Pandora Report 10.24.2025

Welcome to this week’s Pandora Report! 🍂 This issue unprecedented workforce disruptions at the CDC, as mass layoffs and leadership changes raises questions about ‘America’s first’ public health readiness; a deeper dive into the global fallout of U.S. foreign health aid cuts; and a look at the new biotech and AI race, where China’s rapid rise and fragile U.S. supply chains expose risks for both national security and innovation.

Thinking About Graduate Study in Biodefense?

The Schar School of Policy and Government has several upcoming recruitment events, including one for prospective PhD students:

🔗 See all upcoming events here.

☕ Plus: Regional coffee chats with faculty and admissions staff across Maryland, Virginia, and DC. Learn more here.

💡 Tuition Benefit: Master’s and certificate students living in Maryland and DC quality for in-state tuition rates. Learn more and register here.

CDC in Crisis: Mass Layoffs, Leadership Turmoil, and Vaccine Controversy

By Carmen Shaw, Co-Managing Editor

Wired said it best: “A Quarter of the CDC Is Gone.”

Following multiple rounds of mass firings, partial reversals, and several terminations still pending legal review, the union representing the employees at the U.S. Centers for Disease Control and Prevention (CDC) estimates that roughly 3,000 of its 13,000 staff received RIF (reduction-in-force) notices this year. Many of these affected worked on chronic disease prevention, nutrition and health initiatives, or handled state requests to investigate overdose and drowning deaths. Others were mental health professionals who supported staff after the August shooting at CDC headquarters in Atlanta.

Officials warn that these layoffs have left the CDC dangerously unprepared to protect Americans’ health and safety. “The CDC cannot protect all of us in the U.S. if they continue to have staff and resource cuts,” said Debra Houry, the former Chief Medical Officer.

The leadership turmoil doesn’t end there. In recent weeks, former acting CDC Director, Richard Besser, called the cuts “absolutely heartbreaking” and criticized current acting Director Jim O’Neill’s proposal to split the measles, mumps, and rubella (MMR) vaccine into three separate shots – despite O’Neill’s lack of public health or scientific training. The proposal has raised alarms from health experts, who warn that dividing the vaccine into multiple doses would increase the number of health care visits needed; reduce access to the vaccines; and lower overall vaccination rates.

Current CDC employees also missed IDWeek, the nation’s largest infectious disease conference – amid a recent uptick in measles and whooping cough cases across the U.S. During the conference, the New England Journal of Medicine  (NEJM) and the Centers of Infectious Disease Research and Policy (CIDRAP) announced a new collaboration to fill gaps in federal public health communication. Together, they plan to publish “public health alerts” in the coming month, serving as an alternative to CDC’s paused Morbidity and Mortality Weekly Report (MMWR) – often referred to as “the voice of the CDC.”

Broader Impacts Across Health and Security Agencies in the U.S.

The CDC is not the only federal agency reeling from disruptions. The Centers for Medicare and Medicaid Services (CMS) has faced furloughs and staffing cuts – just days before the start of open enrollment. CMS later confirmed that workers would return on Oct. 27, noting that the agency would cover user operation fees as the federal government shutdown enters its fourth week.

Meanwhile, the National Nuclear Security Administration (NNSA) – responsible for overseeing the U.S. nuclear stockpile – furloughed 1,400 employees on Monday as part of the ongoing shutdown, with fewer than 400 remaining  to safeguard the stockpile. Earlier this year, the Trump administration also fired hundreds of NNSA employees, before reversing the decision following criticism of jeopardizing national security.

Further Reading:

The Fallout of U.S. Aid Cuts: Threats to Global Health

Global health leaders are sounding the alarm over a fractured aid system and declining U.S. support. At the World Health Summit in Berlin last week, executives from major institutions – including the Global Fund, Gavi, and the World Health Organization (WHO) – called to addressed the financial crisis facing global health as the abrupt withdrawal of U.S. aid under the Trump administration exposed structural problems that officials acknowledged had existed for years.

Between 2024 and 2025, global development assistance for health fell 21%, driven primarily by a 67% drop in U.S. funding – over $9 billion – according to the Institute for Health Metrics and Evaluation. Health Policy Watch notes: “Tens of millions of lives, particularly among children under five and people in the world’s poorest countries, are threatened by the cuts.”

Therefore, ongoing RIFs in the U.S. now unfortunately also include reductions-in-funding. This reflects a shift in foreign aid priorities, exemplified by the State Department’s America First Global Health Strategy. While the strategy promotes bold U.S. leadership, observers warn that it overlooks the realities faced by communities on the ground. Disregarding the needs of low- and middle-income countries (LMICs) risks worsening the very problems the strategy aims to solve.

The Swift American Exit Threatens Communities Worldwide – from Somalia to the DRC

The consequences of U.S. aid cuts to LMICs are already being felt. For years, funding from the U.S. Agency for International Development (USAID) sustained hundreds of community health clinics, food programs, and maternal health initiatives worldwide. When the Trump administration dismantled the agency and slashed foreign aid, much of this support abruptly ended – including programs run by Save the Children and the International Medical Corps.

U.S. humanitarian aid to Somalia, for example, has plummeted – from an average of $450 million per year over the past decade to just $128 million in 2025, crippling programs that once provided fortified food and basic healthcare services. The impact is devastating: in Baidoa, a city in southern Somalia, emergency feeding centers are overwhelmed with malnourished children suffering from preventable diseases like measles, diphtheria, cholera, and whooping cough. Save the Children had to close some emergency centers and other countries, including the UK, Germany, and the Netherlands, have also reduced contributions.

Global initiatives are also affected. The Global Polio Eradication Initiative (GPEI), a coalition to eradicate polio including the World Health Organization (WHO) and the Gates Foundation, will see a 30% budget reduction in 2026 and a $1.7bn funding gap through 2029, largely due to the U.S. withdrawal from WHO. To copy, GPEI plans to prioritize surveillance, vaccination in high-risk areas, and adopt strategies such as fractional dosing, which stretches limited vaccine supplies while protecting children from infection.

These funding shortfalls exacerbate ongoing health crises. In Democratic Republic of Congo (DRC), one of the worst cholera outbreaks in a decade is rapidly spreading, with 20 of 26 provinces affected. Since mid-October, more than 58,000 suspected cases and over 1,700 deaths have been reported. Doctors Without Borders warns that the country’s healthcare system is ill-equipped to contain the outbreak amid shortages of medical supplies and vaccines.

Further Reading:

The New Biotech Race: How Supply Chain Fragility and China’s Rise Threaten U.S. Health Security

From life-saving medicines to AI, U.S. leadership in critical technologies and supply chains is under pressure. The pandemic revealed how fragile global supply chains for essential drugs had become – and how quickly technological dependencies can turn into security risks. Now, these vulnerabilities are deepening, spanning from the factory to the cloud.

China is rapidly becoming a global biotech powerhouse. Over the past five years, Chinese companies producing cancer and gene therapy drugs have more than doubled licensing agreements for their intellectual property, while they’ve also invested heavily in raw material production and advanced manufacturing capacity. In contrast, the U.S. still lacks a coordinated national biotechnology strategy. Federal research funding in the U.S. has also stagnated, regulatory systems remain fragmented burdened with barriers to slow the translation of discoveries from lab to market, and private investors remain cautious to fund cutting-edge research in the face of political and economic uncertainty. As Todd Young writes in Foreign Affairs, failure for the U.S. to act decisively could mean ceding control over the technologies that define global health, economic power, and national and international security in the decades ahead.  

The consequences of this drift are already visible. Nearly 700 medicines approved in the U.S., including antibiotics and generics for heart disease, seizures, and HIV, rely on at least one chemical solely sourced from China. A new module on the USP Medicine Supply Map highlights vulnerabilities in the U.S. upstream pharmaceutical supply chains. They highlighted three key findings:

  1. Most key starting materials (KSMs) used to synthesize active pharmaceutical ingredients (APIs) are extremely concentration, with 58% sole-sourced from a single country.
  2. There are sourcing clusters in China and India, with China supplying 41% of KSMs used in US-approved APIs and India 16%.
  3. Many APIs rely on one country for key ingredients.

From USP:  “To strengthen American medicine supply chain, we should incentivize diverse manufacturing through onshoring and friend-shoring and modernize procurement practices to prioritize reliability and resilience alongside cost.”

Further Reading:

Avian Influenza Updates

By Margeaux Malone, Pandora Report Associate Editor

PAHO Reports Continued Spread of Bird Flu Across the Americas

Last week, the Pan American Health Organization (PAHO) released its latest epidemiological update on highly pathogenic avian influenza A subtype H5N1 (HPAI), documenting the ongoing expansion of the virus across the Americas. Since 2022, 19 countries and territories in the Americas Region have reported 5,063 outbreaks of HPAI to the World Organization for Animal Health (WOAH), with 115 additional outbreaks recorded since PAHO’s last update published May 2025.

Between 2022 and October 2025, 76 human infections and two deaths caused by HPAI were reported across five countries in the Americas (United States, Canada, Chile, Mexico, and Ecuador). On October 2, Mexico confirmed its second human H5 infection this year (the neuraminidase of the strain has yet to be identified). A 23-year-old female with no history of seasonal influenza vaccination or recent travel developed symptoms including fever, runny nose, and difficulty swallowing which progressed to hemoptysis (coughing up blood) and chest pains requiring hospitalization. Subsequent RT-PCR testing of the patient’s respiratory samples confirmed infection with influenza type A (H5). The patient was treated with oseltamivir (Tamiflu) and discharged on October 11. Environmental investigation revealed influenza A(H5)-positive samples from poultry and pigeons found in her apartment building’s courtyard. Fortunately, this patient recovered; however, globally, the cumulative fatality rate of H5N1 since 2003 remains alarmingly high at 48%, with 475 deaths among 990 cases across 25 countries.

The PAHO report also noted the continued unprecedented jump of avian influenza from birds to mammalian species. In the United States alone, 1,080 dairy herds across 18 states have been affected since March 2024, with 27 additional herds identified since May. The Canadian Food Inspection Agency has reported 20 detections in wild mammals in Canada this year. PAHO emphasized the concerning increase in HPAI detection in both terrestrial and marine mammals worldwide, including companion and production animals, and the need for heightened surveillance and implementation of biosecurity measures to reduce virus spread. This week, USDA’s Animal and Plant Health Inspection Service (APHIS) reported dozens of new detections in wild waterfowl across multiple states, including mallards in New Hampshire, black vultures in four states, and various species in Minnesota, Montana, and Oregon. The ease with which the virus transmits from wild birds to domestic flocks underscores ongoing surveillance challenges.

Although avian influenza outbreaks primarily affect animals, the virus still poses ongoing risks to public health. PAHO urges continued intersectoral collaboration between Member States to strengthen human-animal surveillance and improve infection prevention and control in health and agricultural settings.

Further Reading:

NEW: The Role of the Media in Investigating the Origin of the COVID-19 Pandemic

From Brookings: Free media institutions are essential for informing the public and serving as a check on those in power — uncovering corruption and other malfeasance through investigative reporting, and elevating transparency in our governing processes. The media was perhaps even more important when the COVID-19 pandemic started in 2020, as it played a key role in disseminating public health information and shaping public perception.

On October 27, the Brookings Center on Regulation and Markets will hold an event to examine the role of the media in investigating the origin of the SARS-CoV-2 virus and draw important lessons for journalistic investigations of future crises to ensure independence and accountability in reporting. This event is part of a CRM workstream on biosafety regulation and pandemic prevention, which also included a recent event on “Building resilience: Enhancing biosafety, biosecurity, and pandemic preparedness.”

This event will take place from 1:30 – 3:15 PM EDT on October 27 in Washinton, DC, and virtually. Learn more and register here.

NEW: DC Biosecurity Happy Hour at Blackfinn DC!

This will be an informal event for biosecurity enthusiasts and professionals in DC to get to know each other outside of email and Zoom calls and talk about new ideas in this space.

The next event will be from 5:30 – 7:30 PM ET in Washington, DC, on Monday, November 3. Register here.

2025 Scowcroft Institute Pandemic Policy Summit, “Bridging the Gaps: Resilient Supply Chains in the Age of Pandemics.”

From the Scowcroft Institute of International Affairs: “This summit will convene scholars, policymakers, emergency managers, international partners, and industry leaders to examine the vulnerabilities exposed by recent global health emergencies and explore innovative policy solutions to strengthen domestic and global supply chain resilience. Together, we will identify strategies to ensure the reliable flow of critical goods and services in the face of future pandemics and public health crises.”

The summit will take place on October 27-28 in College Station, TX. Learn more and register here.

Exploring Applications of AI in Genomics and Precision Health: A Workshop

From NASEM: “The National Academies’ Roundtable on Genomics and Precision Health will host a hybrid public workshop on October 28 to explore current and potential future applications for AI in genomics and precision health along the continuum from translational research to clinical applications. The workshop will:

  • Explore the current implementation of AI in genomics and precision health (e.g., variant interpretation, data integration, patient and participant identification, return of results, treatment selection).
  • Discuss potential benefits and challenges of future AI applications (e.g., data harmonization and security, workforce, and usefulness for all).
  • Consider evaluations for and impact of the accuracy of, and bias inherent to, AI technologies in genomics-related research and clinical care.
  • Examine lessons learned from applications of AI in other fields that may be transferable to genomics and precision health throughout the translational research process.”

This workshop will take place 8:30am-5:00pm ET on October 28. Register here.

Global Conference on Biological Threat Reduction

From the World Organisation for Animal Health: “In October 2025, WOAH is hosting its third Global Conference, with the goal of galvanising advocacy efforts to manage the rising risk of biological threats from across the world.”

“The Global Conference on Biological Threat Reduction – which will take place in Geneva on 28-30 October 2025 – will bring together top minds in the fields of
health-security, emerging technologies, and biothreat reduction policies, from the public and private sectors – to focus on the latest strategies, challenges and innovations in combating biological threats to our interconnected ecosystems.”

“The Conference will bring together approximately 400 participants from different sectors, including animal health, law enforcement and security, public health, international and regional organisations, investment and development partners, private sector and industry representatives, research, academia and regulatory authorities, youth organisations.”

“Attendees will engage in thought-provoking discussions and innovative technical presentations aimed at strengthening prevention, preparedness and response capabilities across the world.”

“The event will be guided by a narrative that traces WOAH’s commitment to biological threat reduction and the increasingly relevant role it plays at the health-security interface. Against the backdrop of an uncertain future, WOAH believes that synergies between sectors can drive positive change – making the world a safer and healthier place. ”

Learn more and register here.

AI-Accelerated Biological Risk: Delving into Asia’s Challenges and Emerging Solutions

From Singapore AI Safety Hub: “As AI-enabled biodesign accelerates, so do the questions around responsible development, risk mitigation, and international cooperation. This 90-minute virtual roundtable brings together experts from AI safety, biosecurity research and policy to explore:

🔬 What are the most urgent AI-bio risks we face today—and which ones aren’t getting enough attention?

🌏 How does Asia’s unique regulatory and research landscape shape these challenges and opportunities?

🛡️ What solutions and interventions show the most promise for responsible governance?

🚀 What practical steps should researchers, policymakers, and practitioners prioritize in the next 12 months?

This panel will explore the convergence of AI and biosecurity—unpacking Asia’s unique challenges, emerging solutions, and the pathways toward responsible governance. From urgent risk assessment to practical next steps for researchers and policymakers, this is a conversation you won’t want to miss.”

This virtual roundtable will take place from 9:00 AM-10:30 AM EDT on Thursday, October 30. Register here.

Nexus Series: AI x Bio: Workshop 1

From AI for SynBio: “Agentic AI and Biological Design Tools reduce the required expertise for new biotech developments enabling new benefits and novel harms. To guard against these harms, technical and policy solutions leveraging these AI and biotech advances should be deployed proactively to help red-team and safeguard against misuse in an exponentially changing landscape. This workshop series will shape the safeguards necessary to prevent harm and empower the community with technical and policy resources for the changing threat landscape. The workshop seeks participation from academia, non-profits, industry, and government.”

This event will take place on November 13. Register here.

GHS 2026

From GHS: “We’re excited to officially announce that the 4th Global Health Security Conference (GHS2026) will be held in Kuala Lumpur on the 9 – 12 June, 2026!”

“Building on the incredible momentum of GHS2024 in Sydney, we look forward to bringing together the global health security community once again – this time in one of Southeast Asia’s most vibrant and dynamic cities.”

“Registration and Call for Abstracts are now live!”

Learn more, submit abstracts, and register here.

The Human Biosafety Health Foundation – A New Hub for Biosafety in the Mediterranean

From the Human Biosafety Health Foundation: “The Human Biosafety Health Foundation has been established to promote research, training, and international cooperation in the fields of biosafety, public health, and health resilience. The Foundation aims to serve as a Mediterranean hub for the development of shared and innovative strategies in response to global challenges related to conventional and non-conventional biological threats, climate change, and health emergencies. The Scientific Committee is composed of medical officers and biosafety experts in high biocontainment transport from the Italian Air Force, ensuring a highly qualified, interdisciplinary, and operationally secure approach. By bringing together academic expertise, institutions, and civil society, the Foundation seeks to build an integrated network for health security, based on knowledge, prevention, and prediction.”

Learn more and get involved here.

Notice of Funding Opportunity (NOFO) – Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research

“There is a global recognition that the current evidence base to inform laboratory and on-farm biological risk management has gaps, and that applied agricultural biosafety and biosecurity policies are not always based on evidence. This notice of funding will support the design and implementation of applied agricultural biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop or similar gap analysis like the WOAH working group agent specific biorisk gap analysis. ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the key focus areas and at least one component under that area.”

Learn more and submit your proposal by October 31 here.

Cyberbiosecurity Quarterly Call for Papers

“We are pleased to announce the launch of Cyberbiosecurity Quarterly, a new academic and trade journal dedicated to the intersection of cybersecurity and the bioeconomy. Published by Kansas State University’s New Prairie Press and sponsored by the Bioeconomy Information Sharing and Analysis Center (BIO-ISAC), this quarterly journal will serve as an important resource for professionals, researchers, and policymakers working to safeguard digital and physical biological infrastructures. Cyberbiosecurity is an emerging discipline that addresses the protection of biomanufacturing, biomedical research, synthetic biology, digital agriculture, and other life sciences sectors from digital threats. This journal will explore topics at the nexus of cybersecurity, digital biosecurity, and the bioeconomy, including but not limited to:

  • Best practices for network configuration and management in biomedical environments (ingress/egress protection, segmentation, isolation, access control, traffic protection, etc.)
  • Cybersecurity Vendor Management and Assessment
  • Cyber and Digital Biosecurity Education for the Bioeconomy’s Workforce
  • The Quality-Cybersecurity Tension in Practice and Techniques for Mitigation
  • Threat Intelligence for Cyber-Physical Biological Systems
  • Regulatory and Policy Perspectives on Cyberbiosecurity
  • Incident Response and Risk Mitigation in Biomanufacturing
  • AI and Machine Learning in Digital and Cyber Biosecurity”

Learn more and submit your papers here.

Applied Biosafety Call for Papers

“The Editors of Applied Biosafety are pleased to announce a forthcoming Special Issue focused on the myriad of topics associated with global biosafety management. This special issue will showcase examples of innovative approaches, creative solutions, and best practices developed and used around the world for managing risks associated with the handling, use, and storage of infectious biological agents, toxins, and potentially infectious materials in research and clinical settings.”

Learn more and submit by November 1 here.

AIxBio Research Fellowship

From ERA: “ERA, in partnership with the Cambridge Biosecurity Hub, is now accepting applications for our AIxBio Fellowship – an eight-week, fully-funded research programme focused on addressing biosecurity risks amplified by advances in frontier AI. Running from 25th January to 22nd March, 2026 in Cambridge, UK, this fellowship offers researchers the opportunity to design and execute concrete research projects at the AIxBiosecurity interface.”

Learn more and submit your application by November 5 here.

Harvard LEAD Fellowship for Promoting Women in Global Health

From Harvard’s Global Health Institute: “To equip and empower more leaders in global health, the Harvard Global Health Institute, in collaboration with the Department of Global Health and Population at Harvard T.H. Chan School of Public Health, offers a transformational 1-year fellowship specifically designed to promote leadership skills in individuals in low- and middle-income countries who will, in turn, mentor future female leaders in global health. Candidates should be currently based/working in a LMIC, and plan to return there after their fellowship.

The fellowship experience provides global health leaders time to reflect, recalibrate, and explore uncharted territories. To date, fellows have come from 18 different countries, with representation from Africa, Asia, Eastern Europe, and South America. Their areas of focus have ranged from HIV/AIDS and healthcare to health policy at the highest levels of government. Past fellows’ areas of expertise span disciplines including research, advocacy, administration, and policy.”

Learn more and submit your application by November 30 here.

64th ISODARCO Course

From ISODARCO: “In recent years, the global security landscape has become increasingly volatile, shaped by a convergence of geopolitical tensions, technological advancements, and evolving nuclear doctrines. The post-Cold War order that once provided a measure of predictability in global security has eroded. Conflicts such as the wars in Ukraine and Gaza, rising tensions in the Indo-Pacific, and strategic competition between major powers have reshaped alliances and strategic postures.”

“At the same time, disruptive technologies including artificial intelligence, quantum computing, hypersonic missiles, and cyber threats – are adding new layers of complexity to both nuclear and conventional deterrence dynamics. These technologies are not only distorting the information landscape but also compressing decision-making timelines and complicating signaling mechanisms, increasing the risk of miscalculation.”

“Effectively managing nuclear escalation risks in this environment will require a combination of innovative diplomacy, technological safeguards, and renewed dialogue mechanisms to rebuild trust, reduce misperceptions, and stabilize strategic relations.”

“The ISODARCO 2026 Winter Course presents an invaluable opportunity for students and experts to discuss and examine these dynamics in depth and explore approaches to re-establishing strategic stability and reducing nuclear dangers in a volatile world.”

This course will take place January 11-18, 2026, in Andalo. Learn more and apply here.

Pandora Report 10.17.2025

Welcome to this week’s Pandora Report! This issue features unprecedented disruptions across U.S. federal health agencies, including mass layoffs at the CDC and HHS, emerging challenges in biotechnology governance with BIOSECURE 2.0 and AI-drive generative biology, and new global health security initiatives from WHO and GPMB to improve early detection and pandemic preparedness across governments and communities.

Thinking About Graduate Study in Biodefense?

The Schar School of Policy and Government has several upcoming recruitment events, including one for prospective PhD students:

🔗 See all upcoming events here.

☕ Plus: Regional coffee chats with faculty and admissions staff across Maryland, Virginia, and DC. Learn more here.

💡 Tuition Benefit: Master’s and certificate students living in Maryland and DC quality for in-state tuition rates. Learn more and register here.

Fragmented Foundations: The Consequences of Mass Firings, Government Shutdown, and Political Turmoil Across U.S. Federal Agencies

By Carmen Shaw, Co-Managing Editor

The U.S. public health system is reeling from an unprecedented wave of mass firings, rehirings, and leadership reshuffles across federal health agencies. The Hill reports that more than 4,100 federal employees were laidoff on Friday, Oct. 10 – what many are describing as a “workforce massacre.” More than 1,000 staff at the CDC received layoff letters, while another 1,100-1,200 were terminated from the HHS. This marks the latest blow to the CDC that was already strained by mass resignations, a shooting at its Atlanta headquarters in August, and the recent firing of its director, Dr. Susan Monarez, under pressure from the HHS Secretary Robert F. Kennedy Jr.

Many of the CDC layoffs were later rescinded following public outcry, with the Trump administration claiming the decisions were made in error. The reversals, however, only deepened the sense of confusion and unease within the agency, and were not without consequences – as critical teams in biodefense and preparedness were still gutted. Those affected included staff from the Epidemic Intelligence Service (EIS), known as “disease detectives,” experts from the Morbidity and Mortality Weekly Report (MMWR) – the CDC’s flagship alert system for emerging infectious diseases, and teams working on chronic disease, immunization, respiratory illnesses, and responses to the growing measles outbreak in the U.S.

“The effect of the on-again, off-again RIF on the psyche of a traumatized organization is not inconsequential,” said Dr. Demetre Daskalakis, one of the three senior CDC leaders who resigned in August to protest Monarez’s firing. “Americans are going to get hurt,” he warned. Daskalakis, formerly the director of the National Center for Immunization and Respiratory Diseases, saw his leadership team laid off – and then hastily brought back.

Other agencies were also affected. According to The Hill, “Friday’s RIFs also impacted approximately 466 Education Department employees, 442 Department of Housing and Urban Development employees, 315 Commerce Department employees, 187 Energy Department employees and 176 Department of Homeland Security employees.”

The cuts came during the second week of a government shutdown – a move both unusual and legally contested. Lawsuits have since been filed by the American Federal of Government Employees, the nation’s largest federal employee union, among others, which sued hours before the government funding lapsed on Oct. 1, arguing that the administration lacks the authority to permanently eliminate positions during a shutdown and may only furlough workers.

Taken together, these mass firings and policy shifts represent more than bureaucratic mismanagement; they signal a strategic and dangerous devaluation of scientific integrity and public health. Each day of the shutdown leaves federal research programs in limbo, delaying critical work in university labs that rely on federal funding. Experts warn that if the shutdown continues for even a few more weeks, the disruptions could become “devastating,” echoing challenges from the longest shutdown in 2019. Every dismissal, delayed report, and frozen study further erodes national preparedness against biological risks. Unless decisive action is taken to restore transparency, scientific independence from political motives, and stable leadership, the United States risks entering the next public health emergency with a fractured, demoralized workforce and a weakened scientific infrastructure.

Further Reading:

From BIOSECURE 2.0 to Generative Biology: Evolving Challenges in Biotechnology Governance

Lawmakers and analysts are sounding the alarm over the rapid pace of biotechnology advanced abroad – particularly in China – arguing that U.S. leadership in defense biotech is slipping at a critical moment. As Defense One reports, Sen. Todd Young (R-Ind.), Rep. Chrissy Houlaha (D-Pa.), and other members of Congress are urging greater investment in defense-oriented biotech research to counter China’s growing dominance in gene editing, biomanufacturing, and pharmaceutical innovation. RealClear World similarly warns that the American biotech ecosystem is increasingly “made in China,” with U.S. supply chains, active pharmaceutical ingredients (APIs), and chemical industries deeply dependent on Chinese firms.

In response, the House and Senate services committees have added a number of biotechnology measures into the most recent National Defense Authorization Act bill, including a new amendment named “BIOSECURE 2.0,” building on 2024’s BIOSECURE 1.0 Act. While BIOSECURE 1.0 explicitly named four Chinese firms as “biotechnology companies of concern,” the updated legislation shifts toward a process-based identification system. Instead of naming any specific companies, BIOSECURE 2.0 will identify companies of concern based on whether they meet certain statutorily defined criteria and national security risk assessments, allowing for more adaptive and transparent enforcement.

