Pandora Report 8.31.14

Fall classes at George Mason have already started and this Labor Day weekend marks the official end of summer. This week, we have stories covering a wide range of topics—an Ebola update (of course), a fascinating article on vaccinia infections acquired through shaving, Haj precautions, and the ISIS “laptop of doom.”

Best wishes for a safe and enjoyable holiday!

Ebola Virus Outbreak Could Hit 20,000 Within Nine Months, Warns WHO

There were many stories this week covering the continuing Ebola outbreak in West Africa. Senegal saw its first (imported) case of the virus this week and has banned flights to and from the affected countries while shutting its land border with Guinea and Nigeria saw its first death outside of the capital city of Lagos. In the Democratic Republic of Congo, where Ebola first emerged in 1976, there have been reported cases of a hemorrhagic gastroenteritis similar to Ebola. I read conflicting accounts this week of the “patient zero” for the Ebola outbreak—a young boy or an older traditional healer. There were reports of some U.S. universities screening students from West Africa for Ebola. There was coverage of a Toronto medical isolation unit ready for patients and information about GlaxoSmithKline’s experimental ebola vaccine which would be tested on humans in the next few weeks.

All of this news came among World Health Organization estimates that this West African outbreak could affect 20,000 people over the next nine months and that half a billion dollars would be needed to stop the spread of the disease.

The Wall Street Journal—“The WHO program will likely cost around $490 million and require contributions from national governments, some U.N. and non-governmental agencies, as well as humanitarian organizations, it said.”

First Reported Spread of Vaccinia Virus Through Shaving After Contact Transmission

This week, reports in the August issue of Medical Surveillance Monthly Report from the Armed Forces Health Surveillance Center covered vaccinia virus infection—the virus used for smallpox vaccinations—within the U.S. Air Force. The infections in the report occurred in June 2014, and affected four individuals.

Infection Control Today—“Over the past decade, most cases of contact vaccinia (i.e., spread of the virus from a vaccinated person to an unvaccinated person) have been traced to U.S. service members, who comprise the largest segment of the population vaccinated against smallpox. Most involve women or children who live in the same household and/or share a bed with a vaccinee or with a vaccinee’s contact. Of adult female cases, most are described as spouses or intimate partners of vaccinees or secondary contacts. Of adult male cases, most involve some type of recreational activity with physical contact, such as wrestling, grappling, sparring, football, or basketball. Household interactions (e.g., sharing towels or clothing) and “unspecified contact” are also implicated.”

Government to Keep Haj Infection-Free 

This week, the Saudi Arabian Ministry of Health announced mandatory measures for Haj and Umrah pilgrims coming from countries with active outbreaks or high rates of infectious diseases. The Health Ministry sent information to embassies outlining health requirements for those seeking pilgrim visas.

Arab News—“‘Although we do not issue Haj visas for pilgrims coming from endemic countries, we will still be monitoring pilgrims coming from other African countries for Ebola symptoms,’ said [Sami] Badawood [Jeddah Health Affairs director.]

He said the ministry would also focus on diseases such as yellow fever, meningitis, seasonal influenza, polio and food poisoning.”

Is the ISIS Laptop of Doom an Operational Threat?

Discovery of a laptop, which has been linked to ISIS, raises new questions about the organization’s plans relating to use of WMD—specifically chemical or biological weapons. Over 35,000 files on the laptop are being examined and has offered new insight into ISIS and their WMD aspirations.

Foreign Policy—“Most troubling is a document that discusses how to weaponize bubonic plague. But turning that knowledge into a working weapon requires particular expertise, and it’s not clear that the Islamic State has it.”

 

Image Credit: Wikimedia Commons

Tuberculosis and Seals: Sea Mammals as Harbingers of Disease

By Chris Healey

Seals introduced one of the deadliest illnesses in history to the Western Hemisphere centuries before Europeans carried it over. Researchers at the University of Tubingen in Germany published findings in the research journal Nature describing the role seals played in introducing tuberculosis to the Americas.

Before these findings, the presence of tuberculosis in North and South America prior to European exploration was unexplained. Tuberculosis spread across Africa, Europe, and Asia, but there was no evidence demonstrating tuberculosis concurrently existed in the Americas. The bacteria made its first appearance in Peruvian skeletal remains dating back to approximately A.D. 700 – centuries before the arrival of European explorers.

