the thousands of laboratories around the world capable of making a dangerous pathogen. If the worst-case scenario unfolds, strong pandemic preparedness planning would save millions of lives. But progress is possible only with effective leadership.”

Rebuilding Health Security in the Wake of Ebola
GMU Biodefense graduate student Stephen Taylor discusses the latest talk from Georgetown University on global health security following the 2013-2016 Ebola outbreak. “In the midst of this disaster, the U.S. Centers for Disease Control turned to health security experts at the Georgetown Center for Global Health Science and Security to support the expansion and augmentation of the Guinean public health infrastructure.  Dr. Alpha Barry, Dr. Erin Sorrell, Dr. Claire Standley, and Ms. Aurelia Attal-Juncqua supported on-the-ground efforts to develop and implement improved health security policy that would make Guinea more resilient against future infectious disease outbreaks.  The Guinean government’s priorities for capacity and capability building were to prevent further outbreaks of zoonotic diseases, improve the capacity of surveillance laboratories and capabilities of the healthcare workforce to identify outbreaks, and to better respond to outbreaks by streamlining and coordinating emergency response operations.  On September 14th, 2018, as part of its Global Health Security Seminar Series, Georgetown University hosted a panel discussion of Dr Sorrell, Dr. Standley, and Ms. Attal-Juncqua on their efforts in Guinea.”

 The AMR Challenge
The United Nations (UN) General Assembly was held this week and one particular topic captured our attention – antimicrobial stewardship and a new initiative to combat resistance. “The AMR Challenge is a way for governments, private industries, and non-governmental organizations worldwide to make formal commitments that further the progress against antimicrobial resistance. The challenge encourages a One Health approach, recognizing that the health of people is connected to the health and animals and the environment. The AMR Challenge launches at the United Nations (UN) General Assembly in September 2018. Organizations can make commitments beginning September 25, 2018 until September 2019. CDC will feature commitments throughout the year. At the 2019 UN General Assembly, antimicrobial resistance will continue to be a priority topic for world leaders.” Within the Challenge, there are commitments to tracking and sharing data, reducing the spread of resistant germs through infection prevention and control, improving antibiotic use, decreasing antibiotics and resistance in the environment, and investing in vaccines, therapeutics, and diagnostics.

NASEM – Review & Assessment of Planetary Protection Policy Development Processes
How do we protect the Earth from contamination following space exploration? How can we avoid bringing microorganisms from Earth to other planets and solar system bodies? The latest NASEM report discusses how scientists tackle these issues and implement such policies. As you read the text, you’ll also see one of the Center for Health Security’s ELBI fellows in there – Betsy Pugel of NASA. “For decades, the scientific, political, and economic conditions of space exploration converged in ways that contributed to effective development and implementation of planetary protection policies at national and international levels. However, the future of space exploration faces serious challenges to the development and implementation of planetary protection policy. The most disruptive changes are associated with (1) sample return from, and human missions to, Mars; and (2) missions to those bodies in the outer solar system possessing water oceans beneath their icy surfaces.” This gives new insight into a field we may not be considering in health security – what about interstellar health security?

The Spanish Flu, Epidemics, and the Turn to Biomedical Responses
We already discussed the impact of poor pandemic preparedness, but what about biomedical efforts? A recent article from AJPH discusses the role of the 1918/1919 pandemic in bringing biomedical approaches to the forefront of outbreak response. “A century ago, nonpharmaceutical interventions such as school closings, restrictions on large gatherings, and isolation and quarantine were the centerpiece of the response to the Spanish Flu. Yet, even though its cause was unknown and the science of vaccine development was in its infancy, considerable enthusiasm also existed for using vaccines to prevent its spread. This desire far exceeded the scientific knowledge and technological capabilities of the time. Beginning in the early 1930s, however, advances in virology and influenza vaccine development reshaped the relative priority given to biomedical approaches in epidemic response over traditional public health activities. Today, the large-scale implementation of nonpharmaceutical interventions akin to the response to the Spanish Flu would face enormous legal, ethical, and political challenges, but the enthusiasm for vaccines and other biomedical interventions that was emerging in 1918 has flourished.”

HHS Sponsors TPOXX
Speaking of biomedical measures…the Department of Health and Human Services (HHS) just announced its sponsorship of a new formulation of the world’s first approved smallpox treatment – TPOXX. This purchase will be used for the Strategic National Stockpile and will work with Siga Technologies to develop an IV formulation of the drug. “Purchase of TPOXX in pill form and development of an IV formulation will be completed under a contract between Siga Technologies and the Biomedical Advanced Research and Development Authority (BARDA), part of the HHS Office of the Assistant Secretary for Preparedness and Response. BARDA will use funding from the Project BioShield Special Reserve Fund. The contract can be extended for up to 10 years and $629 million if necessary to complete development of the IV formulation.”

