Pandora Report 5.9.14

The stories this week cover topics that I am especially interested in: avian flu in Antarctica, wild poliovirus, and the Russia biological weapons program. Have a great weekend!

Avian Influenza Present in Antarctic Penguins

A team of international researchers have discovered a new strain of avian influenza among Adelie penguin populations in Antarctica which has been identified as H11N2. Presence of this strain of influenza was found in eight penguins from a sample size of 301 swabbed penguins and 270 penguins who had had blood drawn. Though the six adult penguins and two chicks only represent 2.6% of the total group, approximately 16% of the samples contained antibodies for H11N2, indicating the virus has likely been present in the population for “some length of time.”

Guardian Liberty Voice—“There has already been a theory posited which might explain how the H11N2 virus was transmitted to the Antarctic region. Due to both the relatively small incidence of the virus in the sample population, and the region from which the sample size was drawn. Hurt has posited that the introduction of the virus into the Antarctic ecosystem was conducted by migratory birds from South America, such as the yellow-billed pintail duck. This conclusion has been supported by the fact that distant similarities between the H11N2 strain of the virus and South American AIVs, primarily from Brazil and Chile, do in fact exist.”

Wild Poliovirus Making a Comeback, WHO says

In a statement made on Monday, the WHO applauded worldwide efforts to eradicate polio while cautioning that the wild poliovirus is spreading and may negate the hard fought eradication efforts. They declared this spread of wild poliovirus a Public Health Emergency of International Concern and warned that if the spread remains unchecked “this situation could result in failure to eradicate globally one of the world’s most serious vaccine preventable diseases.” The WHO declared that Pakistan, Cameroon, and Syria pose the greatest risk of wild poliovirus exportation while Afghanistan, Guinea, Ethiopia, Iraq, Israel, Somalia and Nigeria are infected with wild poliovirus but are not exporting it.

National Geographic—“The effort is to break the chains of transmission. The WHO is recommending that countries currently infected with polio ensure that their people who are traveling outside the country get vaccinated. About 72 percent of the people who are infected with the polio virus have no symptoms, but they can still spread the disease. Polio is now in just a few countries. The concern is not to re-infect the countries that have gotten rid of polio.”

Lawmakers Mull Biological Weapons Threat from Russia

Providing an opportunity for me to majorly geek out, the U.S. House of Representatives held a committee hearing this week regarding the biological weapons threat from Russia and beyond. Witnesses included Dr. Christopher Davis, a biomedical weapons expert and former member of the U.K.’s Defense Intelligence Staff; Dr. Amy E. Smithson, a senior fellow at the James Martin Center for Nonproliferation Studies; Milton Leitenberg, a senior research scholar at the University of Maryland and author of The Soviet Biological Weapons Program; and Dr. David Franz, former Commander of USAMRIID.

Time—“Leitenberg said it’s almost impossible to evaluate the extent of the Russian biological weapons stockpile because three Russian laboratories remain closed to outside inspection. “We don’t know what they’re doing,” Leitenberg said. ‘They may or may not have an active offensive program—I presume they do. I do not believe that the U.S. government thinks they are producing and stockpiling agent any more, but we don’t know that.’”

A recording of the hearing is available here.

 

Image Credit: Andrew Mandemaker/ Wikimedia Commons

Meet Your 2014 Summer Program Faculty: Sonia ben Ouagrham-Gormley

In preparation for the GMU Summer Program in International Security, this week we will highlight the course directors. Remember, EARLY BIRD REGISTRATION ENDS MAY 15! Register by May 15 to save $300 on a three-day course and $200 on a two-day course. Use the links below for more details including registration.  Questions? Comment to this post or email spis@gmu.edu.


 

GormleyDr. Sonia ben Ouagrham-Gormley, Associate Professor of Government and International Affairs and member of the Biodefense faculty at George Mason University, is the director for this summer’s WMD Export Controls course in the Summer Program in International Security. This course will run July 10-11 and aims to increase participants’ awareness and understanding of WMD proliferation, export controls and trafficking of related materials.