Research findings indicate approximately 2500 years ago, seals contracted a Mycobacterium strain from Africa and carried it across the ocean to the shores of Peru and Northern Chile. Possibly through seal predation, costal humans contracted a version of the seal Mycobacterium which had adapted to humans. Tuberculosis has been found in skeletal remains in North America dating back to approximately A.D. 900, indicating the seal-derived strain spread person-to-person from South America.

One limitation of this study was the inability to rule out humans passing the agent to seals. The researchers deemed that alternative a distant possibility; humans did not treat seals as livestock. A close relationship, such as between farmer and animal, is required to pass a pathogen from human to animal.

The seal-derived strain did not last long in the Western Hemisphere. Following European settlement, European tuberculosis strains outcompeted and eliminated those from seals. Today, viable seal-derived strains do not exist.


Tuberculosis is a condition caused by Mycobacterium tuberculosis, a slow-growing bacterium adept at evading host immune response. The illness is one of the greatest threats to public health worldwide. According to the World Health Organization, tuberculosis kills more people than any other infectious agent except HIV/AIDS.

Despite advancements in therapeutic techniques, there has been a resurgence of tuberculosis fueled by the emergence of HIV/AIDS in the late 20th century. As an opportunistic pathogen, tuberculosis kills more AIDS patients than any other illness.

Tuberculosis is not the first human illness associated with seals. They are susceptible to certain subtypes of influenza, including H7N7, H4N5, and H3N2. Influenza subtypes maintained in seal populations could be re-assorted in other animals, such as fowl or swine, to produce subtypes which are highly virulent in humans.

 

Image Credit

Image of the Week: Rotavirus!

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Under a very high magnification of 455,882X, this transmission electron micrograph (TEM) revealed some of the ultrastructural morphology exhibited by numbers of rotovirus icosahedral protein capsid particles.

Rotavirus disease is most common in infants and young children, but adults and older children can also become infected with rotavirus. Once a person has been exposed to rotavirus, it takes about 2 days for symptoms to appear.

Symptoms include:
– Fever
– Vomiting
– Diarrhea
– Abdominal pain

Vomiting and watery diarrhea may last from 3 to 8 days in a child who is infected with rotavirus. Additional symptoms include loss of appetite and dehydration (loss of body fluids), which can be especially harmful for infants and young children.

Vaccinated and unvaccinated children may develop rotavirus disease more than once because there are many different types of rotavirus and because neither vaccine nor natural infection provides full immunity (protection) from future infections. Usually a person’s first infection with rotavirus causes the most severe symptoms.

 

Image Credit and Caption: CDC

This Week in DC: Events

August 25, 2014 

Turkey, Iraq, and the Kurdistan Regional Government
Date: August 25, 2:00pm
Location: Woodrow Wilson International Center for Scholars, 1300 Pennsylvania Ave NW, 6th Floor Conference Room, Washington DC

The advances of ISIS have reheated the debate on the future of Iraq. The country is threatened by a new wave of violence and destruction, as a large swath of territory has turned into a conflict zone and an uprising has shaken the political order. The relative stability of Northern Iraq appeared to be strengthened, as the Kurdistan Regional Government (KRG) initially managed to keep the conflict at bay in the territories it controls. However the recent advances of ISIS have also underscored the fragile security environment in the country to which the KRG is also subject. The developments also highlighted the delicate position of many ethnic and religious groups most notably Turkmen, Yazidis and Christians. Turkey has both opportunities and challenges in Iraq, and keeps a close eye on the situation there. In this discussion, experts will address the future of Iraq and the KRG in the context of the current crisis, and will shed light on Turkey’s perspectives on the KRG, energy issues, minorities, and Iraq in general.

This event is co-organized by the Center for Middle Eastern Strategic Studies (ORSAM).

RSVP here.