NASEM – Engaging the Private-Sector Health Care System in Building Capacity to Respond to Threats to the Public’s Health and National Security
Don’t miss the latest NASEM report on the intersection of preparedness and healthcare. From Ebola patients to natural disasters, and even terrorism, the private-sector healthcare system plays a critical role in response. “As a result, disasters often require responses from multiple levels of government and multiple organizations in the public and private sectors. This means that public and private organizations that normally operate independently must work together to mount an effective disaster response. To identify and understand approaches to aligning health care system incentives with the American public’s need for a health care system that is prepared to manage acutely ill and injured patients during a disaster, public health emergency, or other mass casualty event, the National Academies of Sciences, Engineering, and Medicine hosted a 2-day public workshop on March 20 and 21, 2018. This publication summarizes the presentations and discussions from the workshop.”

USDA ARS 5th International Biosafety & Biocontainment Symposium
ABSA has just announced this event being held on February 11-14, 2019 in Baltimore, Maryland. “The focus of the symposium will be Biorisk and Facility Challenges in Agriculture. Seven professional development courses will address topics including life science security, facility maintenance and operational issues, agricultural risk assessment, emergency response and preparedness for livestock disease outbreaks, waste management, and strategic leadership. Courses will be held on Monday, February 11. There will be 2 1/2 days of scientific presentations covering various topics including; governance updates, design methodologies, deferred maintenance, rabies, occ health laboratory to the field, gene editing, risk management and communication, and many others. The poster and networking reception will be held on Wednesday, February 13, attendees will have the opportunity to meet with presenters and discuss their presentations. Exhibits showcasing the latest biosafety, biosecurity, and biocontainment products and services will be open February 12-13.”

Next Generation Biosecurity Webinar 
Don’t miss this webinar today, Friday 9.28, at 11am (CDT, Mexico City). Hosted by Next Generation GHSA, this webinar will be with Luis Alberto Ochoa Carrera, Coordinator of Biosafety and Biochemistry of the GHSN and Coordinator of the Biosafety Laboratory Level 3 of the National Reference Laboratory (InDRE) of Mexico.

Stories You May Have Missed:

  • Airplanes and Airports – Hubs for Germs: GMU biodefense doctoral candidate Saskia Popescu discusses the latest on germ transmission during air travel. “Most people have a general sense that air travel tends to involve exposure to germs. Whether it’s through the thousands of people we will come into contact with, the sick person next to us on the plane, or the dirty surfaces, many of us get a sense of unease knowing there is a real chance we may arrive at our destination with a microscopic companion.”


Pandora Report: 9.21.2018

U.S. National Biodefense Strategy
On Tuesday, President Trump released the National Biodefense Strategy, which “sets the course for the United States to combat the serious biothreats our country faces, whether they arise from natural outbreaks of disease, accidents involving high consequence pathogens, or the actions of terrorists or state actors. The strategy enables risk awareness to inform decision-making across the biodefense enterprise; ensures biodefense enterprise capabilities to prevent bio-incidents; strives for biodefense enterprise preparedness to reduce the impacts of bio-incidents; enables rapid response to limit the impacts of bio-incidents; and facilitates recovery to restore the community, the economy, and the environment after a bio-incident.” The strategy is implemented through a National Security Presidential Memorandum (NSPM), “Support for National Biodefense“. A Biodefense Steering Committee is to be established, which will be chaired by the Secretary of Health and Human Services. Robert Kadlec, HHS Assistant Secretary for Preparedness and Response, released a statement here, noting that “Coordination of such complex actions requires a sound strategy, commitment, and governance structure. As an initial step in implementing the strategy, leaders from every federal department involved in biodefense formed a steering committee, led by Secretary Azar, that provides strategic guidance in preparing for, countering, and responding to biological threats. I am honored that Secretary Azar asked me to lead the day-to-day coordination team that supports this committee in improving biodefense readiness.” The new strategy includes goals related to enabling risk awareness to inform decision-making, ensuring biodefense enterprise capabilities to prevent or reduce the impact of bioincidents, rapidly respond to limit the impacts of bioincidents, etc. Each goal has a series of measures regarding implementation and strategies. A personal favorite is Goal 2 (Ensuring Biodefense Enterprise Capabilities to Prevent Bioincidents) 1.1 and 1.2 – strengthening infection prevention measures domestically and internationally, and reducing the spread of antimicrobial-resistant pathogens domestically and internationally. Ultimately, the new strategy will “better coordinate the often overlapping efforts of 15 departments and agencies and 16 branches of the intelligence community.” Biodefense Twitter is also a great source for feedback on this – Check out Greg Koblentz here or simply search #biodefense.

 Passing of Raymond Zilinskas
The biodefense world is mourning the loss of Dr. Raymond Zilinskas this week – a man whose work helped to lay the foundation for the field. “Zilinskas was one of the world’s foremost experts on chemical and biological weapons. He directed the Chemical and Biological Weapons Program at the James Martin Center for Nonproliferation Studies (CNS) and taught courses on the subject since joining the Institute in 1998. Working as a clinical microbiologist, Zilinskas became interested in ‘the area where microbiological science meets policy and ethics,’ as he recounted in a 2016 interview in Communiqué. Much of what is now known about the Soviet biological weapons program from its inception in the 1920s comes from the 11 years of research Zilinskas and Milton Leitenberg conducted for their book The Soviet Biological Weapons Program: A History.” The Middlebury Institute of International Studies at Monterey also released this statement regarding Zilinskas – “As my CNS colleague Sandy Spector recalls, Ray was always ready to take his research into the field, even if that meant plucking fleas from a captured rodent in search of bubonic plague or inspecting the dilapidated storage facility of a post-Soviet Anti-Plague Institute. He also had a knack for writing about overlooked dimensions of the BW problem, including agro-terrorism, synthetic biology, and a major article in Scientific American on counterfeit Botox.”

