Deadly Pig Virus from China

According to a new study research, porcine epidemic diarrhea virus (PEDV) striking piglets across farms in the US may have originated in China. After comparing strains from an outbreak in China and the recent US strains, research from Virginia Tech indicates the virus’ source is in the Anhui province.

Fox News – “The report should help diagnostic researchers and federal officials, who have been trying to trace the origin of the porcine epidemic diarrhea virus (PEDv) since it was first identified in the United States this past spring. Previously, investigators and veterinary researchers tracking the outbreak said that there was some indication that the PEDv strain seen in the U.S. was 99.5 percent similar in genetic make-up to that identified in China. But exactly where it came from and how it arrived in the United States were mysteries. According to the report published last week in the American Academy of Microbiology journal mBio, the researchers extracted strains of PEDv virus from infected animals in Minnesota and Iowa.”

Image of the Week: Bacterial Growth!

This week’s image is brought to us via the Nikon Small World Photomicrography Competition. It wasn’t first place, but we thought it was a vivid depiction of bacterial life. Taken by Neil James Egan of PPG Industries, the image depicts two distinctive nodes during bacterial separation. Head over to Nikon’s website to see many more entries!

Entry_24604_Entry_21667_Entry_19975_bacteria-seperate-forms-and-nodules--mag-20x--3-17-06

New MERS Case in France

French health officials have reported a new case of the Middle Eastern Respiratory Virus in an individual returning from a trip to Saudi Arabia. The individual is in stable condition, and has been in isolation since October 28th.

Globally, there have been 144 cases of the respiratory virus to date, with 62 fatalities. In the last few weeks, transmission of the virus seemed to have slowed, before Saudi Arabia experienced a further five cases in a three day period.  The virus usually presents with respiratory symptoms, although more severe cases can result in rapid kidney failure. MERS’ primary host, reservoir, vector, and mode of transmission are all uncertain.

Read more.

This Week in DC: Events

Tuesday, October 29

Hearing: Next Steps on Egypt Policy
US House Committee on Foreign Affairs
10:00AM

Witnesses: The Honorable A. Elizabeth Jones, Acting Assistant Secretary Bureau of Near East Affairs, U.S. Department of State; The Honorable Derek Chollet, Assistant Secretary of Defense for International Security Affairs, U.S. Department of Defense; Ms. Alina Romanowski, Deputy Assistant Administrator Bureau for the Middle East, U.S. Agency for International Development.

Amodiaquine an Antimalarial Drug Inhibits Dengue Virus Type 2 Replication and Infectivity
Georgetown University
12:00PM

Speaker: Siwaporn Boonyasuppayakorn, PhD Candidate, GUMC Department of Microbiology & Immunology

The Prospect of Peace in Sudan
Institute of World Politics
4:30 PM

About the lecture: Prof. Hashem Mekki will give a brief history of the conflict in the Sudan, and will review the consequences and impact it has had on the civilian population. He will discuss the Comprehensive Peace Agreement that led to the separation between the two countries, and the issues these countries will face moving forward, including modern political and economic tensions and the implications of international community involvement in trying to resolve the conflict. About the speaker: Born and raised in Sudan, Prof. Mekki gives public speeches on the region and advocates to raise awareness of the plight of the Sudan. He has been an Arabic language instructor at The Institute of World Politics since August 2012. He also teaches Arabic language to professionals at the U.S. Department of Energy’s National Nuclear Security Administration (NNSA). Prior to moving to the United States in 2005, Prof. Mekki lived in Egypt for five years, where he worked as an Arabic-English translator and interpreter. Prof. Mekki graduated from the City College of New York in May 2010 with a double major in Political Science and International Studies, and also served there as a Colin Powell Fellow from 2008-2010.

