Biodefense Policy Seminar: “Health Threats in a Security World”

Alexander Garza, MD, MPH, FACEPApril Seminar: ”Health Threats in a Security World”
Speaker: Dr. Alexander Garza
When: 7:20PM, Thursday April 18th, 2013
Where: Meese Conference Room, Mason Hall, George Mason University

The Biodefense Policy Seminar is  the D.C. area’s premiere speaker series focused on biodefense and biosecurity issues. The monthly seminars – free and open to the public – feature leading figures within the academic, security, industry, and policy fields of biodefense.

About the Speaker: Dr. Alexander Garza is the Assistant Secretary for Health Affairs and Chief Medical Officer of the Department of Homeland Security. He manages the Department’s medical and health security matters, oversees the health aspects of contingency planning for all chemical, biological, radiological and nuclear hazards, and leads a coordinated effort to ensure that the Department is prepared to respond to biological and chemical weapons of mass destruction. Prior to joining the Department in August 2009, Dr. Garza spent 13 years as a practicing physician and medical educator.

Refreshments will be available!

The Pandora Report

Highlights include the H7N9 update, funding for the NBAF, using flight patterns to stop pandemics, North Korean biosurveillance, and why biotech companies matter. Happy Friday!

North Korean bioweapons are coming for us all (Credit: Karl Baron)

Report on 3 in China Who Died From Bird Flu Points to Severity of Strain

Update: 43 cases, 10 fatalities

H7N9 continues apace in China, with the total number of cases up to 43. The virus is especially difficult to track because birds are asymptomatic carriers. While the number of laboratory-confirmed cases is closely monitored, it’s possible there are many more human cases going unnoticed due to a milder disease presentation. Still, there have been no confirmed cases of person-to-person transmission, and scientists in the US have just received the first batch of the virus, and are working on developing a diagnostic.

New York Times – “A report on three of the first patients in China to contract a new strain of bird flu paints a grim portrait of severe pneumonia, septic shock and other complications that damaged the brain, kidney and other organs. All three died…During a telephone news briefing on Thursday, Nancy J. Cox, of the influenza division at the Centers for Disease Control and Prevention, said that several features of H7N9 were particularly troubling: it causes severe disease, it has genetic traits that help it infect mammals and humans probably have no resistance to it.”

Obama proposes $714M for Kansas biodefense project

The National Bio- and Agro-Defense Facility has received the strongest funding endorsement to date from the Obama Administration, with $714 million included for the lab in the President’s FY2014 budget. The lab is slated to replace Plum Island as the nation’s premier   research center on agricultural pathogens.

Wall Street Journal – “Republican Sen. Pat Roberts of Kansas said the recommendation signals the administration’s support for building the $1.15 billion lab, which will study large animal diseases and develop measures to protect the nation’s food supply…Roberts said the proposal will require additional financial commitments from Kansas, which will be worked out by Republican Gov. Sam Brownback and legislators…Kansas agreed when it was awarded the project to contribute 20 percent of the cost of construction. Thus far, the state has issued $105 million in bonds and $35 million from the Kansas Bioscience Authority.”

New tool to identify air travelers with infectious disease developed

Researchers in Toronto, after studying the 2009 H1N1 pandemic, developed basic guidelines for passenger screenings during a pandemic. The results are relatively intuitive – screening passengers as they leave a region in which the pathogen is spreading is more useful than screening them upon arrival at their final destination.

Medical News – “Dr. Khan used his experience analyzing air traffic patterns to review the flights of the nearly 600,000 people who flew out of Mexico in May 2009, the start of the H1N1 pandemic. He found that exit screening would have caused the least disruption to international air traffic. In fact, all air travelers at risk of H1N1 infection could have been assessed as they left one of Mexico’s 36 international airports. Exit screening at just six airports in Mexico coupled with entry screening at two airports in Asia (Shanghai and Tokyo) would have allowed for screening of about 90 per cent of the at-risk travelers worldwide.”

APG working on biosurveillance in response to North Korea threats

Anything that is related to biological warfare and is also called the Kracken is automatically included in the Pandora Report. Here, the Kracken is a 15ft high thermal, acoustic, and infrared sensor.