Emerging Infectious Disease Issue – Influenza – The Mother of All Pandemics 
The latest CDC publication brings forth images of the 1918/1919 influenza pandemic with a colorful cover – a painting by John Singer Sargent of the interior of a hospital tent during the pandemic. The issue contains a wide variety of articles from Candida auris in healthcare facilities, to influenza epidemic predicting in Sweden, and more. City Lab‘s Linda Poon underscores 1918/1919 flu as the mother of all pandemics, noting that “When the first wave crept up in New York City during the spring, residents and officials alike saw it as just another round of the seasonal flu. By mid-summer, the number of related deaths waned, and that first wave barely received a mention in the health department’s weekly bulletins. A century later, though, historians remember the 1918 Spanish flu as the ‘mother of all pandemics‘.”

FDA Plan – Antibiotic Development & Stewardship
The FDA has released their goals for supporting antimicrobial stewardship in veterinary settings for FY2019-2023. “‘We can’t count on outracing drug resistance,’ FDA Commissioner Scott Gottlieb, MD, said in announcing the strategy. ‘But we can use stewardship and science to slow its pace and reduce its impact on human and animal health.’ Noting the agency’s role in overseeing and regulating drug development, safety, and use, Gottlieb said the strategy aims to combat AMR by addressing the ‘full continuum’ of antibiotic development and use in both humans and animals. ‘Because of the FDA’s statutory responsibility for assuring safe and effective products that promote and protect both human and animal health, we have a unique vantage point for coordinating all of these aspects of a product’s development and application to health,’ Gottlieb said.” The FDA release includes several goals – align antimicrobial drug product use with the principles of antimicrobial stewardship, foster antimicrobial stewardship in veterinary settings, enhance monitoring of antimicrobial resistance and antimicrobial drug use in animals, etc. Pew Charitable Trusts also released updated information regarding the pipeline of antibiotic development – “Of the 42 antibiotics in development, 15 were in Phase 1 clinical trials, 12 in Phase 2, 11 in Phase 3, and four have had new drug applications submitted. Two drugs had been approved by the FDA since Pew’s last analysis. Historically, about 60 percent of drugs that enter Phase 3 will be approved. (See the glossary of terms for descriptions of each phase.)” You can also read some of the live Tweeting from the FDA/Pew event that discussed this report here (or by searching #FDAatPew).

DARPA- Defense Advanced Research Projects Agency 1958-2018
Check out where we’ve been and where we’re going with this overview of DARPA’s history and innovative future plans. The online magazine includes a reflection from former directors, a mosaic of warfare, inventions of new materials for national security, future plans, and the tactical edge. Don’t miss the section on page 102 regarding security and surprise at biological scales, which focuses on biotechnologies and the threat of outbreaks. Goals of halting a pandemic within 60 days are discussed within this section, as are the medical countermeasures and diagnostics of responding to biological threats.

 Blue Ribbon Study Panel Meeting – Fits and Starts: Reactionary Biodefense
The next Blue Ribbon Study Panel On Biodefense meeting is on October 9th at 10am. “The Panel will examine our national experience with the anthrax events of 2001, Hurricane Katrina, Ebola, a primate research laboratory, and the H1N1 pandemic, to answer the question – are we better positioned today to defend the nation against today’s biological threats?” The panel meeting will include a section on dealing with anthrax, preparedness for the future, dealign with dangerous diseases, etc. Make sure to RSVP before October 2nd here, or watch via the live webcast!

The Rise of Resistant Staphylococcus Epidermis 
GMU Biodefense doctoral student Saskia Popescu discusses why the increasing resistance of a common skin bug is raising concern. “Staphylococcus epidermidis is a skin bacteria that is so prevalent, the US Centers for Disease Control and Prevention (CDC) classifies it as a common commensal for certain health care-associated infections. Its presence can cause infections, especially in patients with invasive procedures and compromised immune systems; however, the bacteria often fail to get the kind of attention that would make headlines. The results of a new study may soon change the wallflower status of S epidermidis. The results of this study reveal not only the genomic mutations and different lineages that result in resistant S epidermidis, but also the global spread. Given that resistance to rifampicin encourages resistance to other antibiotics, these findings should be weighed seriously as we consider what bacteria are considered normal and often ignored.”