Wednesday, October 30

The Innovation Economy: Information Revolution – A Policy Forum on the Use of Big Data in Homeland Security
Bipartisan Policy Center
9:00AM

The Bipartisan Policy Center and Intel Corporation will host a forum exploring the potential for big data innovation to improve homeland security, current and future challenges to overcome, and policy principles that will encourage innovation while safeguarding privacy and security in our increasingly connected society. This event is part of the ongoing Innovation Economy conversation convened by Intel in 2009, focused on the vital role of innovation in sustaining and building upon U.S. competitiveness in the global economy.

Subcommittee Hearing: China’s Maritime and other Geographic Threats
U.S. House Committee on Foreign Affairs
10:00AM

Chairman Rohrabacher on the hearing:  “The Subcommittee on Europe, Eurasia, and Emerging Threats will hold an open hearing with outside witnesses to assess Communist China’s maritime and other territorial claims that threaten regional and global stability. China’s greatly expanded offensive naval, air, and missile forces, coupled with its commercial fleet, numerous paramilitary organizations, and conventional military forces have projected power and asserted sovereignty far beyond Chinese self-defense, risking rapid and unpredictable escalation towards war between several of the largest economies in the world. We intend to highlight this situation and address solutions.”

Careers, Jobs, and Opportunities in International Health and Nutrition: Who, What, When, Where and How
Society for International Development
12:30PM

This panel will provide SID members with insights and practical advice on how to get started and have a successful international development career in the field international health and nutrition. Presenters will include Sharon Rudy who will talk about the “Global Health Fellows Program”. Vina HuLamm, Global Health Manager at the American Public Health Association, will talk about the importance of getting involved in professional organizations as well as opportunities for students in leadership, policy advocacy, professional development, and networking will be highlighted. Sharon Rudy will share the role of the Global Health Fellows Program in getting new professionals started in their international careers; Kathryn Goldman will present the opportunities to make a big impact by becoming a Peace Corps Volunteer; Kate Warren, Director of Global Recruitment Services at Devex, will talk about trends in the industry and their impact on career opportunities as well as practical tips to break in or advance your career in global health; and Dr. Barry Karlin will share advice from his five decades in international health from his latest book “Choosing a Career in Development: My Five Decades in International Public Health.” Copies will be available for sale.

Thursday, October 31

The Way Forward in Afghanistan: Embracing Opportunity in the Midst of Transition
New America Foundation
12:15 PM

Since 2001, the United States has been heavily engaged in Afghanistan. The failures of this effort have been well documented, but what has often been overlooked are the immense gains that have been achieved. As Afghanistan enters a turbulent transition period,including presidential elections in April 2014, the ongoing transition from U.S.-led to Afghan-led security operations, and the draw down of U.S. troops, it is important that U.S. policymakers keep the full picture in mind. Calls for the United States to walk away from Afghanistan ignore the progress that has been made, and such a result would be catastrophic for the people of Afghanistan. It would also call into question the last 12 years of U.S.efforts in the country. The New America Foundation and the Alliance in Support of the Afghan People are pleased to invite you to a discussion about the prospects for Afghanistan’s future, in light of past progress and upcoming challenges.

 

The Pandora Report 10.25.13

Highlights include a new dengue serotype, bird flu in Australia, Peruvian bats and influenza A, mutating viruses, and HHS bolstering international pandemic preparedness. Happy Friday, and Happy Halloween!

First New Dengue Virus Type in 50 Years

For the first time in half a century, a new serotype of dengue has been discovered. The strain, found in Malaysia, is phylogenetically distinct from the existing four serotypes. The discovery will complicate existing vaccine efforts, which are already quite complex – prior to this discovery, dengue possessed four distinct serotypes. To date, this newest serotype has only been identified in one outbreak.

Science – “Scientists have discovered a new type of the virus that causes a centuries-old pestilence, dengue. The surprising find, announced at a major dengue conference here today, is bound to complicate efforts to develop a vaccine against a tropical disease that is becoming a more pervasive global menace. But it could shed light on where the pathogen came from and whether it is evolving into a greater threat. The finding “may change the way we think about dengue virus evolution and emergence,” says Duane Gubler, a dengue expert at the Duke-NUS Graduate Medical School in Singapore.”