Baltimore Sun – “While the danger of missiles is more pressing, Army officials said developing better capabilities to detect biological warfare threats has also been a priority for the past six years. The Joint Program Executive Office for Chemical and Biological Defense is working with APG’s Edgewood Chemical Biological Center on the program, which is called the Joint United States Forces Korea Portal and Integrated Threat Recognition, or JUPITR. The program will also serve to detect naturally occurring biological threats. A key part of the program is the Kraken, which Army officials described as ‘a massive, multifunctional, all-seeing sensor suite designed to rapidly establish a defensive perimeter.'”

Funding Issues Stymie Pandemic Preparation

Collaboration between the biotech industry and the US government has been notoriously difficult, starting with the threat of breaking Bayer’s patent on Cipro during the Amerithrax attacks and continuing into today. While relations have improved, and the hurdles to a successful working relationship are significant, we can’t afford to not work on this.

Genetic Engingeering and Biotechnology News – “Despite product success Acambis has had a bumpy ride with its funding. ‘Any biotech that believes developing products to serve public health emergencies is access to easy money needs to think again,’ Dr. Lewin cautioned. ‘Collaborating with the U.S. government is different from working in the biotech world. You have to produce a proposal for the government to digest, a cost of around $400,000, and if you don’t get the contract that’s all money down the drain.'”

Image of the Week

This week’s image come via Microbiology and Immunology, and is of cell lytic enzymes attached to nanoparticles, which are then used to kill listeria!

“Fighting Listeria with Nanobiotechnology: Using nature as their inspiration, the researchers successfully attached cell lytic enzymes to food-safe silica nanoparticles, and created a coating with the demonstrated ability to selectively kill listeria—a dangerous foodborne bacteria that causes an estimated 500 deaths every year in the United States. The coating kills listeria on contact, even at high concentrations, within a few minutes without affecting other bacteria. The lytic enzymes can also be attached to starch nanoparticles commonly used in food packaging.”

Read more here.

The Pandora Report

Highlights include H7N9, China’s SARS lessons, H5N1, the seminal UN global arms treaty, bird flu bureaucracy, and the problems with the term “WMD”. Happy Friday!

H7N9 Update: 14 cases, five fatalities, no evidence of person-to-person transmission

(image credit: Matt Karp)
(image credit: Matt Karp)

Scientists race to gauge pandemic risk of new bird flu

We’re keeping a very close eye on news about the H7N9 avian flu strain emerging from China. To date there have been fourteen cases with five fatalities.   Unlike the H5N1 strain of avian influenza, this is the first time we’re seeing H7N9 in humans. It’s pandemic potential is still considered low due to its current inability to transmit person-to-person. However, although there have been no confirmed cases of person-to-person transmission, it’s been reported that a person caring for one of the people who died of H7N9 has since developed similar, flu-like symptoms.

Reuters – “Genetic sequence data on a deadly strain of bird flu previously unknown in people show the virus has already acquired some mutations that might make it more likely to cause a human pandemic, scientists say. But there is no evidence so far that the H7N9 flu – now known to have infected nine people in China, killing three – is spreading from person to person, and there is still a chance it might peter out and never fully mutate into a human form of flu.”

Ten years after SARS, what has China learned?

The short answer? It depends on whom you ask. China has improved its communication with the international and scientific community. However, there have been complaints about the lack of clear communication by the Chinese government with its own people, particularly at the time of the virus’ original emergence.

Xinhua – “The news of two men dying from a new variant of bird flu has reminded Chinese of the SARS pandemic that hit the country one decade ago. Many are wondering if the government will handle the situation any better than it did in 2003, should another pandemic break out…Now, on the 10th anniversary of the pandemic, fear is spreading following reports of two Shanghai men who died from H7N9 avian influenza, a strain that has not previously been detected in humans. That fear was aggravated this week after four more patients in neighboring Jiangsu Province were confirmed to have contracted the virus. All four are in critical condition.”