Stories You May Have Missed:

  • UK Monkeypox Healthcare Worker Exposure – A friendly reminder of why infection control is so important – “Because monkeypox was not immediately suspected in the most recent UK monkeypox case, healthcare workers (HCWs) were not wearing adequate personal protective equipment (PPE) and may have been exposed to the virus, UK officials reported today in Eurosurveillance. They also noted that the patient—the second recently reported by Public Health England (PHE), on Sep 11—had two potential exposures. The patient had contact with a person who had a “monkeypox-like rash,” and he also ate bush meat while visiting Nigeria. Nigeria has had 262 suspected and 113 confirmed monkeypox cases since September 2017.”
  • Navy Researchers Work to Reduce Risk of Melioidosis Among Deployed Military – “Dr. Kevin Schully, contractor and chief science officer with Naval Medical Research Center’s (NMRC) Austere environments Consortium for Enhanced Sepsis Outcomes Department (ACESO) recently returned stateside after screening Sailors and Marines deployed to Darwin, Australia, who are at risk of developing melioidosis. While in Darwin, Schully used a tool he developed with colleagues to continuously screen U.S. forces serving in B. pseudomallei endemic areas. He asked volunteers to fill out a brief questionnaire and give blood samples at the beginning of their deployment, mid-deployment, and again post-deployment. Each time, samples were screened for serological evidence of infection and then compared to the questionnaire responses to identify potential risk factors.”
  • Cyclospora Surges Linked to Tainted Produce – “The US Centers for Disease Control and Prevention (CDC) said yesterday that 2,173 lab-confirmed domestically acquired Cyclospora cases in 33 states were reported from May through August, markedly higher than the past 2 years, and that some of the illnesses reflect several restaurant clusters linked to contaminated basil and cilantro.”

Pandora Report: 9.14.2018

Happy Friday fellow biodefense gurus – we’re happy to have you read our weekly report on all things from anthrax to Zika.

George Mason Global Health Security Ambassadors Program
The Schar Biodefense program is excited to announce an opportunity for two current biodefense students (MS or PhD) to attend the  5th Annual Global Health Security Agenda (GHSA) Ministerial Meeting in Bali, Indonesia from November 6-8, 2018. The GHSA Ministerial Meeting provides an unparalleled opportunity to share experiences and engage in meaningful discussions on global health security with senior government officials from the GHSA member states and implementing partners from civil society and the private sector. One of the main goals of this year’s summit is to launch the GHSA 2024 Framework to guide GHSA members and partners in their collective effort to tackle current and future global health security issues. Therefore the theme of this year’s meeting is Advancing Global Partnerships. The two lucky biodefense students will participate in the meeting as members of a delegation representing the Next Generation Global Health Security Network which is led by Dr. Jamechia Hoyle. The Biodefense program is grateful to Dr. Hoyle and Dean of the Schar School, Mark Rozell, for providing this opportunity. If you’re interested in attending, please make sure to reference the email that was sent out on Friday as this opportunity is only available for current GMU Biodefense MS/PhD students. 

South Korean Man Infected With MERS
South Korea’s preparedness against MERS is being tested again as a man hospitalized in Seoul has tested positive for MERS following a trip to Kuwait. “‘As far as found by now, 20 people including flight attendants and medical staff have been in close contact with the patient and they are under isolation at home,’ KCDC director Jeong Eun-kyeong told a press briefing. The patient, who was suffering from diarrhea, headed directly to Samsung Medical Center from the airport, Jeong said. He is now in an isolation ward at Seoul National University Hospital. The KCDC director said all flights from Middle East countries have been put into quarantine. ‘The KCDC and local governments will do our best to prevent spread of the MERS,’ Jeong noted.” The last time South Korea experienced a MERS case, in 2015, a significant outbreak occurred due to poor infection control and hospital practices. A recent update found that the number of contacts was higher, at 21 people, all of whom are being monitored and are currently asymptomatic.

GMU Biodefense Master’s Open House
Next Thursday, September 20th, is your chance to learn about Schar School’s MS in Biodefense. Located in Arlington, this is a great chance to learn about the program requirements, curriculum, and how you can study biodefense online or in person! The session will provide an overview of our master’s degree programs, an introduction to our world-class faculty and research, and highlights of the many ways we position our students for success in the classroom and beyond. Our admissions and student services staff will be on hand to answer your questions.

Medical Countermeasures: Mission, Method, and Management
The latest issue of AJPH focuses on medical countermeasures (MCMs) and future innovations. “Medical countermeasures (MCMs) are critical for minimizing morbidity and mortality in the event of a large-scale public health emergency. MCMs involve a broad spectrum of medical assets, including biological products and personal protective equipment. Whether the emergency results from a chemical, biological, radiological, or natural disaster or from widespread infectious disease and contagions, a well-prepared public health community will readily access and deploy lifesaving MCMs. Ensuring appropriate distribution and dispensing of MCMs can be logistically complex, but coordinated planning between local, state, and federal agencies facilitates an efficient public health response.” The issue includes articles on MCM history, lessons learned by rapid deployment force 3, planning considerations, Taiwan’s annual seasonal flu mass vaccination program, etc.