Dr. Ouagrham-Gormley’s research and teaching focuses on WMD and proliferation issues. Her recent publications include “The social context shaping bioweapons (non) proliferation,” “An Unrealized Nexus? WMD-Related Trafficking, Terrorism and Organized Crime in the Former Soviet Union,” and “Banking on Nonproliferation: Improving the Implementation of Financial Sanctions.”  Her forthcoming book from Cornell University Press, Barriers to Bioweapons, extends on her article by the same name and provides the most detailed examination to date of how and why biological weapons programs succeed or fail.

Prior to joining George Mason, Dr. Ouagrham-Gormley served 10 years as a Senior Research Associate at the Monterey Institute of International Studies, Center for Nonproliferation Studies (CNS), and Editor-in-Chief of the International Export Control Observer, a monthly newsletter devoted to the analysis of WMD export control issues in the world. Dr. Ouagrham-Gormley was also an adjunct professor at the School of Advanced International Studies (SAIS), Johns Hopkins University, where she taught a course on WMD in the former Soviet Union (FSU). She received her Ph.D. in Economics of Development at the Advanced School of Social Sciences in Paris, France.

Click here to register for WMD Export Controls.

Antibiotic Anomaly: Disparity Between Lawmakers and Health Experts on Antibiotics

By Chris Healey

State lawmakers are working to protect doctors who prescribe antibiotics in excess of recommended guidelines. Those efforts come after the CDC declared antibiotic resistance from antibiotic overuse one of the greatest threats to public health.

The controversy stems from state lawmakers in northeastern states affected by Lyme disease, an amorphous bacterial illness transmitted through tick bites. The Infectious Disease Society of America endorses a four-week antibiotic regimen which they say cures most cases. However, some individuals claim their symptoms persist after the conclusion of antibiotic therapy, a condition called Post Lyme Disease Syndrome.

Individuals reporting Post Lyme Disease Syndrome often harangue doctors for further antibiotic treatment, believing previous treatment was ineffective or inadequate. However, studies on Post Lyme Disease Syndrome indicate persistent infection is unlikely. Instead, lingering perceptions of malaise are likely the result of lasting physiological damage from infection known as sequela. Doctors often resume antibiotic treatment at patient request despite research findings not supportive of continued treatment.

Antibiotics are not harmless therapeutics. They produce negative effects in patients and bacteria alike. Extended antibiotic treatments sometimes lead to severe physiological damage including mitochondrial impairment, aplastic anemia, and Stevens-Johnson syndrome. Unless absolutely necessary, antibiotics should be avoided.

Harm from lengthy antibiotic regimens extend beyond the patient. Prolonged antibiotic exposure allows more opportunity for bacterial selection of respective antibiotic resistance. Bacteria can pass resistance to posterity, complicating treatment in new patients.

A 2013 report released by the CDC served as a call to arms for the medical community concerning the growing threat of antibiotic resistance. The report lists four core actions to stymie resistance. One of the four is improved stewardship – commitment to antibiotic use within established guidelines. The CDC report, and other efforts to increase antibiotic resistance awareness, has placed pressure on health officials to conform to new standards of judicious antibiotic use.

Instead of allowing antibiotic conformity pressure to curb prescriptions, lawmakers have interpreted it as an occupational nuisance in need of remedy. An article in the Wall Street Journal discusses bills in the Vermont and New York state legislature to protect doctors from punishment for over prescribing antibiotics.

There is a clear disconnect between government health officials and state lawmakers. Misguided attempts to protect doctors from antibiotic reform pressures reflect a lack of antibiotic understanding. Health officials must improve efforts to communicate the importance and severity of antibiotic resistance.

Meet Your 2014 Summer Program Faculty: Gregory Koblentz

In preparation for the GMU Summer Program in International Security, this week we will highlight the course directors. Remember, EARLY BIRD REGISTRATION ENDS MAY 15! Register by May 15 to save $300 on a three-day course and $200 on a two-day course. Use the links below for more details including registration.  Questions? Comment to this post or email spis@gmu.edu.


