Pandora Report 9.25.2015

You didn’t think a Papal visit would slow us down, did you? Even in the event of a zombie apocalypse, we GMU Biodefense folks would still find a way to get out the weekly report – perhaps pigeon carrier? Until that happens, don’t forget to check us out on Twitter! This week saw a lot of great focus on collaborations to fight public health threats like antimicrobial resistance and epidemics. Schools in Chicago were closed for concerns over Legionnaires’ disease, yours truly provided a piece on Ebola infection prevention, and we have a wonderful opportunity to contribute to World Medical & Health Policy regarding women’s health on a global stage.

Learned Lessons from Ebola in the US
Sylvia Burwell, Secretary of Health & Human Services, discusses the clinical complexity and reality that “our clinical approach to treating Ebola in a hospital setting posed different challenges.” Several key US health experts weighed in on the pivotal first patient, Thomas Duncan, to unknowingly bring Ebola to the US. The implications for healthcare and preparedness sent a tidal wave of response across US hospitals. Dr. Tom Frieden, director of the Centers for Diseases Control and Prevention (CDC), also highlights three main lessons from not only the cases in Dallas, but also the Ebola epidemic as a whole. He points to the necessity of a strong surveillance and response system, need for rapid international aid, and better infection control in hospitals….which segues beautifully into our next story.

The Infection Prevention Angle of the 2014 Ebola Crisis
Reports and analyses from a range of responders to the crisis have been trickling out for several months now, but there’s a constant in all of them – infection control. Given my background and experiences in this field, I wanted to take our readers down the rabbit hole of what exactly it was like to be an Infection Preventionist during this time. A hopeful start to a series of pieces on this subject, it will give you a taste of not only the daily struggles, but the brevity of what potential Ebola patients meant for US healthcare preparedness.

Partnerships to Support Antibiotic Development
564px-Penicillin_Past,_Present_and_Future-_the_Development_and_Production_of_Penicillin,_England,_1943_D16963The ASPR’s (Office of the Assistant Secretary for Preparedness and Response) Biomedical Advanced Research and Development Authority (BARDA) is part of a larger initiative to use Other Transaction Authority (OTA – flexible advanced research and development funding instruments) to start developing business relationships between government and private industry. The relationships are mutually beneficial, allowing both parties to invest and develop products for biodefense and the growing threat of antibiotic resistance. Given the slowing of new antibiotic development, this joint agreement comes at a pivotal time for antimicrobial resistance efforts.

Three Chicago-area Schools Close in Response to Legionnaires’ Disease Concerns
Three schools in the Illinois U-46 district were shut down on Wednesday and Thursday after cooling tower test results showed “higher than normal levels of Legionella bacteria”. The OSHA recommended threshold is no higher than 1,000 CFU/ml (colony-forming units per milliliter) and with the outbreak among residents of the Illinois Veteran’s Home, it’s not surprising to see many water towers being frequently tested, etc. The important thing to note is that Legionella pneumophila infections are a result of the intensity of the exposure and the immune status of the exposed person. Legionella can’t be totally eradicated from the water supply and a majority cooling towers will contain some amount of growth.

Call for Papers – Women’s Health in Global Perspective
Papers sought for a special issue and workshop of World Medical & Health Policy on “Women’s Health in Global Perspective,” to contribute to understanding and improve policy related to women’s health and wellbeing.  Forces ranging from the economic to the climactic have human repercussions whose genesis and solutions demand consideration of their global context.  A wealth of recent research and inquiry has considered the particular plight of women, who often suffer disproportionately from lack of education, compromised nutrition, poverty, violence and lack of job opportunities and personal freedom.  The Workshop on Women’s Health in Global Perspective will consider the broad ranging social determinants of health on a global scale that importantly influence health outcomes for women everywhere, which in turn has implications for economic, political and social development.
Abstract submission deadline (250 words): October 16, 2015 
Contact: Bonnie Stabile, Deputy Editor, bstabile@gmu.edu
Notification of selected abstracts: November 13, 2015
Workshop March 3rd, 2016
Completed papers due: March 11, 2016

Stories You May Have Missed:

  • Personal Microbial Cloud – researchers found that a person’s microbiome form a cloud around them, allowing scientists to identify a specific person just by sampling their microbial cloud. Food for thought: would this be our microbial cloud version of a fingerprint?
  • C. Difficile Drug Success – Researchers at Stanford University School of Medicine were successful in their ability to get rid of the deadly gastrointestinal toxin via a drug that didn’t focus on the organism, Clostridium difficile, but rather the toxin itself. C. difficile is responsible for 250,000 hospitalizations and 15,000 deaths per year while costing the US more than $4 billion in healthcare expenses. Yay for successful treatments!
  • EC, EU, and WHO Work To Better Share Private Drug Data – The European Commission, European Medicines Agency, and World Health Organization are working to “step up coordination” on EU medicines regarding safety, quality, and efficacy of new drug candidates. The first step in solving a problem is recognizing you have one, right? The new focus on global public health threats is one we can all appreciate!
  • WHO Makes Changes to Southern Hemisphere Flu Vaccine – The WHO committee recommended changes for two of the three trivalent influenza vaccines for the Southern Hemisphere next year due to changes in the circulating viral strains. They suggested using H1N1, H3N2 an A/Hong Hong/4801/2014-like virus, and for influenza B, the Brisbane/60/2008-like virus. In the quadrivalent vaccine, they recommended adding the influenza B Yamagata lineage component, with the A/H1N1 strain staying.