Meanwhile, the World Economic Forum highlights the urgent need to build safeguards around generative biology, which integrates AI, automation, and computational design to accelerate the creation of novel biological systems. While this convergence is transforming industries – from Google DeepMind’s AlphaFold, which has successfully predicted 3D structures of millions of proteins, to food companies like Perfect Day and Impossible Foods using engineered microbes to produce alternatives to conventional dairy and livestock –  generative biology also introduces profound security concerns. One group of risks include emerging AI threats, warning that these systems could lower barriers to misuse, are vulnerable to adversarial attacks that could compromise the model’s accuracy, and allow for the insertion of poisoned datasets that could distort results, leading to inflated false positives and negatives.  

A recent NBC News investigation found that certain versions of OpenAI’s ChatGPT and other large language models (LLMs) could be “tricked and manipulated” to provide detailed instruction on creating chemical, biological, and nuclear weapons, underscoring how AI may inadvertently expand access to dangerous expertise. These vulnerabilities illustrate the dual-use dilemma of emerging technologies, emphasizing the urgent need for pre-deployment testing, regulatory oversight, and ethical frameworks to prevent malicious applications while advancing scientific progress.

Further Reading:

Advancing Global Health Security: WHO and GPMD Launch New Preparedness Systems

The Global Preparedness Monitoring Board (GPMD) launched its 2025 report, The New Face of Pandemic Preparedness, during the World Health Summit in Berlin on Oct. 13, calling for a paradigm shift in pandemic preparedness through scaled up investment in primary healthcare, real-time risk assessment, and strengthened international cooperation to ensure local, regional and global communities are ready to prevent and respond to the next pandemic.

Complementing this, the WHO has introduced two major initiatives to bolster global health security. First, the PHSM Decision Navigator, a first-of-its-kind decision navigator framework designed to support governments in making complex, evidence-informed, and threat-agnostic public health and social measures (PHSM) decisions during global health emergencies. By offering a step-by-step guide to prioritize and adjust interventions like quarantine, masking, and mobility restrictions, the navigator aims to balance epidemiological risks, economic and social impacts, and ethical considerations.

Second, WHO launched version 2.0 of the Epidemic Intelligence from Open Sources (EIOS) system, which leverages AI and expanded data sources to provide early detection of public health threats worldwide. Together, these tools exemplify the critical need for agile, transparent, and science-driven systems in preparing governments and communities to respond effectively in health emergencies.

Further Reading:

Avian Influenza Updates

By Margeaux Malone, Pandora Report Associate Editor

Bird Flu Season Kicks into High Gear Across the United States

Fall bird flu season appears well under way as H5N1 activity surges across the United States in commercial poultry operations, backyard flocks, and wild bird populations. The U.S. Department of Agriculture confirmed multiple significant outbreaks in the last month, with 47 flocks affected, including 28 commercial operations and 19 backyard locations, totaling more than 4.4 million birds.

The geographic distribution appears concentrated in Midwest and Southern states. Three large commercial turkey farms in Minnesota experienced major losses this week, with facilities reporting 30,000, 61,000, and 92,000 infections across three counties. The Pacific Northwest also faces rising bird flu fears following detection of H5N1 in a commercial egg layer facility in Washington, housing nearly 2 million birds. Oregon and Idaho identified additional cases in both backyard flocks and, in Idaho’s case, a preliminary confirmation in a dairy herd as well.

Wild bird detections have spiked particularly among migratory waterfowl species. Hunter-harvested blue-winged teal in Kansas tested positive for H5N1, as did specimens collected in Louisiana. Black vultures, turkey vultures, Canada geese, and trumpeter swans have shown H5 positivity across multiple states including Wyoming, Ohio, Colorado, Kentucky, Virginia, New York, and Michigan.

From Farm to Table: Bird Flu May be Hiding in Artisanal Cheeses

As bird flu expands into cattle populations, emerging research has identified an unexpected food safety concern in cheese. The virus has been shown to survive the aging process in certain raw milk cheeses, potentially reaching consumers on supermarket shelves months after contaminated milk was used.

A study published in early October in Nature Medicine revealed that in cheeses with moderate pH levels between 5.8 and 6.6, infectious H5N1 persisted after 120 days of aging at a temperature of 39 Fahrenheit. The FDA requires that raw milk cheese must be aged a minimum of 60 days at or above 35 degrees Fahrenheit, meaning there is a potential health risk for consumers. However, not all raw milk cheeses appear to pose a risk. Researchers found that highly acidic cheeses like feta, which has a pH around 4.6 or lower, showed no detectable virus, suggesting acidity acts as a natural antiviral barrier.

These findings create a troubling situation for the cheese industry as the qualities that give artisanal cheeses their prized flavors and textures are the same conditions that may allow H5N1 to persist. It also puts additional strain on dairy farmers already grappling with herd infections across 17 states. A single contaminated milk batch could produce hundreds of wheels of cheese destined for distribution before any problem is detected.

Mitigation pathways exist but will require industry coordination: screening milk samples prior to cheese making to ensure only virus-free milk is used or heating milk to sub-pasteurization temperatures to preserve the desirable raw milk characteristics while rendering the pathogen harmless. The challenge lies in implementing these measures rapidly enough to protect both industry viability and public health.

H5N1 Vaccine Project Aims to Meet 100-Day Development Target

This week the Coalition for Epidemic Preparedness Innovations (CEPI) announced a significant partnership with the Serum Institute of India (SII), the world’s largest vaccine manufacturer, to develop a new H5N1 vaccine as a prototype for Disease X, an as-yet unknown pathogen with pandemic potential.

The goal of the project, which has been granted $16.4 million in financial support, is to allow rapid development of broadly protective vaccines capable of responding to multiple H5 virus strains. The vaccine will be developed on a baculovirus platform and will compare two H5 antigens for a recombinant protein vaccine: a wild-type and an artificial intelligence (AI)-optimized, broad-spectrum H5 antigen designed by scientists at Houston Methodist Research Institute. 

According to CEPI leadership, the project is a key component of the organization’s ambitious 100-day mission, which aims to compress vaccine development timelines to within 100 days of identifying a pandemic threat.

Further Reading:

“Milton Leitenberg: Pioneering Work on Weapons of Mass Destruction, Wars and Arms Control”

Kathleen M. Vogel, Nicole J. Ball, and Milton Leitenberg are pleased to announce the publication of Milton Leitenberg: Pioneering Work on Weapons of Mass Destruction, Wars and Arms Control (Springer, 2025). This nearly 900-page book is a collection of 44 representative publications and papers by Milton Leitenberg on nuclear and biological arms control, wars, conflicts, genocide and humanitarian intervention, and weapons of mass destruction. Several chapters explore aspects of disinformation, notably on the use and production of biological weapons and the origins of Covid.  In addition to publications that appeared in journals and books, this volume contains several previously unpublished reports prepared for national and international organizations. Spanning 55 years, these studies made substantial contributions to policy literature and discussions over the years and are of continued interest to security studies, political science, and policy audiences today.

This book is available in hard copy and eBook formats here

NEW: 2025 Scowcroft Institute Pandemic Policy Summit, “Bridging the Gaps: Resilient Supply Chains in the Age of Pandemics.”

From the Scowcroft Institute of International Affairs: “This summit will convene scholars, policymakers, emergency managers, international partners, and industry leaders to examine the vulnerabilities exposed by recent global health emergencies and explore innovative policy solutions to strengthen domestic and global supply chain resilience. Together, we will identify strategies to ensure the reliable flow of critical goods and services in the face of future pandemics and public health crises.”

The summit will take place on October 27-28 in College Station, TX. Learn more and register here.

AI, Health, and the Future of Scientific Cooperation: A Seminar

From Harvard Kennedy School: “This seminar explores how artificial intelligence is transforming healthcare, global health, and the scientific enterprise: accelerating discovery, strengthening biosecurity, and reshaping international collaboration. Moderated by Dr. Syra Madad, fellow and biosecurity expert, the discussion will highlight both the opportunities and risks at the intersection of AI, medicine, and scientific cooperation in a rapidly evolving world.”

This event will take place from 12:00-2:00pm ET on October 20. Register here.

Improving Resiliency in the U.S. Pharmaceutical Supply Chain Through Make-Buy-Invest Strategic Actions: A Workshop

From NASEM: “The National Academies will convene a hybrid public workshop, October 22-23, to develop a framework to inform policymakers and stakeholders on how to apply Make, Buy, or Invest strategies across the U.S. pharmaceutical supply chain. Discussions will consider variables such as national security and health; drug manufacturing practices; systemic enablers to support implementation practices; methods to assess market conditions; and the roles of key public and private stakeholders to influence the resilience of the domestic drug supply chain.”

This event will take place from 8:30am-5:30pm ET on October 22-23. Register here.

Governance of Dual-Use Risks of Synthetic Biology: Recent Efforts in China

From the Asia Centre for Health Security: “Scientific progress in cutting-edge biotechnology has enabled the development of new medical countermeasures and disease surveillance capabilities. With the increasing ease of use and accessibility, and lower cost of biotechnology, unintentional misuse or deliberate abuse of dual-use cutting edge biotechnology will result in serious economic and security consequences.

Professor Zhang will explain how the Tianjin University Center for Biosafety Research and Strategy, the first scientific think tank focusing biotechnology-related biosecurity governance in China, raises awareness of the dual-use risks of biotechnology, develops solutions and policies to address these risks, and reinforces ethical practice in the scientific community.”

This event will take place from 6:00–7:00 pm (GMT+08:00) on October 23. Register here.

Exploring Applications of AI in Genomics and Precision Health: A Workshop

From NASEM: “The National Academies’ Roundtable on Genomics and Precision Health will host a hybrid public workshop on October 28 to explore current and potential future applications for AI in genomics and precision health along the continuum from translational research to clinical applications. The workshop will:

  • Explore the current implementation of AI in genomics and precision health (e.g., variant interpretation, data integration, patient and participant identification, return of results, treatment selection).
  • Discuss potential benefits and challenges of future AI applications (e.g., data harmonization and security, workforce, and usefulness for all).
  • Consider evaluations for and impact of the accuracy of, and bias inherent to, AI technologies in genomics-related research and clinical care.
  • Examine lessons learned from applications of AI in other fields that may be transferable to genomics and precision health throughout the translational research process.”

This workshop will take place 8:30am-5:00pm ET on October 28. Register here.

Global Conference on Biological Threat Reduction

From the World Organisation for Animal Health: “In October 2025, WOAH is hosting its third Global Conference, with the goal of galvanising advocacy efforts to manage the rising risk of biological threats from across the world.”

“The Global Conference on Biological Threat Reduction – which will take place in Geneva on 28-30 October 2025 – will bring together top minds in the fields of
health-security, emerging technologies, and biothreat reduction policies, from the public and private sectors – to focus on the latest strategies, challenges and innovations in combating biological threats to our interconnected ecosystems.”

“The Conference will bring together approximately 400 participants from different sectors, including animal health, law enforcement and security, public health, international and regional organisations, investment and development partners, private sector and industry representatives, research, academia and regulatory authorities, youth organisations.”

“Attendees will engage in thought-provoking discussions and innovative technical presentations aimed at strengthening prevention, preparedness and response capabilities across the world.”

“The event will be guided by a narrative that traces WOAH’s commitment to biological threat reduction and the increasingly relevant role it plays at the health-security interface. Against the backdrop of an uncertain future, WOAH believes that synergies between sectors can drive positive change – making the world a safer and healthier place. ”

Learn more and register here.

AI-Accelerated Biological Risk: Delving into Asia’s Challenges and Emerging Solutions

From Singapore AI Safety Hub: “As AI-enabled biodesign accelerates, so do the questions around responsible development, risk mitigation, and international cooperation. This 90-minute virtual roundtable brings together experts from AI safety, biosecurity research and policy to explore:

🔬 What are the most urgent AI-bio risks we face today—and which ones aren’t getting enough attention?

🌏 How does Asia’s unique regulatory and research landscape shape these challenges and opportunities?

🛡️ What solutions and interventions show the most promise for responsible governance?

🚀 What practical steps should researchers, policymakers, and practitioners prioritize in the next 12 months?

This panel will explore the convergence of AI and biosecurity—unpacking Asia’s unique challenges, emerging solutions, and the pathways toward responsible governance. From urgent risk assessment to practical next steps for researchers and policymakers, this is a conversation you won’t want to miss.”

This virtual roundtable will take place from 9:00 AM-10:30 AM EDT on Thursday, October 30. Register here.

Nexus Series: AI x Bio: Workshop 1

From AI for SynBio: “Agentic AI and Biological Design Tools reduce the required expertise for new biotech developments enabling new benefits and novel harms. To guard against these harms, technical and policy solutions leveraging these AI and biotech advances should be deployed proactively to help red-team and safeguard against misuse in an exponentially changing landscape. This workshop series will shape the safeguards necessary to prevent harm and empower the community with technical and policy resources for the changing threat landscape. The workshop seeks participation from academia, non-profits, industry, and government.”

This event will take place on November 13. Register here.

GHS 2026

From GHS: “We’re excited to officially announce that the 4th Global Health Security Conference (GHS2026) will be held in Kuala Lumpur on the 9 – 12 June, 2026!”

“Building on the incredible momentum of GHS2024 in Sydney, we look forward to bringing together the global health security community once again – this time in one of Southeast Asia’s most vibrant and dynamic cities.”

“Registration and Call for Abstracts are now live!”

Learn more, submit abstracts, and register here.

NEW: The Human Biosafety Health Foundation – A New Hub for Biosafety in the Mediterranean

From the Human Biosafety Health Foundation: “The Human Biosafety Health Foundation has been established to promote research, training, and international cooperation in the fields of biosafety, public health, and health resilience. The Foundation aims to serve as a Mediterranean hub for the development of shared and innovative strategies in response to global challenges related to conventional and non-conventional biological threats, climate change, and health emergencies. The Scientific Committee is composed of medical officers and biosafety experts in high biocontainment transport from the Italian Air Force, ensuring a highly qualified, interdisciplinary, and operationally secure approach. By bringing together academic expertise, institutions, and civil society, the Foundation seeks to build an integrated network for health security, based on knowledge, prevention, and prediction.”

Learn more and get involved here.

Scoville Peace Fellowship

“The fellowship ensures a pipeline of the brightest, most dedicated, and diverse next-generation experts into leading think tanks and advocacy groups in order to inspire creative new approaches to the pervasive challenges to peace and security. Its goal is to bridge the gap between academia and the professional world by providing an entree for mission-driven grads eager to learn about and contribute to public-interest organizations. The fellowship was established to honor longtime nuclear arms control activist Dr. Herbert (Pete) Scoville, Jr., a Ph.D. in physical chemistry and dedicated public servant, who encouraged young people to become involved in arms control and national security.”

Learn more and submit your application by October 20 here.

Notice of Funding Opportunity (NOFO) – Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research

“There is a global recognition that the current evidence base to inform laboratory and on-farm biological risk management has gaps, and that applied agricultural biosafety and biosecurity policies are not always based on evidence. This notice of funding will support the design and implementation of applied agricultural biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop or similar gap analysis like the WOAH working group agent specific biorisk gap analysis. ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the key focus areas and at least one component under that area.”

Learn more and submit your proposal by October 31 here.

Cyberbiosecurity Quarterly Call for Papers

“We are pleased to announce the launch of Cyberbiosecurity Quarterly, a new academic and trade journal dedicated to the intersection of cybersecurity and the bioeconomy. Published by Kansas State University’s New Prairie Press and sponsored by the Bioeconomy Information Sharing and Analysis Center (BIO-ISAC), this quarterly journal will serve as an important resource for professionals, researchers, and policymakers working to safeguard digital and physical biological infrastructures. Cyberbiosecurity is an emerging discipline that addresses the protection of biomanufacturing, biomedical research, synthetic biology, digital agriculture, and other life sciences sectors from digital threats. This journal will explore topics at the nexus of cybersecurity, digital biosecurity, and the bioeconomy, including but not limited to:

  • Best practices for network configuration and management in biomedical environments (ingress/egress protection, segmentation, isolation, access control, traffic protection, etc.)
  • Cybersecurity Vendor Management and Assessment
  • Cyber and Digital Biosecurity Education for the Bioeconomy’s Workforce
  • The Quality-Cybersecurity Tension in Practice and Techniques for Mitigation
  • Threat Intelligence for Cyber-Physical Biological Systems
  • Regulatory and Policy Perspectives on Cyberbiosecurity
  • Incident Response and Risk Mitigation in Biomanufacturing
  • AI and Machine Learning in Digital and Cyber Biosecurity”

Learn more and submit your papers here.

Applied Biosafety Call for Papers

“The Editors of Applied Biosafety are pleased to announce a forthcoming Special Issue focused on the myriad of topics associated with global biosafety management. This special issue will showcase examples of innovative approaches, creative solutions, and best practices developed and used around the world for managing risks associated with the handling, use, and storage of infectious biological agents, toxins, and potentially infectious materials in research and clinical settings.”

Learn more and submit by November 1 here.

AIxBio Research Fellowship

From ERA: “ERA, in partnership with the Cambridge Biosecurity Hub, is now accepting applications for our AIxBio Fellowship – an eight-week, fully-funded research programme focused on addressing biosecurity risks amplified by advances in frontier AI. Running from 25th January to 22nd March, 2026 in Cambridge, UK, this fellowship offers researchers the opportunity to design and execute concrete research projects at the AIxBiosecurity interface.”

Learn more and submit your application by November 5 here.

Harvard LEAD Fellowship for Promoting Women in Global Health

From Harvard’s Global Health Institute: “To equip and empower more leaders in global health, the Harvard Global Health Institute, in collaboration with the Department of Global Health and Population at Harvard T.H. Chan School of Public Health, offers a transformational 1-year fellowship specifically designed to promote leadership skills in individuals in low- and middle-income countries who will, in turn, mentor future female leaders in global health. Candidates should be currently based/working in a LMIC, and plan to return there after their fellowship.

The fellowship experience provides global health leaders time to reflect, recalibrate, and explore uncharted territories. To date, fellows have come from 18 different countries, with representation from Africa, Asia, Eastern Europe, and South America. Their areas of focus have ranged from HIV/AIDS and healthcare to health policy at the highest levels of government. Past fellows’ areas of expertise span disciplines including research, advocacy, administration, and policy.”

Learn more and submit your application by November 30 here.

64th ISODARCO Course

From ISODARCO: “In recent years, the global security landscape has become increasingly volatile, shaped by a convergence of geopolitical tensions, technological advancements, and evolving nuclear doctrines. The post-Cold War order that once provided a measure of predictability in global security has eroded. Conflicts such as the wars in Ukraine and Gaza, rising tensions in the Indo-Pacific, and strategic competition between major powers have reshaped alliances and strategic postures.”

“At the same time, disruptive technologies including artificial intelligence, quantum computing, hypersonic missiles, and cyber threats – are adding new layers of complexity to both nuclear and conventional deterrence dynamics. These technologies are not only distorting the information landscape but also compressing decision-making timelines and complicating signaling mechanisms, increasing the risk of miscalculation.”

“Effectively managing nuclear escalation risks in this environment will require a combination of innovative diplomacy, technological safeguards, and renewed dialogue mechanisms to rebuild trust, reduce misperceptions, and stabilize strategic relations.”

“The ISODARCO 2026 Winter Course presents an invaluable opportunity for students and experts to discuss and examine these dynamics in depth and explore approaches to re-establishing strategic stability and reducing nuclear dangers in a volatile world.”

This course will take place January 11-18, 2026, in Andalo. Learn more and apply here.

Pandora Report 9.26.2025

Welcome to this week’s Pandora Report! This issue features federal undercutting on U.S. science funding and the risk of a brain drain, the U.S. “America First” global health strategy and its implications for international aid, the narrowing of COVID-19 vaccine guidance and state-level responses, the escalating Ebola outbreak in the Democratic Republic of the Congo, and a breakthrough in biotechnology with the first AI-designed viruses capable of targeting E. coli.

Thinking About Graduate Study in Biodefense?

The Schar School of Policy and Government has several upcoming recruitment events:

For Prospective MS Students:

For Prospective PhD Students:

🔗 See all upcoming events here.

☕ Plus: Regional coffee chats with faculty and admissions staff across Maryland, Virginia, and DC. Learn more here.

💡 Tuition Benefit: Master’s and certificate students living in Maryland and DC quality for in-state tuition rates. Learn more and register here.

From Classroom to Commission: Mason Biodefense Students Shaping Biotechnology Policy

By Jay Bickell

Jay Bickell is pursuing a MS in Biodefense at George Mason University and works as a Staff Scientist at MRIGlobal supporting biorisk management programs.

Earlier this year, the National Security Commission on Emerging Biotechnology (NSCEB) released its final report, Charting the Future of Biotechnology. What emerged was not a victory lap or a reassurance, but both an inspiring reminder of the promise of biotechnology and a stark warning about what is at stake in the biotechnology innovation race. The report’s executive summary wastes no time, bluntly stating that “countries that win the innovation race tend to win actual wars, too.” From the outset, the message is clear: the U.S. cannot afford complacency in biotechnology.

Given the breadth of issues at play, the Commission relied on expertise from many different disciplines. Among those involved were George Mason University Biodefense students and alumni, who contributed their expertise and academic training to the practical work of shaping U.S. biotechnology policy.

This article explores the origins of the commission, the key findings of its report, and the role of GMU biodefense students and alumni who served as policy advisors and fellows.

The Commission

The NSCEB was established by Congress in 2022 as an independent legislative advisory body, created in response to the rapid pace of emerging biotechnology and its profound implications for both the U.S. bioeconomy and national security. Its establishment was a bicameral decision, reflecting bipartisan concern, and its commissioners brought a wide range of expertise from across science, industry, defense, and policy.

The Commission had an ambitious charge to provide Congress with an assessment of biotechnology’s role in national security and to recommend concrete steps for harnessing its benefits while mitigating risks. Modeled in part on the National Security Commission on Artificial Intelligence, the NSCEB conducted an extensive two-year study, gathering insights from more than 1,800 professionals worldwide. Beyond analysis, its task was also pragmatic in nature, to ensure recommendations were actionable and capable of being translated into policy. The NSCEB will continue turning those recommendations into bills before the commission winds down in December 2026.

The Report

The final report, Charting the Future of Biotechnology, begins with a sobering vision of a not-so-distant future where the U.S. fails to keep pace in biotechnology innovation and with it, risks losing both economic and military advantages. Over the course of nearly 400 pages the report delivers 49 specific and concrete recommendations ranging from establishing a National Biotechnology Coordination Office (NBCO) in the Executive Office of the President, to providing workforce training. Ultimately every recommendation culminates in the main recommendation that “the U.S. government should dedicate a minimum of $15 billion over the next five years to unleash more private capital into our national biotechnology sector.”

Behind the Report: GMU Students and Alumni  

Behind the report’s recommendations lies the work of 63 commission staff as well as countless other participants. Notably, among them were several students and alumni from George Mason University’s Biodefense (BIOD) program, who brought their expertise to an effort that will shape U.S. biotechnology policy for years to come.

Aishwarya Sriraman is a third-year PhD student in the BIOD program and served as a research and policy fellow supporting Commissioners in developing the report. Her work focused on recognizing how education and workforce development will build tomorrow’s biotechnology workforce. Drawing on her technical background in biochemistry and biotechnology, she helped connect the policymaking process to the realities facing biotechnology and biosecurity professionals. Aishwarya hopes “that professionals get excited by the potential of emerging biotechnology (the science and its potential impact) while also recognizing their roles and responsibilities in ensuring its success.”

Olivia Parker, joined the commission as a policy advisor in August of 2024, shortly after earning her Master of Science in Biodefense in May 2024. She credits the multidisciplinary nature of the Biodefense program as preparing her for this role. According to Olivia, “One of the things I’ve appreciated most about working on the Commission staff has been learning from my colleagues. The folks on staff come from a broad range of professional worlds, and it’s been really illuminating to see the different perspectives they bring while contributing my own.”

Kimberly Ma is a third-year PhD student in the BIOD program and is a policy advisor with the commission where she is co-leading the infrastructure workstream and closely supporting the biosecurity workstream. When it comes to thinking about policy she credits both time in Georgetown’s MS Biohazardous Threat Agents & Emerging Infectious Diseases program and GMU’s Biodefense program with complementing her hands-on career experience in U.S. government biotechnology spaces. Kimberly commented that, “Even for someone trained in molecular biology and biosecurity, I think I had not truly internalized or experienced how vast the bioeconomy is. During my time at the Commission, the breadth of folks who have shown interest in our work, provided us their expertise and anecdotes, reposted our press releases on social media, or showed up to our launch event absolutely blew my mind. I feel a sense of awe, as well as increased obligation to ensure that promoting and protecting biotech are national priorities for our country.

Looking Forward

The contributions of these Biodefense students and graduates are not just a testament to their training, they are a reminder that the future of biotechnology and biosecurity leadership is already taking shape. Their experiences reflect the heart of the Commission’s work: recognizing both the opportunities and risks that lie ahead and preparing the next generation to meet them.

Though the report is sobering in its assessment, the example set by these students and alumni offers reason for optimism. They show that the next wave of scientists and policy experts are already stepping into roles of national importance. Opportunity and risk both loom large, but as their work illustrates, the direction biotechnology takes will depend on the choices and the commitments we make today.

Science Under Siege: Federal Cuts and the Risk of a U.S. Brain Drain

From Nature: “Months into President Trump’s second term, science and scientists are under attack as never before in the United States. The administration is forcing devastating cuts to previously stable US research investments, dismantling federal science agencies and programmes, ousting independent scientific officials and blatantly disregarding evidence on issues that affect us all, including vaccines, air pollution, and fossil fuels.”

Both early-career and seasoned specialists have been left bewildered and, in many cases, unemployed by these aggressive actions. Experts warn that the U.S. risks losing scientific expertise across multiple fields – a phenomenon many are calling a “brain drain” – with recovery potentially taking decades. “There will be lasting damage, and it will likely take multiple political administration to get over and to rebuild what has been lost,” said Jennifer Jones, Director of the Center for Science and Diplomacy at the Union of Concerned Scientists.  

Scientists, however, are pushing back. Some are filing lawsuits to reinstate grants, others are compiling budgetary records to help in lawsuits, and many are speaking out against the administration’s actions, often at the risk of their own careers. Groups like Stand Up for Science, a non-profit dedicated to countering harmful policy and funding changes to science under the current administration, are working to spotlight these issues and support scientific integrity. These efforts have led to some victories, for example, with judicial decisions reinstating hundreds of terminated projects at the NIH, or the restoration of $500 million in UCLA and other University of California school research grants.

Further Reading:

America First Global Health: Cuts, Conditions, and Questions Ahead

This week, the State Department unveiled its “America First Global Health Strategy,” a policy framework emphasizing U.S. priorities in global health. Just days before, the House advanced its FY26 Labor-HHS appropriations bill, proposing severe cuts to CDC funding, eliminating certain prevention programs, and drastically scaling back USAID’s role in global health initiatives. Under the new strategy, the U.S. plans to shift from global health aid to fostering self-reliance in partner countries, requiring them to co-invest in health programs and meet “performance benchmarks” before additional U.S. foreign health assistance is released. According to the document, the administration aims to finalize multi-year bilateral agreements with recipient nations by April 2026, aiming to reduce “the culture of dependency.” Taken together, these moves reflect a broader shift in U.S. health policy toward prioritizing domestic interests over multilateral cooperation. In a related development, President Trump also called for a global ban on bioweapons at the UN, proposing the use of artificial intelligence (AI) to verify compliance with the Biological Weapons Convention (BWC). While presented as a high-tech initiative to strengthen the BWC, the plan’s limited details leave open questions about how effectively it will be implemented and whether it can gain broad international support.