Koblentz

Dr. Greg Koblentz, Associate Professor of Government and International Affairs and Deputy Director of the Biodefense Program at George Mason University, is the course director for this summer’s short course: Pandemics, Bioterrorism, and International Security. The course will run July 21-23.

Dr. Koblentz’s research and teaching focus on international security, biosecurity, and weapons of mass destruction. His recent publications include “Biosecurity reconsidered: Calibrating biological threats and responses.” and “The threat of pandemic influenza: why today is not 1918.” His book, Living Weapons: Biological Warfare and International Security, remains one of the most influential publications in the field of biodefense since its publication in 2009. In fact, we often tell prospective students to read his book for a “one book version” of our Biodefense Master’s program. He is at work now on a book on nuclear proliferation.

Dr. Koblentz is also a Research Affiliate with the Security Studies Program at the Massachusetts Institute of Technology and a member of the Scientist Working Group on Chemical and Biological Weapons at the Center for Arms Control and Non-Proliferation in Washington, DC. He received his PhD in political science from the Massachusetts Institute of Technology, his Master in Public Policy from the John F. Kennedy School of Government at Harvard University, and his Bachelor of Arts from Brown University.

Click here to register for Pandemics, Bioterrorism, and International Security.

Meet Your 2014 Summer Program Faculty: Charles Blair

In preparation for the GMU Summer Program in International Security, this week we will highlight the course directors. Remember, EARLY BIRD REGISTRATION ENDS MAY 15! Register by May 15 to save $300 on a three-day course and $200 on a two-day course. Use the links below for more details including registration.  Questions? Comment to this post or email spis@gmu.edu.


 

Headshot_BlairCharles P. Blair is a Washington, D.C.-based university instructor, researcher, writer, and thinker specializing in terrorism and the history, technical underpinnings, and potential futures of Weapons of Mass Destruction. He is the director for two courses in the Summer Program in International Security: 21st Century Terrorism: Emerging Trends and Evolving Tactics which runs July 14-16 and Terrorism Analysis: Quantitative and Qualitative Research Methodologies and Tools which runs July 17-18.

Since visiting Moscow as a student in 1985, Blair has worked on issues relating to globalization and the diffusion and diversification of WMD in the context of the rise of mass casualty terrorism incidents. He teaches graduate-level classes on terrorism and the technology of WMD at Johns Hopkins University and George Mason University and is a columnist for the Bulletin of the Atomic Scientists.

Recent works include: “Terrorist Nuclear Command and Control,” which was completed under the auspices of the Department of Homeland Security; a two-year DHS-backed study which investigated the U.S. extreme right-wing and radiological and nuclear terrorism; “Target Sochi: The threat from the Caucasus Emirate,”; and  “Barely Lethal: Terrorists and Ricin.”

Mr. Blair is a Senior Fellow on State and Non-State Threats at the Federation of American Scientists. Before joining FAS, he has worked at the National Consortium for the Study of Terrorism and Responses to Terrorism (START), the James Martin Center for Nonproliferation Studies, the National Nuclear Security Administration, the Anti-Defamation League, and the Center for Terrorism and Intelligence Studies.

Click here to register for 21st Century Terrorism: Emerging Trends and Evolving Tactics.

Click here to register for Terrorism Analysis: Quantitative and Qualitative Research Methodologies and Tools

Meet Your 2014 Summer Program Faculty: Charles Ferguson

In preparation for the GMU Summer Program in International Security, this week we will highlight the course directors. Remember, EARLY BIRD REGISTRATION ENDS MAY 15! Register by May 15 to save $300 on a three-day course and $200 on a two-day course. Use the links below for more details including registration.  Questions? Comment to this post or email spis@gmu.edu.


ferguson

Dr. Charles D. Ferguson, President of the Federation of American Scientists (FAS), is the course director for this summer’s CBRN Weapons: Science & Policy in the Summer Program in International Security. This course will run July 7-9.