Cambodia reports 10th bird flu case this year

In all the chatter about H7N9, H5N1 seems almost tame. While it may seem high, ten cases in four months is in keeping with expected numbers.

Xinhua – “A six-year-old boy from Southwestern Kampot province was confirmed to have contracted with Avian Influenza H5N1, bringing the number of the cases to 10 and the death toll remained at eight in 2013, a health expert said Wednesday. ‘The boy was admitted to the Kantha Bopha Hospital in Phnom Penh on March 31 for severe pneumonia, and he was tested positive for H5N1 at the Instituts Pasteur on Tuesday,’ Dr. Denis Laurent, deputy director of the hospital, told Xinhua.’The boy is still alive, but in severe conditions (sic).”

UN general assembly passes first global arms treaty

Including everything from battle tanks to light weapons, this is the first UN treaty “aimed at controlling the trade in conventional weapons”, and prohibits the sale of conventional weapons to state in violation of arms embargoes, in support of terrorism, war crimes, genocide, or in use against civilians (it doesn’t regulate domestic sales of arms).

The Guardian – “The United Nations…vot[ed] it through by a large majority despite earlier being blocked by three countries. Member states represented in the UN general assembly voted by 154 to three, with 23 abstentions, to control a trade worth an estimated £46bn a year. The landmark deal went to a vote after Syria, Iran and North Korea – all at odds with the US – blocked its adoption by consensus….It is expected to come into force after the first 50 ratifications next year”

Clinical Notes: Bird Flu Vaccine Delayed at FDA

It’s been an avian-themed report. This piece included in commiseration with of all of us just now getting around to taxes – filing paperwork appropriately with the government is apparently as important for billion-dollar corporations as it is for the rest of us.

MedPage – “GlaxoSmithKline’s (GSK) human vaccine against H5N1 avian influenza did not win approval from the FDA, but only on technical grounds that should not keep it off the market for long, the company said. Called Q-Pan H5N1, the product is meant to be stockpiled in case the H5N1 virus becomes capable of causing a pandemic. It received a unanimous endorsement from an FDA advisory committee last November. Nevertheless, GSK said last week that it had received a so-called complete response letter from the agency, indicating that approval was not immediately forthcoming. The company said it was ‘triggered due to an administrative matter that has recently been rectified.'”

Soapbox we love: Let’s All Stop Saying ‘Weapons of Mass Destruction’ Forever

The title says it all. It was arguably too broad when it was just chemical, biological, radiological (mass destruction? a rad bomb? really?) and nuclear, and it seems to only be getting broader.

Wired – “In fact, as a fascinating paper by W. Seth Carus at the National Defense University shows, the Defense Department’s definition of the term has long been problematic. For years, its official definition included ‘high explosives,’ to make it consistent with the federal statute that Harroun ran up against. But ‘most military weaponry relies on high explosive charges,” Carus writes, ‘meaning that even the mortars and grenades used by infantrymen might qualify as WMD.’ The doctrinal answer was ultimately to limit the definition to “chemical, biological, radiological and nuclear weapons capable of a high order of destruction or causing mass casualties.”

Image of the Week: Monocyte Astronauts

This week’s image falls within one of our favorite topics here at GMU Biodefense – cells in space.

Actin_and_vinculin_in_adherent_monocyte

The picture, titled “Goldfinger” due to the placement of the immune cells on gold-coated slides, depicts monoctyes in zero gravity.  Monocytes are critical immune defenders, helping fight off bacteria and viruses.

For more information on the image, check out the European Space Agency site.

(Image credit: ESA/MIA G.Pani)

This Week in DC: Events

Roundup of the week’s most interesting (and free) international security, science & technology, and health events.

DC EventsTuesday, April 2nd

Middle East Turmoil and American Decline: Views from Singapore and Asia
Middle East Institute
12:00PM – 1:00PM

The relationships between the Middle East and maritime Asia are becoming ever more extensive. Against the backdrop of this deepening cross-regional interdependence with Asian economies and middle classes expanding rapidly, the Arab Middle East is grappling with profound political changes and challenges, and the United States is engaged in strategic “rebalancing.” Dr. Michael Hudson will discuss how the political upheaval in the Middle East and US involvement in the Arab world are viewed in Singapore and, more broadly, in maritime Asia.