Second bird flu outbreak in Australia

New South Wales has experienced its second outbreak of avian influenza. For some reason, none of the press is including the nueraminidase type, refering to the virus simply as “H7” or as HPAI (highly pathogenic avian influenza). This is misleading – the strain is actually H7N2, which has a low pathogenicity. While a serious threat to poultry farmers – 18,000 birds have died from the virus already and a further 400,000 have been culled – it isn’t a serious threat to humans at this point.

ABC Australia – “Initial testing at the Elizabeth Macarthur Agricultural Institute confirmed the virus earlier today and the infected property has been placed under strict quarantine. The department says tests are being carried out to try to confirm the origin of the latest incidence, but it’s the H7 strain, not the H5N1 strain that’s dangerous to humans. It says all eggs and poultry in NSW remain safe to eat. NSW DPI chief vet, Ian Roth, says he can’t yet confirm how the virus spread.”

New flu virus found in Peruvian bats

If there’s one thing we’ve learned here at the Pandora Report it’s never touch a bat. Just don’t do it. Halloween is great, bats can be cute, but as carriers of everything from rabies (scary) to Ebola (very scary), we’re keeping our distance.  In further confirmation of this truism, a new influenza virus has been discovered in Peruvian bats. The Influenza A virus, appropriately named A/bat/Peru/10, and contains hemagglutinin (H) and neuraminidase (N) surface proteins entirely distinct from any seen before, prompting researchers to classify them as novel – H18N11. While the virus is thought to be capable of infecting humans.  thus far researchers have been unable to culture it in human cells. Hopefully, it will stick to bats – H18N11 is just too hard to say.

LiveScience – “The researchers found the new virus after testing samples from 114 bats in Peru. One sample, from a flat-faced fruit bat known as Artibeus planirostris, was found to have H18N11. Blood testing of other bats suggested that they may have been infected with H18N11 in the past. The researchers still do not know how H18N11 attaches to cells to enter them…So far, flu viruses from bats are not known to infect people. But bats are known reservoirs for other types of pathogens that have found their way to humans, such as Severe Acute Respiratory Syndrome. Bats are also are suspected to be the original source of the virus causing the current outbreak of MERS.”

Single mutation gives virus new target

By changing a single amino acid in the BK polyomavirus, researchers were able to completely alter its preferential binding site. Understanding this mechanism is a small step towards understanding things like why a virus switches to infect different cells (potentially increasing pathogenicity) or, in the case of viruses like MERS and H7N9, different hosts. Understanding this mechanism can help us predict which viruses may switch hosts  to eventually infect us.

R&D Mag – “Different cells have different bindings targets on their surfaces. A change in a virus’s binding target preference can be a key step in changing how that virus would affect different cells in a victim—or move on to a different species…Brown postdoctoral researcher Stacy-ann Allen, one of two lead authors on the paper, said the team learned of the single amino acid difference by comparing high-resolution structural models of the two polyomaviruses bound to their favorite sugars. Collaborators, including co-lead author Ursula Neu and co-corresponding author Thilo Stehle at the Univ. of Tübingen in Germany, produced those models using nuclear magnetic resonance spectroscopy.”

HHS Boosts Global Ability to Respond to Pandemics

HHS through BARDA has awarded four interrelated grants, to the WHO, PATH, Utah and North Carolina States universities respectively to boost funding for pandemic preparedness in developing countries. The WHO is receiving approximately $10 million in grants to support H7N9 preparedness in developing countries, while the university grants are each supporting onsite training programs in the same countries. This makes a lot of sense – helping other states by providing them the tools to develop their own pandemic preparedness efforts makes us all  healthier.