With more than twenty years’ experience in policy and national security, Dr. Ferguson has researched and written extensively on energy policy, nuclear nonproliferation, missile defense, and prevention of nuclear and radiological terrorism. His publications include 2011’s Nuclear Energy: What Everyone Needs to Know, The Four Faces of Nuclear Terrorism (with William Potter) in 2005, and the report Commercial Radioactive Sources: Surveying the Security Risks, which was the first in-depth, post-9/11 study of the “dirty bomb” threat. This report won the 2003 Robert S. Landauer Lecture Award from the Health Physics Society.

Dr. Ferguson has worked as the Philip D. Reed senior fellow for science and technology at the Council on Foreign Relations (CFR), consulted with Sandia National Laboratories and the National Nuclear Security Administration on improving the security of radioactive sources, and as a physical scientist in the Office of the Senior Coordinator for Nuclear Safety at the U.S. Department of State. He graduated with distinction from the United States Naval Academy, served in the U.S. Navy as a nuclear engineering officer, and earned a PhD in physics from Boston University. He has previously taught as an adjunct professor at Georgetown University and the Johns Hopkins University.

Click here to register for CBRN Weapons: Science & Policy.

This Week in DC: Events

May 7, 2014

The Future of the Syrian Revolution
Date: May 7, 11:00 am
Location: U.S. Institute of Peace, 2301 Constitution Ave NW, Washington DC 20037

The U.S. Institute of Peace invites you to join us for “The Future of the Syrian Revolution,” a conversation with President Ahmad Jarba, head of the National Coalition for Syrian Revolutionary and Opposition Forces. The event will be President Jarba’s first public address in Washington, DC.

The collapse of the Geneva talks in January has stalled efforts to negotiate a peaceful solution to the conflict. The future of the revolution itself appears increasingly cloudy as the situation on the ground grows more chaotic. The Syrian government’s announcement that it will hold presidential elections in June – elections that President Bashar Assad is widely expected to win – limits chances for a political resolution to the crisis. Many, including the Syrian opposition, have called the elections a democratic charade.

Syrian Opposition Coalition leader Jarba will discuss these dynamics and the role the inte community might play, and assess the delivery of humanitarian assistance as outlined by UN Security Council Resolution 2139. Join the conversation on Twitter with #USIPJarba.

RSVP here.

The Gulf Rising: Defense Industrialization in Saudi Arabia and the UAE
Date: May 7, 12:00 pm
Location: Atlantic Council, 1030 15th Street NW, 12th Floor, Washington DC

Dramatic changes in the world of defense, coupled with increasing political, financial, and fiscal pressures in the transatlantic community, have forced some of the most advanced US industrial allies and partners to make tough choices regarding their national defense programs, leaving them either more dependent on the United States or with capability shortages.

Facing even more stringent circumstances, Saudi Arabia and the United Arab Emirates (UAE)—two modernizing US partners in the Gulf —confront a challenging path to domestic military industrialization. But with carefully articulated goals, modest expectations, smart strategies, effective financial management, and cooperation with Washington, Riyadh and Abu Dhabi can navigate some of the complexities of defense industrialization and overcome some of its key challenges.

This event will launch a report by Bilal Y. Saab entitled The Gulf Rising: Defense Industrialization in Saudi Arabia and the UAE. In it, Saab provides new analysis of and key policy insights on military industrialization in Saudi Arabia and the UAE and adds an important, though often overlooked, dimension to the US policy debate on the US-Gulf partnership.

Register here.