August 26, 2014

What About Jordan: Does Regional Crisis Threaten the Security of a Longstanding American Ally?
Date: August 26, 12:00pm
Location: Hudson Institute, 1015 15th Street NW, 6th Floor, Washington DC 20005

A U.S. ally for more than half a century, the Hashemite Kingdom of Jordan is one of the pillars of American Middle East policy. But this longtime bulwark of stability in an otherwise dangerous and volatile region is now being buffeted by powerful—and unwelcome—winds of change. Two of its bordering neighbors, Syria and Iraq, are engulfed in civil wars featuring both active Iranian involvement and well-resourced Sunni extremists like the Islamic State. Moreover, the role of Hamas in West Bank politics remains an unsettled question. Domestically, Jordan has been suffering a severe refugee crisis for more than a decade, to which the Syrian conflict alone has recently added another million-plus civilian exiles. Can Jordan continue to manage the various emergencies on its doorstep? What can the American government do to help one of its key Middle East partners?

On August 26th, Hudson Institute will host an expert panel—Senior Fellow and moderator Lee Smith joined by Faysal Itani, Salameh Nematt, and David Schenker—for a discussion about the present state and future prospects of Jordan and its central role in American Middle East policy.

Event will be streamed live online here.

August 27, 2014

The Islamic State of Iraq and Syria: Return of the Caliphate?
Date: August 27, 2:00pm
Location: Washington Times, 3600 New York Ave NE, Washington DC

In June, the Islamic State of Iraq and Syria (ISIS, also called ISIL) — a former al-Qaeda affiliate fighting against the Syrian government of Bashar al-Assad — declared itself simply the “Islamic State” (the IS).  Claiming to have reestablished the Caliphate (in Arabic: Khilafah) that existed from 632 AD until it was abolished in 1924 by Mustafa Kemal Ataturk, founder of the Turkish Republic, the IS controls large parts of Iraq including the city of Mosul and the predominantly Sunni areas abutting Syria, Saudi Arabia, and Jordan.  In addition, the IS has reportedly seized over $400 million looted from Mosul’s central bank, as well as gold bullion, in addition to potential oil revenues from fields in Syria and Iraq.  IS has applied a ruthless set of policies, seemingly designed both to demonstrate its ideological bona fides and to terrify its enemies: crucifixions and beheadings, forced conversion of Christians, and destruction of Islamic shrines.

To register, email William Selig.

August 28, 2014

Public Opinion and War
Date: August 28, 2:00pm
Location: Cato Institute, 1000 Massachusetts Ave NW, Hayek Auditorium, Washington DC

Featuring Adam Berinsky, Professor of Political Science, MIT; John Mueller, Professor of Political Science, Ohio State University, Senior Fellow, Cato Institute; Jason Reifler, Senior Lecturer in Politics, University of Exeter; and Trevor Thrall, Associate Professor of Public and International Affairs, George Mason University; moderated by Justin Logan, Director of Foreign Policy Studies, Cato Institute.

When and why does the American public support war? Washington politicians and pundits often puzzle over these questions as they try to win support for their policies, but there is a large body of academic research on public opinion and war. Do events, such as casualties or the prospect of victory, affect support more, or do partisan identities or other attachments play a larger role? What sorts of arguments should hawks and doves make if they hope to win support for their views? Please join four leading political scientists as they examine the causes of public support for war.

Register here or watch online.

Fatal Assistance
Date: August 28, 5:00pm
Location: Center for Global Development, 2055 L Street NW, 5th Floor, Washington DC 20036

CGD is pleased to announce a screening of Fatal Assistance, part of our film series, Global Development Matters.

Haitian born filmmaker Raoul Peck takes us on a 2-year journey inside the challenging, contradictory and colossal rebuilding efforts in post-earthquake Haiti. Through its provocative and radical point of view, Fatal Assistance offers a devastating indictment of the international community’s post-disaster idealism. The film dives headlong into the complexity of the reconstruction process and the practices and impact of worldwide humanitarian and development aid, revealing the disturbing extent of a general failure. We learn that a major portion of the money pledged to Haiti was never disbursed, nor made it into the actual reconstruction. Fatal Assistance leads us to one clear conclusion: current aid policies and practice in Haiti need to stop immediately.

Following the screening of the film, CGD Senior Fellows Vijaya Ramachandran and Michael Clemens will provide commentary, before opening the floor to questions from the audience.

Register here.

Pandora Report 8.22.14

Did you see that the destruction of Syria’s most lethal chemicals is now complete? Well, it is! Its good news among so many biodefense stories covering Ebola. I have no interest in making the Pandora Report the “All Ebola, All the Time” newsletter. As such, we will look at one Ebola story as well as stories covering new discoveries in tuberculosis and influenza.