Further Reading:

ACIP Narrows COVID-19 Vaccine Guidance, Prompting State and Expert Divergence

Last Friday, the CDC’s Advisory Committee on Immunization Practices (ACIP) voted to narrow its COVID-19 vaccine recommendations, reserving a routine recommendation for adults 65 and older while shifting younger groups to “shared clinical decision-making” through consultation with providers. While the vaccine remains available to anyone over six months, this change could reduce ease of access compared to prior years and has raised concerns about sowing doubt among the public. As former acting CDC director Richard Besser noted, “What this process over these two days did was it instilled doubt in a lot of people who didn’t have doubt. And it’s going to lead people who were trying to do the right thing for their families, for their children, to make wrong decisions.” Meanwhile, ACIP voted to postpone a decision on whether to delay the first hepatitis B vaccine dose for newborns, temporarily maintaining the current recommendation. In response to federal uncertainty, several states and medical societies, including the American Academy of Pediatrics (AAP), which had long worked in concert with the CDC, are breaking with federal recommendations and issuing their own vaccine guidance, citing a lack of confidence and trust in federal leadership.

Further Reading:

DRC Faces Escalating Ebola Outbreak Amid Reduced Global Aid

The Ebola outbreak in Kasaï province continues to escalate, with the latest reports indicating 47 confirmed cases and 25 deaths, according to the World Health Organization (WHO), with a probably 10 additional cases and deaths. Vaccination campaigns are ongoing, with an initial shipment of 400 doses of Ervebo (rVSV-ZEBOV) being deployed to Bulape and another 360 doses arriving in Tshikapa. The WHO has launched an appeal for US$21million to support the DRC’s governmental response. While the DRC has learned from previous outbreaks and in many ways is now better prepared to respond, experts warn cuts to global aid spending risk constraining response efforts. “Viruses do not respect political decisions or borders. Disengaging in global leadership and slashing funding to countries like the DRC will have serious consequences,” said Ms. Kate Phillips-Barrasso, Mercy Corps Vice President of Global Policy and Advocacy.

During previous Ebola outbreaks, the U.S. provided critical support through USAID, funding laboratories, vaccines, treatments, personal protective equipment (PPE), and community awareness programs. Since cuts to these programs, stockpiles of drugs and PPE have not been consistently maintained, and key prevention initiatives – like clean water and hygiene campaigns – have been scaled back. Shortages of PPE and difficulties distributing information, vaccines and treatments to remote areas, however, long predate recent funding cuts. While some analysts have speculated that China could fill the gap left by U.S. aid reductions, its capacity and willingness to do so remain limited. Beijing seems to emphasize a “trade, not aid” model, prioritizing trade over large-scale development assistance and intervening only in countries of immediate strategic interest. Humanitarian organizations stress that maintaining robust international support, rather than piecemeal substitutes, is critical to containing Ebola and supporting the DRC’s health system.

Further Reading:

AI Creates Functional Bacteriophages Targeting E. coli

Scientists at Stanford University and the Arc Institute have created the first ever viruses designed by artificial intelligence (AI), capable of infecting and killing E. coli bacteria. The work, described in a preprint paper, used AI models called Evo 1 and Evo 2, which were pre-trained on over two million phage genomes. These models were developed to generate DNA, RNA, and protein sequences. The AI models were given a template virus called ΦX174 to start with, which was simple and safe. The AI models were trained to create similar viruses aimed at infecting E. coli, especially resistant strains. From thousands of AI-generated genome sequences, the researchers identified 302 viable bacteriophages, of which roughly 16 phages showed host specificity for E. coli and could successfully infect the bacteria. “This study provides a compelling case study of what is possible today and sets the stage for more-ambitious applications in the future,” says Peter Koo, a computational biologist at Cold Spring Harbor Laboratory in Laurel Hollow, New York. “It provides a spotlight for an interesting application domain,” he adds.

Further Reading:

Avian Influenza Updates and More

By Margeaux Malone, Pandora Report Associate Editor

September Signals Start of H5N1 Resurgence Worldwide

Just as wildlife experts predicted, highly pathogenic avian influenza (HPAI) H5N1 is surging internationally as fall bird migration kicks into high gear. Europe has already logged 263 commercial poultry outbreaks of bird flu so far in 2025. Hungary leads the tally with 105 outbreaks, followed by Poland (85) and Italy (21). On Monday, Poland reported two new detections resulting in the death of nearly 4,000 birds. An outbreak in Spain earlier this month was particularly devastating, wiping out over 761,000 laying hens in a single facility in Castile and Leon.

Meanwhile, the U.S. continues to see a steady resurgence as well. Multiple Mid-West states continue to fight outbreaks in commercial turkey flocks, with over half a million cases confirmed by the USDA across the Dakotas and Minnesota since the start of September. Iowa also confirmed the presence of HPAI in Canada geese, mallards, and red-tailed hawks this week following reports of dead birds in Dubuque.

With migration season just beginning, case numbers are expected to continue. The question isn’t whether H5N1 will spread further, it’s whether current containment efforts can keep pace with nature’s own distribution network.

Further Reading:

New World Screwworm Inches Closer to U.S. Border

The New World screwworm (NWS) outbreak in Central America took a concerning turn this week as Mexico confirmed its northernmost case yet, only 69 miles from the Texas border. A young cow in Sabinas Hidalgo, Nuevo Leon, tested positive for the flesh-eating parasite, marking a significant geographic leap from the previous detection in Veracruz in July, some 370 miles south of the U.S. border. The location is especially worrying as Sabinas Hidalgo sits along the major highway from Monterrey, Nuevo Leon’s capital and largest city, to Laredo, Texas, one of the world’s busiest commercial corridors.

The U.S. response has been swift but costly for bilateral relations. USDA continues the suspension on all imports of Mexican cattle, bison, and horses while the NWS outbreak is handled, a move that could cost Mexico’s ranching industry up to $400 million if maintained through the year. In response to the new detection near the border, Agriculture Secretary Brooke Rollins stated that Washington will take “decisive measures to protect our borders, even in the absence of cooperation.” Nearly 8,000 traps across Texas, Arizona, and New Mexico have screened over 13,000 samples without detecting screwworm flies stateside. The USDA has also allocated $100 million for enhanced sterile-fly production and advanced detection tools.

With over 500 active cases across Mexico’s southern states and the parasite’s ability to infect any warm-blooded animal, this outbreak represents a significant agricultural security challenge that will require sustained binational cooperation.

Typologies of Terrorist Organizations: Conceptual Lenses and Counterterrorism Measures

This forthcoming book was authored by Mahmut Cengiz, Mitchel P. Roth, and Huseyin Cinoglu. Cengiz is an associate professor in the Schar School of Policy and Government and a research faculty member with Mason’s Terrorism, Transnational Crime and Corruption Center who teaches courses in the Biodefense Graduate Program: “Explore the complex landscape of global terrorism with Typologies of Terrorist Organizations: Conceptual Lenses and Counterterrorism Measures. This essential volume provides a comprehensive examination of hundreds of terrorist groups and employs a detailed framework of typological classifications—religious, left-wing/revolutionary, ethnonationalist, anarchist, right-wing, ecoterrorism, state terrorism, cyberterrorism, and narcoterrorism—to analyze each group in depth, focusing on their ideologies, key actors, methods, and underlying motives.”

“What sets this book apart is its multidimensional approach, using conceptual lenses to delve into the causes of terrorist actions, the motivations driving these groups, and their strategies. This approach not only aids in combating terrorism but also enhances understanding of the broader context in which these groups operate. It provides insights into their organizational structures, tactics, weaponry, victim profiles, target types, funding sources, and networks, painting a comprehensive picture of the evolving nature of terrorism.”

“Additionally, Typologies of Terrorist Organizations offers a critical review of domestic and global counterterrorism strategies, examining how these strategies have evolved to address emerging threats. Each chapter provides a detailed perspective on counterterrorism efforts, making this book a valuable resource for understanding both the development of terrorist tactics and the responses designed to counter them.”

“Ideal for scholars, policymakers, and security professionals, this book is not only crucial for those engaged in counterterrorism but also for anyone seeking to understand the broader contextual dynamics of global terrorism. Its combination of theoretical depth and practical analysis makes it a significant contribution to the field of counterterrorism studies and an indispensable guide for navigating contemporary security challenges.”

“Upward and Onward: 2025 Preparedness Summit”

Read about Biodefense PhD student Kimmy Ma’s experience at the  the National Association of County and City Health Officials’ (NACCHO) 2025 Preparedness Summit in this article from the Pandora Report. In it, Ma writes in part, “It will by no means be a simple or easy road, but I believe my public health preparedness colleagues’ adamant desire and mindset to serve their constituents is what brings them back to their work and keep attending Prep Summit, year after year. It seems like, deep down, they never truly give up on their belief that there is a way to reach the light at the end of the tunnel and serve their communities in the process.”

“Physical Approaches to Civilian Biodefense: Identifying Potential Preparedness Measures for Challenging Biological Threats”

From the RAND Corporation: “This research project was initiated in response to emerging evidence on three possible biological threat scenarios that could have catastrophic effects on the United States: a fast scenario involving a rapidly spreading outbreak of a lethal human-to-human-transmissible pathogen, a silent scenario involving a pathogen that infects much of the population before infected people display visible symptoms, and a saturating scenario involving a pathogen that replicates and persists in the environment. Although these three broad scenario categories have been discussed elsewhere, the goal of this report is to better define the possibilities and limits of physical approaches to civilian biodefense against these scenarios. In this report, we offer initial frameworks for thinking about how the United States could achieve resilience against these scenarios (as well as any less severe versions), and we recommend actions that governments and civil society can take to work toward resilience. This work is not precise or conclusive; it can and should be verified and analyzed in a more detailed and expanded manner to support more-precise recommendations. This report is intended primarily for policymakers and technical staff, as well as philanthropists, who work on pandemic preparedness and catastrophic threat mitigation.”

Personal Protective Equipment for Influenza A (H5N1) in High-Risk Farm Settings: A Workshop

From NASEM: “A planning committee of the National Academies of Sciences, Engineering, and Medicine will organize a virtual public workshop to examine personal protective equipment (PPE) needs and best practices to protect workers in high-risk U.S. farm settings and control Influenza A (H5N1) transmission between livestock and humans. This workshop will provide the opportunity to exchange knowledge and ideas among interested and impacted parties–including technical experts, policy makers, livestock industry leaders and farm owners, and PPE users in farm settings (e.g., farmworkers, veterinarians).”

These workshops will take place 10 am-4:30pm ET on September 29-30. Register here.

Mirror Image Biology: Pushing the Envelope in Designing Biological Systems – A Workshop

From NASEM: “Most biological molecules are chiral entities where their mirror images have different structures and functional characteristics. Scientists have begun synthesizing left-handed DNA and RNA and creating proteins that can write left-handed nucleic acids. This, and other related research, is described as “mirror biology” and includes research toward creating mirror-image self-replicating living systems. The National Academies will host a foundational workshop on mirror biology, focusing on the state of the science, trends in research and development, risks and benefits of this research, and considerations relating for future governance of relevant enabling technologies.”

This event will take place virtually, September 29-30. Register here.

Doing More with Less: Practical Biosafety on a Budget

“Led by Azelia Labs biosafety experts, Katerina Semenyuk, PhD, RBP (ABSA) and Sarah Ziegler, PhD, RPB, CBSP (ABSA) this webinar will provide a comprehensive guide to maintaining a robust biosafety program in resource-constrained environments. We will address the unique challenges that arise when faced with limited funding or leadership hesitation to invest in safety protocols.”

“This session will focus on practical, actionable strategies to overcome these obstacles. Topics will include how to prioritize essential safety measures when budgets are tight, creative solutions for providing adequate personal protective equipment (PPE), and innovative approaches to maintaining equipment and facilities without costly upgrades. We will also discuss methods for effectively communicating the value of biosafety to leadership to secure the necessary support for your program.”

This online event will take place on October 2, 12-1 pm EDT. Register here.

Feeding Resilience: Risk and Readiness in Food Security

From CSR: “This event will convene a multidisciplinary group interested in food security, agriculture, climate, security, and development in-person at KSU and virtually for other US and international audiences. Throughout the day, attendees will have opportunities to network and engage with expert speakers on food and water security challenges, agricultural trade and innovation, workforce development, and the way forward in today’s global policymaking environment. The event is part of CCS’s Feeding Resilience program, which has analyzed and developed policy recommendations on food, climate, and security risks for the United States and is now deepening analysis and policy engagements for European and global audiences.”

This event will take place 8:30am-2:35pm CDT in Manhattan, KS, on October 7. Register here.

EMBRACE 2025 – Scientific Pathways to Biotoxin Preparedness Online Event

From CMINE: “Join us at the forefront of chemical and biological security for EMBRACE 2025 – a key event dedicated to cutting-edge research on biotoxins and human biomarkers of intoxication. This international symposium will spotlight ground-breaking scientific work and host the inauguration of EMBRACE’s Biotoxin Task Force.”

“What to Expect:

A unique opportunity to shape the scientific landscape of biotoxin threat preparedness and learn more about the EU EMBRACE project and the Biotoxin Task Force

A platform for showcasing innovation in biotoxin detection and response

Networking with global experts in biological forensics and toxicology”

This event will take place on October 15, 0900-1700 CEST. Register here.

Exploring Applications of AI in Genomics and Precision Health: A Workshop

From NASEM: “The National Academies’ Roundtable on Genomics and Precision Health will host a hybrid public workshop on October 28 to explore current and potential future applications for AI in genomics and precision health along the continuum from translational research to clinical applications. The workshop will:

  • Explore the current implementation of AI in genomics and precision health (e.g., variant interpretation, data integration, patient and participant identification, return of results, treatment selection).
  • Discuss potential benefits and challenges of future AI applications (e.g., data harmonization and security, workforce, and usefulness for all).
  • Consider evaluations for and impact of the accuracy of, and bias inherent to, AI technologies in genomics-related research and clinical care.
  • Examine lessons learned from applications of AI in other fields that may be transferable to genomics and precision health throughout the translational research process.”

This workshop will take place 8:30am-5:00pm ET on October 28. Register here.

Global Conference on Biological Threat Reduction

From the World Organisation for Animal Health: “In October 2025, WOAH is hosting its third Global Conference, with the goal of galvanising advocacy efforts to manage the rising risk of biological threats from across the world.”

“The Global Conference on Biological Threat Reduction – which will take place in Geneva on 28-30 October 2025 – will bring together top minds in the fields of
health-security, emerging technologies, and biothreat reduction policies, from the public and private sectors – to focus on the latest strategies, challenges and innovations in combating biological threats to our interconnected ecosystems.”

“The Conference will bring together approximately 400 participants from different sectors, including animal health, law enforcement and security, public health, international and regional organisations, investment and development partners, private sector and industry representatives, research, academia and regulatory authorities, youth organisations.”

“Attendees will engage in thought-provoking discussions and innovative technical presentations aimed at strengthening prevention, preparedness and response capabilities across the world.”

“The event will be guided by a narrative that traces WOAH’s commitment to biological threat reduction and the increasingly relevant role it plays at the health-security interface. Against the backdrop of an uncertain future, WOAH believes that synergies between sectors can drive positive change – making the world a safer and healthier place. ”

Learn more and register here.

GHS 2026

From GHS: “We’re excited to officially announce that the 4th Global Health Security Conference (GHS2026) will be held in Kuala Lumpur on the 9 – 12 June, 2026!”

“Building on the incredible momentum of GHS2024 in Sydney, we look forward to bringing together the global health security community once again – this time in one of Southeast Asia’s most vibrant and dynamic cities.”

“Registration and Call for Abstracts are now live!”

Learn more, submit abstracts, and register here.

NEW: Emerging Leaders in Biosecurity (ELBI) Fellowship

“The Emerging Leaders in Biosecurity (ELBI) Fellowship inspires and connects the next generation of biosecurity leaders and innovators. Launched in 2012, ELBI is a highly competitive, part-time program that provides an opportunity for talented graduate students and professionals to deepen their expertise, expand their network, and build their leadership skills through a series of events coordinated by the Johns Hopkins Center for Health Security. The fellowship boasts over 300 alumni with backgrounds in government, national security, private industry, science, law, public health, medicine, global health, journalism, the social sciences, and academia.”

Learn more and submit your application by October 12 here.

NEW: AI & National Security Convergence Fellowship

In this context, the Converging Risks Lab (CRL), an institute of the Council on Strategic Risks (CSR), is partnering with the Future of Life Institute (FLI) on the “AGI and National Security Convergence Project,” a new initiative endeavoring to arm decision-makers with the understanding and capabilities required to future-proof national security against the potential perils of AGI while maximizing its promise. This partnership combines CRL’s experience in training and engaging national security leaders on convergence topics through experiential learning methods with FLI’s commitment to educating policymakers on the national security implications of developing AGI.”

Learn more and submit your application by October 13 here.

NEW: Council on Foreign Relations Internships

In an ever-changing world, CFR’s work as a leading nonpartisan resource for information and ideas about foreign policy is more important than ever. At CFR, interns participate in one of the foremost paid internship programs in the foreign policy arena. They do work that matters alongside smart and dedicated staff in a diverse and inclusive environment. Interns are paid a competitive hourly wage while gaining valuable experience through exposure to leading foreign policy experts. They are also offered professional development training as a foundation for future work in the field of foreign policy and international affairs. Internship opportunities are offered through the Blavatnik Internship Program and Robina Franklin Williams Internship Program.

Learn more and submit your application by October 13 here.

NEW: Scoville Peace Fellowship

“The fellowship ensures a pipeline of the brightest, most dedicated, and diverse next-generation experts into leading think tanks and advocacy groups in order to inspire creative new approaches to the pervasive challenges to peace and security. Its goal is to bridge the gap between academia and the professional world by providing an entree for mission-driven grads eager to learn about and contribute to public-interest organizations. The fellowship was established to honor longtime nuclear arms control activist Dr. Herbert (Pete) Scoville, Jr., a Ph.D. in physical chemistry and dedicated public servant, who encouraged young people to become involved in arms control and national security.”

Learn more and submit your application by October 20 here.

NEW: Notice of Funding Opportunity (NOFO) – Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research

“There is a global recognition that the current evidence base to inform laboratory and on-farm biological risk management has gaps, and that applied agricultural biosafety and biosecurity policies are not always based on evidence. This notice of funding will support the design and implementation of applied agricultural biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop or similar gap analysis like the WOAH working group agent specific biorisk gap analysis. ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the key focus areas and at least one component under that area.”

Learn more and submit your proposal by October 31 here.

NEW: Cyberbiosecurity Quarterly Call for Papers

“We are pleased to announce the launch of Cyberbiosecurity Quarterly, a new academic and trade journal dedicated to the intersection of cybersecurity and the bioeconomy. Published by Kansas State University’s New Prairie Press and sponsored by the Bioeconomy Information Sharing and Analysis Center (BIO-ISAC), this quarterly journal will serve as an important resource for professionals, researchers, and policymakers working to safeguard digital and physical biological infrastructures. Cyberbiosecurity is an emerging discipline that addresses the protection of biomanufacturing, biomedical research, synthetic biology, digital agriculture, and other life sciences sectors from digital threats. This journal will explore topics at the nexus of cybersecurity, digital biosecurity, and the bioeconomy, including but not limited to:

  • Best practices for network configuration and management in biomedical environments (ingress/egress protection, segmentation, isolation, access control, traffic protection, etc.)
  • Cybersecurity Vendor Management and Assessment
  • Cyber and Digital Biosecurity Education for the Bioeconomy’s Workforce
  • The Quality-Cybersecurity Tension in Practice and Techniques for Mitigation
  • Threat Intelligence for Cyber-Physical Biological Systems
  • Regulatory and Policy Perspectives on Cyberbiosecurity
  • Incident Response and Risk Mitigation in Biomanufacturing
  • AI and Machine Learning in Digital and Cyber Biosecurity”

Learn more and submit your papers here.

Applied Biosafety Call for Papers

“The Editors of Applied Biosafety are pleased to announce a forthcoming Special Issue focused on the myriad of topics associated with global biosafety management. This special issue will showcase examples of innovative approaches, creative solutions, and best practices developed and used around the world for managing risks associated with the handling, use, and storage of infectious biological agents, toxins, and potentially infectious materials in research and clinical settings.”

Learn more and submit by November 1 here.

64th ISODARCO Course

From ISODARCO: “In recent years, the global security landscape has become increasingly volatile, shaped by a convergence of geopolitical tensions, technological advancements, and evolving nuclear doctrines. The post-Cold War order that once provided a measure of predictability in global security has eroded. Conflicts such as the wars in Ukraine and Gaza, rising tensions in the Indo-Pacific, and strategic competition between major powers have reshaped alliances and strategic postures.”

“At the same time, disruptive technologies including artificial intelligence, quantum computing, hypersonic missiles, and cyber threats – are adding new layers of complexity to both nuclear and conventional deterrence dynamics. These technologies are not only distorting the information landscape but also compressing decision-making timelines and complicating signaling mechanisms, increasing the risk of miscalculation.”

“Effectively managing nuclear escalation risks in this environment will require a combination of innovative diplomacy, technological safeguards, and renewed dialogue mechanisms to rebuild trust, reduce misperceptions, and stabilize strategic relations.”

“The ISODARCO 2026 Winter Course presents an invaluable opportunity for students and experts to discuss and examine these dynamics in depth and explore approaches to re-establishing strategic stability and reducing nuclear dangers in a volatile world.”

This course will take place January 11-18, 2026, in Andalo. Learn more and apply here.

Pandora Report 9.19.2025

Welcome to this week’s Pandora Report! This issue features sweeping changes in U.S. vaccine policy and the state-level battles they’ve sparked, major shakeups across the intelligence community and pharmaceutical supply chains, and new developments at the intersection of AI, biosecurity, and biotechnology risks. From public health politics to national security and emerging technologies, here’s what you need to know.

Thinking About Graduate Study in Biodefense?

The Schar School of Policy and Government has several upcoming recruitment events:

For Prospective MS Students:

For Prospective PhD Students:

🔗 See all upcoming events here.

☕ Plus: Regional coffee chats with faculty and admissions staff across Maryland, Virginia, and DC. Learn more here.

💡 Tuition Benefit: Master’s and certificate students living in Maryland and DC quality for in-state tuition rates. Learn more and register here.

State Pushback and Federal Tensions Over Vaccine Policy

Recent federal changes to vaccine policy under HHS Secretary Robert F. Kennedy Jr. have prompted a strong state-level reaction: blue and swing states including Colorado, Maryland, Minnesota, New Jersey, New York, Pennsylvania, and others are moving to preserve vaccine access through legislation, bills, executive orders, and regional collaborations that can issue independent recommendations and expand pharmacy-based administration of vaccines regardless of federal guidance. State lawmakers and medical experts warn, however, that these piecemeal measures may not fully mitigate the harm of an expected federal rollback of vaccine access across different age groups, leaving tens of millions – including Medicare enrollees, military members and veterans, and people on employer plans – exposed to higher out-of-pocket costs and potential loss of coverage.

Conversely, some red states, like Florida, are taking a more restrictive approach to vaccines. Florida Surgeon General Joseph Ladapo has called for mRNA COVID-19 vaccines to be “not available to anyone,” clarifying that other vaccines would remain accessible to Floridians but singling out mRNA shots as unsafe in his view. This news comes amid waning public confidence in federal vaccine policy: a recent Reuters/Ipsos poll found that only one in four Americans believe recent vaccine policy changes are grounded in scientific evidence, with the majority expressing skepticism and concerns about the politicization of public health decisions. “Infectious diseases do not respect political boundaries,” said Pennsylvania Democratic state Rep. Arvind Venkat. “We’re talking about contagious illnesses. What you do affects me and what I do affects you.”

On Wednesday, former CDC Director Susan Monarez testified before the Senate Committee on Health, Education, Labor and Pensions that she was fired for resisting Secretary Kennedy’s demands to pre-approve vaccine recommendations for the public and fire career scientists. “Even under pressure, I could not replace evidence with ideology,” says Monarez. Just days before a high-stakes meeting this week, HHS and CDC announced five new members to the Advisory Committee on Immunization Practices (ACIP), with votes expected on recommendations for vaccines for COVID-19, hepatitis B, measles, mumps, rubella and varicella (MMRV), and respiratory syncytial virus.

In a perplexing conclusion to the otherwise tense meeting on Thursday, the panel seemed to contradict itself when voting on the MMRV recommendation: the members voted 8 to 3, with one abstention, in favor of recommending that children under 4 receive MMR and varicella vaccines separately rather than the combined MMRV shot. However, on a follow-up vote regarding whether this decision should apply to coverage under the nation’s Vaccines for Children (VFC) program, the panel backpedaled, issuing eight no votes, one yes vote, and three abstentions, citing confusion over how to reconcile coverage with the updated recommendations. Analysts at Citi noted that while the decision may impact parental choice and Merck’s vaccine specifically, overall vaccination rates for the four diseases “are likely to remain stable.”

These deliberations occur against a broader backdrop of declining childhood vaccination rates across the U.S. A six-month NBC News investigation, in collaboration with Stanford University, found that since 2019, 77% of counties and jurisdictions in the U.S. have reported notable declines in core childhood vaccines–including MMR, polio, whooping cough and diphtheria shots–with some countries seeing drops of more than 40 percentage points. Rising exemption rates for school children further exacerbate the problem: among states tracking MMR vaccine data, 67% of counties now fall below the 95% herd immunity threshold needed to protect outbreaks. “As childhood vaccination rates fall, we’ll see more diseases like measles,” Dr. Sean O’Leary of the American Academy of Pediatrics said.

Further Reading:

From Intelligence to Supply Chains: Evolving National Security Challenges

The Office of the Director of National Intelligence (ODNI) is reportedly considering reductions to the National Counterintelligence and Security Center (NCSC) and the National Counterterrorism Center (NCTC), key hubs for coordinating the U.S. government’s counterintelligence activities against espionage campaigns. These changes come as part of a broader restructuring across several federal agencies and the intelligence community, including CISA, the FBINSACIA, and other agencies. A previous reorganization already reduced NCSC leadership from six senior directors and assistant directors to a single acting director, according to one former senior official, and further cuts are expected. In the meantime, the White House has nominated George Wesley Street to serve as the next director of the center.

National security concerns extend into the pharmaceutical sector. The Trump administration is reportedly weighing several restrictions on medicines sourced from China, including experimental treatments, amid warnings from prominent investors and corporate executives with close ties to the White House that such measures could help crackdown against what they view as an existential threat by China to U.S. biotechnology. A draft of the executive orders under consideration would prioritize domestic production of key medicine, including antibiotics and acetaminophen, and offer tax credits to companies relocating manufacturing to the U.S. The policy debates highlight concerns that America’s reliance on China for essential medicines represents a national security vulnerability, especially as major pharmaceutical companies like Pfizer and AstraZeneca have invested heavily in Chinese experimental drug markets.