Wednesday, April 3rd

NATO’s European Allies: Military Capability and Political Will
SAIS
10:00 – 11:30AM

At a time when Europe really has to lead in its own region, is it able to do? This is the first in-depth analysis of this key question for the transatlantic relationship. Janne Haaland Matlary, professor in the Department of Political Science at University of Oslo in Norway and co-editor of NATO’s European Allies: Military Capability and Political Will, will discuss this topic.

Russian Security and Defense Policy: Why Russia Is Not Stuck in the Cold War and Why That Is a Problem
SIAS
12:30 – 1:45PM

Celeste Wallander, associate professor and director of the International Politics Program at American University’s School of International Service and former U.S. deputy assistant secretary of Defense for Russia/Ukraine/Eurasia in the Office of the Under Secretary of Defense for Policy, will discuss this topic.Note: Attendees are welcome to bring their lunch to the event.

Thursday, April 4th

Mitigating the National Security Impact of Cost Cutting: How to Ensure Innovation & Development in Lean Times
Ronald Reagan Building (hosted by Government Executive)
7:30AM – 9:30AM

Ever increasing global threats coupled with the financial constraints our nation is addressing make it imperative that agencies and private sector stakeholders have the resources and path forward for a critical component to ensuring National Security. Join Nextgov and INSA on April 4th and hear from key leadership at IARPA, DIA, and the Applied Research Laboratory, Penn State University who will address these issues and more

U.S. Foreign Policy: The Next Four Years
George Washington University
6:00PM – 7:15PM

Panel discussion

Friday, April 5th

U.S. Policy Priorities for Global Health Diplomacy and Multilateral Engagement in the Second Obama Term
Center for Strategic and International Studies
10:30AM – 12:00PM

During the first Obama term, global health diplomacy took on elevated importance as a U.S. foreign policy objective. Both the Department of State and the Department of Health and Human Services appear poised to continue to raise the diplomatic profile of global health during the second Obama term. Over the next year, U.S. diplomats will be challenged to help ensure: smooth, sufficient replenishments of the GAVI Alliance, the World Bank International Development Association, and the Global Fund to Fight AIDS, Tuberculosis and Malaria; the articulation of a robust set of goals to advance the post-2015 Millennium Development agenda; and mutually beneficial relationships with emerging powers, many of which are active global health actors. This session will feature a lively discussion with high-level officials and experts from inside and outside the U.S. government.

The Pandora Report

Highlights include H5N1: to mutate or not to mutate, the Galveston Lab we’ve all shaken our heads at this week (we all lose a vial of virus sometimes), the UK stepping-up its bioterror prevention, the new foot-and-mouth vaccine (cloven-hoofed animals matter too – a lot, actually), antibiotic-resistant jumping from farm animals to us, and what may soon be a mumps outbreak in Richmond. Happy Friday!

short-tailed cane mouse aka Guanarito target #1
short-tailed cane mouse aka Guanarito target #1

H5N1 viral-engineering dangers will not go away

Technically we tweeted this story on Wednesday, but it presented such a nice summation against the gain-of-function research that we wanted to include it here. Not because we agree, but because the points are coherent and well-argued.

Nature – “Rather than use the avian flu moratorium to seek advice, listen and foster debate, many influenza scientists engaged in an academic exercise of self-justification. There was a single large open meeting, at the Royal Society in London, which engaged a wider audience, including bioethicists. The recent calling off of the moratorium by 40 flu researchers alone — not funders, governments or international bodies — says it all. The flu community simply hasn’t understood that this is a hot-button issue that will not go away.”

Texas Biolab Loses Deadly Virus

Before everyone freaks out, it’s only Guanarito virus – yes, losing a vial of any virus from a BSL-4 lab is not great, and yes, if you’re going to lose a vial of something, it would be better if it didn’t cause hemorrhagic fever, but 1) Guanarito virus’ natural host is thought to be  Venezuelan “short-tailed cane” mice, 2) it doesn’t replicate in US rodents, and 3) it’s not transmissible person-to-person.  And before we start a heated discussion about the disturbingly impressive ability of viruses to evolve and adapt to new hosts, 4) the vial in question is thought to have been destroyed internally.