Have a fabulous weekend, and students, enjoy your last one before classes start on Monday!

Tuberculosis is Newer Than Thought, Study Says

A recent study published in Nature reports that tuberculosis originated less than 6,000 years ago and was carried to the new world by seals. Seals! This new research contradicts original timeline and species genesis and some scientists think this study provides more questions than answers.

The New York Times—“In the new paper, the team proposes that humans acquired tuberculosis in Africa around 5,000 years ago. The disease spread to people across the Old World along trade routes. Meanwhile, Africans also spread the disease to animals such as cows and goats. Seals that hauled out onto African beaches to raise their pups became infected. The bacteria then spread through seal populations until reaching South America. Ancient hunters there became infected when they handled contaminated meat.”

Enzyme Holds the Door for Influenza

As the fall season and semester approach, the flu season travels with it. I was delighted to read that Walgreens, in addition to CVS, will now offer seasonal flu shots in their stores. More interesting news about flu came out of Vanderbilt University, too. Researches have investigated enzyme phospholipase D (PLD) and it ability to help the influenza virus escape immune response. Blocking PLD could assist in preventing the flu.

Bioscience Technology Online—“Normally the virus slips into its host cell in the epithelial lining of the lungs through internalized membrane compartments called endosomes. By delaying this process, the researchers propose, PLD2 inhibitors may give the cell’s innate immune response more time to destroy it.”

Patient Checked for Ebola Virus in Sacramento

Internationally, the good news is that quarantines have been set up in Liberia, in attempt to contain the spread of Ebola. The bad news is that they have become fairly violent. Stateside, this week Dr. Kent Brantly and Nancy Writebol were released from Emory University Hospital after recovering from Ebola infections acquired in West Africa.

There was news of a possible case in Northern California. With few details provided as to the patient and transmission route, we learned that there is a patient being tested for Ebola in Sacramento. California Department of Health reported that the cases is low risk but that testing is being done out of “abundance of caution.”

San Francisco Chronicle—“‘In order to protect our patients, staff and physicians, even though infection with the virus is unconfirmed, we are taking the actions recommended by the CDC as a precaution, just as we do for other patients with a suspected infectious disease,” said Dr. Stephen Parodi, an infectious disease specialist at Kaiser Permanente North California. “This includes isolation of the patient in a specially equipped negative pressure room and the use of personal protective equipment by trained staff, coordinated with infectious disease specialists.’”

 

Image Credit

Plants and Their Growing Role in the Pharmaceutical Industry

By Chris Healey

Pharmaceutical production using plants has been in the spotlight after Mapp Pharmaceutical revealed its experimental Ebola serum ZMapp—credited with saving the lives of two Americans—was created using antibodies harvested from genetically-modified tobacco plants.

ZMapp is part of a growing trend of pharmaceuticals created from proteins produced in plants, a practice considered safer, cheaper, and more practical than common production methods.

There has been outcry about claims ZMapp will not be sent to Africa to combat the ongoing Ebola epidemic. Those claims come after the pharmaceutical industry has been slow to adopt plant production methods, despite cost-effectiveness relative to traditional production methods.

Large pharmaceutical powerhouses, such as Pfizer and Merck, have adhered to traditional production methods despite newer and cheaper techniques. However, smaller companies, such as Mapp Pharmaceutical and IBio, have taken advantage of the low cost of plant production to produce their pharmaceutical ingredients.

Transgenic techniques allow scientists to hijack existing cellular processes in plants to produce desired proteins, such as enzymes and antibodies. DNA instructions for a desired protein (also called a gene) can be created in laboratory settings and inserted into a plant cell nucleus. After insertion, the gene instructs the cells how to make the desired proteins.

Once the proteins are produced, scientists can harvest them for use in pharmaceuticals. Transgenic techniques can be repeated and scaled to fit need. There are two methods commonly used to insert genes into plants.

One widely-used transgenic technique involves Agrobacterium tumefaciens bacteria as a gene transportation medium. Scientists introduce a gene into bacteria prior to plant inoculation. Bacteria then release desired DNA into plant cell nuclei and gene expression proceeds normally.

An alternative method, called biolistic transformation, involves the use of a gene gun to launch desired genes at clusters of plant cells. Some of the clusters will land inside cell nuclei, where the introduced DNA will integrate with the plant’s genome for expression.