Further Reading:

AI, Biosecurity, and the Fragile Line Between Promise and Peril

OpenAI is collaborating with the U.S. Center for AI Standards and Innovation (CAISI) and the UK’s AI Standards Institute (AISI) to strengthen safeguards in AI systems, particularly in domains with national security relevance such as cyber and chemical-biological risk domains. The partnership focuses on joint red-teaming of safeguards against biological misuse, end-to-end product testing for security issues, and rapid feedback loops to address vulnerabilities. Since July, OpenAI and CAISI have worked to identify potential security vulnerabilities in agentic systems, such as OpenAI’s ChatGPT Agent, while the UK AISI began red-teaming safeguards against biological misuse in May–ongoing collaboration to continuously improve the effectiveness of OpenAI’s safety stack.

In parallel, Boston University has recently developed an AI tool to enhance surveillance of disease outbreaks across the globe. This project known as the Biothreats Emergence, Analysis and Communications Network (BEACON), launched in April, combines algorithmic analysis and expert oversight to track emerging diseases in the U.S. and abroad. “Our main goal is to reduce the time between the reporting of a disease and its response,” said Nahid Bhadelia, an infectious disease physician who served in the Biden administration’s COVID response team. “You want a potential alarm bell.” In just three months, BEACON has flagged about 420 outbreaks and mapped 134 pathogens affecting humans, animals and other species, with active users spanning 162 countries, including the World Health Organization (WHO) and the International Criminal Police Organization (INTERPOL).

At the same time, scientists are revisiting older fears about biotechnology’s risks. In the late 2024, a team of Nobel-winning biologists and experts warned of the dangers of creating “mirror life” – synthetic organisms built from molecules with the opposite handedness of all known biology. Such organisms could theoretically infect cells while remaining potentially invisible to immune defenses, posing catastrophic ecological risks. Though purely hypothetical today, the idea dates to Louis Pasteur’s 19th-century discovery of molecular asymmetry, underscoring the long history of anxieties over humanity accidentally unleashing forces beyond its control.

Further Reading:

Avian Influenza Updates

By Margeaux Malone, Pandora Report Associate Editor

Early Birds: H5N1 Gets a Head Start on Migration Season

This week saw a flurry of new H5N1 bird flu developments across the country in both wild bird populations and agricultural settings, potentially signaling a rise in virus spread as the fall migration season takes flight.

In Maryland, Charles County health officials reported that several dead vultures found near La Plata tested presumptively positive for highly pathogenic avian influenza on September 12th. While confirmatory results are pending, the detection underscores H5N1’s continued circulation in wild bird populations, particularly among scavenging species like vultures. The public is urged not to handle sick or dead birds and report any encounters to the USDA Animal Plant and Health Inspection Service.

Meanwhile, Nebraska announced its first confirmed H5N1 detection in dairy cattle. USDA officials identified the virus in a central Nebraska herd through pre-movement milk sampling, a testament to the value of proactive surveillance measures. Genetic analysis confirmed the strain matches the B3.13 genotype seen in circulating in dairy operations in other U.S. states, including California.

Minnesota also saw its disease-free status end this week following confirmation of H5N1 in a Redwood County turkey flock that saw increased bird mortality over the weekend. This marks the state’s first detection since April 23rd, just weeks after officials declared Minnesota free from the disease on August 25th.

These new detections come shortly after outbreaks in North and South Dakota last month that have already claimed nearly 200,000 birds. South Dakota state veterinarian Beth Thompson said South Dakota is at the “leading edge” of this season’s bird flu infections with 134,900 turkeys killed across three facilities to contain the spread. North Dakota reported 60,300 turkey deaths in response to outbreaks there.

With fall migration season set to intensify over the coming weeks and months, the recent wave of detections highlights the importance of ongoing surveillance across both wild bird populations and agricultural settings. Effective coordination between state agriculture departments and federal agencies will prove increasingly vital as the virus capitalizes on seasonal bird movements to spread across the country to new flocks and farms.

Further Reading:

“Saving Lives, Spending Less: The Global Investment Case for Noncommunicable Diseases”

From WHO: “Saving lives, spending less: the global investment case for noncommunicable diseases outlines why urgent investment in cost-effective interventions for NCDs is essential for health and sustainable development. Drawing on the World Health Organization’s package of NCD best buys, the report demonstrates how these evidence-based measures can help countries reduce premature deaths, strengthen health systems, and advance progress towards the Sustainable Development Goals. It provides policymakers, donors, advocates, and partners with a clear economic and social rationale for scaling up implementation of proven solutions. By framing NCD prevention and control as both a health and development priority, the report offers a roadmap for action that delivers benefits across populations, economies, and generations. The evidence is clear: investing in WHO’s best buys is not only possible—it is imperative. The time to act is now.”

NEW: Personal Protective Equipment for Influenza A (H5N1) in High-Risk Farm Settings: A Workshop

From NASEM: “A planning committee of the National Academies of Sciences, Engineering, and Medicine will organize a virtual public workshop to examine personal protective equipment (PPE) needs and best practices to protect workers in high-risk U.S. farm settings and control Influenza A (H5N1) transmission between livestock and humans. This workshop will provide the opportunity to exchange knowledge and ideas among interested and impacted parties–including technical experts, policy makers, livestock industry leaders and farm owners, and PPE users in farm settings (e.g., farmworkers, veterinarians).”

These workshops will take place 10 am-4:30pm ET on September 29-30. Register here.

NEW: Feeding Resilience: Risk and Readiness in Food Security

From CSR: “This event will convene a multidisciplinary group interested in food security, agriculture, climate, security, and development in-person at KSU and virtually for other US and international audiences. Throughout the day, attendees will have opportunities to network and engage with expert speakers on food and water security challenges, agricultural trade and innovation, workforce development, and the way forward in today’s global policymaking environment. The event is part of CCS’s Feeding Resilience program, which has analyzed and developed policy recommendations on food, climate, and security risks for the United States and is now deepening analysis and policy engagements for European and global audiences.”

This event will take place 8:30am-2:35pm CDT in Manhattan, KS, on October 7. Register here.

NEW: Exploring Applications of AI in Genomics and Precision Health: A Workshop

From NASEM: “The National Academies’ Roundtable on Genomics and Precision Health will host a hybrid public workshop on October 28 to explore current and potential future applications for AI in genomics and precision health along the continuum from translational research to clinical applications. The workshop will:

  • Explore the current implementation of AI in genomics and precision health (e.g., variant interpretation, data integration, patient and participant identification, return of results, treatment selection).
  • Discuss potential benefits and challenges of future AI applications (e.g., data harmonization and security, workforce, and usefulness for all).
  • Consider evaluations for and impact of the accuracy of, and bias inherent to, AI technologies in genomics-related research and clinical care.
  • Examine lessons learned from applications of AI in other fields that may be transferable to genomics and precision health throughout the translational research process.”

This workshop will take place 8:30am-5:00pm ET on October 28. Register here.

Mirror Image Biology: Pushing the Envelope in Designing Biological Systems – A Workshop

From NASEM: “Most biological molecules are chiral entities where their mirror images have different structures and functional characteristics. Scientists have begun synthesizing left-handed DNA and RNA and creating proteins that can write left-handed nucleic acids. This, and other related research, is described as “mirror biology” and includes research toward creating mirror-image self-replicating living systems. The National Academies will host a foundational workshop on mirror biology, focusing on the state of the science, trends in research and development, risks and benefits of this research, and considerations relating for future governance of relevant enabling technologies.”

This event will take place virtually, September 29-30. Register here.

Doing More with Less: Practical Biosafety on a Budget

“Led by Azelia Labs biosafety experts, Katerina Semenyuk, PhD, RBP (ABSA) and Sarah Ziegler, PhD, RPB, CBSP (ABSA) this webinar will provide a comprehensive guide to maintaining a robust biosafety program in resource-constrained environments. We will address the unique challenges that arise when faced with limited funding or leadership hesitation to invest in safety protocols.”

“This session will focus on practical, actionable strategies to overcome these obstacles. Topics will include how to prioritize essential safety measures when budgets are tight, creative solutions for providing adequate personal protective equipment (PPE), and innovative approaches to maintaining equipment and facilities without costly upgrades. We will also discuss methods for effectively communicating the value of biosafety to leadership to secure the necessary support for your program.”

This online event will take place on October 2, 12-1 pm EDT. Register here.

EMBRACE 2025 – Scientific Pathways to Biotoxin Preparedness Online Event

From CMINE: “Join us at the forefront of chemical and biological security for EMBRACE 2025 – a key event dedicated to cutting-edge research on biotoxins and human biomarkers of intoxication. This international symposium will spotlight ground-breaking scientific work and host the inauguration of EMBRACE’s Biotoxin Task Force.”

“What to Expect:

A unique opportunity to shape the scientific landscape of biotoxin threat preparedness and learn more about the EU EMBRACE project and the Biotoxin Task Force

A platform for showcasing innovation in biotoxin detection and response

Networking with global experts in biological forensics and toxicology”

This event will take place on October 15, 0900-1700 CEST. Register here.

Global Conference on Biological Threat Reduction

From the World Organisation for Animal Health: “In October 2025, WOAH is hosting its third Global Conference, with the goal of galvanising advocacy efforts to manage the rising risk of biological threats from across the world.”

“The Global Conference on Biological Threat Reduction – which will take place in Geneva on 28-30 October 2025 – will bring together top minds in the fields of
health-security, emerging technologies, and biothreat reduction policies, from the public and private sectors – to focus on the latest strategies, challenges and innovations in combating biological threats to our interconnected ecosystems.”

“The Conference will bring together approximately 400 participants from different sectors, including animal health, law enforcement and security, public health, international and regional organisations, investment and development partners, private sector and industry representatives, research, academia and regulatory authorities, youth organisations.”

“Attendees will engage in thought-provoking discussions and innovative technical presentations aimed at strengthening prevention, preparedness and response capabilities across the world.”

“The event will be guided by a narrative that traces WOAH’s commitment to biological threat reduction and the increasingly relevant role it plays at the health-security interface. Against the backdrop of an uncertain future, WOAH believes that synergies between sectors can drive positive change – making the world a safer and healthier place. ”

Learn more and register here.

GHS 2026

From GHS: “We’re excited to officially announce that the 4th Global Health Security Conference (GHS2026) will be held in Kuala Lumpur on the 9 – 12 June, 2026!”

“Building on the incredible momentum of GHS2024 in Sydney, we look forward to bringing together the global health security community once again – this time in one of Southeast Asia’s most vibrant and dynamic cities.”

“Registration and Call for Abstracts are now live!”

Learn more, submit abstracts, and register here.

Applied Biosafety Call for Papers

“The Editors of Applied Biosafety are pleased to announce a forthcoming Special Issue focused on the myriad of topics associated with global biosafety management. This special issue will showcase examples of innovative approaches, creative solutions, and best practices developed and used around the world for managing risks associated with the handling, use, and storage of infectious biological agents, toxins, and potentially infectious materials in research and clinical settings.”

Learn more and submit by November 1 here.

64th ISODARCO Course

From ISODARCO: “In recent years, the global security landscape has become increasingly volatile, shaped by a convergence of geopolitical tensions, technological advancements, and evolving nuclear doctrines. The post-Cold War order that once provided a measure of predictability in global security has eroded. Conflicts such as the wars in Ukraine and Gaza, rising tensions in the Indo-Pacific, and strategic competition between major powers have reshaped alliances and strategic postures.”

“At the same time, disruptive technologies including artificial intelligence, quantum computing, hypersonic missiles, and cyber threats – are adding new layers of complexity to both nuclear and conventional deterrence dynamics. These technologies are not only distorting the information landscape but also compressing decision-making timelines and complicating signaling mechanisms, increasing the risk of miscalculation.”

“Effectively managing nuclear escalation risks in this environment will require a combination of innovative diplomacy, technological safeguards, and renewed dialogue mechanisms to rebuild trust, reduce misperceptions, and stabilize strategic relations.”

“The ISODARCO 2026 Winter Course presents an invaluable opportunity for students and experts to discuss and examine these dynamics in depth and explore approaches to re-establishing strategic stability and reducing nuclear dangers in a volatile world.”

This course will take place January 11-18, 2026, in Andalo. Learn more and apply here.

Pandora Report 3.7.2025

This week’s Pandora Report covers updates on the Trump administration’s response to the West Texas measles outbreak, challenges at NIH, possible budget cuts to DOD programs focused on WMDs and pandemic preparedness, and more.

Biodefense MS Information Session

“Prospective students are invited to attend a information session to hear more about the Biodefense M.S. program offered at the Schar School. The online session will provide an overview of the program, as well as the application process, student experience and graduate outcomes. This session admissions will be led by the Graduate Admissions team.”

This sessions will take place at 12 pm EDT on March 20. Learn more and register here.

Updates on the Trump Administration

Top HHS Officials Retire and Resign

Francis S. Collins, the well-known geneticist who ran the National Institutes of Health for 12 years, announced on Saturday that he has retired from the NIH and the federal government. Collins did not provide a reason for his departure, and he has refused to do any interviews. His parting statement offered a subtle yet pointed message to the Trump administration, with Collins writing in part “As I depart N.I.H., I want to express my gratitude and love for the men and women with whom I have worked side by side for so many years. They are individuals of extraordinary intellect and integrity, selfless and hard-working, generous and compassionate. They personify excellence in every way, and they deserve the utmost respect and support of all Americans.”

Tom Corry, Assistant Secretary of Public Affairs at HHS, also abruptly resigned from the department last Friday, just two weeks after starting his new role. Corry did not provide a reason for his departure either. He previously served as a senior advisor and Director of Communications at the Centers for Medicare & Medicaid Services during the first Trump administration.

Kennedy Embraces Unconventional Remedies as Measles Outbreak Grows

As the West Texas measles outbreak grows, HHS Secretary RFK Jr. has touted several unconventional remedies while continuing to not urge all Americans to get vaccinated against the disease. In an interview, Kennedy said the federal government is shipping doses of vitamin A to Gaines County, Texas, the epicenter of the outbreak, and helping to arrange ambulance rides. He also claimed that physicians in Texas have seen “very, very good results” treating measles with budesonide, clarithromycin, and cod liver oil. This has prompted strong backlash from many in the medical community.

As of March 6, 222 cases have been reported in Alaska, California, Florida, Georgia, Kentucky, New Jersey, New Mexico, New York City, Pennsylvania, Rhode Island, Texas, and Washington. The US eliminated measles in 2000. Today, an unvaccinated adult in New Mexico has been reported dead, a little over a week after the death of an unvaccinated child in Lubbock, Texas. The Pan American Health Organization issued an epidemiological alert in response to the outbreak earlier this week.

Bhattacharya Promises “Scientific Dissent” at NIH

Jay Bhattacharya, Donald Trump’s nominee for NIH director, said on Wednesday that NIH officials “oversaw a culture of coverup, obfuscation, and a lack of tolerance for ideas that differed from theirs” in recent years. He promised to, in response to this, “establish a culture of respect for free speech in science and and scientific dissent at the agency.”

Bhattacharya infamously co-authored the Great Barrington Declaration in October 2020, which argued for allowing people at lower risk of COVID-19 complications to go about life as normal, assuming that, if infected, they would experience mild disease and contribute to herd immunity. NPR explains that, “During the COVID pandemic, Bhattacharya clashed with the mainstream medical establishment, including the NIH, over lockdowns and other measures designed to control the spread of the virus. He says he was shunned and penalized for his views and he didn’t want anyone else to suffer the same fate.”

NIH Set to Terminate Active Research Grants

The NIH has begun mass terminations of research grants funding active scientific projects that no longer meet “agency priorities”. According to Nature News, “NIH staff members have been instructed to identify and potentially cancel grants for projects studying transgender populations, gender identity, diversity, equity and inclusion (DEI) in the scientific workforce, environmental justice and any other research that might be perceived to discriminate on the basis of race or ethnicity, according to documents and an audio recording that Nature has obtained. Grants that allot funding to universities in China and those related to climate change are also under scrutiny.”

This comes after a federal court temporarily blocked the administration’s proposed cut to NIH funding for universities’ indirect costs like facilities and administration. However, as Politico points out, the administration may pivot to renegotiating the payments with individual universities.

DOD Cuts Threaten Pandemic Preparedness, WMD Proliferation Prevention, and More

DOD agencies responsible for preventing WMD proliferation and building security capacity globally are at risk of intense budget cuts or outright abolition. According to a recent draft working paper, DOD is asking all agencies and services that oversee security cooperation programs to assess potential impacts of funding realignment. The paper was prepared in response to an RFI from Secretary of Defense Pete Hegseth that asked agencies to assess consequences of four levels of staff reduction, including 25%, 50%, 75%, and 100%. The authors of the working paper, according to WIRED, “…warn that the cuts could hobble the fight against organized crime in South America, impair the battle against the Islamic State, increase the likelihood of a rogue state producing and using chemical weapons, and defund pandemic surveillance measures.”

CDC Staff Now Prohibited from Co-Authoring Papers with WHO Personnel

Scientists at the CDC are now prohibited from co-authoring publications with WHO staff, according to reporting from HuffPost. An interim guidance document obtained by the news agency explained that “CDC staff should not be co-authors on manuscripts/abstracts with WHO staff,” while also adding that CDC staff should not author publications related to work that is “funded by WHO.” The guidance further instructs CDC staff who are lead authors on such publications to either pause all action on those publications, or to recuse themselves as authors if the publication process cannot be paused. It also says that manuscripts not in compliance with Trump’s executive orders that were submitted prior to January 20 should be withdrawn, or CDC staff should recuse themselves as authors.

US Funding Cuts Threaten Global Fight Against TB

The WHO issued a warning on Wednesday explaining that severe funding cuts (namely, those in the United States) threaten decades of progress in the global fight against tuberculosis. The agency explained that essential prevention, testing, and treatment services are collapsing, leaving millions at risk. The regions most affected include Africa, Southeast Asia, and the Western Pacific, where national TB programs depend on international support.

The TB Community Coordination Hub said in a statement about the funding cuts, “[We] strongly condemn this callous, abrupt and totally one-sided act that is unprecedented, and calls upon the US Administration to take immediate measures to restore funding and support projects globally that are crucial to contain and prevent a resurgence of this deadly disease.”

Further Reading:

CDC Monitoring Mysterious Disease in DRC

In a statement on Tuesday, the CDC said it is closely monitoring the outbreak of an unknown disease that has already killed dozens in the Democratic Republic of Congo. According to WHO, at least 1,318 people have exhibited symptoms of the disease, and 60 had died from it by February 27. A new mpox variant was also recently discovered in the country. The new variant has a mutation known as APOBEC3, which indicates it may be more easily transmissible than previously identified strains.

“WHO Technical Advisory Group on the Responsible Use of the Life Sciences and Dual-Use Research: Report of the Meeting, 30 October 2024”

From WHO: “The World Health Organization (WHO) Technical Advisory Group on the Responsible Use of the Life Sciences and Dual-Use Research (TAG-RULS DUR) was established to provide independent advice to WHO on the monitoring and mitigation of biorisks, the advances in the life sciences and related technologies, the governance of dual-use research and the responsible use of the life sciences. This report summarizes the meeting that was virtually held on 30 October 2024. Over the course of the meeting, participants discussed and provided feedback on activities to operationalize the framework and delivered updates on activities of the TAG-RULS DUR’s four working groups.”

“A WHO Global Framework to Guide Investigations Into Origins of Potentially Epidemic and Pandemic Pathogens”

The Scientific Advisory Committee for the Origins of Novel Pathogens (SAGO) and WHO SAGO Secretariat recently published this comment in Nature, writing in its introduction “In outbreak situations involving a novel pathogen timely and coordinated response is crucial. The WHO Scientific Advisory Group for the Origins of Novel Pathogens recently released a global framework to guide future scientific investigations into the origin of emerging pathogens.”

“Recent Virus Research Should Raise the Alarm”

W. Ian Lipkin and Ralph Baric recently published this opinion piece in The New York Times: “There’s a central question that many scientists face: How can scientific discoveries drive humanity’s progress without posing a dire risk to it? As virus experts, we’re committed to research that uncovers pandemic threats and helps protect people from them. But we are concerned about how some scientists are experimenting with viruses in ways that could put all of us in harm’s way.”

“From Inception to Fielding: Meeting the Challenges of Medical Countermeasure Development”

Sarah M. Wiles recently published this article in CBNW: “The U.S. Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense has a robust development process for new CBRN medical countermeasures. Sarah M. Wiles explains the process and its rationale.”

“Automated Grading for Efficiently Evaluating the Dual-Use Biological Capabilities of Large Language Models”

Bria Persaud, Ying-Chiang Jeffrey Lee, Jordan Despanie, Helin Hernandez, Henry Alexander Bradley, Sarah L. Gebauer, Greg McKelvey, Jr. recently published this RAND Corporation working paper: “The authors of this working paper developed a proof-of-concept automated grader and used it to assess large language models’ abilities to answer knowledge-based questions and generate protocols that explain how to perform common laboratory techniques that could be used in the creation of proxies for biological threats.”

“UNIDIR Empowers Emerging Leaders in Biological Disarmament and Biosecurity”

From UNIDIR: “As the world marks the 50th anniversary of the Biological Weapons Convention (BWC), UNIDIR alongside the DiploFoundation and the Fondation pour la Recherche Stratégique celebrates the successful completion of the inaugural BWC Advanced Education Course (BWCedu). This five-month advanced training programme – funded by the UK’s Foreign, Commonwealth & Development Office – brought together 25 emerging leaders from a diverse range of States, with a focus on participants from the Global South.”

Read here.

“Seven Years Since Salisbury Was Centre of Novichok Attack”

Isabella Holliday recently authored this news article about the anniversary of the Novichok attack targeting the Skripals in Salisbury, UK. Read it in the Salisbury Journal here.

“Syria’s Caretaker Foreign Minister Addresses OPCW’s Executive Council”

From OPCW: “In a landmark visit to OPCW’s Headquarters in The Hague, caretaker Foreign Minister al-Shaibani reaffirmed the commitment of the new Syrian authorities to cooperate with the OPCW to eliminate the chemical weapons programme of the former Syrian regime”.

Read here.

ICYMI: The Cost of Defunding PEPFAR and the Impact on the Fight Against HIV/AIDS

Brown’s Pandemic Center hosted this webinar in late February. Watch the recording here. Key topics included:

“Call for Action – How policymakers, philanthropists, and institutions can mobilize to address these urgent gaps.”

“PEPFAR Changes & Uncertainty – Concerns about funding gaps, particularly affecting pediatric HIV treatment, maternal health, and job losses in healthcare.”

“Impact on South Africa & Beyond – The success of PEPFAR in South Africa and the potential consequences of its reduction, including rising HIV cases and strain on health systems.”

“Future of Global Health Funding – Exploring alternative funding sources, the role of UNICEF, private sector involvement, and the need for governments to step up.”

NEW: Building Trust in the H5N1 Response: Perspectives from the Field

From NASEM: “Since avian influenza (H5N1) was first detected in dairy cattle in March 2024, H5N1 has resulted in human infections, diminished livestock production, and decimated wildlife populations. Uncoordinated policies at the national, state, and local levels have challenged mitigation efforts, and mistrust has hindered the urgent response needed for the rapidly evolving threat. The National Academies Forum on Microbial Threats will host a public webinar on March 27 where agricultural producers and workforce health specialists will explore strategies to build greater mutual trust and a coordinated One Health response.”

This webinar will take place on March 27 at 2 pm ET. Register here.

2025 Scowcroft Institute Pandemic Policy Summit

From the Scowcroft Institute: “The Scowcroft Institute of International Affairs at Texas A&M University invites you to attend the 2025 Scowcroft Institute Pandemic Policy Summit examining the ongoing H5N1 outbreak across the U.S. Dairy industry. This summit will bring together experts from government, academia, and industry to review the response efforts, discuss current challenges and opportunities, and identify options for moving forward. Listen to panels of subject matter experts, explore case studies from the field, and participate in networking opportunities.”

This event will take place on March 18 in Washington, DC. Learn more and RSVP here.

Sustainable Manufacturing: Building and Preserving a Resilient Medical Industrial Base

“Join industry and government partners for our second annual industry summit! During this event, leaders from IBMSC will share our strategic vision and organizational priorities. Speakers will also share potential opportunities for building and preserving the medical industrial base.  This event will be in-person only and space is limited!”

This event will take place March 11-12 in Washington, DC. Learn more and register here.

Gaming Weapons of Mass Destruction Course – From Policy to Practice

From MORS: “Gaming Weapons of Mass Destruction (WMD – defined as Nuclear, Chemical, and Biological agents) will be a three-day course focused on developing and executing games related to WMD in all its forms. While the basics of WMD capabilities and game design will be discussed, this will be a course focused on the intersection of WMD and gaming. It will not be either a WMD or gaming course; for those topics see other offerings.”

“No prior experience is required for this course, though a basic familiarity with various agents and their effects would be helpful, as would a basic understanding of professional gaming and how it is used.  The instructors will adapt in real time to class requirements (e.g., if the class is interested in animal and plant targets, the instructors have extensive experience in designing games on those subjects as well).”

This course will take place March 18-20 on Zoom. Learn more and register here.

NEW: Apply for the 2025 Youth for Biosecurity Fellowship

“The global norm against biological weapons cannot be maintained without the inclusion of youth voices in the multilateral discussions taking place in the framework of the Biological Weapons Convention (BWC). Youth perspectives are key to create innovative solutions and generate long-term engagement. There are benefits to including the perspectives of young people from developing countries, where over 90% of the world’s youth reside.”

“Organized by the United Nations Office for Disarmament Affairs in Geneva, in partnership with key international actors that empower youth in science diplomacy and global biosecurity, the Youth for Biosecurity Fellowship provides a unique learning and networking experience in the framework of the Biological Weapons Convention.”

“Launched in 2019 as a Biosecurity Diplomacy Workshop, the Youth for Biosecurity Initiative organized its first fellowship in 2023. For the third edition, the fellowship will provide the opportunity for 20 competitively selected young scientists from the Global South to join an online interactive training programme prior to a field visit during the meeting of the BWC Working Group on the Strengthening of the Convention in Geneva.”

Learn more and apply by April 7 here.

NASEM Has Questions 

The National Academy of Science, Engineering, and Medicine (NASEM) is hosting a workshop on Navigating the Benefits and Risks of Publishing Studies of In Silico Modeling and Computational Approaches of Biological Agents and Organisms on April 3-4 in Washington, DC. In preparation for the workshop, NASEM is soliciting input on how publishing computational models can support biological research while minimizing potential DURC/PEPP risks. The purpose of the questionnaire is to ascertain if organizations that publish or disseminate scientific knowledge have considered or created guidelines or policies to review, host or interact with in silico and computational models and tools, studies, datasets, etc. research that constitutes dual usedual use research of concern (DURC) or pathogens with enhanced pandemic potential (PEPP). Have answers? Then fill out the In Silico Research Publications Pre-event Questionnaire

NOFO, Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research
“There is a global recognition that the current evidence base to inform laboratory biological risk management has gaps, and that biosafety and biosecurity policies are not always based on evidence.1 This notice of funding will support the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop2 or similar gap analysis like the WOAH working group agent specific biorisk gap analysis.1  ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the three key focus areas and at least one component under that area.”