ABC News – “The Galveston National Laboratory lost one of five vials containing a deadly Venezuelan virus, according to the University of Texas Medical Branch, which owns the $174 million facility designed with the strictest security measures to hold the deadliest viruses in the country. Like Ebola, the missing Guanarito virus causes hemorrhagic fever, an illness named for “bleeding under the skin, in internal organs or from body orifices like the mouth, eyes, or ears,” according to the Centers for Disease Control and Prevention.”

UK: Biological attacks ‘getting easier for terrorists’

Intelligence officials in the United Kingdom have prioritized the fight against bioterrorism, using lessons from the 2012 London Olympics to inform their revamped strategy.

The Telegraph – “Charles Farr, the Director of the Office for Security and Counter-Terrorism [in the United Kingdom], said that extremists have ever greater access to the information and technology required to create and spread germ agents or other biological weapons…Factors facilitating such attacks include the availability of formulae and other information on the internet; increasing teaching of biological sciences at universities, and ‘greater availability of technology,’ he said. Mr Farr, a former MI6 officer, declined to give further details of the threat, but the Home Office report hints at a range of new precautions.

Scientists develop new foot and mouth vaccine

Foot-and-mouth disease is like the be-all-end-all of animal diseases – it’s tremendously infectious, has a high mortality rate, and because we don’t vaccinate (for trade reasons – when you vaccinate an animal, when that animal is later tested for FMD it’s impossible to tell whether it has the antibodies because it was vaccinated or because it actually had the disease – if the latter, no one wants to eat it), the disease would spread like wildfire. Also, current policy dictates “containment” (read: mass culling) rather than “treatment”, which means mountains of burning carcasses. Very scary and very possible.

The Guardian – “Scientists have developed a new kind of vaccine that could prevent devastating outbreaks of foot and mouth disease among livestock. The “synthetic” vaccine was created by taking protein shells that encase the virus and strengthening them, so the vaccine can be used in warm countries without refrigeration. The technique overcomes major shortcomings of existing foot and mouth vaccines, which are made with live virus. The infectious risk means the conventional vaccine must be produced in high containment facilities, which are costly to build and maintain. Vaccines made from the live virus are also fragile, and degrade unless they are kept cool.”

Study Shows Bacteria Moves From Animals to Humans

Bessie the cow might just be another weapon in the arsenal of the superbug. This possibility is especially disturbing given our ongoing difficulties countering antibiotic-resistant bacteria we make ourselves.

The New York Times – “A new study used genetic sequencing to establish that a strain of antibiotic-resistant bacteria has been transmitted from farm animals to people, a connection that the food industry has long disputed. Representative Louise M. Slaughter, Democrat of New York, said the study by researchers in Britain and Denmark, which drew on data from two small farms in Denmark, ‘ends any debate’ about whether giving antibiotics to livestock is a risk to humans”

LOCAL: Mumps virus infiltrates Richmond, VA campus

Before this launches a debate about the importance of vaccination, all but just six students on the Richmond campus have had  the MMR vaccine. What this illustrates instead is that no vaccine is 100% efficacious in every instance (MMR is approximately 95%).

The Collegian – “As of Tuesday, 15 cases of mumps have been confirmed on campus, said Dr. Lynne Deane, the director of the Student Health Center. Mumps is a communicable viral illness and typically carries symptoms like fever, head and body aches, tiredness and swollen or tender glands in the jaw, according to the Virginia Department of Health (VDH) Web site.Tests administered to other students are still being processed, she said. In total, 39 students have been tested for the virus since January, Deane said…The cluster of mumps outbreaks has not been limited to Richmond. Loyola University, Maryland, has seen at least 12 cases of mumps arise in the past month, according to CBS news Baltimore.”