Regardless of technique, using plants to create proteins eliminates the threat of human pathogen contamination which is possible with animal-derived mediums. Plants and animals do not share common pathogens, so a potential infection present at the time of harvesting will have no effect on protein recipients.

 

Image Credit: HPR2

Image of the Day: CDC Ebola Infographic!

Ebola Infographic CDCOne thing you may not know about me is that I absolutely LOVE CDC infographics!

After this weekend’s events in Liberia, when people were seen carrying out bloody and fluid filled mattresses and other bedding, let’s take a look at how Ebola is actually transferred.

Please post this through your social media connections so we can work on spreading the correct information about the virus.

This Week in DC: Events

 August 19, 2014

History Impeded Future Progress in Northeast Asia
Date: August 19, 2:00 – 5:30pm
Location: Heritage Foundation, Lehrman Auditorium, 214 Massachusetts Ave NE, Washington DC 20002

The United States and its allies face growing security threats in Asia from North Korea and China. Given these challenges, it is critical that trilateral U.S.-Japan-South Korea relations remain strong. Yet Tokyo-Seoul relations are strained due to a difficult legacy of historical problems. What are the challenges to reconciliation and what steps can Japan and South Korea take? What role should Washington play to redirect attention toward common allied objectives? Join us for an expert discussion on Japan-Korea relations, and what it means from a U.S. perspective.

RSVP here.

August 20, 2014

Preempting Environmental and Human Security Crises in Africa: Science-Based Planning for Climate Variability Threats
Date: August 20, 10:00am
Location: Woodrow Wilson International Center for Scholars, 6th Floor, 1300 Pennsylvania Ave NW, Washington DC

According to the Intergovernmental Panel on Climate Change, devastating impacts of climate variability are already being observed in Africa through increased wildfires, shrinking rivers, reduced crop yields, increased water and vector-borne diseases, and other forms. In coming decades, these climatic changes are predicted to impact human and state security via increased resource conflict, radicalization, economic crises, and humanitarian disasters. These threats all have global implications and require urgent rethinking of African and international security strategy. To this end, the Wilson Center’s Africa Program and Environmental Change and Security Program, in partnership with the Africa Center for Strategic Studies, will host a dialogue aiming to more effectively link science-based analysis of climate variability with security planning.

This dialogue will build on the findings of the Water, Energy and Security in Africa Conference at the Stellenbosch Institute for Advanced Study, which explored innovative and sustainable strategies for minimizing negative impacts of climate variability on human security across Africa, with specific focus on case studies from Lake Chad, Lake Victoria, and the Nile and Congo River basins. The dialogue will entail a moderated discussion with African water security experts and policymakers aiming to identify lessons learned from mitigation and adaptation interventions to date as well as strategies for future collaboration.

RSVP here.

The Ukraine Crisis and Russia’s Place in the International Order
Date: August 20, 2:00pm
Location: Carnegie Endowment for International Peace, 1779 Massachusetts Ave NW, Washington DC

For over two decades, the United States and Europe have been trying to integrate Russia into the international order. This post-Cold War strategy yielded some success, but has now come crashing down over following Russia’s aggressive turn and the ensuing crisis over Ukraine. The United States is seeking to isolate President Putin while Russia is trying to distance itself from what it sees as a Western-dominated order. President Obama says this is not the beginning of a new Cold War, but a new era seems all but inevitable, with potentially severe consequences for the global economy, counter-terrorism, the non-proliferation regime and climate change.

On August 20, 2014, the Foreign Policy program at Brookings will host a discussion on what Russia’s foreign policy turn means for the international order and for U.S. foreign policy. Thomas Wright, fellow with the Project on International Order and Strategy (IOS), will moderate a conversation with Brookings President Strobe Talbott, Senior Fellow Clifford Gaddy of Brookings’ Center on the United States and Europe (CUSE) and Susan Glasser, editor at Politico Magazine.

Following the discussion, the panelists will take questions from the audience. Register here.

Scientific Statecraft: What is it, who does it, and why it’s important
Date: August 20, 4:30pm
Location: Institute of World Politics, 1521 16th Street NW, Washington DC 20036

Prof. Billauer will give an overview of all the areas in which science can impact policy, and discuss the work of several scientists who left their mark on world policy.