Governing Uranium: Security in the Front-End of the Fuel Cycle
Date: May 7, 1:30 pm
Location: Center for Strategic and International Studies, 1616 Rhode Island Ave NW, Washington DC 20036

The path from ‘ore to bomb’ is long, challenging, and requires sophisticated technologies, but natural uranium is where it starts.  Most attention in nuclear security and nonproliferation has focused on restricting the highest risk material, but recent shifts in the market for natural uranium will introduce new challenges for export controls, transport security, physical protection and tracking of materials.  For example, long-standing uranium consumers such as Japan and Germany are scaling back their reliance on nuclear power, but the ambitious nuclear energy programs of India and China may soon increase global demand for natural uranium.  Meanwhile, new uranium suppliers such as Malawi, Tanzania, and Greenland are entering the global marketplace.  CSIS has partnered with the Danish Institute for International Studies (DIIS) and other international think-tanks in the on-going “Governing Uranium” project to explore the dimensions of security of natural uranium in a changing global market.

Please join us for a discussion with Dr. Cindy Vestergaard, director of the Governing Uranium project and senior researcher at the Danish Institute for International Studies, on the results of the ‘Governing Uranium’ project thus far. Sharon Squassoni, senior fellow and director of the Proliferation Prevention Program at CSIS, will moderate the discussion.

Register here.

Subcommittee Hearing: Assessing the Biological Weapons Threat: Russia and Beyond
Date: May 7, 2:00 pm
Location: U.S. House Committee on Foreign Affairs, 2200 Rayburn House Office Building, Washington DC 20515

Witnesses Amy Smithson, Ph.D, Senior Fellow at the James Martin Center for Nonprolferation Studies, and David R. Franz, Ph.D., Former Commander, U.S. Army Medical Research Institute of Infectious Diseases, discuss this topic on the Subcommittee on Europe, Eurasia, and Emerging Threats.

Watch here.

May 8, 2014

Hearing: Russia’s Destabilization of Ukraine
Date: May 8, 10:00 am
Location: U.S. House Committee on Foreign Affairs, 2172 Rayburn House Office Building, Washington DC 20515

Witnesses Victoria Nuland, Assistant Secretary of the Bureau of European and Eurasian Affairs at the U.S. Department of State, and Daniel Glaser, Assistant Secretary at the Office of Terrorism and Financial Intelligence of the U.S. Department of the Treasury discuss in the Foreign Affairs Committee.

Asymmetric Threats and Space: China, Russia, Non-State Actors, and the Need for Quick Launch Capabilities
Date: May 8, 12:30 pm
Location: American Security Project, 1100 New York Ave NW, 7th Floor-West Tower, Washington DC 20005

In the 21st century, an increasing number of critical national security and intelligence systems are dependent upon technology orbiting our planet.  These technologies may be as covert as imaging systems over enemy territories, or as ubiquitous as the global positioning systems in the average person’s car.  Regardless of the specific type of technology, the threats to it remain consistent.  In order to properly prepare for the attack or destruction of key space infrastructure systems, the United Sates must support domestic suppliers and businesses on the forefront of the sector.

Join ASP Adjunct Fellow, August Cole, along with President of NexGen Space and former NASA advisor, Charles Miller, and Peter Wegner, Director of Advanced Concepts at Space Dynamics Laboratory for a discussion regarding the threats we currently face in space.

Register here.

 

 

Pandora Report 5.2.14

Highlights this week include Smallpox Redux, Antibiotic Resistance, and MERS in America. Check us out @PandoraReport for additional stories about the 1918 flu, Obstacle races and their health impact, the deadliest creature on earth, and Stephen Colbert vs. Anti-Vaxxers. Have a great weekend!

A Smallpox like virus found in the Republic of Georgia

This week, doctors from the Centers for Disease Control and Prevention reported that two herdsmen in the Republic of Georgia have been infected with a new virus that is very similar to smallpox. The news comes in addition to a lot of smallpox talk this week. After unearthing a corpse in Queens, NY, the issue of the virus spreading from dead bodies was raised again. Meanwhile, this month The World Health Assembly (WHA) will meet to discuss destruction of remaining smallpox virus being held in Russia and the U.S. Though the smallpox virus has been eradicated, this new virus in the same family raises concerns about protection from bioterrorists using agents we have no immunity or vaccinations for.