Biodefense Faculty Member Charles Blair on Syria

(originally published in the Bulletin of the Atomic Scientists)

The thin red line

By Charles P. Blair and Mila Johns| 26 March 2013

Article Highlights

  • An attack on the village of Khan al-Assal is the latest in a number of incidents during which the use of chemical weapons has been claimed by either, or both, sides of the Syrian civil war.
  • In reporting chemical attacks, citizen journalists have apparently conflated lethal and non-lethal chemical agents, creating the perception that the United States has failed to act, even though President Obama’s “red line” warning against chemical weapons use has been crossed.
  • US policy toward Syria may unintentionally have helped erode the international taboo against chemical weapons use; to buttress that taboo, the United States now must make clear what would and would not constitute crossing the chemical warfare red line, in Syria and elsewhere.

Both opposition forces and the Syrian government have alleged that chemical weapons were used in last Tuesday’s attack on the village of Khan al-Assal, bringing to the fore one of the most potentially far-reaching of the many dangers that have arisen during Syria’s civil war. Now entering its third year, the Syrian revolt — by far the longest uprising of the Arab Spring — is the first in history that threatens to violently topple a government armed with weapons of mass destruction (WMD). This unique case naturally precipitates profound concerns that elements of Syria’s large stockpiles of chemical agents and munitions will find themselves in the hands of insurgents or terrorist groups. To date, however, the West has largely ignored the threat of non-state acquisition of such arms, instead focusing its concern around the use of chemical weapons by the regime of Bashar al-Assad.

With more than 70,000 dead and over one million Syrians displaced by civil war, international pressure mounts for more substantive intervention by Western powers. Even absent confirmed use of WMD, France and the United Kingdom are moving toward greater support of the disparate forces fighting the Assad regime.

In contrast, the United States has refrained from direct military support of the opposition. At the same time, President Obama has clearly, directly declared the use of chemical weapons in Syria as the red line that would call for substantive action from the United States. While avoiding any carte blanche backing of opposition forces that include significant numbers of jihadists and other terrorists, the US policy places significant emphasis on reinforcing the international moral norm against the use of weaponry that is considered “beyond the pale.” But recent allegations highlight the potential unintended consequences of this strategy: Khan al-Assal is the latest in a growing series of incidents in the country during which the use of chemical weapons has been claimed by either, or both, sides of the conflict.

Undoubtedly anticipating that violation of this boundary will spur American intervention, the Syrian rebels have significant motivation to charge the Assad regime with the use of chemical weapons. Conversely, the Syrian government has a vested interest in casting the rebels as a fringe element willing to use any means necessary to overthrow the regime, including violating the opprobrium against chemical weapons use. The extreme stakes created by the American red line make it is incumbent upon the United States to articulate precisely what is meant by the term chemical weapon — which, under international law, includes non-lethal agents as well as more well-known and lethal agents such as sarin and VX.

Given the general absence of foreign media from the conflict, reports of chemical attacks increasingly are based on citizen journalism. As Western news standards evolve with the growth of social media, the nuances that differentiate classes of chemical weapons appear to be dissolving. The public conflation of lethal and non-lethal chemical agents increasingly creates the perception that the United States has failed to act, despite evidence that President Obama’s red line has been crossed. In short, US policy may unintentionally have created a situation in which the public is desensitized to chemical weapons use, eroding the international taboo against them. To buttress and even strengthen that taboo, the United States now must make crystal clear to the international community what would and would not constitute crossing the chemical warfare red line, in Syria and elsewhere.

Many chemical weapons, no proven use. Most experts assume that the Assad regime possesses a vast and sophisticated chemical arsenal. Chemical agents most frequently cited as components of the Syrian arsenal include mustard gas, a blistering agent with properties that historically have generated large numbers of casualties, the vast majority requiring long-term medical care. A persistent chemical, mustard agent also creates long-term battlefield contamination. Vastly more toxic and lethal than mustard agent, sarin nerve agent is reportedly easily readied for use by the Syrian military for delivery via aircraft, artillery, and the country’s 100 to 200 Scud missiles. Syria likely also possesses VX nerve agents; several hundred times more lethal than sarin, VX is the most deadly of all chemical agents. Apart from these three agents, some experts expand their assessment of Syrian’s probable chemical arsenal to include choking agents such as chlorine gas and phosgene, which, according to a 1997 report by the US Surgeon General and US Army, was last used militarily in 1918. The latter agent, the effects of which appear only after a delay, was responsible for 80 percent of those killed by chemicals during World War I.