Pandora Report 10.11.14

With so many stories being dedicated to Ebola, I was absolutely delighted to see coverage of influenza this week. We’ve also got stories about the proliferation of antibiotic resistant bugs in nursing homes, George Washington as the first father of vaccination, and of course, an Ebola update.

There will be no news round up next week, so I will see you all back here on October 25. Enjoy your weeks and don’t forget your flu shot!

Ebola’s Bad, but Flu’s Worse

With the coverage of the Ebola outbreak in media (and even on this blog) it may have inadvertently caused unreasonable panic in the American populace. The fact of the matter is one person in the U.S. has died from Ebola. Every year, according to the CDC, more than “226,000 Americans are hospitalized with flu and approximately 36,000 die from flu-related complications.” News outlets this week quietly reported on flu vs. Ebola and offered points of clarification about both diseases as well as tips for staying well. These include getting your flu vaccination, washing hands frequently especially after using the restroom and before eating or preparing food, and avoiding touching eyes, nose, or mouth to limit spread of germs.

Times Union—“‘The reality is there are vaccinations and treatment options available for the flu that are not available for Ebola. The reason for concern is there is no magic bullet to stop Ebola,’ said [Dr.Edward] Waltz [director of the Center for Public Health Preparedness at the University at Albany]. ‘I think the most important message to get is, take action on the things that you can control. We have so many things that affect our health that we can’t control, get yourself a vaccination if it is available.’”

Medical Superbugs: Antibiotic-resistant Bacteria Carried by More than a Third of Nursing Home Residents

A study out of Melbourne, Australia, reported that more than 1/3 of nursing home residents tested were carriers of antibiotic-resistant bacteria. And this problem isn’t just plaguing other countries. In fact, a report from the U.S. Centers for Medicare and Medicaid Services found rising rates of pneumonia, urinary tract infections, viral hepatitis and MRSA. The Australian study also found that more than half of the tested residents had received antibiotics within three months of being tested. Overuse of antibiotics can lead to higher rates of superbugs or other infections like C. difficile, which can be lethal in seniors. (On a personal note, my grandmother recently died from complications after a C. diff infection.)

ABC—“‘(Our concern is) that nursing homes are acting as a kind of reservoir, if you like, of antibiotic-resistant bacteria. We know these residents have fairly frequent movement in and out of acute care institutions, and this obviously poses risks to acute care hospitals for transmission. It could be transmitted to other patients in an acute care hospital, if the resident actually has an infection they might be infected with a more resistant bacteria – they’re the two main concerns.’”

George Washington, the First Vaxxer

This week, the Daily Beast provided an excerpt from historian Tom Shachtman’s new book, Gentlemen Scientists and Revolutionaries: The Founding Fathers in the Age of Enlightenment. At a time where people are choosing to forgo vaccinations and alarm over Ebola grows worldwide, it is amazing to see George Washington—Virginian, 1st President, Founding Father, serious boss, and old fashioned speller—decide that army immunization would not only save the lives of soldiers, but indirectly safeguard a young American nation. Shachtman recounts a February 1777 letter from Washington to John Hancock, President of the Continental Congress.

The Daily Beast—“‘The small pox has made such Head in every Quarter that I find it impossible to keep it from spreading thro’ the whole Army in the natural way. I have therefore determined, not only to innoculate all the Troops now here, that have not had it, but shall order Docr Shippen to innoculate the Recruits as fast as they come in to Philadelphia. They will lose no time, because they will go thro’ the disorder while their cloathing Arms and accoutrements are getting ready.’”

This Week in Ebola

The first (and only) patient with a domestically diagnosed case of Ebola died this week in Dallas, TX amid calls, and responses, about tightening airport screening and travel restrictions. Six major American international airports have enhanced screening for travellers arriving from West Africa while airline workers at LaGuardia have protested over what they say are inadequate protections from potential Ebola exposure. In other air travel related news, a passenger was removed from a US Airways flight after joking about being infected with Ebola and a sick passenger traveling from West Africa to Newark airport does not have Ebola. A nurse in Spain did get infected with the virus this week, as other European nations fear further spread inside their countries. American Ebola survivor Dr. Rick Sacra was hospitalized and treated this week for pneumonia and another American Ebola survivor, Dr. Kent Brantly donated his blood in order to help treat an infected NBC cameraman.

Evidently one fifth of Americans, according to a Gallup poll, are concerned about getting Ebola which is causing the ‘apocalypse business’ to boom. Meanwhile, West Africans living in the U.S. are taking action to spread information within their communities about the virus and there was a wonderful piece on how Nigeria beat Ebola. Finally, CDC director Dr. Tom Frieden spoke this week on how this Ebola outbreak is like the AIDS epidemic and why he doesn’t support a travel ban to combat the outbreak. All of this comes at a point in time where the number of deaths from the outbreak has reached over 4000.

Stories You May Have Missed

Image Credit: Immunize.ca