“This funding opportunity aims at the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens.”

“This work will contribute to recommended guidance on laboratory biosafety and agricultural biosecurity, using research techniques to evaluate the application and effectiveness in operational contexts. All proposals must make a clear experimental plan for how the applicant will test the application and outcomes of their focus area(s)/component(s) in their facility.”

Learn more and submit application by April 14 here.

Pandora Report 3.1.2025

This week’s Pandora Report covers the West Texas measles outbreak, cancellation of the Vaccines and Related Biological Products Advisory Committee’s annual flu vaccine meeting, H5N1 updates, and more.

Biodefense MS Information Session

“Prospective students are invited to attend a information session to hear more about the Biodefense M.S. program offered at the Schar School. The online session will provide an overview of the program, as well as the application process, student experience and graduate outcomes. This session admissions will be led by the Graduate Admissions team.”

This sessions will take place at 12 pm EDT on March 27. Learn more and register here.

Texas Child Killed in Growing Measles Outbreak

An unvaccinated, school-age child has died from measles in Lubbock, Texas, amid the state’s worst outbreak of the disease in three decades. The child was hospitalized last week according to the Texas Department of State Health Services. This is the first known US measles fatality since 2015. At least 124 cases have been reported, though thousands have potentially been exposed. Measles was considered eliminated in the US by 2000, following the introduction of a vaccine for it in 1963.

Further Reading:

Trump Administration Updates

FDA Abruptly Cancels Meeting to Select Strains for Next Season’s Flu Shots

A meeting of the FDA’s Vaccines and Related Biological Products Advisory Committee  that was scheduled to meet in March to select which strains will be included in next season’s flu shot was abruptly cancelled this week. Members of the committee were notified of the cancellation via email, which did not offer any explanation for the cancellation, on Wednesday afternoon. This comes during a particularly challenging flu season for the US, with 86 kids and 19,000 adults having died from flu this season so far.

RFK Jr. Says Panel Will Examine Childhood Vaccine Schedule

Just weeks after promising Sen. Bill Cassidy of Louisiana he would not change the nation’s current vaccine schedule, RFK Jr. vowed in his first speech to HHS employees that the department he now leads will be “investigating” the childhood vaccine schedule. He delivered these remarks during a welcome ceremony at the HHS headquarters in Washington, DC, held just after thousands of employees were fired over the weekend.

Firings, Disorder Across Federal Health Agencies Continues

Mass firings have continued on across federal health agencies in recent weeks, with several thousand probationary employees at HHS fired in the so-called “Valentine’s Day massacre.” Massive cuts were made at the NIH, including dismantling programs focused on climate change. The impact on NIH so far has been so devastating that research funding for diseases like cancer, diabetes, and heart disease is lagging by around $1 billion compared to recent years. Furthermore, HHS officials have reportedly pressured NIH staff to ignore court orders to resume funding. Legislation has also been proposed that would break the National Institute of Allergy and Infectious Diseases into three separate research institutes led by directors appointed directly by the president.

Meanwhile, the CDC laid off large numbers of probationary employees. This was set to include all 50 first-years officers in the famous Epidemic Intelligence Service (EIS), in addition to some second-years, as bird flu fears continue to grow and a CDC flu vaccine campaign was pulled. Apparently the EIS was, for now, spared after all. CDC training programs like the Public Health Associate Program and the Laboratory Leadership Program are also at risk.

This has continued outside of HHS as well. For example, the National Science Foundation fired at least 10% of its workforce, and the dismantling of USAID has crippled the Demographic and Health Surveys. The National Nuclear Security Administration also reportedly scrambled to try and reverse firings of probationary employees last week, but struggled to do so as they did not have their new contact information.

Meanwhile, an attempt to purge anything containing language related to, or that could be interpreted as, containing “DEIA or gender ideology” led to the Occupational Safety and Health Administration trashing documents like “OSHA Best Practices for Protecting EMS Responders During Treatment and Transport of Victims of Hazardous Substance Release.” DEI is not discussed in the document. Rather, the term “diversity” is used in it in reference to varying kinds of state-specific certifications, regulations, and training, in addition to the diversity of roles within EMS.

US DOGE Service “Accidentally Canceled” USAID Ebola Program

On Wednesday, Elon Musk claimed that the US DOGE Service “accidentally cancelled” efforts by USAID to prevent the spread of Ebola, claiming that the initiative was quickly restored. Musk said in a cabinet meeting, “We will make mistakes. We won’t be perfect. But when we make a mistake, we’ll fix it very quickly…So we restored the Ebola prevention immediately. And there was no interruption.”

However, according to The Washington Post, “…current and former USAID officials said that Musk was wrong: USAID’s Ebola prevention efforts have been largely halted since Musk and his DOGE allies moved last month to gut the global-assistance agency and freeze its outgoing payments, they said. The teams and contractors that would be deployed to fight an Ebola outbreak have been dismantled, they added. While the Trump administration issued a waiver to allow USAID to respond to an Ebola outbreak in Uganda last month, partner organizations were not promptly paid for their work, and USAID’s own efforts were sharply curtailed compared to past efforts to fight Ebola outbreaks.”

Further Reading:

Munich Security Conference

On February 15, 2025 at the 61st Munich Security Conference, the Coalition for Epidemic Preparedness Innovations (CEPI), the Pandemic Center at the Brown University School of Public Health, and the Nuclear Threat Initiative (NTI), in partnership with Foreign Policy, convened emerging biosecurity leaders from the Global South. Together with top-level decision-makers, they discussed concrete next steps to accelerate the 100 Days Mission to reduce threats posed by deliberate, accidental, and naturally occurring biological threats. Strengthening biosecurity and biosafety will unleash the benefits of new technologies by minimizing risks, which will enable progress towards achieving the 100 Days Mission safely, securely and equitably. The groups issued a Biosecurity Emerging Leaders Declaration embodying these commitments and objectives.

H5N1 Updates

By Meredith Fletcher, Pandora Report Associate Editor

Egg Prices Plan 02.27

According to the USDA, egg prices are expected to continue rising, possibly by as much as 41%. With the possibility of a poultry vaccine created by Zoetis, hope is on the horizon. The company was given the go-ahead for a conditional license on February 18 and has plans to continue working on a similar vaccine that was started in 2022. President Trump and his team have announced their plan for the cost of eggs and response to combat the bird fu, which involves outsourcing the country’s egg needs to other countries by purchasing millions of eggs, increasing biosurveillance capabilities, and removing “unnecessary regulatory burdens on the chicken and egg industry.” Brooke Rollins, the US Secretary of Agriculture, says the administration expects egg prices to return to normal by the summer.

02.20

As the bird flu continues to devastate the American poultry market, causing millions of chicken deaths across the country, hope for a vaccine arrives. On February 17, a company announced its “conditional license” approval from the USDA. This vaccine is meant to protect chicken from the H5N2 subtype of the avian flu. Zoetis, the company responsible for this vaccine, has been working on developing a bird flu vaccine since 2022. Canada announced February 19 its human vaccine against H5N1 to give to those most at risk. The Public Health Agency of Canada (PHAC) stated it has secured 500,000 doses and will be used as part of Canada’s contingency plan. Canada joins the US and European Union who have stockpiled the avian flu vaccine in humans and plans to follow Finland, who has already begun vaccinating high risk individuals.

“WHO Global Framework to Define and Guide Studies Into the Origins of Emerging and Re-Emerging Pathogens with Epidemic and Pandemic Potential”

From WHO: “The WHO global framework to define and guide studies into the origins of emerging and re-emerging pathogens with epidemic and pandemic potential, developed by the Scientific Advisory Group for the Origins of Novel Pathogens (SAGO) has been designed as a resource for Member States. It provides, for the first time, comprehensive guidance on the studies that are needed to investigate the origins of emerging and reemerging pathogens.”

“Timely investigations into pathogens’ origins are critical for preventing and containing global health crises. Their findings provide the basis for stopping outbreaks before they begin, halting transmission chains and reducing the risk of pathogen spillover from animals to humans. They can also confirm or exclude the possibility of an unintentional breach in laboratory biosafety and biosecurity.”

“The framework also offers recommendations on the capacities needed to conduct these studies and the critical importance of sharing all findings as soon as possible to guide next steps.”

“Giant-Killers: 7 Historic Deaths and the Diseases That Did It”

Maya Prabhu for Gavi: “From Alexander the Great to Mozart, some of our mightiest historical figures were felled by the tiniest of microbes. But which diseases killed them and – more importantly – how can you avoid their fate?”

Read here.

“Piloting of the Global Guidance Framework for the Responsible Use of the Life Sciences”

From WHO: “The convergence of life sciences, biotechnology, and artificial intelligence presents a unique and powerful opportunity to address many of the world’s pressing health challenges. With rapid advancements in these fields, new possibilities emerge for disease prevention, diagnosis, and treatment—offering immense potential to improve global health outcomes.”

“However, alongside these benefits comes a growing recognition of the inherent risks associated with dual-use research, where scientific innovations designed for good can also be misused for malicious purposes or inadvertently result in harmful biological events.”

Read the report here.

International Biological Security Education Network (IBSEN) 3rd Quarterly Newsletter

“This 3rd Quarterly Newsletter will address the achievements of the International Biological Security Education Network (IBSEN) during its first year and LMU BSRC’s current activities on strengthening global biosecurity education.  The feature column within this Newsletter analyses the aim and structure of the Global guidance framework for the responsible use of the life sciences: Mitigating biorisks and governing dual-use research by the World Health Organisation (WHO).  This review will focus on the biosecurity education elements of the report.”

“The Quarterly Newsletter also aims to share the recent activities of the International Biological Security Education Network and Biological Security Research Centre.”

Read the newsletter here.

“The Security Implications of Developments in Biotechnology”

From IISS: “This report analyses the security implications of the developments that have taken place in recent decades in the fields of genomics, genetic engineering and synthetic biology. The relevant international regulatory frameworks need to be enhanced to keep pace with biotechnological advances, while a whole-of-society approach appears to be the best way to deal with the pressing ethical issues that biotechnology raises.”

“WMD Nonproliferation Regimes: An Overlooked Casualty of Russia’s War on Ukraine”

Christina McAllister discusses how Russia’s war on Ukraine has been accompanied by an “assault on WMD nonproliferation regimes and nuclear security norms” in this commentary piece from the Stimson Center.

“The Biological Weapons Convention at Fifty: Codifying 100 Years of Efforts to Combat Biological Warfare”

“This publication has been developed by the United Nations Office for Disarmament Affairs (UNODA), with the support of the European Union, on the occasion of the 50th anniversary of the entry into force of the Biological Weapons Convention.”

“By bringing together different stakeholders, including, among others, experts and practitioners from the diplomatic field, academia and civil society, the publication highlights the achievements and obstacles encountered over the past fifty years, current discussions related to the strengthening of the Convention as well as future opportunities and challenges.”

“522. Drones and Biotechnological Weaponry: Emerging Risks, Strategic Threats, and Viable Readiness”

From TRADOC’s Mad Scientist Laboratory blog: “Today’s submission — co-authored by frequent contributor and proclaimed Mad Scientist Dr. James Giordano and returning contributor Dr. Diane DiEuliis — addresses the “nexus of drones and bioweapons” in Twenty-first century conflict, exploring how “drone technology, synthetic biology, and gene-editing pose a formidable challenge to global security.”  This convergent challenge demands we “invest in fostering interagency and international collaboration, advanced surveillance systems, and develop robust countermeasures to mitigate the risks associated with these technologies” — Read on!]”

Read here.

“Evo 2 Can Design Entire Genomes”

Eryney Marrogi and Niko McCarty for Asimov Press: “A new AI model for biology, released today by Arc Institute and NVIDIA, can predict which mutations within a gene are likely to be harmful and even design small, eukaryotic genomes.”

Read here.

“‘Turn it Off’: Grok Under Fire After Providing Assassination Advice, Chemical Weapons Recipes”

Katherine Huggins for Daily Dot: “Some tech influencers are sounding the alarm over Grok—the artificial intelligence chatbot developed by Elon Musk’s xAI—after social media users were easily able to gain potentially dangerous information about chemical weapons and more from the new edition of the AI model.”

Read here.

“More than 160 Gazan Medics Held in Israeli Prisons Amid Reports of Torture”

Annie Kelly for The Guardian: “At least 160 healthcare workers from Gaza, including more than 20 doctors, are believed to still be inside Israeli detention facilities as the World Health Organisation expressed deep concern about their wellbeing and safety…Healthcare Workers Watch (HWW), a Palestinian medical NGO, said it had confirmed that 162 medical staff remained in Israeli detention, including some of Gaza’s most senior physicians, and a further 24 were missing after being taken from hospitals during the conflict.”

What We’re Listening To 🎧

Osterholm Update Episode 177: We Cannot Give Up or Give In

“In “We Cannot Give Up or Give In” Dr. Osterholm and Chris Dall discuss the confirmation of RFK Jr. as HHS Secretary, recent layoffs at the CDC and NIH, and a new vaccine policy being adopted in Louisiana. They also discuss seasonal and H5N1 influenza activity and a measles outbreak in Texas.”

Listen here.

Unconfined Episode 16: Is Animal Agriculture Contributing to Bird Flu Spread?

From the Johns Hopkins Center for a Livable Future: “In episode 16 of Unconfined, two leading experts, Meghan Davis and Erin Sorrell, discuss the current bird flu outbreak affecting poultry, dairy cattle, and farm workers—and unpack risks to food supply and public health.”

Listen here.

NEW: Blockchain for Monitoring and Tracking Chemicals (MATCH)

From the Stimson Center: “The future of chemical security may rely on blockchain technologies. Join the MATCH team and industry leaders to discuss how innovative Distributed Ledger Technology is revolutionizing the monitoring and reporting of dual-use chemicals.”

“Since its first kick-off meeting in September 2021, the Monitoring and Tracking Chemicals (MATCH) project has gone through several phases of research, scenario building and testing to understand the feasibility of Distributed Ledger Technology (DLT) as an innovation for streamlining and improving the accuracy of declarations on international transfers of dual-use chemicals. These “Scheduled Chemicals” covered by the Chemical Weapons Convention (CWC) have many legitimate medical, commercial and industrial uses but also represent the small subset of the global chemical trade that also pose the highest risk of misuse for chemical weapons.”

“Join us for a discussion with the MATCH team and its stakeholders, including MATCH developers True North and DataTrails, along with Global Affairs Canada, and the Organisation for the Prohibition of Chemical Weapons (OPCW) for insights on the successes achieved and lessons learned along the way.”

This event will take place on March 3 at 12:30 pm ET. Learn more and RSVP here.

NEW: Synthesis Screening Workshop 3, Securing Bioproduction Against an Evolving Threat Landscape

From AI for SynBio: “Advances in AI are changing the threat landscape in many fields, including in the field of biology. With AI assisted design tools, the complexity and obfuscation potential of the synthetic biological materials is expected to increase. Conversely, the same AI advances can be deployed to help screen DNA/RNA synthesis requests before they can be used for malicious purposes. This workshop seeks insight on current and future advances that will shape both the threat and countermeasure landscapes and prepare the community for the changing threat landscape. The workshop seeks perspectives from academia, industry, and government.”

This workshop will take place March 5-6 in Washington, DC. Learn more and register here.

NEW: 2025 Scowcroft Institute Pandemic Policy Summit

From the Scowcroft Institute: “The Scowcroft Institute of International Affairs at Texas A&M University invites you to attend the 2025 Scowcroft Institute Pandemic Policy Summit examining the ongoing H5N1 outbreak across the U.S. Dairy industry. This summit will bring together experts from government, academia, and industry to review the response efforts, discuss current challenges and opportunities, and identify options for moving forward. Listen to panels of subject matter experts, explore case studies from the field, and participate in networking opportunities.”

This event will take place on March 18 in Washington, DC. Learn more and RSVP here.

Sustainable Manufacturing: Building and Preserving a Resilient Medical Industrial Base

“Join industry and government partners for our second annual industry summit! During this event, leaders from IBMSC will share our strategic vision and organizational priorities. Speakers will also share potential opportunities for building and preserving the medical industrial base.  This event will be in-person only and space is limited!”

This event will take place March 11-12 in Washington, DC. Learn more and register here.

Gaming Weapons of Mass Destruction Course – From Policy to Practice

From MORS: “Gaming Weapons of Mass Destruction (WMD – defined as Nuclear, Chemical, and Biological agents) will be a three-day course focused on developing and executing games related to WMD in all its forms. While the basics of WMD capabilities and game design will be discussed, this will be a course focused on the intersection of WMD and gaming. It will not be either a WMD or gaming course; for those topics see other offerings.”

“No prior experience is required for this course, though a basic familiarity with various agents and their effects would be helpful, as would a basic understanding of professional gaming and how it is used.  The instructors will adapt in real time to class requirements (e.g., if the class is interested in animal and plant targets, the instructors have extensive experience in designing games on those subjects as well).”

This course will take place March 18-20 on Zoom. Learn more and register here.

NEW: NASEM Has Questions 

The National Academy of Science, Engineering, and Medicine (NASEM) is hosting a workshop on Navigating the Benefits and Risks of Publishing Studies of In Silico Modeling and Computational Approaches of Biological Agents and Organisms on April 3-4 in Washington, DC. In preparation for the workshop, NASEM is soliciting input on how publishing computational models can support biological research while minimizing potential DURC/PEPP risks. The purpose of the questionnaire is to ascertain if organizations that publish or disseminate scientific knowledge have considered or created guidelines or policies to review, host or interact with in silico and computational models and tools, studies, datasets, etc. research that constitutes dual usedual use research of concern (DURC) or pathogens with enhanced pandemic potential (PEPP). Have answers? Then fill out the In Silico Research Publications Pre-event Questionnaire

NOFO, Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research
“There is a global recognition that the current evidence base to inform laboratory biological risk management has gaps, and that biosafety and biosecurity policies are not always based on evidence.1 This notice of funding will support the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop2 or similar gap analysis like the WOAH working group agent specific biorisk gap analysis.1  ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the three key focus areas and at least one component under that area.”

“This funding opportunity aims at the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens.”

“This work will contribute to recommended guidance on laboratory biosafety and agricultural biosecurity, using research techniques to evaluate the application and effectiveness in operational contexts. All proposals must make a clear experimental plan for how the applicant will test the application and outcomes of their focus area(s)/component(s) in their facility.”

Learn more and submit application by April 14 here.

Pandora Report 2.14.2025

Happy Valentine’s Day from the Pandora Report! This week’s edition covers a recent OPCW delegation visit to Syria, a Russian drone attack that damaged the sarcophagus over Chornobyl’s damaged reactor, RFK Jr.’s confirmation as HHS Secretary, and much more.

Biodefense MS Information Session

“Prospective students are invited to attend a information session to hear more about the Biodefense M.S. program offered at the Schar School. The online session will provide an overview of the program, as well as the application process, student experience and graduate outcomes. This session admissions will be led by the Graduate Admissions team.”

This sessions will take place at 12 pm EDT on March 27. Learn more and register here.

OPCW Director-General Visits Syria

Last week, the Director-General of the Organisation for the Prohibition of Chemical Weapons (OPCW), Amb. Fernando Arias, traveled to Damascus with a high-level delegation from the OPCW to meet with interim Syrian President Ahmad al-Sharaa and caretaker Foreign Minister Assad Hassan al-Shaibani. According to a statement from OPCW, “The meetings were long, productive and very open, with an in-depth exchange of information, which will serve as a basis to reach tangible results and break the stalemate that has lasted for over eleven years.”

“The visit marked a first step towards re-establishing a direct working relationship between the OPCW Technical Secretariat and Syria, following eleven years of stagnation and lack of progress with the former authorities. In their meeting, both sides discussed Syria’s obligations under the Chemical Weapons Convention (CWC), the role and mandate of the OPCW, and the type of support the Technical Secretariat can provide to the Syrian caretaker authorities in eliminating the remnants of Syria’s chemical weapons programme.”

Russian Drone Attack Damages Chornobyl Sarcophagus

Ukrainian President Volodymyr Zelensky announced this morning that a Russian drone attack hit the radiation shield that protects Chornobyl’s damaged nuclear reactor. Ukraine and the International Atomic Energy Agency (IAEA) have both said that radiation levels remain normal in the area. Russia has denied its role in this attack, with a spokesperson for the Ministry of Foreign Affairs of the Russian Federation accusing Zelensky of orchestrating the attack to coincide with the Munich Security Conference.

In February of 2022, Ukraine alerted the IAEA that Russian forces had taken control of all facilities at the nuclear power plant in Chornobyl, prompting concerns about radiation exposure. Control of the plant was eventually returned to Ukrainian personnel in late March of that year. Since January of 2023, the IAEA has maintained a permanent presence at all Ukrainian nuclear power plants.

RFK Jr. Confirmed as HHS Secretary, White House Establishes MAHA Commission

Robert F. Kennedy Jr. has been confirmed by the Senate to serve as the United States Secretary of Health and Human Services, putting an anti-vaccine activist lawyer with no relevant experience in charge of the nation’s federal health agencies and their nearly $2 trillion combined budget. Kennedy was confirmed in a 52-48 vote, with Sen. Mitch McConnell, the former Senate Majority and Minority Leader and childhood polio survivor, being the only Republican to break party lines and vote against his confirmation.

Following his confirmation, Kennedy appeared on Fox News to outline his priorities. While on Laura Ingraham’s show, Kennedy claimed that the US is “the sickest country in the world,” while saying that the US faces not just a health crisis but also a “spiritual crisis.” In response to a clip of Senate Minority Leader Chuck Schumer criticizing Kennedy’s lack of qualifications, he said “The qualifications that Senator Schumer is talking about there, are the very qualifications that got us to where we are today. We do need a break. We need somebody different who can come in and say, ‘I’m going to be a disruptor. I’m not going to let the food industry and the pharmaceutical industry run health policy anymore.’”

Shortly after the confirmation, President Trump issued yet another executive order, this time establishing the “President’s Make American Healthy Again Commission.” This commission will be chaired by the Secretary of HHS, with the Assistant to the President for Domestic Policy as its executive director. Members of the commission will include the Secretaries of Agriculture, Housing and Urban Development, Education, and Veterans Affairs, the EPA Administrator, the Director of the Office of Management and Budget, the Assistant to the President and Deputy Chief of Staff for Policy, the Director of the National Economic Council, the Chairman of the Council of Economic Advisers, the Director of the Office of Science and Technology Policy, the Commissioner of Food and Drugs, the Directors of the CDC and NIH, and other members invited by the chair and executive director.

The order says in part, “To fully address the growing health crisis in America, we must re-direct our national focus, in the public and private sectors, toward understanding and drastically lowering chronic disease rates and ending childhood chronic disease.  This includes fresh thinking on nutrition, physical activity, healthy lifestyles, over-reliance on medication and treatments, the effects of new technological habits, environmental impacts, and food and drug quality and safety.  We must restore the integrity of the scientific process by protecting expert recommendations from inappropriate influence and increasing transparency regarding existing data.  We must ensure our healthcare system promotes health rather than just managing disease.”

Further Reading:

Chaos Continues Across the Federal Government

White House Fires USAID IG After Warning About Funding Oversight

The White House fired the inspector general for USAID on Tuesday, according to officials, after the IG warned that the administration’s dismantling of the agency made it essentially impossible to monitor $8.2 billion in unspent funds. In an advisory notice released by the IG’s office on Monday, officials wrote, “In this alert, we identify risks and challenges to the safeguarding and distribution of USAID’s $8.2 billion in obligated but undisbursed humanitarian assistance funds following (1) the Department of State’s pause on foreign assistance programs and (2) subsequent personnel actions by USAID that have substantially reduced the operational capacity of its Bureau of Humanitarian Assistance (BHA).”

Federal Judge Orders Restoration of Federal Health Agencies’ Websites and Datasets

A federal judge has issued a temporary restraining order in response to a lawsuit filed by Doctors for America against the federal government following the abrupt takedowns of federal health agencies’ websites and data sets late last month. The judge, Judge John Bates of the U.S. District Court for the District of Columbia, is a George W. Bush appointee who emphasized that the loss of these resources jeopardized the work of clinicians and public health. Bates wrote in his opinion, “It bears emphasizing who ultimately bears the harm of defendants’ actions: everyday Americans, and most acutely, underprivileged Americans, seeking healthcare.”

According to NPR, “The pages that are now set to be revived include information for patients about HIV testing and HIV prevention medication, guidance on contraceptives, datasets that show vulnerability to natural disasters and emergencies, and an action plan for improving enrollment of underrepresented populations in clinical trials.”

Despite this ruling and the subsequent restoration of sites and datasets, it is still unclear how much has been altered on them. However, many pages and datasets have been added to the Internet Archive, including this upload of all CDC datasets uploaded before January 28, 2025.

Federal Judge Halts Trump Cuts to NIH Research Payments in 22 States

District Court Judge Angel Kelley of the U.S. District of Massachusetts granted a temporary restraining order that blocks the Trump administration’s cuts to NIH funding after 22 states filed a lawsuit challenging the administration’s order. The lawsuit was filed on Monday, seeking to block a change that would cut NIH payments to universities, medical centers, and researchers studying things like cancer, rare diseases, and other health issues. A hearing has been set for February 21.

The Freeze on Foreign Aid Has Officially Killed People

A 71-year-old woman named Pe Kha Lau died after her oxygen supply was cut off by the US freeze on foreign aid. She was a refugee from Myanmar living in a displacement camp in Thailand, and she is thought to be one of the first people to have died as a direct consequence of this funding freeze. She was discharged from a USAID-funded healthcare facility that was operated by the International Rescue Committee (IRC) four days before her death following a stop-work order.

The Thai government is trying to make up for the loss of IRC care in its nine refugee camps near the country’s border with Myanmar, with most critical condition patients having been transferred to Thai hospitals. Locals are reported to be “self-mobilizing” to try and offer what they can to these people in the sudden absence of US-funded care.

Furthermore, the stop-work order on all USAID-funded research has left many of people participating in research studies around the world in precarious situations. Thousands have been left with experimental drugs and devices in their bodies with a sudden lack of access to monitoring or care. This includes Asanda Zondi, a woman in South Africa who was a participant in a research study evaluating a new device to prevent pregnancy and HIV infection. As a result of the stop-worker order, Zondi was left with the device inserted into her vagina that needed to be removed immediately, but staff at the clinic were not allowed to help study participants remove the devices. Fortunately, some decided to help anyway.

The stop-work order is damaging not just because of its immediate impacts, but because of the harm it will cause to trust it took many years to build with the people and communities participating in studies. This is especially true in South Africa, where years of white rule under apartheid meant medical experiments were inappropriately conducted on Black South Africans.

Further Reading:

Louisiana Department of Health Says It Will Stop Promoting “Mass Vaccination”

An internal memo sent within Louisiana’s Department of Health yesterday explained that the organization will no longer use media campaigns or health fairs to promote vaccination against preventable diseases. The memo was authored by Ralph L. Abraham, the Surgeon General of Louisiana and a former Republican member of Congress who holds both a DVM and an MD. Abraham said in the memo that his state would “encourage each patient to discuss the risks and benefits of vaccination with their provider,” but it will “no longer promote mass vaccination.”