PharmPro – “The program provides cost-sharing to build vaccine manufacturing facilities that can produce influenza and other vaccines in developing countries and trains personnel from developing countries at U.S.-based universities in advanced vaccine production. The program also supports technical assistance for foreign countries to operate and regulate their facilities and to conduct clinical trials with influenza vaccines produced in the facilities.”

And because everyone needs a little good news occasionally: Baby born with HIV is still showing no sign of the infection after treatment stopped 18 months ago

(image via Leyo/Wikimedia)

Image of the Week: Coxiella burnetti

This week’s image is of Coxiella burnetti, a HHS select agent and the causative bacteria of Q fever. The bacteria is primarily found in farm animals, and can be passed along through infected milk and in waste products, although the greatest number of bacteria are shed during birthing. Q fever has an incubation period of 2-3 weeks, with 50% of cases remaining asymptomatic. The disease presents with fever, myalgia, as well as broad GI symptoms. Acute forms of the disease can be much more severe, including symptoms affecting the central nervous system.

coxiella burnetti(image: Kat Masback/NIAID)

Frankenstein Bug

Scientists at the Universities of Yale and Harvard have rewritten the entire genome of E.coli bacteria, re-engineering the bug to be resistant to viral infection. Their successful rewriting of E.coli is the first instance in which a genome was completely altered through human agency.

“‘This is the first time the genetic code has been fundamentally changed,’ said Farren Isaacs, assistant professor of molecular, cellular, and developmental biology at Yale. ‘Creating an organism with a new genetic code has allowed us to expand the scope of biological function in a number of powerful ways.’ Isaacs co-authored the study published in the Science journal this month with George Church of Harvard Medical School and the research is based out of the field of synthetic biology, which seeks to re-design natural biological systems for useful purposes. To change the bacteria, Isaacs worked with other researchers to substitute different codons or letters (that make up the nucleic acids of DNA) to create amino acids not found in nature. ”

Read more here.

(Image of E.coli courtesy of NIAID)

Video: Dr. Paul Walker’s talk on Chemical Weapons Destruction

For those of you unable to attend our October Biodefense Policy Seminar last week, Dr. Paul Walker gave a very interesting and timely presentation on the challenges of chemical weapons destruction, both in Syria and globally. See the first part of his presentation below, and then head over to our YouTube channel to watch the rest. His slides are also included below.

Dr. Walker’s Slides: October Biodefense Policy Seminar_Dr. Paul Walker

This Week in DC: Events

Monday, October 21st, 2013

The New Political Landscape of Afghanistan’s Neighborhood After ‘2014’
Wilson Center
12:00 – 1:00PM

So much attention is being devoted to the changing security situation in Afghanistan as US/NATO forces prepare to end the current mission and begin a new status in the country. Already, Afghanistan’s immediate neighbors (and somewhat distant, such as Russia) are addressing what they see as the key concerns of the coming years. Some focus on the security challenges and the potential for civil war. Others are hedging their bets and look to the economic gains that could be made by dealing with a stable Afghanistan. Pessimists and optimists alike are looking to regional organizations as necessary in the coming years. Roger Kangas will speak about potential regional outcomes as the balance of security changes in the coming years.

Climate And Security: Views From The Global North And South
Stimson Center
1:00 – 2:30PM

The fourth installment of Stimson’s 2013 Environment and Security Discussion Series will explore the various ways that climate change is impacting the national security and economic development of two key countries in the Global North and Global South, respectively. Shiela Riordon will discuss the intersection of climate and security from a Canadian perspective, highlighting how a warming Arctic is influencing commercial shipping and economic development in Canada’s far north. Ambassdor Djalal will provide insights into how climate change is viewed through the lens of the Global South, discussing environmental pressures as they pertain to natural disasters, sea-level rise, and natural resource management in Indonesia.