ABSA International Call for Abstracts
“ABSA International announces the CALL FOR ABSTRACTS for posters for the USDA Agricultural Research Service (ARS) 5th International Biosafety & Biocontainment Symposium to be held February 11-14, 2019, in Baltimore, Maryland. We are anticipating over 200 attendees and over 30 vendors showcasing the latest biosafety and biocontainment products and services. ABSA International is pleased to offer funding support to help selected students and young professionals* (see definition at end of announcement) to attend the symposium. The selection will be made by a panel of judges who will evaluate the submitted abstracts and identify the top submissions. In addition, ABSA International/USDA ARS will present a Student and Young Professional Poster Award* and a Professional Poster Award for the best posters in the categories listed below. The awards will be announced during the reception on Wednesday, February 13th.”

Responding to Airline Outbreaks – A Hidden Safety Net
Helen Branswell lifts back the curtain on the hidden safety net we have regarding ports of entry and infectious diseases. The Emirates flight that was quarantined at NYC last week due to reports of 100 passengers becoming sick mid-flight, raised several questions regarding how we respond to such events. “The fact that a rapid and aggressive response involving a number of agencies and response teams could be pulled together so quickly is thanks to work that has been underway to build this safety net since the early 1990s. That’s when a seminal report from the Institute of Medicine — now called the National Academy of Medicine — issued a clarion call of the threat emerging infectious diseases posed to the U.S. Many such incidents happen over the course of any given year, but in most cases, the CDC does not get immediate word that someone who was on a plane had a disease such as active tuberculosis or measles. In those scenarios, the agency or its partners work to track down passengers who might have been at risk.” While the news of such events much be worrisome, it’s nice to know we have a strong response in place.

Releasing Genetically Modified Mosquitoes 
Africa will see its first release of GMO mosquitoes by researchers sometime this year or next, as the government of Burkina Faso granted permission for the experiment. “The release, which scientists are hoping to execute this month, will be the first time that any genetically engineered animal is released into the wild in Africa. While these particular mosquitoes won’t have any mutations related to malaria transmission, researchers are hoping their release, and the work that led up to it, will help improve the perception of the research and trust in the science among regulators and locals alike. It will also inform future releases. Teams in three African countries—Burkina Faso, Mali, and Uganda—are building the groundwork to eventually let loose “gene drive” mosquitoes, which would contain a mutation that would significantly and quickly reduce the mosquito population. Genetically engineered mosquitoes have already been released in places like Brazil and the Cayman Islands, though animals with gene drives have never been released in the wild.” Success isn’t just based off the scientific outcomes of the project, but also the consent of those living in the areas. 10,000 mosquitoes will be released and are not planned to have a lasting impact on the insect population as they have a “sterile male” mutation meaning that they are unable to procreate.

Skin Bacterium Gets Feisty With Antibiotics
Well, maybe not feisty, but the common skin commensal, Staphylococcus epidermis, has recently become resistant to almost all antibiotics and has spread around the world. “The researchers also found that some of the genetic mutations identified in these lineages confer resistance not only to an antibiotic called rifampicin but also to last-resort antibiotics such as vancomycin. Clinical guidelines often recommend co-administering both rifampicin and vancomycin for the treatment of Staphylococcus infections to prevent the development of drug resistance. But the authors’ findings suggest that the combination may instead fuel resistance in S. epidermidis.”

Stories You May Have Missed:

  • Bionic Bug Podcast with Natasha Bajema – Looking for a new podcast where fiction meets reality? Check out Dr. Natasha Bajema’s podcast on the latest tech news. The most recent episodes (19 & 20) discuss gene drive, mosquitoes, exoskeletons, and artificial intelligence!

Pandora Report: 9.7.2018

This was a pretty busy week in the world of global health security, so we’ll start with something that’s supposed to be relaxing – a CW coloring book?  Look no further than the OPCW one that explains the importance of the OPCW and the elimination of chemical weapons, which is available here! We’re also watching the latest Amazon show, Jack Ryan, which might just have an infectious disease/biological weapon event in the plot….

 GMU Biodefense Master’s and PhD Open Houses
Don’t miss out on the chance to chat with faculty and students about the Schar Biodefense graduate programs. The GMU Schar PhD Open House is next Wednesday (9/12) at 7pm in Arlington and is a great way to learn about the doctoral process and why our PhD students are the ultimate biodefense nerds. The next Master’s Open House is on September 20th at 7pm and is a great way to learn about the in-person and online biodefense MS program. These are informative opportunities to learn about expanding your biodefense knowledge through graduate school and provides wonderful insight into why our program is the place for all things health security, from anthrax to Zika.

Suspects Identified in Salisbury Novichok Attack 
This week, Prime Minister Theresa May reported that two members of the Russian military intelligence (GRU) were considered responsible for carrying out the attack in March. Sufficient evidence has been found to name the GRU members- Alexander Petrov and Russian Boshirov. May noted that “The GRU is a highly disciplined organization with a well-established chain of command, so this was not a rogue operation, it was almost certainly also approved outside the GRU at a senior level of the Russian state.” Following this announcement, Russia has been under heavy scrutiny from the international community. The United States, Canada, France, and Germany, joined in supporting the UK, urging “Russia to disclose in full its novichok programme. The case against Moscow laid out on Wednesday by the UK ‘further strengthens our intent to continue to disrupt together the hostile activities of foreign intelligence networks on our territories’, they said. One notable European country was missing from the declaration supporting the UK: Italy.” Foreign Policy‘s Mark Galeotti notes that “Although Russia’s various security services (and its other instruments of geopolitical struggle against the West) are granted considerable operational autonomy, major operations with potentially serious international implications need a green light from the Kremlin. Besides, there have been none of the usual indications—from mysterious resignations to well-sourced and damning leaks—which usually show that an individual or agency overstepped the mark. Whether Putin instigated the attack or, more likely, simply approved it, it was surely a state operation.”