Abraham later wrote, “Vaccines should be treated with nuance, recognizing differences between seasonal vaccines and childhood immunizations, which are an important part of providing immunity to our children.”

New Orleans, the state’s largest city, quickly showed it will not follow the state’s lead. Jennifer Avegno, the Director of the New Orleans Health Department, said in an email “We will continue to strongly promote childhood and seasonal vaccination, and expand our efforts locally to fill any gaps left by the state’s new direction.”

Louisiana is currently experiencing a surge in influenza cases, and it borders Texas, which is currently battling a measles outbreak, and Mississippi, where multiple schools have been forced to close due to the spread of an unspecified illness.

Further Reading:

Bird Flu: 02.13 Egg Knapper

By Meredith Fletcher, Pandora Report Associate Editor

The bird flu continues to mutate, as Americans notice the rising cost of eggs. This has led to drastic measures as police are reporting a rise in egg thieves. Last week hundreds of eggs were stolen from a café in Seattle, coming just a few days after 100,000 organic eggs were reported stolen from a Pennsylvania distribution trailer. Ohio has reported its first human case of H5N1 in a Mercer County farmer. Ohio public health officials say the farmer was exposed due to dead poultry and contracted the virus. Ohio is currently the leader in bird flu cases, with 50 flocks impacted over the last 30 days. Human cases have risen as well, now reporting 68 across 11 states. Public Health officials assure the public the human-human risk is low, however experts at Johns Hopkins are saying the bird flu is steps away from mutating to affect humans. The combination of rising egg prices, mutating strains and communication freeze from authorities are causing many Americans to scramble and wonder if this is the next rising pandemic.

“Tulsi Gabbard as US Intelligence Chief Would Undermine Efforts Against the Spread of Chemical and Biological Weapons”

Gregory D. Koblentz, Director of George Mason’s Biodefense Graduate Program, published this article in The Bulletin of the Atomic Scientists ahead of Tulsi Gabbard’s confirmation to be the Director of National Intelligence. In it, he discusses Gabbard’s longstanding history of parroting Russian propaganda talking points, unfounded claims about Syria’s use of chemical weapons, and conspiracy theories all in efforts to undermine the quality of the community she now leads. He writes at the end of the article, “During her confirmation hearing, Gabbard committed to “checking my own views at the door” and providing intelligence “that is collected, analyzed, and reported without bias, prejudice, or political influence.” Gabbard, however, has demonstrated a clear pattern of denying chemical threats posed by hostile states and inventing biological threats from our allies. Her bias in favor of the regimes of Assad and Russian President Vladimir Putin as well as her prejudice against the Organization for the Prohibition of Chemical Weapons and the US intelligence community are clear. Her judgment on the risks presented by chemical and biological weapons cannot be trusted. This is particularly concerning since the annual threat assessment released by the current director of national intelligence in February 2024 highlighted the growing threat posed by these weapons.”

“Based on this track record, it is difficult to see how Gabbard can be relied upon to provide the quality of intelligence and national security advice needed by the commander in chief during these perilous times. For the Senate to confirm Gabbard would be national security malpractice.”

“Is There a Biological Weapons Taboo, and Does It Matter?”

Glenn A. Cross, an alumnus of the Biodefense PhD Program, recently published this review of Michelle Bentley’s book, The Biological Weapons Taboo, in The Nonproliferation Review.

“Biosafety Approaches: Applying the LOPA Method to High Containment Facilities”

Andrian Harsono, Ryan Waters, Jason Tearle, and Graeme Harkess recently published this article in Nature: “The Layers of Protection Analysis (LOPA) method is a semi-quantitative risk assessment tool that is used to determine the ability of safeguards to protect against unplanned hazardous scenarios. One possible outcome of a LOPA is that existing and proposed safeguards are deemed sufficient to reduce the risk associated with the hazardous scenario to a level that can be deemed as acceptable. Alternatively, the LOPA may also show that the safeguards are insufficient and therefore additional Safety Instrumented Function(s) (SIF) would be required to reduce risk to an acceptable level. In the latter case, the LOPA method will inform the end user as to the reliability requirements of the safety function in question. The LOPA method has been used extensively in the process industries (e.g., oil and gas) as a useful tool to manage and understand risk and to demonstrate if the facility is ‘safe’ to operate, but much less so in the biosafety sector. This paper describes the LOPA method and provides some practical examples of how it may be applied in microbiological high Containment Level (CL) facilities.”

“Global Epidemiology of Outbreaks of Unknown Cause Identified by Open-Source Intelligence, 2020–2022”

Honeyman et al. recently published this article in Emerging Infectious Diseases: “Epidemic surveillance using traditional approaches is dependent on case ascertainment and is delayed. Open-source intelligence (OSINT)–based syndromic surveillance can overcome limitations of delayed surveillance and poor case ascertainment, providing early warnings to guide outbreak response. It can identify outbreaks of unknown cause for which no other global surveillance exists. Using the artificial intelligence–based OSINT early warning system EPIWATCH, we describe the global epidemiology of 310 outbreaks of unknown cause that occurred December 31, 2019–January 1, 2023. The outbreaks were associated with 75,968 reported human cases and 4,235 deaths. We identified where OSINT signaled outbreaks earlier than official sources and before diagnoses were made. We identified possible signals of known disease outbreaks with poor case ascertainment. A cause was subsequently reported for only 14% of outbreaks analyzed; the percentage was substantially lower in lower/upper-middle–income economies than high-income economies, highlighting the utility of OSINT-based syndromic surveillance for early warnings, particularly in resource-poor settings.”

“Exploring Blood-Based Biosurveillance, Part 3: The Blood Virome”

Harmon Bhasin, Michael McLaren, and Lennart Justen recently published this post with the Nucleic Acid Observatory: “This is the third post in a series of blogs exploring blood-based biosurveillance for novel pathogen detection as part of the NAO’s effort to evaluate different biosurveillance approaches. We once again thank our colleagues at the NAO, particularly Jeff Kaufman and Will Bradshaw, for their valuable feedback.”

“The Private Sector’s Role in Advancing Global Health Security”

Sara Kaufman recently authored this blog post for NTI’s Risky Business blog, writing in part “Emerging biological risks have the potential to significantly impact business opportunities locally and globally. The private sector can play an important role in strengthening global health security and mitigating biological risks.”

“The continued spread of H5N1 flu virus is raising significant concerns within the public health community. This growing public health threat also poses considerable risks to supply chains, agricultural production, business operations, and food prices. And this is just one example. Biological risks – whether natural, intentional, or accidental in origin – are capable of grinding private enterprise to a halt.”

“In the years ahead, there are key opportunities that the private sector can take to prevent, prepare for, and reduce biological threats.”

Introducing INTERFACE

From the Harvard Sussex Program: “Welcome to the first issue of INTERFACE, a newsletter focused on the intersection of artificial intelligence (AI) and chemical and biological weapons (CBW). This initiative was inspired by discussions with colleagues and insights gathered at various events, reflecting a shared desire for a clearer perspective on the growing discourse around AI in our field.”

“If you would like to to receive future updates of INTERFACE, you can sign up here.”

“DeepSeek Offers Bioweapon, Self-Harm Information”

This article from The Wall Street Journal discusses the popular Chinese AI app, DeepSeek, and some of the more disturbing answers it shares with users: “Instructions to modify bird flu. A manifesto in defense of Hitler. A social-media campaign to promote cutting and self-harm among teens. ..Those are some of the potentially hazardous things it’s easier to get the Chinese artificial intelligence app DeepSeek to talk about compared with its leading American competitors, according to testing by AI safety experts and The Wall Street Journal.”

What We’re Listening To 🎧

With public health agencies and the information they provide now being restricted in the United States, here are some resources that create new content very frequently on relevant topics:

Public Health On Call

“The Public Health On Call podcast makes important public health topics accessible to all through quick, informative conversations. Hosts tackle complex topics through engaging interviews and real-world perspectives.”

“Our ever-growing list of guests have included researchers, public health commissioners, elected leaders, patients, clergy, ethicists, front line clinicians, and even former health officials who were fired for doing their jobs.”

“Since launching in March 2020 with the purpose of sharing credible expertise and debunking misinformation about the COVID-19 pandemic, Public Health On Call has covered a range of topics, including other viral outbreaks, reproductive health, gun violence prevention, international humanitarian crises, antimicrobial-resistant bacteria, health equity, racial and environmental justice, the opioid crisis, and so much more. In 2023, the show’s success was chronicled in The Journal of Health Security.

The American Medical Association YouTube Channel

The American Medical Association also provides frequent updates and presentations on its YouTube channel. Recent videos have focused on IPC in different clinical settings, updates on tuberculosis, Ebola, and H5N9, H5N1, and the role of stigmatizing language in credentialing applications.

NEW: How North Korea Managed the Covid-19 Pandemic

From 38 North: “Join NCNK, the Council of Korean Americans, 38 North, the United States Institute of Peace, the Harvard Medical School Program in Global Surgery and Social Change, and Children of Korea for the second installment of a four-part webinar series on health in North Korea.”

This event will take place on February 18 at 9 am ET. Register here.

NEW: UKHSA Presents: mSCAPE Genomics

From UKHSA: “UKHSA Presents is a webinar series which will give our stakeholders an insight into the organisation’s work on how the UK Health Security Agency (UKHSA) prevents, prepares for and responds to infectious diseases and environmental hazards to keep all our communities safe.”

“On Wednesday 19th February 2025, 11am-12pm, we will be hosting our third UKHSA Presents webinar which will explore UKHSA’s groundbreaking work in the use of pathogen genomics to improve health security. ”

“In January, the UK Health Security Agency (UKHSA) launched a world-first metagenomics initiative to aid in the rapid detection of infectious diseases that could threaten the UK. The metagenomics Surveillance Collaboration and Analysis Programme (mSCAPE), which has been in development over the last year, is piloting the use of metagenomic data for public health surveillance and pathogen analysis. The programme  will allow for assessment of the ability to significantly improve identification of new outbreaks as well as enabling the source of an outbreak to be better understood, predictions to be made about the effectiveness of potential treatments, and any concerning mutations can be identified. ” 

“The programme is a collaborative initiative, led by UKHSA and involving a consortium of NHS and academic partners including the University of Birmingham, University of Edinburgh, and the NHS Clinical Respiratory Metagenomics Network led by Guy’s and St Thomas’ NHS Foundation Trust.”  

“At this webinar, attendees will hear from Professor Susan Hopkins (Chief Medical Adviser, UKHSA), Dr Meera Chand (Deputy Director, TB, Acute Respiratory Infections, Zoonoses, Emerging Infections and Travel Health, UKHSA) and Professor Nicholas Loman (Professor of Microbial Genomics and Bioinformatics, University of Birmingham). The speakers will talk more about the development of the programme, its application and the positive impact it will have on preventing, diagnosing and treating illness.”

Learn more and register here.

Hubs of Illicit Trade in the Global Economy Book Discussion

From the Terrorism, Transnational Crime and Corruption Center (TraCCC): “This book, authored by a global team of researchers and experts, the Hubs of Illicit Trade (HIT) team, examines how centers of illicit trade pose myriad threats to global security and sustainable development.”

“The exponential growth of illicit trade, resulting in annual losses amounting to trillions of dollars for the global economy, is increasingly concentrated within specific geographic areas. These locales serve as safe havens for smugglers and their accomplices, fostering a criminal ecosystem that facilitates the convergence of various criminal activities. The book underscores the detrimental impact of these hubs, characterized by opaque governance and lax regulatory oversight. It explores the spectrum of illicit trade present in notorious hubs such as the Argentina-Brazil-Paraguay Tri-Border Area, Dubai, Panama, Belize, Guatemala, and Ukraine. Emphasizing the phenomenon of crime convergence associated with these hubs, the book offers actionable recommendations for disrupting their interconnected illicit supply chains, infrastructures, and networks.”

This hybrid event will take place on February 19 from 12-2 pm EST at George Mason’s Arlington campus. Learn more and RSVP here.

Cyberbiosecurity Summit

From Johns Hopkins APL and Bio-ISAC: “Advancements in biomanufacturing and biotechnology drive the science we need to thrive, everything from apples to vaccines. The Cyberbiosecurity Summit 2025 convenes leading experts in biotechnology, biosecurity, and cybersecurity to explore the intersection of these fields and discuss the strategies to create a safe, secure future for us all.”
This event will take place February 25-26 in Laurel, MD. Register here and review the call for sessions here (closes 12/12).

Sustainable Manufacturing: Building and Preserving a Resilient Medical Industrial Base

“Join industry and government partners for our second annual industry summit! During this event, leaders from IBMSC will share our strategic vision and organizational priorities. Speakers will also share potential opportunities for building and preserving the medical industrial base.  This event will be in-person only and space is limited!”

This event will take place March 11-12 in Washington, DC. Learn more and register here.

Gaming Weapons of Mass Destruction Course – From Policy to Practice

From MORS: “Gaming Weapons of Mass Destruction (WMD – defined as Nuclear, Chemical, and Biological agents) will be a three-day course focused on developing and executing games related to WMD in all its forms. While the basics of WMD capabilities and game design will be discussed, this will be a course focused on the intersection of WMD and gaming. It will not be either a WMD or gaming course; for those topics see other offerings.”

“No prior experience is required for this course, though a basic familiarity with various agents and their effects would be helpful, as would a basic understanding of professional gaming and how it is used.  The instructors will adapt in real time to class requirements (e.g., if the class is interested in animal and plant targets, the instructors have extensive experience in designing games on those subjects as well).”

This course will take place March 18-20 on Zoom. Learn more and register here.

NEW: NOFO, Addressing Agricultural Biorisk Evidence Base Gaps with Applied Research
“There is a global recognition that the current evidence base to inform laboratory biological risk management has gaps, and that biosafety and biosecurity policies are not always based on evidence.1 This notice of funding will support the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens as identified during the RAV3N Biorisk and Biosafety Gap Assessment Workshop2 or similar gap analysis like the WOAH working group agent specific biorisk gap analysis.1  ERGP is seeking proposals that address one or more key focus area components listed below. Each proposal will go through an internal ERGP and external expert review. Successful proposals should address at least one of the three key focus areas and at least one component under that area.”

“This funding opportunity aims at the design and implementation of applied biorisk research to address evidence gaps in working with high-consequence veterinary and agricultural pathogens.”

“This work will contribute to recommended guidance on laboratory biosafety and agricultural biosecurity, using research techniques to evaluate the application and effectiveness in operational contexts. All proposals must make a clear experimental plan for how the applicant will test the application and outcomes of their focus area(s)/component(s) in their facility.”

Learn more and submit application by April 14 here.

Research Opportunity, The Gene Synthesis Regulatory Landscape in Asia: Towards Enhanced Biosecurity

From the Asia Centre for Health Security: “DNA synthesis technology is revolutionising our ability to engineer biological systems, offering transformative benefits in areas like vaccine development and sustainable energy. However, it also presents significant risks, particularly the potential misuse of synthetic DNA to create harmful pathogens, raising concerns within the biosecurity community.”

“To minimise biosecurity concerns related to DNA synthesis, some governments and industry groups have adopted policies requiring or encouraging providers to screen DNA synthesis orders. However, there seems to be less comprehensive regulation and oversight of DNA synthesis activities across many Asian countries”

“The Asia Centre for Health Security (ACHS) is leading a study to map the policy and regulatory landscape of DNA synthesis screening across the region. Our research aims to identify gaps and opportunities in existing frameworks and provide actionable recommendations to support the revision of existing laws and policies and/or or the development of new policies for regulating DNA synthesis screening in Asia.”

“Case Study Researchers for a Research Project on DNA Synthesis Screening in Asia”

“We are seeking experienced researchers to contribute to this research project by developing country-specific case studies on the regulation of DNA synthesis screening across Asia. Learn more about the opportunity here.”

Pandora Report 2.07.2025

This week’s Pandora Report discusses the 9th Meeting of the International Experts Group of Biosafety and Biosecurity Regulators, updates on the situation with USAID and from across the Trump administration, and more.

Biodefense MS Information Session

“Prospective students are invited to attend a information session to hear more about the Biodefense M.S. program offered at the Schar School. The online session will provide an overview of the program, as well as the application process, student experience and graduate outcomes. This session admissions will be led by the Graduate Admissions team.”

This sessions will take place at 12 pm EST on February 13. Learn more and register here.

9th Meeting of the International Experts Group of Biosafety and Biosecurity Regulators

The 9th Meeting of the International Experts Group of Biosafety and Biosecurity Regulators (IEGBBR) was held on February 3-5, 2025, in Pari, France. Since 2007, the biennial meeting has provided a crucial platform for experts from 11 member countries, as well as representatives from the World Health Organization (WHO) and the World Organisation for Animal Health (WOAH), to collaborate on enhancing global biosafety and biosecurity oversight mechanisms. This year, the meeting agenda includes: High Risk Biocontainment Facilities in Urban Areas; Global Biosafety and Biosecurity Challenges; and Biosafety and Biosecurity Concerns related to Emerging Issues. The IEGBBR was formed under the leadership of the Public Health Agency of Canada and comprises of biosafety and/or biosecurity regulatory authorities from 11 member countries. The purpose of the IEGBBR is to provide a forum for the sharing of knowledge and experience with regard to current human and zoonotic pathogen biosafety and biosecurity oversight issues.

Gerald Parker Reportedly Tapped to Lead White House Office of Pandemic Response

The White House has reportedly selected Gerald Parker, DVM, PhD, to lead the White House Office of Pandemic Response, according to CBS News. Parker is the Associate Dean for Global One Health at the Texas A&M College of Veterinary Medicine & Biomedical Sciences. He is also on the faculty of the Bush School of Government and Public Service at Texas A&M University, serving as the Director of the Pandemic and Biosecurity Policy Program at the Scowcroft Institute for International Affairs. Among Parker’s many accomplishments are previous stints as the Commander and Deputy Commander of the U.S. Army Medical Research Institute of Infectious Diseases, as well as time serving in the senior executive level as a federal civilian in DHS, HHS, and DOD, including serving as the Principal Deputy Assistant Secretary for Preparedness and Response at HHS, and Deputy Assistant Secretary of Defense for Chemical and Biological Defense at DOD. He is also the former chairperson of the National Science Advisory Board for Biosecurity, and he currently serves on the Defense Science Board Permanent Subcommittee for Threat Reduction.

Ashish Jha, MD, MPH, former White House COVID-19 response coordinator under President Biden, said in a statement to CBS News, “I’ve not been a fan of every choice that Donald Trump has made. And I’ve been very critical of many of them. This one is a very good choice,” describing Parker as “deeply knowledgeable, serious, not particularly partisan, but really just very focused on important issues.”

Shock and Awe as Trump Administration Dismantles USAID

If last week at USAID was chaotic, this week has proven to be a complete disaster. On Monday, Secretary of State Marco Rubio announced in a letter to lawmakers that he is the acting administrator of USAID, confirming his department’s de-facto takeover of the agency. Rubio explained in the letter that he has delegated authority to Pete Marocco, a Trump appointee who served at USAID under the first Trump administration and has been criticized by aid group and officials for, allegedly, intentionally dismantling the organization. Notably, Marocco is the one who drafted the initial order to freeze virtually all foreign aid.

On Tuesday, USAID’s previously-down website was updated with a simple announcement indicating all direct hire personnel will be placed on administrative leave globally by 11:59 pm EST on Friday, February 7. It does indicate there is an exception for mission-critical functions, core leadership, and specially designated programs, and that people in those roles would be notified of the expectation they continue working by 3 pm EST on February 6. The administration also ordered all overseas missions for USAID to shut down, and for all staff to be recalled by Friday. More than 6,000 USAID employees are currently overseas. According to CBS, just 294 are considered essential out of roughly 14,000 employees. Furthermore, it is unclear what will happen to foreign nationals who are employed by USAID at overseas missions.

The agency’s announcement explains in part that, “For USAID personnel currently posted outside the United States, the Agency, in coordination with missions and the Department of State, is currently preparing a plan, in accordance with all applicable requirements and laws, under which the Agency would arrange and pay for return travel to the United States within 30 days and provide for the termination of PSC and ISC contracts that are not determined to be essential. The Agency will consider case-by-case exceptions and return travel extensions based on personal or family hardship, mobility or safety concerns, or other reasons. For example, the Agency will consider exceptions based on the timing of dependents’ school term, personal or familial medical needs, pregnancy, and other reasons. Further guidance on how to request an exception will be forthcoming.”

One official told The Washington Post, “You find yourself in a foreign country, in all likelihood a place you moved to despite the terrorism or security risks, and you’re being treated as if you’re somehow an enemy of the state.  That’s not even the worst of it. You know that your career matters far less than the lives of those you were trying to help, and … a lot of them are going to die without American aid.”

USAID-provided ultra-low temperature freezer in a biomedical laboratory in Nanyuki, Kenya, sticker text: “USAID, From the American People”|Photo Credit: Danyale C. Kellogg

As the destruction unfolded at USAID, the White House released a fact sheet entitled “At USAID, Waste and Abuse Runs Deep,” that claims USAID “has been unaccountable to taxpayers as it funnels massive sums of money to the ridiculous — and, in many cases, malicious — pet projects of entrenched bureaucrats, with next-to-no oversight.”

The statement then lists 12 examples of this alleged waste and abuse, linking to questionable news sites like the Daily Caller and Breitbart. Several of them link to the Daily Mail, a British tabloid. One of the bulleted examples reads, “Millions to EcoHealth Alliance – which was involved in research at the Wuhan Lab”. Most of these claims were found to be false or misleading when fact checked. The statement then concludes with, “The list literally goes on and on — and it has all been happening for decades.”

In addition to the bizarre tone of this official White House statement, the cited examples are problematic. For starters, some of them are State Department grants, not USAID grants, while one of them actually comes from the first Trump administration. Some of them are so low that The Washington Post reports they were made at the ambassador level, without input from Washington. The White House has also incorrectly claimed USAID gave Politico over $8 million in funding. In reality, between 2023 and 2024, USAID paid Politico $44,000 for subscriptions to Politico publications. This is not an uncommon thing to do across the US government.

The claims made by the White House are part of a broader narrative that a large portion of the federal budget “goes to other countries.” In reality, as we discussed last week, it really only accounts for around 1% of the budget. Furthermore, much of this money does not ever leave the US, and the portion that does largely goes to NGOs, not host governments. Furthermore, much of this is obligated to go to US-based entities. An example of this is food aid, which has to be purchased in the US and must be shipped by US carriers. As a result, this attack on USAID and foreign aid in general is actually threatening to US farmers.

In a statement this week, President Trump said of the agency “It’s been run by a bunch of radical lunatics, and we’re getting them out, and then we’ll make a decision.” Irreversible decisions have already been made that will have far-reaching, long-lasting implications not just for USAID and the federal workforce, but for those receiving foreign aid through USAID and the organizations that facilitated that. PII and classified information has been accessed by the supposed Department of Government Efficiency, and lives have been upended, seemingly at the whim of Elon Musk.

Former Administrators React

A group of former USAID administrators issued a sharp rebuke of the administration’s attacks on the agency this week, including J. Brian Atwood, Peter McPherson, Andrew Natsios, Gayle Smith, and Samantha Power. In a statement signed by the former administrators, they explain “While we don’t agree on all issues, we wholeheartedly agree that USAID and America’s foreign assistance programs are vital to our interests, that the career men and women of USAID have served each of us well, and that it is the duty of the Administration and Congress to swiftly protect the Agency’s statutory role.”

They write later in the statement, “Failure to maintain the global engagement that foreign aid enables, to honor the men and women of our civilian service as we do those in the military, or weaken and even destroy the Agency is to the benefit of neither political party and the detriment of all Americans.”

Further Reading:

Further Trump Administration Updates

RFK Jr., Gabbard Advance Past Senate Committees

Tulsi Gabbard and RFK Jr. both cleared key hurdles on Tuesday in their efforts to be confirmed by the Senate. Both of their committee votes came down to the wire, with Republicans ultimately making the decision to back them after pressure from members of the administration. Both are thought to likely be confirmed by the full Senate.

CDC Restores Some Purged Files and Pages

Intense backlash following the purge of files on the CDC’s website seems to have prompted the reinstatement of some online resources. Last Friday, the agency suddenly removed thousands of pages from its site that included terms like “transgender,” “LGBT,” and “pregnant person,” rushing to meet a deadline to remove such terms from its website. While many pages have since been restored, many databases and pages on topics like contraception guidelines have not been restored. The site now has a banner explaining it is being modified to comply with President Trump’s executive orders.

Beyond ideological arguments, this has massive implications for public health. For example, the now gone pages on contraception provided lists of drug interactions for providers to consider when prescribing newer forms of birth control. Similarly, pages with vaccine information have yet to be restored, despite not being targeted by the executive order.

Note: All CDC datasets that were uploaded before January 28, 2025, have been uploaded to the Internet Archive and are available here.

NSF Flagging Research Grant Proposals for Reviews Based on DEI-Related Keywords

While the National Science Foundation has unfrozen its grant funding, a list of keywords that will flag proposals has reportedly been introduced at the organization. The list of keywords is extensive, according to an internal document that has been reviewed by media outlets and multiple NSF employees with knowledge of the review process who spoke under the condition on anonymity. Terms on the list allegedly include basic ones like biases, diversity, ethnicity, excluded, female, gender, historically, inequities, institutional, minority, racially, socioeconomic, systemic, trauma, underserved, victims, and women. While the list is concerning in general, many of these terms have multiple meanings, some of which would not fall under DEI.

This comes after a notice was given at the organization last week warning about activities that do not comply with the administration’s DEI executive order. A message to investigators said in part, “In particular, this may include, but is not limited to conferences, trainings, workshops, considerations for staffing and participant selection, and any other grant activity that uses or promotes the use of diversity, equity, inclusion and accessibility (DEIA) principles and frameworks or violates federal anti-discrimination laws.”

Further Reading:

Argentina Announces Exit from WHO

Argentinian President Javier Milei announced his intention to withdraw his country from the WHO this week. Milei, a self-described “anarcho-capitalist” who has sought to mirror Donald Trump, attributed this decision to the WHO’s management of the COVID-19 pandemic, which he said consisted of a “caveman quarantine that involved…one of the most outlandish crimes against humanity in history.”

This prompted immediate criticism from the Argentinian opposition as well as health organizations who are concerned this move will limit the country’s access to needed funding. Critics also say Milei is not able to do this unilaterally, requiring instead congressional approval. Milei’s administration refused to sign the WHO-supported Pandemic Treaty last year, citing concerns about national sovereignty.