Tuesday, October 22nd

2013 FPI Forum: Will America Lead?
Foreign Policy Initiative
9:00AM – 4:00PM

Featuring panels on: ‘Choosing to Lead – A Conversation with General John R. Allen’, ‘What Defense Does America Need?’, ‘The Crisis in Syria’, ‘Afghanistan 2014: What are the Stakes?’,’Assessing the Asia Rebalance’

Food Security and Sociopolitical Stability
Wilson Center
10:00AM

Global food price spikes in 2008 and again in 2011 coincided with a surge of political unrest in low- and middle-income countries. Citizens took to the streets in scores of nations, and in some places food riots turned violent. Governments and philanthropic foundations have begun redoubling efforts to resuscitate agricultural research and technology transfer, as well as to accelerate the modernization of food value chains to deliver high quality food inexpensively, faster, and in greater volumes to urban consumers. But is this enough? This seminar presents a newly published Oxford University Press volume that explores the complex relationship between food security and sociopolitical stability. A key message of the study is that actions taken in an effort to address food security stressors may have consequences for food security, stability, or both, that ultimately matter far more than the direct impacts of biophysical drivers such as climate or land or water scarcity. The means by which governments, firms, and private philanthropies tackle the food security challenge of the coming decade will fundamentally shape the relationship between food security and sociopolitical stability.

Securing The Nuclear Enterprise: What Nuclear Crises Teach Us About Future Security Threats
Stimson Center
11:30AM – 1:00PM

Next spring, the U.S will join other world governments and organizations in The Hague for the 2014 Nuclear Security Summit. Like previous gatherings in 2010 and 2012, the upcoming summit will include debate about the steps the global community must take to prevent nuclear materials from falling into the hands of non-state actors. Central to this objective is the ability of nuclear armed states to maintain control over their weapons and sensitive materials. One way the U.S. can identify existing gaps in the control regime and prepare for the summit is by carefully studying previous nuclear weapons crises. During its Cultural Revolution, China nearly lost control of its nuclear arsenal. This history – little known in the U.S. – is both chilling and critical to understanding Chinese attitudes towards nuclear security. In the Nonproliferation Policy Education Center’s (NPEC) new study, Nuclear Weapons Security Crises: What Does History Teach?, Chinese nuclear weapons management expert and Executive Director of Project 2049 Institute Mark Stokes tells the story of China’s near-nuclear crisis and the lessons that can be learned from it. Come join us to celebrate the release of NPEC’s latest book and learn more about this important history. Lunch will be served and free copies of Nuclear Weapons Security Crises: What Does History Teach? will be available.

The Terrorist’s Dilemma: Managing Violent Covert Organizations
New America Foundation
12:15 – 1:30PM

In his new book, The Terrorist’s Dilemma: Managing Violent Covert Organizations, Dr. Jacob Shapiro uses an agency theory, a broad range of historical case studies, and the terrorists’ own documents to answer these questions. The first book to systematically examine the structural differences between terrorist groups, The Terrorist’s Dilemma discusses the core managerial challenges these groups face, and illustrates how the organizations are affected by their political goals and operational environments. Shapiro provides a historically-informed explanation for why some groups have little hierarchy, while others resemble miniature firms. Looking at groups in Africa, Asia, Europe, and North America, he highlights how consistent and widespread the terrorist’s dilemma — balancing the desire to maintain control with the need for secrecy — has been since the 1880s. Please join the New America Foundation’s National Security Studies Program for a conversation about how Dr. Shapiro’s findings inform our current understanding of al-Qaeda, as it increasingly operates as a network of powerful regional affiliates.

Countering Violent Extremism
Johns Hopkins SAIS
4:00 – 6:30PM

Azar Nafisi, executive director of SAIS Cultural Conversations and SAIS Foreign Policy Institute (FPI) fellow, and Mahnaz Afkhami, president and founder of the Women’s Learning Partnership for Rights, will discuss this topic.