Barbara Billauer, Research Professor of Scientific Statecraft at The Institute of World Politics, is also the founder of the Foundation for Law and Science Centers (FLASC Inc.), a non-profit educational organization dedicated to teaching judges and policy-makers the principles of the scientific method, where she designed a patent-pending method of teaching science to lay-decision makers. Formerly an active trial lawyer who handled complex medical malpractice, pharmaceutical, toxic tort, and environmental cases, she currently serves on a UNESCO Bioethics Expert Advisory Committee where she is working on a judicial education project.

Prof. Billauer is a graduate of Cornell University (Hons.) and holds a J.D. degree from Hofstra University, a Master’s Degree in Occupational Health and Safety from New York University, has done advanced work in Bioethics, and holds a certificate in Risk Management Sciences from John Hopkins University where she completed doctoral studies in public health. She has served on numerous Boards, has published extensively and lectured nationally on various science-policy issues including national security. She has also written the entry on Benjamin Franklin for the John Wiley Encyclopedia of Political Thought, forthcoming this October.

Register here.

Pandora Report 8.17.14

Another 12 hours at Dulles Airport on Friday and, fortunately, no new travel alerts. This week we look at TB detecting rats, an experimental Chikungunya vaccine, and the latest from West Africa.

Giant Rats Trained to Sniff Out Tuberculosis in Africa

APOPO, the Belgian nonprofit organization known for using rats to sniff out land mines, has been training the African giant pouched rat to detect tuberculosis since 2008 in Tanzania and 2013 in Mozambique. The trained rats are used in medical centers in Dar es Salaam and Maputo to double check potential TB samples. The rats are unable to differentiate between standard and drug-resistant strains of the disease however, the cost of training and maintenance of the rats is significantly cheaper than the new GeneXpert rapid diagnostic tests.

National Geographic—“‘What the rats are trained to do is associate the smell of TB with a reward, so it’s what they call operative conditioning,’ [Emilio] Valverde [manager of the APOPO Mozambique TM Program] said.

It is the same principle applied to detecting land mines, only the rats are trained to recognize the scent of specific molecules that reflect the presence of the tuberculosis germ—not the explosive vapor associated with land mines.”

Experimental Chikungunya Vaccine Shows Promise

Chikungunya, of course, is one of the diseases included in the CDC’s travel alerts, and this week we learned of a promising vaccine for the disease that causes fever and intensely painful and severe arthritis. After the vaccine’s first human trials, the next step is to test in more people and more age groups, including populations where the virus is endemic. The trial leader said that it could be more than five years before a finished vaccine could be offered to the public.

CBS News—“‘This vaccine was safe and well-tolerated, and we believe that this vaccine makes a type of antibody that is effective against chikungunya,’ said trial leader Dr. Julie Ledgerwood, chief of the clinical trials program at the U.S. National Institute of Allergy and Infectious Diseases.”

WHO: Ebola Outbreak Vastly Underestimated

The news from West Africa seems to be getting worse and worse. Earlier in the week there was good news when a new quarantine center opened in Liberia. Then two days later, that same center was destroyed and looted. All of this comes, too, when the World Health Organization has said there is evidence that numbers of cases and deaths are far lower than the actual numbers and MSF has said that the outbreak will take at least six months to get under control.

Al Jazeera—“‘Staff at the outbreak sites see evidence that the numbers of reported cases and deaths vastly underestimate the magnitude of the outbreak,’ the organization said.

‘WHO is coordinating a massive scaling up of the international response, marshaling support from individual countries, disease control agencies, agencies within the United Nations system, and others.’”

Image Credit: James Pursey, APOPO

Mason Researchers Looking for Fresh Answers in a Medieval Disease

George Mason University’s National Center for Biodefense and Infectious Diseases has been researching the causative agent of plague–Yersinia pestis.


George Mason University professor Ramin M. Hakami is searching for new ways to treat modern ailments by studying bacterial and viral biodefense agents, including the medieval disease notoriously known as the Black Death.

Along the way, he’s also coaching the next generation of researchers. The two endeavors are equally critical, says Hakami, who knows firsthand how crucial mentoring can be to young researchers from when he himself was a student earning his doctorate in biochemistry in the laboratory of the Nobel Laureate Professor Har Gobind Khorana at the Massachusetts Institute of Technology (MIT).

Read the full article here.

 

Image credit: George Mason University