H5N1 – “In Your Feeders” 02.07.25

By Meredith Fletcher, Pandora Report Associate Editor

As H5N1 spreads across the bird community, many people raise the question, “should I stop feeding the birds in my backyard?” The simple answer is…well it depends.  If the bird flu is prevalent in your area, it may be best to stop.  It also depends on what type of birds you feed. Right now, those known to be carriers of H5N1 are waterfowl such as ducks/geese, shorebirds (storks/plovers), raptors (hawks/owls) and songbirds such as robins and sparrows. Due to this, it is also spreading to domestic turkeys, chickens, ducks, geese and quail. It is important to note that domestic songbirds only have about a 3% chance of infection, so unless you also keep poultry, there is little risk. The virus is spread from these birds in their saliva, mucus and feces, which can be dropped on the ground and can contaminate areas if you have your own flock. In other H5N1 news, there was a new strain identified in Nevada cows on Wednesday, which led Louise Moncla (an evolutionary biologist specializing in bird flu) to say, “We need to now consider the possibility that cows are more broadly susceptible to these viruses than we initially thought.” While the virus is actively mutating, officials still say the person-to-person transmission risk is low, and little to be concerned about for the average person.

Strengthening a Safe and Secure Nucleic Acid Synthesis Ecosystem: Outcomes of EBRC Stakeholder Engagement

From EBRC: “The report describes central issues and perspectives on nucleic acid synthesis screening, including screening for sequences of concern, customer screening, follow-up screening, and law enforcement reporting. It describes best practices that providers, tool developers, customers, and other stakeholders can implement to further strengthen nucleic acid synthesis screening. It also recommends policies, capabilities, and infrastructure to support the adoption and improvement of screening practices.”

“EBRC developed this report based on information and expertise shared by stakeholders across industry, government, academia, and civil society in six virtual workshops (April–August 2024) and an in-person workshop (September 2024). We thank the 200+ stakeholders who engaged with this effort for their collaborative spirit and dedication to advancing nucleic acid synthesis screening.”

Read the report here.

“Bolstering US Biodefense: Recommendations for the New Administration”

This briefer from the Council on Strategic Risks’ Nolan Center offers recommendations for the Trump administration’s first year in office aimed at improving US biodefense. It explains in part, “In recent years, the US has shown both leadership and progress in establishing and implementing the most advanced policies yet for biodefense and biosecurity. Significant strategic advancements have included the strengthening of the US National Biodefense Strategy in 2018 and 2022, and the Department of Defense (DoD) completing its first-ever Biodefense Posture Review in 2023. Efforts to implement these ambitious strategies have included establishing DoD’s Generative Unconstrained Intelligent Drug Engineering (GUIDE) program to harness the Department of Energy’s supercomputing capabilities to design and evaluate medical countermeasures years faster than standard methodologies, the Advanced Research Projects Agency for Health (ARPA-H), and the Centers for Disease Control and Prevention (CDC) Center for Forecasting and Outbreak Analytics (CFA). Still, given the scale and urgency of the risks the nation faces, the new administration must continue to pursue ever-more ambitious approaches to addressing significant biological risks.”

Transmission Interrupted, “Behind the Scenes: Navigating the COVID-19 Pandemic in Hollywood”

“In this episode of Transmission Interrupted, join hosts Lauren Sauer and Rachel Lookadoo as they continue their Pathogens in Pop Culture series with a dive into the fascinating intersection of infectious diseases and the entertainment industry with esteemed guest, Dr. Saskia Popescu. Dr. Popescu, an internationally recognized infectious disease epidemiologist and global health security expert, shares her unique experiences providing epidemiological guidance and infection prevention strategies on film sets during the COVID-19 pandemic. From creative risk assessments and navigating ever-changing guidelines to the challenges of implementing health measures in diverse climate settings all around the world, Dr. Popescu provides a candid look behind the scenes of Hollywood’s pandemic response. Get a glimpse into how science intersects with Hollywood magic, revealing an industry more receptive and complex than meets the eye. Tune in as we uncover the balance between safety and storytelling, and explore the uncharted territory of infectious diseases in pop culture.”

Listen here.

“Engineering Tomorrow: DARPA’s Push into the Frontier of Synthetic Biology”

Jeff Buguliskis discusses the work of DARPA’s Biological Technologies Office in this piece from Synbiobeta: “For years, synthetic biology has offered tantalizing glimpses of what might be possible—personalized disease treatments, materials grown by microbes instead of extracted from petroleum, and sensors capable of detecting everything from emerging pathogens to chemical toxins. The allure has attracted investors and entrepreneurs, pushing startups to scale up with fermentation bioreactors and gene-editing technologies. But beyond the hype, we hit a sobering truth: biology is messy. Scale-ups that work beautifully on a lab bench often break down in a 10,000-liter tank. Promising genetic designs fail unpredictably because real-world conditions differ from the pristine order of the lab.”

“That’s precisely why now is the right time for deeper, broader investment in SynBio—and why the U.S. Defense Advanced Research Projects Agency (DARPA) is making its move. The mission at DARPA, known more widely for stealth planes and the internet, is to foresee threats, catalyze big ideas, and then supercharge them until they’re world-changing or prove unworkable. Mike Koeris, Director of DARPA’s Biological Technologies Office (BTO), envisions synthetic biology as the next great frontier in that legacy of breakthroughs. And he’s looking for new frontiers, people of science, a.k.a. Program Managers—“PMs,” as DARPA calls them—to push that frontier beyond what anyone could think possible, merging the digital realm of bits with the living realm of atoms.”

“The Value of a Biorisk Management System: Enabling Infectious Disease Laboratory Excellence on all Levels”

Patty Olinger and Stefan Wagener discuss the need for comprehensive biorisk management systems in this piece from Infection Control.tips: “Biosafety and biosecurity are essential components of modern laboratory operations, ensuring that safety and security are seamlessly integrated into daily practices. Far from being burdensome, a well-implemented biorisk management system empowers laboratories through a top management-driven approach to continual improvement, based on clear internal and external stakeholder-based policies and objectives that are monitored and assessed through key performance indicators.  When possible, these measures should be embedded into workflows so effectively that they become part of day-to-day activities or culture. Such a system ensures that resources are directed toward addressing gaps, continually improving biosafety and biosecurity and fostering the integrity of research. This results in scientists taking ownership of biorisk management and focusing better on their core mission—innovative science. Moreover, a comprehensive biorisk management system extends benefits beyond the facility, safeguarding communities and the environment and rebuilding public trust with transparency and external stakeholder input.”

“Monitoring Snapshot 7”

From GP WMD Counter Disinfo: “DFRLab conducts a bimonthly analysis of data based on a search query including Ukrainian, Russian and English languages to identify when spikes of CBRN disinformation narratives are spreading. This report (10 December 2024 – 6 January 2025) saw an emergence of claims of Ukraine biolab origin of H5N1 (avian flu); an influx of unfounded allegations about alleged Ukrainian plans to attack various nuclear power plants (NPPs); and unfounded speculations around the possibility of Western involvement in the assassination of General Igor Kirillov, head of the Chemical, Biological, and Nuclear Defense Troops of the Russian Armed Forces.”

“Russia Consumer Watchdog Falsely Accuses US of Mishandling Pathogens in DR Congo”

Purity Mwambia debunks a claim from the Russia State Consumer Watchdog that the US and France are irresponsibly handling dangerous pathogens in the DRC in this piece for VOA. The claim states, “The activities of this laboratory are financed by the US Agency for International Development and the French Merieux Foundation. This circumstance once again confirms the irresponsible approach of Western countries when working with dangerous infections in the territory of third countries, when biological facilities are created without the proper infrastructure and samples of pathogens of dangerous diseases are accumulated without control.”

“HSToday Threat Forecast 2025: Global Terrorism”

Mahmut Cengiz, an Associate Professor and Research Faculty with Terrorism, Transnational Crime and Corruption Center (TraCCC) and the Schar School of Policy and Government at George Mason University, recently published this article in Homeland Security Today. He writes in part, “The effectiveness of terrorism as a strategic approach has been widely debated. While many scholars argue that terrorism can be a useful tactic for non-state actors, they often believe it ultimately fails to produce lasting, long-term results. However, the Taliban’s use of terror tactics and Hay’at Tahrir al-Sham’s (HTS) recent expansion in Syria challenge this view, suggesting that, in some cases, terrorism can effectively achieve its strategic goals. As a result, both the Taliban and HTS may serve as models for other jihadist groups with similar objectives in 2025. Consequently, shifting priorities within Western governments have contributed to HTS’s rise. The U.S. has focused more on the strategic threat posed by China, while the European Union has been preoccupied with the refugee crisis. In this context, Turkiye has played a central role in facilitating HTS’s growth in Syria, and its actions appear to have been tacitly supported by Western governments. Despite these developments, Syria’s future remains uncertain. There are ongoing concerns about whether an authoritarian and often corrupt Turkish government can help guide Syria toward a stable and representative political system. Moreover, ISIS continues to be the most active and powerful actor in Syria, responsible for about one-third of the country’s terrorist attacks in 2024. There also are concerns over whether Kurdish forces in northern Syria will continue to receive U.S. support in their fight against ISIS. As such, Syria is likely to remain a key issue on the global agenda for counterterrorism in 2025.”

“Feature Article: Organ-on-a-Chip—3D Printed Tissue Allows Researchers to Study Effects of Toxic Vapors”

This article is from the Department of Homeland Security: “The Science and Technology Directorate (S&T) and its Chemical Security Analysis Center (CSAC) have partnered with the Wake Forest Institute for Regenerative Medicine (WFIRM) to 3D print human lung cells and tissue onto microchips for state-of-the-art analysis of the hazards posed by toxic chemicals. S&T’s other partner, the Battelle Memorial Institute (BMI), is serving as the program’s evaluator.”

NEW: 2025’s National Security Challenges: A Hayden Center Open Forum

From the Hayden Center: Join the Michael V. Hayden Center for Intelligence, Policy, and International Security on Wednesday, February 12, 2025, at 7:00 pm ET as we host our third annual open forum examining the year’s national security challenges. At this event, YOU get to drive the discussion with your questions!

Our panel includes:

General (retired) Michael Hayden: former Director of both the Central Intelligence Agency & National Security Agency; the nation’s first Principal Deputy Director of National Intelligence; and Distinguished Visiting Professor at the Schar School of Policy and Government at George Mason University;

Jennifer Victor: Associate Professor of Political Science at the Schar School; Director of Schar School’s Democracy Lab Academic Community; author, researcher, and commentator; and recipient of the National Capitol Area Political Science Association Pi Sigma Alpha Award for undergraduate student mentoring in 2024 and of  the George Mason University Teaching Excellence Award in 2019;

Andrew McCabe: Distinguished Visiting Professor at the Schar School; former Acting Director and Deputy Director of the Federal Bureau of Investigation; CNN senior law enforcement analyst; and co-host of  UnJustified, the successor to Jack: A Special Counsel Podcast; 

Greg Koblentz: Associate Professor and Director of Biodefense Graduate Programs and Associate Faculty at the Center for Security Policy Studies at the Schar School; Editor-in-Chief of The Pandora ReportCo-Director of the Global Labs Initiativemember of the Scientist Working Group on Biological and Chemical Security at the Center for Arms Control and Non-Proliferation in Washington, DC, and the Security Working Group of the Engineering Biology Research Consortium (EBRC); and author and researcher; 

Larry Pfeiffer, Director of the Hayden Center, former Senior Director of the White House Situation Room, and former Chief of Staff at the CIA, will moderate the conversation.

Whether you join us in person or via livestream, we look forward to your incisive questions!

Learn more and register here.

NEW: Hubs of Illicit Trade in the Global Economy Book Discussion

From the Terrorism, Transnational Crime and Corruption Center (TraCCC): “This book, authored by a global team of researchers and experts, the Hubs of Illicit Trade (HIT) team, examines how centers of illicit trade pose myriad threats to global security and sustainable development.”

“The exponential growth of illicit trade, resulting in annual losses amounting to trillions of dollars for the global economy, is increasingly concentrated within specific geographic areas. These locales serve as safe havens for smugglers and their accomplices, fostering a criminal ecosystem that facilitates the convergence of various criminal activities. The book underscores the detrimental impact of these hubs, characterized by opaque governance and lax regulatory oversight. It explores the spectrum of illicit trade present in notorious hubs such as the Argentina-Brazil-Paraguay Tri-Border Area, Dubai, Panama, Belize, Guatemala, and Ukraine. Emphasizing the phenomenon of crime convergence associated with these hubs, the book offers actionable recommendations for disrupting their interconnected illicit supply chains, infrastructures, and networks.”

This hybrid event will take place on February 19 from 12-2 pm EST at George Mason’s Arlington campus. Learn more and RSVP here.

Cyberbiosecurity Summit

From Johns Hopkins APL and Bio-ISAC: “Advancements in biomanufacturing and biotechnology drive the science we need to thrive, everything from apples to vaccines. The Cyberbiosecurity Summit 2025 convenes leading experts in biotechnology, biosecurity, and cybersecurity to explore the intersection of these fields and discuss the strategies to create a safe, secure future for us all.”
This event will take place February 25-26 in Laurel, MD. Register here and review the call for sessions here (closes 12/12).

Sustainable Manufacturing: Building and Preserving a Resilient Medical Industrial Base

“Join industry and government partners for our second annual industry summit! During this event, leaders from IBMSC will share our strategic vision and organizational priorities. Speakers will also share potential opportunities for building and preserving the medical industrial base.  This event will be in-person only and space is limited!”

This event will take place March 11-12 in Washington, DC. Learn more and register here.

Gaming Weapons of Mass Destruction Course – From Policy to Practice

From MORS: “Gaming Weapons of Mass Destruction (WMD – defined as Nuclear, Chemical, and Biological agents) will be a three-day course focused on developing and executing games related to WMD in all its forms. While the basics of WMD capabilities and game design will be discussed, this will be a course focused on the intersection of WMD and gaming. It will not be either a WMD or gaming course; for those topics see other offerings.”

“No prior experience is required for this course, though a basic familiarity with various agents and their effects would be helpful, as would a basic understanding of professional gaming and how it is used.  The instructors will adapt in real time to class requirements (e.g., if the class is interested in animal and plant targets, the instructors have extensive experience in designing games on those subjects as well).”

This course will take place March 18-20 on Zoom. Learn more and register here.

NEW: Call for Experts-Personal Protective Equipment for Influenza A (H5N1) in High-Risk Farm Settings: A Workshop

“The National Academies is seeking suggestions for experts to participate in a new workshop on personal protective equipment (PPE) needs and best practices to protect workers in high-risk U.S. farm settings and control Influenza A (H5N1) transmission between livestock and humans. The workshop will examine the current state of knowledge on H5N1 transmission to humans and implications for PPE use in high-risk farm settings; approaches to overcoming barriers to implementation of PPE recommendations and best practices; the potential for novel technologies to enhance protection provided by PPE in farm settings; and health communication, education, training, and research needs.”

Learn more and submit nominations by February 14 at 5 pm ET here.

NEW: Research Opportunity, The Gene Synthesis Regulatory Landscape in Asia: Towards Enhanced Biosecurity

From the Asia Centre for Health Security: “DNA synthesis technology is revolutionising our ability to engineer biological systems, offering transformative benefits in areas like vaccine development and sustainable energy. However, it also presents significant risks, particularly the potential misuse of synthetic DNA to create harmful pathogens, raising concerns within the biosecurity community.”

“To minimise biosecurity concerns related to DNA synthesis, some governments and industry groups have adopted policies requiring or encouraging providers to screen DNA synthesis orders. However, there seems to be less comprehensive regulation and oversight of DNA synthesis activities across many Asian countries”

“The Asia Centre for Health Security (ACHS) is leading a study to map the policy and regulatory landscape of DNA synthesis screening across the region. Our research aims to identify gaps and opportunities in existing frameworks and provide actionable recommendations to support the revision of existing laws and policies and/or or the development of new policies for regulating DNA synthesis screening in Asia.”

“Case Study Researchers for a Research Project on DNA Synthesis Screening in Asia”

“We are seeking experienced researchers to contribute to this research project by developing country-specific case studies on the regulation of DNA synthesis screening across Asia. Learn more about the opportunity here.”

Pandora Report 12.20.2024

This week’s Pandora Report covers the first severe H5N1 case in the US, growing numbers of mpox cases in the DRC, updates to the BSAT list, the killing of Russian Lieutenant General Igor Kirillov, and more. The Pandora Report will return from the holiday break on January 10.

Congrats to Our December Biodefense MS Grads!

Mpox Cases Rise Steadily

Mpox cases in Africa rose steadily in the last week with 3,095 more cases reported, 2,632 of which were in the Democratic Republic of Congo (DRC). Africa CDC reports that 31 more people have died, 29 of which were in the DRC. Nearly 70,000 cases have been reported in 20 countries is the region this year. Guinea has also moved recently from the controlled stage to active transmission. Read more about mpox’s spread in Africa here.

CDC Confirms First Severe H5N1 Case in the United States

The CDC announced yesterday that a patient has been hospitalized with a severe case of avian influenza A(H5N1) virus infection in Louisiana, marking the first instance of severe illness linked to the virus in the United States. The case was confirmed by CDC on December 13. The CDC’s press release on this matter explains that, “Partial viral genome data of the H5N1 avian influenza virus that infected the patient in Louisiana indicates that the virus belongs to the D1.1 genotype related to other D1.1 viruses recently detected in wild birds and poultry in the United States and in recent human cases in British Columbia, Canada, and Washington state. This H5N1 bird flu genotype is different than the B3.13 genotype detected in dairy cows, sporadic human cases in multiple states, and some poultry outbreaks in the United States. Additional genomic sequencing and efforts to isolate virus from clinical specimens from the patient in Louisiana are underway at CDC.”

An investigation is ongoing, but it has already been determined that the patient was exposed to sick and dead birds in backyard flocks. No person to person spread of H5 bird flu has been detected at this time. This is the first case of H5N1 avian influenza in the US that has been linked to exposure to a backyard flock. The agency explains that, “A sporadic case of severe H5N1 bird flu illness in a person is not unexpected; avian influenza A(H5N1) virus infection has previously been associated with severe human illness in other countries during 2024 and prior years, including illness resulting in death.”

APHIS Updates Select Agents and Toxins Registration List

The US Animal and Plant Health Inspection Service (APHIS) recently completed it biennial review of the Biological Select Agents and Toxins (BSAT) list. As a result of this review, the agency is removing five select agents from the BSAT list, including Brucella abortusBrucella suis, and Brucella melitensis, African horse sickness virus, and Peronosclerospora philippinensis. The agency explained in a press release that, “Removing regulatory barriers will greatly advance research on vaccines and diagnostics, which will improve our efforts to control these diseases in animal populations.” Furthermore, it explained that the delisting of the Brucella spp. does not change the already recommended biosafety levels for work with this species of bacteria.

Russian Lieutenant General Igor Kirillov Assassinated by Ukrainian Security Forces

LTG Igor Kirillov, head of Russia’s Chemical, Biological, and Nuclear Defense Troops, was killed this week just one day after Ukraine accused him of criminal activity in the “massive use of banned chemical weapons” in Ukraine. Kirillov and an aide died after an explosive device that was planted in a scooter by an entryway detonated as they passed by. According to the Security Service of Ukraine (SBU, chemical weapons have been used by Russia more than 4,800 times since the beginning of the full-scale invasion in 2022.

Read more: “Protecting Our Precious Bodily Tissues. The Favourite Conspiracy Theories of General Kirillov, Assassinated in Moscow,” Nikita Sologub, Mediazona

Trump Nominees, Surrogates Continue to Disappoint

Washington Post Does Deep Dive on Dave Weldon’s Anti-Vaccine Past

The Washington Post recently published a piece on President-elect Trump’s pick to lead the CDC, Dave Weldon, and his longstanding history with anti-vaccination rhetoric and beliefs. The piece explains how Trump came to select the 71-year-old former Army physician to lead CDC on the advice of Robert F. Kennedy Jr., Trump’s equally troubling pick to lead HHS. The piece explains in part, “A Washington Post review of Weldon’s public comments, media appearances and congressional letters along with accounts of those who worked with him reveal a portrait of a politician and physician who emphasized the experiences of individuals while dismissing dozens of studies based on data from hundreds of thousands of patients that showed no link between vaccines and autism.”

Furthermore, “In Congress, Weldon was “absolutely and completely dismissive” of data showing vaccines were not associated with autism, recalled Josh Sharfstein, a former Democratic staff member on the House Government Reform Committee in the early 2000s when the Republicans who were in charge held regular hearings questioning vaccine safety.”

Despite this, Weldon has previously expressed support for coronavirus and influenza vaccines, offering them to patients who want them. Sharfstein, who is now Vice Dean for Public Health Practices and Johns Hopkins University and a former top FDA official, explained further that Weldon “…appeared to have a closed mind on the issue…He didn’t seem to understand that the core tool of population data analysis is one of the pivotal aspects of the work of CDC.”

Musk Shares False ‘Bioweapons Lab’ Tweet

This Wednesday, the infamous anti-LGBTQIA+ X account, Libs of TikTok, posted a screenshot of a portion of the resolution introduced by Speaker Mike Johnson aimed at averting a government shutdown on December 21. The bill would fund the government through March 14, but both President-elect Donald Trump and X owner Elon Musk have spoken out against the bill. The portion of the bill shared by Libs of TikTok reads:

SEC. 629. REGIONAL BIOCONTAINMENT RESEARCH LAB-ORATORIES.

(a) IN GENERAL—The Secretary of Health and Human Services (referred to in this section as the “Secretary”) shall make awards to establish or maintain, as applicable, not fewer than 12 regional biocontainment lab-oratories, for purposes of—

(1) conducting biomedical research to support public health and medical preparedness for, and rapid response to, biological agents, including emerging infectious diseases;

The Libs of TikTok account captioned the photo, “BREAKING: New Congressional Resolution bill includes funding for at least 12 new biolabs.” Must quote-tweeted it, adding “We’re funding bioweapon labs in this bill!” Musk’s post has been re-tweeted at least 60,000 times, yet the bill text says nothing about biological weapons. Furthermore, as noted by Politico, “The provision is part of a long-sought reauthorization of the Pandemic and All Hazards Preparedness and Response Act.”

Musk, who was recently denied a clearance and has done his best to insert himself into the Trump team, was named co-chair of the “Department of Government Efficiency” (DOGE) by Donald Trump. DOGE, which is a nod to the meme coin-Doge Coin-promoted by Musk, is a proposed presidential advisory commission that would be tasked with restructuring the federal government and removing regulations. Despite Musk’s only involvement with the government so far being receiving at least $15.4 billion in federal contracts in the last decade, he seems poised to play a prominent role in the incoming administration. That being the case, Musk should brush up on the United States’ role as a State Party to the Biological Weapons Convention, which prohibits states from developing, producing, acquiring, transferring, stockpiling, or using biological and toxin weapons.

“The United States Needs to Step Up Its Response to Bird Flu”

Biodefense MS alumna Sophia Hirshfield recently co-authored this feature from the Center for Strategic and International Studies. The authors write in part, “Since the turn of the century, every presidential administration has highlighted gaps in U.S. public health capabilities, and every Congress has left them underfunded. The H5N1 outbreak has revealed the resulting and dangerous shortcomings in U.S. pandemic preparedness: lagging data, incomplete surveillance, sluggish coordination, considerable mistrust, and insufficient planning and stockpiling of vaccines and therapies. That poor performance cuts across political parties, the federal interagency, and state leadership. Multiple players have sought to downplay the threat: the dairy industry fears further economic setbacks, state leaders are wary of federal intervention, and the Biden administration did not want to aggravate relations during the 2024 election cycle.”

They continue, “It is not too late to change course. Strong interagency, interstate, and global coordination; better protections for farm workers; accelerated planning and investment in surveillance; and the development and promotion of better vaccines and therapies remain the essential elements to prevent the sustained spread of H5N1.”

“Syria Still Has Chemical Weapons: How to Get the Country’s New Rulers to Help Eliminate Assad’s Deadly Arsenal”

Biodefense Graduate Program Director Gregory Koblentz recently co-authored this article in Foreign Affairs. The article describes the threat posed by Syria’s remaining chemical weapons, calls up on the new Syrian government to eliminate these weapons, and provides policy recommendations to the United States and its allies and partners for how they can assist in the process of destroying these weapons and holding accountable members of the former regime who conducting chemical attacks.

Koblentz was also quoted in these articles about Syria’s CW:

“Researcher Daniel Gerstein on Security Threats Posed by Drones”

RAND Corporation Senior Policy Researcher and Biodefense PhD Program alumnus Daniel Gerstein discusses threats posed by unmanned aerial systems in this interview with C-SPAN.

“Chemical and Biological Defense Program Enterprise Strategy”

The Department of Defense released the 2024 Chemical and Biological Defense Program (2024 CBDP) Enterprise Strategy. “It replaces the 2020 CBDP strategy and positions the Department to ensure the total force to carry out its missions in the face of advanced chemical and biological threats…Taking its lead from the 2022 National Defense Strategy, this strategy prioritizes delivery of operationally relevant chemical and biological defense (CBD) capabilities at speed and scale, to sustain and strengthen U.S. deterrence against the People’s Republic of China as the pacing challenge and Russia as the acute threat. The new strategy reinforces other strategic guidance including the 2023 Strategy for Countering Weapons of Mass Destruction, inaugural National Defense Industrial Strategy, and the Biodefense Posture Review. It also calls for tighter integration of CBD capabilities with international Allies and partners to ensure our combined armed forces can deter or prevail against advanced chemical and biological threats.”

“The 2024 Seoul and Tokyo Biosecurity Dialogues”

Christopher East discusses dialogues held by the Council on Strategic Risks in November in this blog post, writing in part “On 18th and 20th November 2024 in Seoul and Tokyo respectively, the Council on Strategic Risks (CSR) convened dialogues with biosecurity experts from the Republic of Korea, Japan, the United States, the United Kingdom, and NATO, concluding with a series of practicable recommendations for the governments of the Republic of Korea and Japan.”

“Securing Benchtop DNA Synthesizers”

Max Langenkamp recently published this report with IFP: “This report examines the present and future of benchtop synthesizers and provides quantitative forecasts. The concrete threat model in the report helps characterize the threat of attack and leads to certain technical mitigations. Modern cryptographic methods can enable secure and centralized screening, even for air-gapped devices…The current benchtop policy would benefit from a security certification system, as well as standardized processes for benchtop and reagent screening. Such safeguards manage to mitigate risk while enabling innovation.”

“DNA Sequencing, Synthesis and Screening in Biosecurity”

From the Cluster for National and Technical Science Arms Control Research: “The second CNTR Fact Sheet by Liska Suckau (CNTR/PRIF) provides an overview of the characteristics of DNA sequencing, synthesis and screening in biosecurity. It compares different sequencing methods and gives a basic overview of DNA synthesis. In addition, it highlights the technologies’ potentials and risks and outlines various application possibilities.”

CNTR Monitor 2024 Perspectives on Dual Use

From CNTR: “The CNTR Monitor is an annual open-access publication and the core product of CNTR’s research. It highlights technological innovations and developments in the natural sciences that are relevant to peace and security. In addition to analyses of individual technologies and reports on research and development (R&D) activities, the Monitor also explores opportunities for arms control and outlines options for political regulation.”

This year’s edition includes articles like “Technological Implications of AI in Biorisk,” “Implications of Technological Advancements for Biosecurity,” and more.

“Toward a Safer and More Secure US Bioeconomy”

Watson et al. recently published this comment in Nature Biotechnology, writing in part “To enhance the safety and security of the US bioeconomy, a new public–private partnership should be established to facilitate information sharing and threat analysis among industry, government and academia, and to develop and deploy safeguards.”