Tackling Antimicrobial Resistance
This week two important articles were run on the battle of the resistant bug. The first was an article in the Lancet Planet Health, that evaluated the anthropological and socioeconomic factors that facilitate antimicrobial resistance. Pulling from several sources, researchers sought to understand the elements that contribute to global AMR – from prescribing habits to contributing factors like governance, education, GDP, healthcare-spending, community infrastructure, corruption, etc. “In the univariate analysis, GDP per capita, education, infrastructure, public health-care spending, and antibiotic consumption were all inversely correlated with the two antimicrobial resistance indices, whereas higher temperatures, poorer governance, and the ratio of private to public health expenditure were positively correlated. In the multivariable regression analysis (confined to the 73 countries for which antibiotic consumption data were available) considering the effect of changes in indices on E coli resistance (R2 0·54) and aggregate resistance (R2 0·75), better infrastructure (p=0·014 and p=0·0052) and better governance (p=0·025 and p<0·0001) were associated with lower antimicrobial resistance indices. Antibiotic consumption was not significantly associated with either antimicrobial resistance index in the multivariable analysis (p=0·64 and p=0·070).” Their findings underscore the obvious importance of antimicrobial stewardship, but ultimately the socioeconomic and cultural factors that encourage the transmission of these resistant infections. Better regulation in the private healthcare sector, improving sanitation, increasing access to clean water, etc., are all things that impact antimicrobial resistance on a global scale. A new article by NPR’s Richard Harris, looked to the predatory bacteria that might be harnessed to “eat” the bad bacteria causing resistant infections. “They’re even living inside us, but at levels so low that they aren’t effectively battling back against dangerous germs. DARPA has been funding research to see if these predatory bacteria can be harnessed as our allies. ‘It’s been very exciting,’ Ringeisen says, as this exploratory phase of research is gradually coming to a successful conclusion.Lab studies that his agency has funded show that the predatory bacteria will attack all sorts of nasties, including bacterial lung infections, the plague and deadly germs that have developed resistance to antibiotics. And the star of this show is an organism called Bdellovibrio, a bacterium that swims around with the aid of a corkscrew tail, and attacks common germs six times its size.”

Blue Ribbon Study Panel on Biodefense – Fits and Starts: Reactionary Biodefense
The next Blue Ribbon Study Panel event will be on Tuesday, October 9th from 10am-3:30pm at the Hudson Institute in Washington, D.C. The meeting will “reexamine the anthrax events of 2001 and other biological events that have occurred in the years since. We want to know where things stand now and how we can better defend the nation against biological threats. Former Senate Majority Leader Tom Daschle will talk about his personal experience with the 2001 anthrax attacks. Among the academic, law enforcement, media, industry, and governmental experts joining us that day are: Dr. Sheri Fink – correspondent, New York Times, and author, Five Days at Memorial: Life and Death in a Storm-Ravaged Hospital; Dr. Scott Lillibridge – Founding Director, Bioterrorism Preparedness Program, Centers for Disease Control and Prevention; Dr. Tara O’Toole – former DHS Under Secretary for Science and Technology; andRear Admiral Stephen Redd – Director, Office of Public Health Preparedness and Response, Centers for Disease Control and Prevention.”

International Flight Quarantined in New York
On Wednesday, there was considerable excitement surrounding a plane that landed from Dubai at JFK International Airport. In mid-air, a reported 100 people became sick, complaining of unknown illness. Following air traffic control notification by the pilots, the plane was met with officials from the CDC to collect information and evaluate symptoms. On Thursday it has been reported that the majority of those sick during the flight were experiencing influenza and other common respiratory illnesses. Perhaps the most entertaining part for those of us watching it unfold was the presence of one 90’s musician – Vanilla Ice. Indeed, the rapper was onboard and quickly became a source for news as he live-tweeted the event. In the words of Global Biodefense‘s Stephanie Lizotte, “Contaminate and glisten”.

Food Insecurity as a Security Challenge
The Center for Strategic and International Studies will be hosting this event on Monday, September 17th, from 6-7pm. “Please join the Center for Strategic and International Studies for a Smart Women, Smart Power conversation with Ambassador Ertharin Cousin. She will discuss global food insecurity and hunger and the role they play in other security issues, including violent extremism.” The discussion will be moderated by Nina Easton, Senior Associate at CSIS and Chair of the Fortune for Powerful Women International. You can register here.