Wednesday, October 23rd

Cybersecurity: 21st Century Threats, Challenges, and Opportunities
CSIS
8:30AM – 10:00AM

Join the Center for Strategic & International Studies (CSIS) and the Financial Services Roundtable on October 23rd, 2013, at 8:30 AM for a panel discussion (Cybersecurity: 21st Century Threats, Challenges, and Opportunities) moderated by FSR CEO and former Minnesota Governor Tim Pawlenty. Topics discussed will include cyber espionage threats from foreign nations, defending the financial services sector from cyberterrorism, and how both the private and public sector can work together to strengthen American cybersecurity.

The Chemicals, the Conflict, and the Challenges in Syria

American Association for the Advancement of Science
5:00 – 6:30PM

On October 23, the American Association for the Advancement of Science’s Center for Science, Technology and Security Policy and the Federation of American Scientists are convening a panel to discuss the science and security involved in the implementation of the Chemical Weapons Convention and U.N. Security Council Resolution 2118 in Syria. The speakers will explore the technical, political, and regional issues surrounding chemical weapons in Syria, including: the technical solutions and expertise required to ensure accelerated destruction of chemical weapons; the broader regional impact of Syria’s accession to the Chemical Weapons Convention; and the challenges involved in carrying out destruction in a civil war environment.

State and Local Fusion Centers: Key Challenges for the Next Decade
Homeland Security Policy Institute (GW)
9:30 – 11:30AM

State and local fusion centers were established in the years after the attacks of September 11th as a bottom-up response to the need for enhanced state and local connectivity to U.S. federal homeland security and counterterrorism activities. Over the past decade, nearly every state and many major urban areas have established a network of 78 fusion centers, which serve as key nodes for federal, state and local coordination on homeland security and terrorism activities.. Fusion centers also address many critical local and regional public safety issues. The Homeland Security Policy Institute is hosting a policy forum to discuss the roles played by state and local fusion centers, examine the challenges that they face, and look ahead to priorities for the future. The conference will feature keynote remarks by The Honorable Michael T. McCaul, Chairman, House Committee on Homeland Security, who recently released (along with former Committee Chairman Peter King) a staff report that examined the issue of state and local fusion centers.

SPP Brown Bag Seminar: Perspectives on the NSA Controversy and Related Surveillance Issues
GMU School of Public Policy
12:00 – 1:00PM

Join General Michael Hayden, former Director of the CIA and Distinguished Visiting Professor at GMU SPP as he discusses the NSA controversy at this brown bag seminar.

Thursday, October 23rd

God’s Century? Assessing the ‘Clash’ of Secular & Religious Trends in the Middle East and North Africa – First Panel and Keynote
Center for Contemporary Arab Studies (Georgetown)
3:30PM – 7:45PM

This conference will feature expert observers of the region from the Georgetown University main campus and from the School of Foreign Service in Qatar, as well as invited scholars from other institutions. The papers presented will address a variety of themes pertaining to the development of secular & religious trends in the Middle East and North Africa (MENA), focusing on different countries and sub-regions, and highlighting the impact of these trends on education; gender relations; family, clan and tribal bonds; print and electronic media; occupational and professional careers; religious beliefs and behavior; as well as political attitudes, political party affiliations, and electoral behavior. They will examine numerous and diverse causal roots, ranging from demography to globalization, and their major consequences, both violent and non-violent, for the political and social evolution of all these states.

Friday, October 25th

Dangerous World? Threat Perception and U.S. National Security
CATO Institute
8:30 – 10:45AM

Last year, Chairman of the Joint Chiefs of Staff Gen. Martin Dempsey contended that “we are living in the most dangerous time in my lifetime, right now.” This year, he was more assertive, stating that the world is “more dangerous than it has ever been.” Is this accurate? At this conference, experts on international security will assess, and put in context, the supposed dangers to American security. Speakers will examine the most frequently referenced threats, including wars between nations and civil wars within nations. Panelists will also discuss the impact of rising nations, weapons proliferation, general unrest, transnational crime, and state failures, as well as technological developments, climate change, and the requirement to maintain a stable global economic system.