“Scientists Urge Halt to Research on Creating Synthetic “Mirror” Bacteria That Could Evade Human Immunity, Disrupt Ecosystems”

Matt Field breaks down concerns about research using mirror molecules in this piece for The Bulletin of the Atomic Scientists, writing in part “Although the capability to create organisms or bacteria that utilize mirror molecules remains at least a decade away by many estimations, 38 authors of an article published in Science Thursday said that investigation into creating such “mirror life” should not be pursued. The authors said they “were initially skeptical that mirror bacteria could pose major risks,” but have since grown “deeply concerned.”’

“A Framework for Effective Risk Assessment of AI-Biotechnology Convergence”

Lakshmy Ramakrishnan recently authored this issue brief for the Observer Research Foundation: “Advances in disruptive technologies have enabled scientists to engineer biological systems and create more efficient and sustainable products for a range of purposes. The convergence of artificial intelligence (AI) with biotechnology has contributed to the development of therapeutics and vaccines, helped address food security, aided in generating innovative processes to mitigate the effects of climate change, and expanded the bioeconomy. However, there are concerns that AI-biotechnology tools can be misused to create harm, with catastrophic global consequences. This brief advocates for a nuanced approach to assess the risks associated with the convergence of AI with biotechnology and its potential for misuse and recommends a coordinated strategy.”

“U.S. Government Support for Global Health Security – Protecting Lives and Safeguarding Economies”

The Biden administration recently released its final annual global health security report-“U.S. Government Support for Global Health Security – Protecting Lives and Safeguarding Economies”. The report highlights progress in global health security and identifies remaining challenges in this area. A White House press release on the document’s announcement explains, “The Biden-Harris Administration has advanced a bold agenda to prevent the devastating toll of outbreaks and pandemics, including investing more than $3 billion in strengthening global health security (GHS) since 2020. These investments have helped to: prepare countries around the world to more effectively prevent, detect and respond to biological threats; build stronger and more effective regional and global institutions to support health emergency preparedness and response; and respond rapidly to numerous outbreaks – from Ebola to mpox – to limit the health and economic impacts on the American people, as well as people living around the world. U.S. leadership in global health security is built on decades of investments in global health and research and development, as well as strong partnerships with other countries, regional and multilateral institutions, civil society, and the private sector.”

ICYMI: In Conversation with Jon Finer: Recent Developments in the Biden Administration’s WMD Policies

Watch the recording of the Carnegie Endowment for International Peace’s December 19 event here: “As the United States approaches the expiration of the New Strategic Arms Reduction Treaty (New START) in February 2026, there are critical questions about the future of nuclear arms control, strategic stability, and global nonproliferation efforts.”

“Join the Arms Control Association and the Carnegie Endowment for International Peace for remarks from U.S. Principal Deputy National Security Advisor Jon Finer on the Biden administration’s efforts to reduce nuclear dangers and adapt U.S. nuclear weapons and nonproliferation policy to an uncertain world, as evidenced by the rapid changes occurring in Syria. Finer will take questions from the Arms Control Association’s Executive Director Daryl Kimball.” 

“Following Finer’s address, a distinguished panel will examine the implications of the looming expiration of New START. Madelyn Creedon, chair of the 2023 Congressional Commission on the Strategic Posture of the United States, Adam Mount, senior fellow and director of the Defense Posture Project at the Federation of American Scientists, and James Acton, co-director of Carnegie’s Nuclear Policy program, will explore key considerations surrounding U.S. nuclear forces and requirements, arms control, and nonproliferation policy.”   

ICYMI: “NTI | bio Proposes New Solutions to Prevent Bioweapons Development and Use”

“The dual-use nature of modern bioscience and biotechnology, combined with the significant resources available to many states, makes it challenging to prevent the development of biological weapons using traditional arms control measures and policy approaches. During the fifth session of the Biological Weapons Convention (BWC) Working Group meetings from December 2-13 in Geneva, Switzerland, NTI | bio presented solutions that could effectively reduce the risk of bioweapons development and use by states and other powerful actors.”

Read more here.

Understanding the Introduction of Pathogens into Humans- Preventing Patient Zero: A Workshop

“The past few decades have seen the emergence of several diseases with drastic public health and economic consequences. Understanding routes of pathogen emergence and transmission is critical to preventing and mitigating disease spillover and amplification. The National Academies Forum on Microbial Threats will host a hybrid public workshop to address gaps in understanding of disease emergence, with a focus on human-animal interaction and laboratory biosafety. The workshop will explore how applications of existing policy structures, emerging technologies, and actionable research can improve biosecurity measures and prevention of future disease emergence.”

This event will take place on January 15 and 16. Learn more and register here.

How to Avoid Human-Made Pandemics

From the Asia Centre for Health Security: “Studying viruses that could potentially cause outbreaks is one of the most effective ways to reduce the risk of pandemics. However, this type of research—especially when it involves collecting samples from the field and manipulating pathogens—can unintentionally lead to a pandemic if not managed carefully. Dr Lentzos will discuss her findings from the Pathogen Project, which brought together an international taskforce of scientists, biosecurity and public health experts, ethicists, and civil society leaders to seek consensus on this question: Can we agree on ways to manage research that carries pandemic risk as safely, securely and responsibly as possible?”

This event will take place on January 23 at 8 pm (GMT +8:00) via Zoom. RSVP here.

Preparedness in Rural Communities: National and State/Local Perspectives and Plans

From Penn State: “The COVID-19 pandemic and recent hurricanes have thrust the preparedness of rural communities into the national spotlight. At the federal level, the Administration for Strategic Preparedness and Response and the Centers for Disease Control and Prevention have recently released national goals and plans for preparedness of rural communities. The overall objective of this virtual, 2-day mini-symposium is to identify opportunities in public health and agricultural preparedness and response in rural communities. The mini-symposium will focus upon national perspectives on Thursday, January 30 and the state/local perspectives on Friday, January 31. Speakers include representatives of the Administration for Strategic Preparedness and Response, the Department of Homeland Security, US Department of Agriculture, the USA Center for Rural Public Health Preparedness, and state/local leaders.”

This event will take place on January 30 and 31, from 11 am to 2 pm ET each day. Learn more and register here.

Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control

Johns Hopkins APL’s colloquium will feature Mindy Weisberger, author of the upcoming book Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control: “Zombies are all around us—insect zombies, that is. In Rise of the Zombie Bugs, Mindy Weisberger explores the eerie yet fascinating phenomenon of real-life zombification in the insect class and among other invertebrates. Zombifying parasites reproduce by rewriting their victims’ neurochemistry, transforming them into the “walking dead”: armies of cicadas, spiders, and other hosts that helplessly follow a zombifier’s commands, living only to serve the parasite’s needs until death’s sweet release (and often beyond).”

Learn more about this January 31 event here.

Cyberbiosecurity Summit

From Johns Hopkins APL and Bio-ISAC: “Advancements in biomanufacturing and biotechnology drive the science we need to thrive, everything from apples to vaccines. The Cyberbiosecurity Summit 2025 convenes leading experts in biotechnology, biosecurity, and cybersecurity to explore the intersection of these fields and discuss the strategies to create a safe, secure future for us all.”
This event will take place February 25-26 in Laurel, MD. Register here and review the call for sessions here (closes 12/12).

NEW: The Independent Panel Solicits Views and Insights on Pandemic Prevention, and Response Efforts

The Independent Panel for Pandemic Preparedness and Response, co-chaired by HE Ellen Johnson Sirleaf and RH Helen Clark, welcomes you to share your insights and expertise on the status of international and regional pandemic-related reform processes and initiatives, and how progress can be continued and accelerated in the months and years ahead.”

Learn more about this survey and submit by December 20 here.

Pandora Report 12.13.2024

This week’s Pandora Report covers the rush to find the former Assad regime’s hidden chemical weapons, a recent study on H5N1’s potential to become an efficient human pathogen, Nobel laureates’ call for the Senate to block RFK Jr. from becoming HHS Secretary, and more.

Assad Regime Falls

On Sunday, Syrian rebels continued their advance, taking the capital city of Damascus and forcing the country’s long-time leader, President Bashar al-Assad, to flee to Moscow. This ended the country’s 13-year-long civil war and toppled a brutal dictatorship known to have, among other things, used chemical weapons against its own civilians. Now, the country is strapped for cash and being led by opposition forces with limited experience in governance.

Adding to the chaos is the mad dash to locate the former Assad regime’s chemical weapons it hid from inspectors. Among the list of missing weapons are more than 360 tons of mustard gas that the Assad regime admitted to making, but never fully accounted for. There are also five missing tons of precursors for sarin that the Assad regime claimed were “Lost during transportation, due to traffic accidents.”

The OPCW said it is monitoring the situation, reaffirming its commitment to “clarifying gaps, discrepancies, and inconsistencies in Syrian chemical weapons declaration amidst political transition.” Rebels in the south of the country have reached out to the OPCW for support in safely disposing of a cache of CW they found. One US official told the press the US is working with other countries in the Middle East to prevent these weapons from falling into the wrong hands. Meanwhile, Israel reported that it has destroyed CW and other weapons caches while seizing areas along its shared border with the country it claims are part of a demilitarized buffer zone.

Further Reading and Listening:

New Study Finds Single Mutation in Bovine Influenza H5N1 Hemagglutinin Switches Specificity to Human Receptors

A recent study in Science found that a single glutamine to leucine mutation in clade 2.3.4.4b-an H5N1 virus widespread in US dairy cattle that has caused a few mild human cases-at residue 226 of the virus hemagglutinin “was sufficient to enact the change from avian to human specificity.” This means that this virus that currently cannot infect humans very easily could be just one mutation away from being able to do so much more effectively. This finding alone does not mean that this mutation in nature would be guaranteed to make this virus an efficient human pathogen, but it might mean that this version of the virus has a higher zoonotic potential than other H5N1 viruses.

Further Reading:

Investigation Launched into Queensland Lab Incident

An investigation has been launched by Australian authorities into the “major breach” of biosafety protocols that occurred at a state-run laboratory in Queensland in 2021. It was revealed that 323 virus samples-nearly 100 of which were live samples of Hendra virus-were missing. According to Health Minister Tim Nicholls, the incident was only discovered in August of 2023, and the lab is unable to confirm whether the materials were removed or destroyed, though there is no suggestion that they were taken or stolen from the lab.

Top Wuhan Virologist Says WIV Holds No Close Relatives to SARS-CoV-2

Shi Zhengli, the virologist leading coronavirus research at the Wuhan Institute of Virology (WIV) when the COVID-19 pandemic began, presented data on dozens of new coronaviruses collected from bats in southern China at a conference in Japan last week. Shi has said repeatedly that SARS-CoV-2 was never seen nor studied in her lab, but some have continued to insist that one of the bat coronaviruses collected by her team was closely related to it. As a result, Shi promised to sequence the genomes of the viruses stored in her freezers and release the resulting data.

The analysis presented at the conference has not been peer reviewed and includes data from the whole genomes of 56 new betacoronaviruses in addition to some partial sequences. All of these viruses were collected between 2004 and 2021. Shi explained at the conference that none of the viruses she has sequenced are the most recent ancestors of SARS-CoV-2 and that “We didn’t find any new sequences which are more closely related to SARS-CoV-1 and SARS-CoV-2.”

The known viruses that are closest to SARS-CoV-2 were found in bats in Laos and southern China. However, years (or decades) have passed since these viruses split from their common ancestor with SARS-CoV-2. Shi has long since collaborated with EcoHealth Alliance, which previously received US federal funding that was suspended because of inadequate oversight of research activities at the WIV. This collaboration has produced a larger analysis of more than 230 sequences that EcoHealth Alliance’s Peter Daszak says will be submitted for peer review and publication in the coming weeks.

Further Reading: “PLA Looks into China-US Collaboration in Biosecurity Research,” Stephen Chen, SCMP

75+ Nobel Laureates Urge Senate Not to Confirm RFK Jr.

77 winners of the Nobel Prize in Medicine, Chemistry, Physics, and Economics have signed a letter (below) urging the Senate not to confirm President-Elect Trump’s pick to lead HHS-Robert F. Kennedy Jr.. This is a rare example of Nobel laureates coming together against a US Cabinet choice, according to Sir Richard Roberts, winner of the 1993 Nobel Prize in Medicine and a drafter of the letter. The letter criticizes Kennedy’s lack of experience in public health in addition to his widely criticized opinions on topics like drinking water fluoridation and vaccines for measles and polio. The letter reads in part, “In view of his record, placing Mr. Kennedy in charge of DHHS would put the public’s health in jeopardy and undermine America’s global leadership in the health sciences, in both the public and commercial sectors…We strongly urge you to vote against the confirmation of his appointment as Secretary of the DHHS.”

Further Reading:

“2024 ABSA Conference Summary”

Biodefense MS Student Lena Kropke discusses her experience at the 67th Annual Biosafety and Biosecurity Conference in this Pandora Report event summary, writing in part “Attending this conference not only reaffirmed that biosafety and biosecurity are vital components of international security, but also showcased the incredible dedication of professionals who work tirelessly toward this mission. Moreover, it offered an introduction to an amazing network of biosafety and security professionals.”

Read more about Lena’s time attending the conference in Phoenix here.

“Disincentivizing Bioweapons: Theory and Policy Approaches”

This NTI essay collection is “…designed to encourage the exploration and identification of potential solutions to disincentivize states from developing or using biological weapons,” and aims to “bridge theory and practical policy-relevant approaches to develop new approaches to invigorate international efforts to reduce biological threats.” Its fifth essay, “Two Competing Bioweapons Nonproliferation Policies: Deterrence by Denial and Discussion,” was authored by Sonia Ben Ouagrham-Gormley, Associate Professor at the Schar School.

Mitigating Arboviral Threat and Strengthening Public Health Preparedness: Proceedings of a Workshop

From NASEM: “Arboviruses, or viruses carried by arthropods like mosquitoes or ticks, are responsible for hundreds of thousands of deaths worldwide each year. As the climate changes globally, the geographic distribution of these diseases, including Zika, dengue, chikungunya, West Nile, and yellow fever, are steadily expanding. The National Academies Forum on Microbial Threats hosted a public workshop in December 2023 to explore avenues of threat reduction from known and emerging arboviral diseases in the context of public health preparedness and capacity building. The workshop featured talks from experts in entomology, public health, ecology, virology, immunology, disease modeling, and urban planning.”

Read this Proceedings of a Workshop for free here.

“The Current Pathogenicity and Potential Risk Assessment of Nipah Virus as Potential Cause of “Disease X”: A Narrative Review”

Mehnaz et al. recently published this article in Health Science Reports: “Background and Aims…The World Health Organization (WHO) recognized the potential for a severe international epidemic and introduced the term “Disease X” to classify pathogens that not yet identified. The Nipah virus (NiV) is highly dangerous due to its zoonotic nature, high mortality rate, and ability to cause severe clinical symptoms in humans. In this review, we gather the latest information on the NiV and its potential to become a significant candidate for Disease X.”

“Methods…We performed a thorough review of articles published in PubMed, Scopus, and Google Scholar using appropriate MeSH terms and keywords. Studies reported NiV infection were considered for this review.”

“Results…The NiV exhibits different epidemiological patterns in different countries that calls for customized prevention and control strategies. Genetic analysis highlights NiV’s ability to mutate that alters possible treatment options. Transmission typically involves bats as the primary reservoir, with humans becoming infected either through intermediate hosts or food. This shows NiV’s complex nature, including its ability to reach the central nervous system through the olfactory nerve. Promising treatment options, such as monoclonal antibodies, antivirals, and ongoing vaccine research, provide hope. However, the virus’s adaptability, human-to-human transmission, and the lack of specific antiviral therapy raise concerns about its potential to cause a global pandemic. The interconnection between animals, humans, and the environment stresses the need for a One Health approach to tackle emerging infectious disease by NiV.”

“Conclusion…Global collaboration, surveillance, and research investments are imperative for the preparation of future pandemics. The ongoing COVID-19 challenges underscoring the critical need for sustained scientific endeavors, global leadership, and recognition of the prominence of NiV as a candidate for the potential Disease X.”

“Engineering Biology Public Trust Survey Findings”

From the UK’s Department for Science, Innovation and Technology, these findings are the result of a survey on public perceptions of engineering biology in relation to five application areas: health, agriculture and food, low carbon fuels, chemicals and materials, and waste and environment. Key findings from this survey include “The majority of respondents felt comfortable with using new and emerging technologies on a day-to-day basis, but relatively few could explain what engineering biology is,” “There was a strong belief amongst respondents that applications of engineering biology could be useful. Similarly, the majority were comfortable with each of the specific applications and believe that they will be positive for society,” “There was broad agreement that the government is well placed to make decisions about the use of engineering biology but the public should also be involved in decision making,” and more.

“CSR Biodefense Scorecard: Winter 2024 Update”

From the Council on Strategic Risks: “In the fall of 2023, we kicked off our Biodefense Scorecard series to help inform the public on the progress and implementation status of past CSR recommendations on reducing biological risks. This update captures several areas of sustained positive action across pathogen early warning, diplomacy, and biomanufacturing.”

“Ignoring the Real Biowarfare Threat”

David Heslop and Joel Keep discuss the potential implications of recent renovations at Sergiev Posad-6 in this piece from the Lowy Institute, writing in part “While much attention has been paid to nuclear arms, Washington and Moscow must also address biological weapons, which both nations claimed to renounce many years ago. The fate of such programs is not only a matter for Russia and the United States, but for global health security at large.”

“Instrumentalising Biological Weapons-Related Allegations: Russia’s Compliance Politics and the Norms Against Biological Weapons”

Una Jakob recently published this working paper with CBWNet discussing Russia’s use of BWC compliance procedures and their effect on norms against BW. Jakob explains in part of the paper’s executive summary, “Seen in this light, the Russian activities may counterintuitively have contributed to strengthening the norms against biological weapons at the discursive level, as no actor has called them into question and as their validity has been reaffirmed repeatedly in the process, including by Russia itself. This stands in contrast, however, to Russia’s policy which may contest biological weapons norms at the action level. This discrepancy between the discursive and practical level and its implications for norm strength merit further theoretical attention. On a policy level, it will be important to increase transparency, counter disinformation, and strengthen the means to demonstrate, verify and enhance confidence in compliance with the BWC. This would also strengthen the possibilities to address biological weapons-related allegations, including those made in bad faith, and help sustain the norms against biological weapons comprehensively and in the long term.”

“Workshop on S&T Developments with Relevance for the CWC and BWC”

Anna Krin and Gunnar Jeremias edited this CBWNet working paper detailing a workshop hosted in June at Hamburg University focused on challenges and opportunities facing biological and chemical arms control. Jeremias explains in the introduction, “Throughout the workshop, four panels delved into key topics: the general concept and application of scientific and technological advice in arms control in general and particularly in chemical and biological arms control; current developments in science and technology that may necessitate attention; potential frameworks for organizing verification under the CWC and the prospects for institution building for S&T advice and verification within the BWC; and the technologies and governance methods that could be employed to enhance the efficacy of arms control measures…The insights gathered during these discussions aim to contribute to the ongoing discourse on arms control, ensuring that both the BWC and CWC remain vital in a landscape marked by rapid scientific change. This compendium encapsulates the collaborative efforts and perspectives of workshop participants, reflecting a shared commitment to advancing arms control in an increasingly complex world.”

“High-Impact, Low-Probability: NATO-EUROPOL Cooperation in Countering the CBRN Terrorist Threat to Europe”

This JCBRN Defence COE report by Mathias Katsuya “…draws on secondary-source research and insights provided by JCBRN Defence COE personnel as well as Europol’s CBRN-E Team Leader. An initial threat assessment is followed by a review of Europol’s CBRN capabilities, centring on the role of its European Counter-Terrorism Centre and inhouse CBRN-E Team as key nodes in law enforcement information-sharing, capacity-building, and operational coordination. Having identified key doctrinal and capability overlaps with NATO in addition to a stated commitment by Europol’s CBRN-E Team to enhance its civil-military relations, the report outlines a three-pillar approach to deepening connections between NATO and Europol: short-term measures to foster staff-level contacts in both organisations, a formalised relationship between Europol’s CBRN-E Team and NATO’s JCBRN Defence COE, and deeper institutional linkages to effectively confront current and emerging CBRN threats.”

“Hybrid Threats in the CBRN Environment: Challenges and Implications”

This JCBRN Defence COE paper by Paulina Frederike Gogacz discusses hybrid CBRN threats and their use by actors like Russia. Gogacz explains in the paper’s summary that “An analysis of the six strategic enablers outlined in NATO’s Chemical, Biological, Radiological and Nuclear (CBRN) Defence Policy (2022) indicates important steps to ameliorate current defences and prepare NATO and its member states for future hybrid CBRN threats, thereby increasing overall resilience. They include important aspects: robust intelligence-sharing mechanisms to ensure timely and accurate threat information; comprehensive exercises to simulate and prepare for various CBRN scenarios; strong partnerships both within the alliance and with external entities to foster cooperation and resource sharing; effective strategic communication to manage information and public perception; collaborative scientific research to advance technological capabilities and countermeasures; and the resilience of medical infrastructure to ensure a rapid and effective response to CBRN incidents. These steps collectively aim to bolster NATO’s preparedness and adaptability in the face of evolving hybrid CBRN threats.”

“Securing a Strategic Advantage in Biosecurity for NATO”

Max Breet and Lauren Ross recently authored this commentary for RUSI, writing in their summary “NATO should recognise the importance of biosecurity by understanding it as a new domain. This would allow the Alliance to more effectively leverage existing structures to defend itself against hybrid biological threats.”

“The Rise of Mpox in a Post-Smallpox World”

McQuiston et al. recently published this article in Emerging Infectious Diseases: “Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox. Sustained human-to-human transmission of mpox is occurring widely in the context of insufficient population immunity, fueling genetic mutations that affect the accuracy of some diagnostic tests and that could lead to changing virulence. Additional research should address complex challenges for control of mpox, including improved diagnostics and medical countermeasures. The availability of vaccines should be expanded not only for outbreak response but also for broader routine use for persons in mpox-endemic countries.”

“Confronting Risks of Mirror Life”

Adamala et al. recently published this Science Policy Forum piece, writing in part, “All known life is homochiral. DNA and RNA are made from “right-handed” nucleotides, and proteins are made from “left-handed” amino acids. Driven by curiosity and plausible applications, some researchers had begun work toward creating lifeforms composed entirely of mirror-image biological molecules. Such mirror organisms would constitute a radical departure from known life, and their creation warrants careful consideration. The capability to create mirror life is likely at least a decade away and would require large investments and major technical advances; we thus have an opportunity to consider and preempt risks before they are realized. Here, we draw on an in-depth analysis of current technical barriers, how they might be eroded by technological progress, and what we deem to be unprecedented and largely overlooked risks (1). We call for broader discussion among the global research community, policy-makers, research funders, industry, civil society, and the public to chart an appropriate path forward.”

Bonus: Read Carl Zimmer’s discussion of this warning in The New York Times here.

NEW: OneLab Network Webinar

“Clinical laboratories must be alert for unusual and potentially infectious agents and immediately notify their Laboratory Response Network (LRN) reference laboratory if routine diagnostic testing results in the potential identification of rare and unusual infectious agents that may be used in a bioterrorist attack or other bio-agent incident. This webinar will describe the LRN and highlight the clinical laboratory’s role and responsibilities in initiating contact with their LRN. Join us as we share an example of a response, new tools, and valuable resources to aid in the clinical laboratory’s response.”

This event will take place on December 17 at 12 pm ET. Register for this event here.

NEW: Understanding the Introduction of Pathogens into Humans- Preventing Patient Zero: A Workshop

“The past few decades have seen the emergence of several diseases with drastic public health and economic consequences. Understanding routes of pathogen emergence and transmission is critical to preventing and mitigating disease spillover and amplification. The National Academies Forum on Microbial Threats will host a hybrid public workshop to address gaps in understanding of disease emergence, with a focus on human-animal interaction and laboratory biosafety. The workshop will explore how applications of existing policy structures, emerging technologies, and actionable research can improve biosecurity measures and prevention of future disease emergence.”

This event will take place on January 15 and 16. Learn more and register here.

NEW: Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control

Johns Hopkins APL’s colloquium will feature Mindy Weisberger, author of the upcoming book Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind-Control: “Zombies are all around us—insect zombies, that is. In Rise of the Zombie Bugs, Mindy Weisberger explores the eerie yet fascinating phenomenon of real-life zombification in the insect class and among other invertebrates. Zombifying parasites reproduce by rewriting their victims’ neurochemistry, transforming them into the “walking dead”: armies of cicadas, spiders, and other hosts that helplessly follow a zombifier’s commands, living only to serve the parasite’s needs until death’s sweet release (and often beyond).”

Learn more about this January 31 event here.

How to Avoid Human-Made Pandemics

From the Asia Centre for Health Security: “Studying viruses that could potentially cause outbreaks is one of the most effective ways to reduce the risk of pandemics. However, this type of research—especially when it involves collecting samples from the field and manipulating pathogens—can unintentionally lead to a pandemic if not managed carefully. Dr Lentzos will discuss her findings from the Pathogen Project, which brought together an international taskforce of scientists, biosecurity and public health experts, ethicists, and civil society leaders to seek consensus on this question: Can we agree on ways to manage research that carries pandemic risk as safely, securely and responsibly as possible?”

This event will take place on January 23 at 8 pm (GMT +8:00) via Zoom. RSVP here.

Preparedness in Rural Communities: National and State/Local Perspectives and Plans

From Penn State: “The COVID-19 pandemic and recent hurricanes have thrust the preparedness of rural communities into the national spotlight. At the federal level, the Administration for Strategic Preparedness and Response and the Centers for Disease Control and Prevention have recently released national goals and plans for preparedness of rural communities. The overall objective of this virtual, 2-day mini-symposium is to identify opportunities in public health and agricultural preparedness and response in rural communities. The mini-symposium will focus upon national perspectives on Thursday, January 30 and the state/local perspectives on Friday, January 31. Speakers include representatives of the Administration for Strategic Preparedness and Response, the Department of Homeland Security, US Department of Agriculture, the USA Center for Rural Public Health Preparedness, and state/local leaders.”

This event will take place on January 30 and 31, from 11 am to 2 pm ET each day. Learn more and register here.

Cyberbiosecurity Summit

From Johns Hopkins APL and Bio-ISAC: “Advancements in biomanufacturing and biotechnology drive the science we need to thrive, everything from apples to vaccines. The Cyberbiosecurity Summit 2025 convenes leading experts in biotechnology, biosecurity, and cybersecurity to explore the intersection of these fields and discuss the strategies to create a safe, secure future for us all.”
This event will take place February 25-26 in Laurel, MD. Register here and review the call for sessions here (closes 12/12).

NEW: The Independent Panel Solicits Views and Insights on Pandemic Prevention, and Response Efforts

The Independent Panel for Pandemic Preparedness and Response, co-chaired by HE Ellen Johnson Sirleaf and RH Helen Clark, welcomes you to share your insights and expertise on the status of international and regional pandemic-related reform processes and initiatives, and how progress can be continued and accelerated in the months and years ahead.”

Learn more about this survey and submit by December 20 here.