Securing the U.S. From Its Most Dangerous Invader – Infectious Disease
Ashley Arabasadi of STAT news discusses why the United States has a pivotal role in global health security and that the latest Ebola outbreak in the DRC is a not-so-gentle reminder of this. Preventing a pandemic is costly though, so where do we start? “First, it’s imperative to continue funding the overseas operations of the Centers for Disease Control and Prevention. These investments help conduct disease surveillance of human and animal populations, which is vital in the low-income countries where the next deadly virus is likely to originate. CDC operations also include training frontline health workers, improving laboratory testing for faster detection, and building efficient reporting systems so disease outbreaks can be caught early and at the source, all vital elements in preventing epidemics and responding to them.” Arabasadi also underscores the importance of supporting global health efforts like USAID, the GHSA, and ultimately establishing a “well-funded, centralized coordinating body for global health security”.

Women Building Bio Conference 
The 2018 Women Building Bio Conference will take place on October 17th, from 7:30am-4:30pm at the Inova Center for Personalized Health in Fairfax, VA. “Challenge new ideas. Discover cutting-edge innovations. Revolutionize best practices. Build a powerful community of collaboration. Women Building Bio is where the vision is transformed into reality. Women advancing the industry with all stakeholders, men and women, front and center joining forces. Come join us for the Third Annual Women Building Bio October 17 at the Inova Center for Personalized Health. Be a part of the vision with Thought Leaders and Change Agents steering the Industry. This is a one-day regional conference converging extraordinary men and women, industry and academia, researchers and innovators, professionals and decision-makers gathering together to cultivate relationships and making an impact.”

Super-Resistant Gonorrhea On the Horizon
Just like a resistant infection, the AMR news isn’t over…the reports of a highly resistant gonorrhea (resistant to both azithromycin and ceftriaxone) swept across the globe earlier this year. Resistant to several other antimicrobials, this case was considered the first reported super-resistant gonorrhea. “It certainly won’t be the last. In the following months, two similar cases would be reported in Australia. Ultimately, the British man’s infection was cured. But not until the patient had received 3 days of intravenous (IV) treatment with ertapenem, a ‘last-resort’ antibiotic normally reserved for severe, life-threatening infections and not intended for garden-variety sexually transmitted diseases (STDs).” Such medical interventions are extremely costly, resource intensive, and prone to issues with patient compliance for those lost to follow-up. The painful truth is that this super-resistant gonorrhea will become more common and a norm. “And that’s where the certainty ends. Because after that happens, a disease that effects 78 million people globally—and has mostly been an unpleasant nuisance since the discovery of antibiotics—will no longer have any known effective antibiotics to treat it. As was seen in the UK case, clinicians may have some weapons in their arsenal for treatment of individual cases, but those options aren’t ideal, nor have they been extensively studied. And new antibiotics for gonorrhea are, at best, still a few years away.”

Stories You May Have Missed:

  • Modernizing the National Disaster Medicine System to Meet the Health Security Threats of the 21st Century – Get the latest from the ASPR blog regarding the NDMS. “In 2017, our nation suffered three back-to-back hurricanes that caused catastrophic damage in Florida, Texas, Puerto Rico, and the U.S. Virgin Islands. That experience highlighted the importance of the National Disaster Medical System (NDMS) – a federally coordinated system that augments the Nation’s medical response capability during times of disasters or public health emergencies. ASPR, the government agency overseeing NDMS, deployed more than 4,600 personnel and 944 tons of medical supplies and equipment to treat approximately 40,200 patients affected by the hurricanes.”
  • Still looking for biodefense news? Check out our Twitter account @PandoraReport

Pandora Report: 8.31.2018

As the summer winds down, here’s a new podcast series on biohacking to get you back into the swing of things or over the holiday weekend.

NASEM Lunch Series on Biodefense and Biosecurity
Did you miss this event hosted by the National Academies on August 21st? We’ve got you covered with two GMU Biodefense student summaries of the talks. Carlos Alvarado writes that “a key point in these slides were to remember that as technology and science advances, so do the potential threats. Dr. Berger used examples of research, development, institutions, applications, and countries as the driving factors of influencing advances on science and technology. Dr. Berger also illustrated how these factors are constantly changing and shifting the biotechnology landscape. An example that was used is how engineering, biology, chemistry, and even health and safety, are a wide variety of disciplines that are growing within the biotechnology realm and that it is no longer just a single discipline of biology. ” Next, Justin Hart noted that “The researchers used a systems-based approach to looking at biosecurity policy in the United States, and considered factors like changes in the structure of organizations with policy responsibility, such as the Department of Homeland Security’s Science and Technology Directorate, the advent of the Congressional Biodefense Caucus, and the development of the forthcoming national health security policy and biodefense strategy. Using these, a review of pertinent regulation, and other factors, they built a basic understanding of all of the prior and existing biodefense policies, discovering that many were reactionary in nature. From this they developed key questions and a roadmap to address such questions as, ‘How can we implement a national biodefense policy with the most relevant emerging technologies, while addressing the real and tangible associated risks?'”