Last week’s incident in Khan al-Assal, the most dramatic to date, is the latest in a series of accusations of chemical weapons use by the Syrian opposition, with counterclaims by the Syrian regime. The attack is reported to have killed at least 31 people and injured more than 100; US and other Western officials place responsibility for the attack with the Syrian government. Still, among the dead were 16 pro-Assad soldiers, and Damascus blames opposition forces for the incident, claiming they used a rocket laden with chemicals. Government officials have requested a UN investigation into chemical weapons use in Tuesday’s incident “by the terrorists groups operating in Syria.” The same day, opposition forces reportedly claimed that Syrian “chemical rockets” had also struck the village of Ataibah near Damascus.

Before recent events, two purported chemical attacks in Homs in December 2012 generated unprecedented allegations of chemical weapons use, with some observers concluding that the American red line had been crossed. In the first instance, on December 6, victims were allegedly targeted with white phosphorus munitions fired by Syrian military helicopters. Two weeks later, on December 23, another incident occurred in Homs, killing at least seven and reportedly wounding more than 70; opposition forces assert that the attack used poisonous gases. Despite some journalistic assertions that nerve agents were responsible, a US State Department investigation concluded that no chemical weapons were used. Demonstrating the need to differentiate lethal and non-lethal chemical agents, US officials reportedly believe that casualties from the December 23 Homs incident are linked to Syrian military “misuse [of] a riot-control gas.”

No internationally sanctioned investigation has yet confirmed the use of chemical agents in any of these incidents. Unverified accounts and video footage of casualties purportedly caused by chemical weapons offer virtually no evidence that lethal chemical agents, including those agents likely constituting the Syrian arsenal, were used. Mustard agent, for example, dramatically affects the victim’s skin, eyes, and internal tracks. None of the filmed victims of last week’s Khan al-Assal attack evidenced the effects of such a blistering agent. Moreover, given its low volatility and high level of persistence, its presence would require victims to be handled with extreme care to avoid secondary contamination. Actions by medical staff treating the victims of the Khan al-Assal attack are incongruous with concerns about secondary contamination, and there are no known reports of subsequent negative health effects on first responders or hospital personnel. Similarly, the effects of sarin or VX nerve agents — manifest, for example, by a victim’s twitching — are absent from video of the Khan al-Assal incident. Like mustard agent, VX also is extremely persistent. Even sarin, which evaporates at a rate similar to water, is persistent enough to cause secondary contamination during transport and treatment in ambulances and hospitals, as evidenced during the response to a 1995 terror attack on the Tokyo subway. Doctors and civilians filmed at the Aleppo hospital treating the victims of the Khan al-Assal incident spoke of the agent emanating from the rocket, post-detonation, as being a powder. But choking agents, including chlorine (the smell of which reportedly was present at the Khan al-Assal attack), are delivered in a gaseous state.

No evidence yet exists to support the accusation that the Assad regime had used traditional chemical warfare agents — that is, those substances posing danger to humans and marked by exceptional lethality.

Evidence does point toward Syrian use of chemical agents designed to be non-lethal — those that are not entirely banned under the international law. With regard to the Chemical Weapons Convention (CWC), certain agents for purposes of “[l]aw enforcement including domestic riot-control purposes” are permitted. Riot-control agents, commonly lumped together in the public consciousness as tear gas or mace, cause rapid, short-lived irritation of the eyes, skin, and respiratory system, producing symptoms such as shortness of breath, choking, rashes, and temporary blindness due to swelling of the eyes. Riot-control agents are not banned under the CWC and are used by governments throughout the world, including the United States.