NPR—“Last year the U.S. government spent about $460 million on a relatively new smallpox medicine, in case the virus was deliberately released in a bioterrorism attack. That stockpile could treat about 2 million people.”

MERS Arrives in the U.S. 

An American man returning from Saudi Arabia has been diagnosed with MERS CoV. The man was hospitalized in Indiana and authorities say he poses very little risk to the public.  At least 400 people have been diagnosed with Middle East Respiratory Syndrome and it has killed over 100. Though the disease has not transferred human to human at this point, the high lethality is a concern to health officials.

The Associated Press—“Experts said it was just a matter of time before MERS showed up in the U.S., as it has in Europe and Asia. “Given the   interconnectedness of our world, there’s no such thing as ‘it stays over there and it can’t come here,'” said Dr. W. Ian Lipkin, a Columbia University MERS expert.”

Antibiotic Resistance Threatens Everyone, Warns UN

A United Nations report, released on Wednesday, outlined that antibiotic resistance is now prevalent in all parts of the world and that for up to half of patients antibiotics may not be effective. Many doctors in Canada are encouraging their colleagues to be careful about over-prescribing antibiotics as a “cure all.” If doctors around the world cannot do that, we may be looking at a post-antibiotic future.

CBC-“‘What it means, is that all of us, our family members, all of the persons in this room, our friends, when we are most vulnerable and in need of these medicines, there is a chance that they are simply not going to be available and we are not going to be able to have access to effective medical care in a number of instances,’ Dr. Keiji Fukuda, one of the agency’s assistant directors-general, told reporters.”

 

(image courtesy of Wikimedia Commons/ Arias,F.J)

No Rabies Treatment After All: Failure of the Milwaukee Protocol

By Chris Healey

Doctors are abandoning the only treatment for rabies.

The Milwaukee protocol, a procedure reported to prevent death after the onset of rabies symptoms, has been performed over 26 times since its inception in 2004 but has only saved one life. Overwhelming failure has lead health officials to label the protocol a red herring.

Rabies is caused by the rabies virus, an RNA-based virus in the genus Lyssavirus. Transmission typically occurs when virus-laden saliva from a rabid animal enters a wound or mucous membrane. Infection typically occurs from a rabid animal bite. The virus travels along peripheral nerves until it reaches the brain and salivary glands. A characteristic rabies symptom is aversive behavior toward water or water consumption called hydrophobia. Individuals demonstrating hydrophobia will generally avoid water and resist drinking it. Other symptoms include anxiety, nerve pain, itching, impaired sensation of touch, convulsions, paralysis, and coma. Cases among unvaccinated individuals almost always result in death.


The Milwaukee protocol was conceived in 2004 by a team of medical professionals, led by Dr. Rodney Willoughby, after a 15-year-old girl was admitted to a Milwaukee hospital after a rabies diagnosis.

After consulting with researchers at the Centers for Disease Control and Prevention in Atlanta, the team formulated and implemented a novel procedure. The patient was placed in a drug-induced coma and given an antiviral cocktail composed of ketamine, ribavirin, and amantadine. Considering the theory that rabies pathology stems from central nervous system neurotransmitter dysfunction, doctors hypothesized suppressed brain activity would minimize damage while the patient’s immune system developed an adequate response.

The patient was discharged from the hospital 76 days after admission. She demonstrated speech impediment and difficulty walking during a clinic visit 131 days after discharge. It is unclear how long those conditions persisted. In subsequent years, the patient attended college. She remains the only Milwaukee protocol success.


There has been confusion regarding the efficacy of the Milwaukee protocol. A 2009 report published by Dr. Willoughby in the journal Future Virology described the efficacy and promise of the procedure. In that article, Dr. Willoughby cited two new instances of rabies patient survival following Milwaukee protocol implementation. Those two cases brought the total number of rabies patients saved by Milwaukee protocol procedure to three. However, those survivor reports were rebuked by a 2013 article published in the journal Antiviral Research. That article explicitly states Dr. Willoughby’s claims in Future Virology are misleading because the two patients mentioned actually succumbed to rabies.