The Pandora Report 10.18.13

Highlights include a MERS-free hajj?, Craig Venter and bioterrorism, coronaviruses in hedgehogs,  DoD contributing to key biodefense infrastructure, bacteriophages eating superbugs, and (briefly) the Ebola cure and the oh-so-secret botulinum toxin. Happy Friday!

Hajj Numbers Down In 2013 By 1 Million Over MERS Virus Fears

Public health officials globally have kept a nervous eye on Saudi Arabia over the last week, as hajj brought 1.5 million pilgrims into Mecca, and potentially into contact with MERS. However hajj is concluding, and so far, not  a single case of MERS has emerged from the Muslim holy city. While it’s too early to tell with certainty whether this year’s hajj has been totally MERS-free, credit where credit is due.  Saudi Arabia was careful to institute a slew of preventative measures designed to prevent the virus’ spread, including severely limiting visas to susceptible populations, mandating mask-wearing in high density spaces, and a broad information campaign emphasizing good hygiene. We’re impressed (and grateful!).

International Business Times – “Hajj placed 1.75 million foreign pilgrims in contact with 1.4 million Saudi pilgrims last year, and officials feared that such contact could prove a deadly mix for a disease that has been, thus far, largely contained within the kingdom. Interior Minister Prince Mohammed bin Nayef said international numbers were down 21 percent to 1.37 million pilgrims from 188 countries this year, while the number of pilgrims from within the kingdom is believed to be half of what it was last year…Saudi Minister of Health, Abdullah bin Abdulaziz Al-Rabeeah, announced late Saturday that all health facilities were ready for hajj pilgrims, with some 22,000 health workers (3,000 more than previous years) on standby to help the ill or injured. He added that there had been no epidemic or coronavirus cases among pilgrims thus far.”

Craig Venter (briefly) Discusses Bioterrorism 

If you’re even tangentially involved in the biosciences, you already know that Craig Venter was the lead scientists of the Human Genome Project, which was the first to successfully characterize an entire human genome. It took Venter and his team thirteen years and nearly three billion dollars to sequence his genome. Today, it’s possible to sequence a human genome in less than a month at under $5,000, leading many scientists to worry about the potential of terrorists simply sequencing highly pathogenic bugs. Popular Mechanics caught up with Venter in advance of his new book, Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life, and asked him about, amongst other things, synthetic biology and biological terrorism.

Popular Mechanics – [Venter, on his biggest concern for synthetic biology] “Certainly the biggest concern is the potential for bioterrorism. But using synthetics for bioterrorism is a huge, huge, huge, challenge. Right now there are so many sources of materials for bioterrorism that it’s unlikely that somebody would go to all the difficulty to synthetically make it. For example, anthrax exists on most cattle farms. Any dead cow has a good chance of having anthrax in it, so it’s not like you need to get anthrax from some high security lab. But certainly, in theory, people could make things like smallpox that aren’t readily available. My main concern is people doing biology in their kitchens. It’s great that so many people are curious about biology, but without proper training these DIY biologists don’t learn the right safety approaches and mechanisms. Someone could inadvertently cause harm to a lot of people. Like any new frontier with powerful technology, people have to think about it carefully. What are its implications? How can we regulate it without over-regulating it?”

Bacteria-eating viruses ‘magic bullets in the war on superbugs’

Researchers at the University of Leicester have isolated a new strain of bacteriophage – viruses which infect and kill bacteria – which specifically targets the bacteria Clostridium difficile. The use of phages instead of comparatively indiscriminate antibiotics in treatment would help diminish the over-prescription antibiotics, reduce the likelihood of antibiotic resistance, and preserve healthy host bacteria. One of the researchers raises a very good point – with fewer and fewer new antibiotics discovered, and more and more cases of antibiotic resistance, an earnest search for viable alternatives is necessary.