The Hajj is A Perfect Lab for Testing Syndromic Surveillance Systems
Maryn McKenna points to the hajj pilgrimage, one of the largest mass gathering in the world, as a potential for testing an early warning system for infectious diseases. Syndromic surveillance is a tool public health utilizes to pick up the first signs of an outbreak before it boils over, and in the case of field testing it, the hajj would be the perfect setting. “Syndromic surveillance systems, as they’re called, aren’t perfect; they’ve rung false alarms before. But Saudi Arabia’s willingness to create one doesn’t just signal an awareness of disease risks. It also indicates new transparency from a government that has been less than forthcoming about diseases in the past. If that transparency continues, it could create a rich data source for public health officials to predict the risks of gatherings to come.” The influx of people, close quarters, shared food and drink, and close contact that occurs during such an event is a perfect environment for an outbreak, which is why the Saudi Ministry of Health requires vaccinations for people (meningitis, flu, yellow fever, and polio). “The new system created by the Saudi health ministry and the WHO’s eastern Mediterranean region aims to boost the kingdom’s own infrastructure by installing an extra—and extra-sensitive—apparatus for the detection of diseases. It pings an alarm at the government’s public health command center for the hajj, based on automated sifting through medical records from hospitals and clinics.”

China Withholds H7N9 Avian Flu Samples
Sharing samples of strains that pop up around the world is a pivotal part of public health and infectious disease response. Unfortunately, for over a year, Chinese officials have been holding onto lab samples of the deadly avian influenza strain H7N9. “Despite persistent requests from government officials and research institutions, China has not provided samples of the dangerous virus, a type of bird flu called H7N9. In the past, such exchanges have been mostly routine under rules established by the World Health Organization. Now, as the United States and China spar over trade, some scientists worry that the vital exchange of medical supplies and information could slow, hampering preparedness for the next biological threat.” In terms of withholding samples, this is similar to what occurred in 2008, in which the Indonesian officials withheld H5N1 influenza samples. Such actions go against an international agreement established by the WHO to share influenza samples in efforts for pandemic preparedness. When asked about the reason for withholding the samples, “the Chinese embassy in Washington did not respond to multiple requests for comment. The Chinese Center For Disease Control and Prevention also did not reply to inquiries regarding the transfer.”

DRC Ebola Virus Disease Outbreak
The latest counts list a single new infection confirmed in the DRC, which brings the outbreak to 112 people, 84 of whom are confirmed. 3,714 contacts have been registered and 1,219 follow-ups have been completed. “On Twitter yesterday, Peter Salama, MD, the WHO’s director-general of emergency preparedness and response, said the majority of new cases are from known contact lists and most are still confined to an area within 20 kilometers (km) to 30 km of the outbreak’s epicenter. However, if responders can’t turn the outbreak around over the next 7 to 10 days, the risk of the disease spreading to more dangerous conflict-ridden areas becomes greater, posing more difficult challenges for health teams.

 The Scary Link Between Resistant E. coli in Poultry and UTIs
The threat of antimicrobial resistance is a lot bigger than people realize. For many, resistance is only a product of prescription antibiotics, but it’s much broader and more sinister that that. A new study underscores the One Health aspects of antimicrobial stewardship and how even resistant bacteria in poultry can cause urinary tract infections in people. “After analyzing thousands of E coli samples from retail meat products and human urine and blood samples collected over the course of a year in a single town, the researchers concluded that E coli ST131-H22, a sublineage of a pandemic, multidrug-resistant E colistrain that has caused serious UTIs worldwide, is prevalent in chicken and turkeys meat and could be responsible for a small percentage of human UTIs. ‘Our results suggest that one ST131 sublineage—ST131-H22—has become established in poultry populations around the world and that meat may serve as a vehicle for human exposure and infection,’ the authors wrote.” If you want to learn more about the link between poultry and antimicrobial resistance, check out Maryn McKenna’s wonderful book on how the use of antibiotics became a norm within the poultry world.

STIs On the Rise
Bad news: sexually-transmitted infections (STIs) are on the rise within the United States. “Nearly 2.3 million cases of chlamydia, gonorrhea, and syphilis were diagnosed in the United States in 2017, according to preliminary data released today by the Centers for Disease Control and Prevention (CDC) at the National STD Prevention Conference in Washington, D.C. This surpassed the previous record set in 2016 by more than 200,000 cases and marked the fourth consecutive year of sharp increases in these sexually transmitted diseases (STDs).” The CDC reports that since 2013, there has been a 67% increase in gonorrhea, primary and secondary syphilis diagnoses have increased by 76%, and chlamydia has remained the most common condition reported. Not only is this news concerning for control efforts, but the three STIs on the rise are treated with antibiotics, which creates new concerns for antimicrobial resistance.

Stories You May Have Missed:

  • The History of Quinine – If you’re a lover of history and infectious diseases, make sure to check out this delightful history on the anti-malarial medication, quinine. “Quinine is an alkaloid extracted from the bark of the Cinchona, or ’fever’ tree (Cinchona spp.) and if you’ve ever had a gin and tonic, you will be familiar with the bitter taste of the tonic which is provided by quinine. While it is now mainly used to add a flavour to the nation’s favourite tipple, the Cinchona tree bark once held a place as one of the most important drugs in history.”