Overwhelming Milwaukee protocol failure has been attributed to anomaly in the initial patient. For example, she was bitten by a bat, but that bat was not recovered. Without the bat, it is impossible to test the causative rabies agent to rule out a less virulent variant. A mild version could be fought off more easily and could help explain her survival. Additionally, researchers cannot rule out the possibility the patient possessed extraordinary physiology that somehow impaired the rabies progression.

Health officials claim Milwaukee protocol repetition impedes efforts to find new treatments. Instead of exploring new techniques, doctors fall back on the Milwaukee protocol because it was once successful. Crushing failure has prompted the health community to place a taboo on the protocol, encouraging experimentation that may lead to different treatment options.

 

Image Credit: CDC

C. botulinium’s Deadliest Toxin: To Share or Not To Share?

By Alena M. James

Two years ago, Dr. Stephen Arnon and Dr. Jason Barash discovered a new strain of Clostridium botulinum. Typical C. botulinum strains are known to express any of the seven different botulinum neuron toxins, Botulinum Toxin Types A-G.  The new strain discovered by Arnon and Barash, after studying infant botulism at the California Department of Public Health in Sacramento, was found to express neurological toxins, Botulinium Toxin Type B and a new Botulinum Toxin Type H.   Dr. Arnon and Dr. Barash published their findings of the new toxin in the Journal of Infectious Diseases in 2013, but elected to withhold from the public and the rest of the scientific community any genetic sequencing information regarding the new strain. The withholding of this information has remained a point of contention between the researchers and individuals representing various organizations wishing to study the bacteria.

After publishing a story on the case last Monday, NPR revealed that Dr. Arnon had not been engaging in scientific information sharing practices regarding the new toxin with other professionals also studying botulinum toxins. According to NPR’s coverage, Dr. Arnon remained reluctant to disseminate information on the newly discovered neurotoxin, Type H, with other scientists or with federal officials. In an article published by New Scientist, the editors of the Journal of Infectious Diseases announced that Arnon and Barash held consultations with several representatives from different federal agencies before deciding against publishing genetic sequencing information on the new stain in their scientific article.

From NPR’s coverage of this case, federal officials claim they were not responsible for the researcher’s decision to not make the genetic sequences available and never said not to publish the information. Given the lack of an antitoxin antidote available to stop the dangerous effects of the Type H toxin, many individuals desire to perform research on the strain of C. botulinum that can produce the Type H toxin. Several scientists and federal institutions have tried to request the sequences and/or live strains of Arnon’s new strain of C. botulinum. However, Arnon remains steadfast in not sharing the bacteria.

The case raises an unresolved issue that persists in the sciences. That issue is defining the parameter by which we are able to distinguish dual use research.  Dual use research in the biological sciences is research that can be performed to benefit humans, but can also be performed to harm humans. In this particular case, the Type H Toxin has been declared the most deadly toxin and has great potential to be deployed as a biological weapon.  The absence of an available antitoxin that can be administered to infected patients raises great cause for concern that the bacteria producing the toxin could be mass-produced to harm innocent people. From NPR’s story, it seems that this sentiment is shared with Type H’s discover Arnon.

Upon Arnon’s discovery of Type H, the CDC, US Army Laboratories, and DHS all expressed interest in acquiring the strain that produces this new neurotoxin. These federal institutions’ interest in studying the toxin in order to develop a cure is the same goal as numerous other scientists who want to perform research on the strain. So how does one build biodefense against a pathogen one cannot gain access?  Maybe from Dr. Arnon’s perspective, keeping Pandora’s Box closed maybe the best weapon of defense for the US against the botulinum Type H neurotoxin.

 

You can listen to NPR’s initial report of this story here.

Image Credit