University of Leicester – “Dr. Clokie and her team have achieved the remarkable feat of isolating and characterising the largest known set of distinct C. diff phages that infect clinically relevant strains of C. diff. Of these, a specific mixture of phages have been proved, through extensive laboratory testing, to be effective against 90% of the most clinically relevant C. diff strains currently seen in the U.K. As a testament to their therapeutic potential, these phages, that are the subject of a patent application, have been licensed by AmpliPhi Biosciences Corporation – a US-based biopharmaceutical company and pioneers in developing phage-based therapeutics. AmpliPhi have already made progress in developing phages targeted against Pseudomonas aeruginosa, a pathogen that causes acute, life-threatening lung infections in cystic fibrosis patients. They were also the first biopharmaceutical company to demonstrate the effectiveness of Pseudomonas phages in controlled and regulated human clinical trials.”

DOD Funding Contributes to U.S. Biodefense Infrastructure

The Department of Defense has co-funded the Texas A&M Center for Innovation in Advanced Development and Manufacturing, which was created in response to the 2009 influenza pandemic. The Center’s primary focus is flexible and fast development of therapeutics in response to novel disease outbreaks. Its primary investigator, Dr. Brett P. Giroir, formerly of DARPA, describing the need for the Center explained that “[l]iterally, what once took weeks during medical school to produce in a multimillion-dollar laboratory can be done [today] in an afternoon on a benchtop by someone with a relatively less degree of scientific training…So the barriers to entry have decreased’. We couldn’t agree more.

DoD – “The facility is called the National Center for Therapeutics, or NCTM, and a key feature there is the use of modular and mobile stand-alone biopharmaceutical clean rooms, called modular clear rooms, or MCRs. The initial MCR concept was funded by DOD through DARPA and the Army Research Office, Giroir said. NCTM is the core facility and main site for developing and manufacturing medical countermeasures and vaccines against chemical, biological, radiological and nuclear threats for the Texas A&M Center for Innovation, he added. Another part of the Center for Innovation’s biomanufacturing infrastructure is the Caliber Biotherapeutics Facility, Giroir said. Caliber was developed and built through Texas A&M and G-CON Manufacturing, with funding from the DARPA Blue Angel Program. According to a 2012 DARPA news release, the Blue Angel Program demonstrated a flexible and agile capability for DOD to rapidly react to and neutralize any natural or intentional pandemic disease.”

Characterization of a novel betacoronavirus related to MERS-CoV in European hedgehogs

It’s understood that bats are the established hosts for viruses similar to human coronaviruses, which prompted researchers to wonder if hedgehogs, which are closely related to bats, carry similar viruses. Researchers at the  University of Bonn in Germany acted on this hunch, and discovered a  novel “sister” betacoronavirus species in European hedgehogs. We’re disappointed – staying away from bats is fine because we don’t want rabies and bats are odd-looking, but hedgehogs? Really?

Journal of Virology – “58.9% of hedgehog fecal specimens were positive for the novel CoV (EriCoV) at 7.9 Log10 mean RNA copies per ml. EriCoV RNA concentrations were higher in the intestine than in other solid organs, blood and urine. Detailed analyses of the full hedgehog intestine showed highest EriCoV concentrations in lower gastrointestinal tract specimens, compatible with viral replication in the lower intestine and fecal-oral transmission. 13 of 27 (48.2%) hedgehog sera contained non- neutralising antibodies against MERS-CoV. The animal origins of this betacoronavirus clade including MERS-CoV may thus include both bat and non-bat hosts.”

In Case You Missed It:

Working on Ebola: We are very supportive of any treatment which helps mitigate our very real fear of Ebola. 
– Scientists Withhold Details of New Botulinum Toxin: We get it. We even agree. We’re curious if you do too.

(image credit: Michael Gäbler)