Loopholes in the CWC allow for use of other non-lethal agents, including so-called incapacitants, for domestic law enforcement and, in other interpretations, counterterrorism activities. In contrast to riot-control agents, the effects of incapacitants can last for days after exposure. Moreover, their effects are psychological or mental, designed to leave the victim confused, disabled, or, in general, ineffective. (Although Syria is not generally thought to possess such agents, some have theorized that the Assad regime may use incapacitants to test the waters of international reaction.) Also not addressed by the CWC is white phosphorus, an incendiary chemical agent that has been traditionally utilized by militaries to provide ground cover for operations as well as to illuminate targets. Its use as an offensive weapon lies in a legal gray area vis-a-vis chemical weapons law; it can produce severe chemical burns, irritation of mucus membranes (particularly of the eyes), and even death. From Homs forward to last week’s attack in Khan al-Assal, the symptoms displayed by victims of alleged chemical weapons are not of a severity that would evince white phosphorus use, though the mere mention of white phosphorus by a doctor treating victims of the Khan-al-Assad incident adds to the growing scrutiny of that chemical. Also, US responses to reports of Syrian use of white phosphorus are complicated by past American and Israeli military operations in which white phosphorus was used.

Strengthening the taboo. A disturbing pattern is emerging in Syria. Each purported use of chemical weapons — instantly communicated by the opposition, citizen journalists, or the Syrian government — is left unresolved, as demonstrated most recently with the Khan al-Assal attack. If chemicals were used in any of incidents to date, they were agents — white phosphorus, riot-control agents, and incapacitants — that the CWC either conditionally allows, addresses in a manner that creates a legal gray zone, or ignores altogether. Atop these realities, the nature of the Syrian conflict has severely curtailed the ability of traditional authorities to verify or refute allegations of chemical weapons use, regardless of type, often leaving international audiences uncertain at best as to whether the United States’ red line has been crossed. This dynamic likely contributes to the number of instances in which the use of chemical weapons has been alleged. More important, repeated unresolved claims of chemical weapons use slowly normalizes the concept that chemical weapons can be used, eroding the taboo against chemical warfare and desensitizing the public to its horrors.

The undermining of this moral prohibition relates directly to the discourse surrounding “non-lethal” chemical agents such as riot-control agents, incapacitants, and white phosphorus. While the technical and legal classifications of these agents are, one assumes, crucial to international leaders, the distinctions are lost on the layperson. With the United States’ casus belli inextricably predicated on Syria’s use of chemical weapons, and the future of the chemical warfare taboo in the balance, it is incumbent on the Obama administration to clearly articulate what definitions are being used in determining whether its red line has been breached, and to make a compelling case for why the use of certain chemical agents is not grounds for another US military foray into the Middle East.

Image of the Week: Ebola

We give you – Ebola!

The Ebola virion (image credit: CDC)

The virus and its sister, Marburg, are both marked by their distinct, filament-like morphology (which lead to their family name, Filoviridae)

Despite its high pathogenicity, filovirus infections have killed less than 2000 people since the virus family’s emergence in the late 1960s. Rigorous containment strategies are a big part of the lower fatality numbers – once infected, supportive care is the only available treatment. The natural reservoirs of the virus (not us) remain unknown.

So if for some reason you find this staring up at you from under an (extremely powerful) microscope, hold your breath and run (joke, that was a joke).

To learn more about everyone’s favorite hemorrhagic fever, check out the Federation of American Scientist’s Fact Sheet.

GMU Faculty Member and NRC Chairwoman Allison Macfarlane Nominated to New Term

Congratulations to GMU PIA Faculty Member Allison Macfarlane on her nomination to a second term as Nuclear Regulatory Commission Chairwoman!

“President Barack Obama has nominated Nuclear Regulatory Commission Chairman Allison Macfarlane to a new five-year term. Macfarlane, a geologist, took over the agency last summer after its former chairman, Gregory Jaczko, resigned amid complaints about an unyielding management style that fellow commissioners and agency employees described as bullying. Macfarlane was initially named to a one-year term that expires in June. Obama named her Thursday to a new five-year term. The appointment requires approval by the Senate.”

Read more here.